Article
Neurosciences
Adolfo E. Cuadra, Fuu-Jiun Hwang, Lindsay M. Burt, William C. Edmonds, Anastasia V. Chobany, Geng-Lin Li
Summary: The study found that clearance of Ca2+ dynamics in paired hair cell synapses follows a double exponential function, with the fast component significantly reduced under prolonged stimulation. Inhibiting PMCA, MCU, or SERCA increased both basal Ca2+ levels and the Ca2+ rise during sinusoidal stimulation, while significantly reducing phase-locking of synaptic vesicle releases from hair cells.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Summary: Long-term depression (LTD) of synaptic strength is associated with circuit remodeling, memory encoding, and erasure. P2XR- and NMDAR-dependent LTD are linked to distinct molecular modifications that lead to specific changes in synapse function.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jing Zhang, Weiwei Qin, Che Hu, Siyu Gu, Xiaocui Chai, Mingkun Yang, Fang Zhou, Xueyan Wang, Kai Chen, Guanxiong Yan, Guangying Wang, Chuanqi Jiang, Alan Warren, Jie Xiong, Wei Miao
Summary: Spirostomum, a giant single-celled eukaryote, demonstrates one of the fastest movements in the biological world. Its ultrafast contraction relies on Ca2+ instead of ATP, distinguishing it from the actin-myosin system in muscles. By analyzing the high-quality genome of Spirostomum minus, we identified key molecular components of its contractile apparatus, including two major Ca2+ binding proteins (Spasmin 1 and 2) and two giant proteins (GSBP1 and GSBP2) that form a complex allowing for repetitive ultrafast cell contraction and extension. These findings enhance our understanding of Ca2+-dependent ultrafast movement and offer insights for future biomimicry and construction of similar micro-machines.
Article
Neurosciences
Marcelo J. Moglie, Diego L. Wengier, A. Belen Elgoyhen, Juan D. Goutman
Summary: Normal cochlear function requires precise control of intracellular Ca2+ levels, with Ca2+ influx occurring at the stereocilia tips and basolateral membrane. Two different sources of Ca2+ influx in the basolateral membrane, VGCCs and alpha 9 alpha 10 receptors, are regulated differently, suggesting well-tuned mechanisms to separate the two OHC synaptic functions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Fang Zheng, Jurgen Wess, Christian Alzheimer
Summary: M1 and M3 receptors have different effects on plasticity at the mossy fiber-CA3 pyramidal cell synapse, with enhancement of plasticity in the absence of M1/M3 and attenuation of plasticity in the absence of M2.
Article
Neurosciences
Nicole F. Wong, Matthew A. Xu-Friedman
Summary: Exposure to nontraumatic noise can cause changes in auditory nerve synapses, potentially affecting hearing. Nitric oxide (NO) plays a crucial role in inducing these synaptic changes, and the activation of auditory nerve fibers leads to the release of NO, causing long-lasting alterations in synaptic function.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Noa Lipstein, Shuwen Chang, Kun-Han Lin, Francisco Jose Lopez-Murcia, Erwin Neher, Holger Taschenberger, Nils Brose
Summary: In this study, it was found that Munc13-1 regulates the recruitment rate of release-ready synaptic vesicles through a calcium-phospholipid-dependent mechanism, impacting the endurance and temporal accuracy of synaptic transmission.
Article
Multidisciplinary Sciences
Chao Li, Xumeng Zhang, Pei Chen, Keji Zhou, Jie Yu, Guangjian Wu, Du Xiang, Hao Jiang, Ming Wang, Qi Liu
Summary: Neuromorphic computing is a promising computing paradigm for next-generation AI machines, and synaptic plasticity is vital for information processing. While long-term plasticity (LTP) has been extensively studied, the implementation of short-term plasticity (STP) in hardware remains challenging. This review discusses the physics and biological behaviors of STP, explores its computational functions in biology, reviews recent progress, and proposes potential approaches to utilize STP in synaptic devices, aiming to enrich neuromorphic machines' capabilities.
Article
Cell Biology
Na Zhao, Wenhui Huang, Bogdan Catalin, Anja Scheller, Frank Kirchhoff
Summary: NG2 glia are essential proliferating cells in the CNS that can differentiate into oligodendrocytes and regulate homeostasis through secretion of growth factors and cytokines. L-type VGCCs in NG2 glia play a crucial role in cell proliferation and proper structural organization of nodes of Ranvier, while not affecting differentiation and myelin compaction. Additionally, L-type VGCCs contribute to the regulation of long-term neuronal plasticity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Jiyoung Kang, Jinseok Eo, Dong Myeong Lee, Hae-Jeong Park
Summary: This study introduces a computational framework for optimal brain control with self-adjustment, focusing on adjusting the brain's effective connectivity after treatment. Simulations demonstrate the feasibility of controlling the self-adjusting neural system within a restricted treatment setting using various treatment strategies. The proposed framework aims to help optimize control of the dynamic brain after treatment.
Article
Chemistry, Multidisciplinary
Hanlin Wang, Yusheng Chen, Zhenjie Ni, Paolo Samori
Summary: In this study, an electrochemical-electret coupled organic synapse (EECS) with a reversible facilitation-to-depression switch is designed, which can emulate the function of biological synapses. By adjusting the energy level offset, the transition threshold of the device can be tuned for specific applications, providing additional responsiveness. This novel synapse architecture represents a significant advancement in the field of artificial organic synapses and opens up new possibilities for the fabrication of abiotic neural networks.
ADVANCED MATERIALS
(2022)
Article
Developmental Biology
Amanda S. Janesick, Mirko Scheibinger, Nesrine Benkafadar, Sakin Kirti, Stefan Heller
Summary: The study found changes in gene expression of immune-related genes in chicken basilar papilla after hair cell loss, and the JAK/STAT signaling pathway plays a crucial role in this process.
Review
Neurosciences
Aditya Asopa, Upinder S. Bhalla
Summary: Short-term plasticity (STP) and excitatory-inhibitory balance (EI balance) are fundamental building blocks of brain circuits across the animal kingdom. Synapses involved in EI are influenced by STP, and experimental studies have shown overlapping effects. Recent computational and theoretical work has highlighted the functional implications of the intersection of these motifs. The findings suggest that the combination of STP and EI balance is a versatile and efficient neural building block for a wide range of pattern-specific responses.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lisa S. Nolan, Jing Chen, Ana-Claudia Goncalves, Anwen Bullen, Emily R. Towers, Karen P. Steel, Sally J. Dawson, Jonathan E. Gale
Summary: Cell cycle associated protein 1 (Caprin1) is an RNA-binding protein that regulates cellular response to stress. Research has found that Caprin1 plays a crucial role in maintaining auditory function by regulating the normal state of the inner hair cell-spiral ganglion neuron synapse.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Mahsa Samadi, Claire A. Hales, Daniel J. Lustberg, Shannon Farris, Madeleine R. Ross, Meilan Zhao, John R. Hepler, Nicholas H. Harbin, Emma S. J. Robinson, Paul J. Banks, Zafar I. Bashir, Serena M. Dudek
Summary: Pyramidal cells in hippocampal area CA2 have distinct synaptic properties, including a lack of typical long-term potentiation. This study investigated the role of metabotropic glutamate receptor (mGluR)-dependent signaling regulators in CA2 synaptic plasticity. The results showed that mGluR agonist-induced long-term depression (mGluR-LTD) is more pronounced in CA2 compared to CA1, and that this process depends on protein synthesis and the presence of STEP and RGS14 proteins. Additionally, RGS14 was found to play a crucial role in CA2 mGluR-LTD. Furthermore, RGS14 knockout mice showed impaired social recognition memory, suggesting a role for CA2 synaptic plasticity in social cognition.
Article
Chemistry, Physical
Zhongrui Wang, Saumil Joshi, Sergey E. Savel'ev, Hao Jiang, Rivu Midya, Peng Lin, Miao Hu, Ning Ge, John Paul Strachan, Zhiyong Li, Qing Wu, Mark Barne, Geng-Lin Li, Huolin L. Xin, R. Stanley Williams, Qiangfei Xia, J. Joshua Yang
Article
Neurosciences
Daniil Frolov, Geng-Lin Li
Article
Neurosciences
Geng-Lin Li, Erica Keen, Daniel Andor-Ardo, A. J. Hudspeth, Henrique von Gersdorff
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Cole W. Graydon, Soyoun Cho, Geng-Lin Li, Bechara Kachar, Henrique von Gersdorff
JOURNAL OF NEUROSCIENCE
(2011)
Review
Neurosciences
Mean-Hwan Kim, Geng-Lin Li, Henrique von Gersdorff
JOURNAL OF PHYSIOLOGY-LONDON
(2013)
Article
Neurosciences
Geng-Lin Li, Soyoun Cho, Henrique von Gersdorff
Article
Multidisciplinary Sciences
Hua Wen, Michael W. Linhoff, Matthew J. McGinley, Geng-Lin Li, Glen M. Corson, Gail Mandel, Paul Brehm
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Neurosciences
Addison Billing, Marcelo Henrique Correia, Diane A. Kelly, Geng-Lin Li, Joseph F. Bergan
Article
Cell Biology
Ning Yin, Jingjing Zhao, Panpan Zhang, Baofu Yu, Renjie Chai, Geng-Lin Li
Summary: Hearing loss, predominantly caused by gene mutations, is a common neurosensory disorder. This study used knock-out and point mutation mice as models to investigate the synaptic changes in inner hair cells related to the complex mechanisms of MYO6 mutations. The results reveal altered exocytosis and calcium influx in both immature and mature hair cells, providing insights for the diagnosis and treatment of deafness.
CELL DEATH DISCOVERY
(2023)
Article
Neurosciences
Geng-Lin Li, Jozsef Vigh, Henrique von Gersdorff
JOURNAL OF NEUROSCIENCE
(2007)
Article
Neurosciences
Court Hull, Geng-Lin Li, Henrique von Gersdorff
JOURNAL OF NEUROSCIENCE
(2006)
Article
Neurosciences
J Vigh, GL Li, C Hull, L von Gersdorff
Article
Neurosciences
RM Leao, C Kushmerick, R Pinaud, R Renden, GL Li, H Taschenberger, G Spirou, SR Levinson, H von Gersdorff
JOURNAL OF NEUROSCIENCE
(2005)
Article
Biochemistry & Molecular Biology
Jian Liu, Geng-Lin Li, Xiong-Li Yang