Article
Biology
Anthea Weng, Erik E. Rabin, Annette S. Flozak, Sergio E. Chiarella, Raul Piseaux Aillon, Cara J. Gottardi
Summary: The adherens junction component, alpha-T-catenin (alpha Tcat), plays an important role in the junction structure of cardiomyocytes and in cell-cell junctions in the nervous system. Recent genomic studies have linked CTNNA3 polymorphisms to various diseases, suggesting its involvement in maintaining neuroglial functions of the central and peripheral nervous systems.
Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Jenica Acheta, Jiayue Hong, Haley Jeanette, Simrandeep Brar, Anish Yalamanchili, M. Laura Feltri, M. Chiara Manzini, Sophie Belin, Yannick Poitelon
Summary: The study found that CC2D1B plays a role in developmental myelination in the central nervous system. These results suggest that CC2D1B could contribute to gene regulation during oligodendrocyte myelination in optic nerves.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Brendan Zotter, Or Dagan, Jacob Brady, Hasna Baloui, Jayshree Samanta, James L. Salzer
Summary: Peripheral nerves are organized into compartments and Gli1 is a crucial transcriptional effector involved in nerve development, regulation of extracellular matrix production, and nerve vascular organization. Gli1 and Dhh have nonredundant roles in peripheral nerve development.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
D. A. Santiago Gonzalez, V. T. Cheli, S. L. Rosenblum, G. Denaroso, P. M. Paez
Summary: Ceruloplasmin is an essential ferroxidase enzyme for cell iron efflux and plays a crucial role in promoting the maturation of OLs and SCs by regulating iron balance and preventing oxidative stress and neurodegeneration in the central and peripheral nervous systems.
Article
Neurosciences
Ruyi Mei, Linyu Huang, Mengyuan Wu, Chunxia Jiang, Aifen Yang, Huaping Tao, Kang Zheng, Junlin Yang, Wanhua Shen, Xianjun Chen, Xiaofeng Zhao, Mengsheng Qiu
Summary: Itpr2 plays a crucial role in the developmental process of oligodendrocytes, with its deficiency leading to increased myelination of small-diameter axons by oligodendrocytes, hence affecting the normal functioning of the nervous system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Deepak Prasad Gupta, Anup Bhusal, Md Habibur Rahman, Jae-Hong Kim, Youngshik Choe, Jaemyung Jang, Hyun Jin Jung, Un-Kyung Kim, Jin-Sung Park, Lee-so Maeng, Kyoungho Suk, Gyun Jee Song
Summary: This study reveals the essential role of EBP50 in the repair function of Schwann cells and regeneration following nerve injury. EBP50 deficiency leads to deficits in Schwann cell functions and delays nerve repair and functional recovery. Additionally, EBP50 enhances regeneration by binding and activating ErbB2.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Cell Biology
Clara Mutschler, Shaline V. Fazal, Nathalie Schumacher, Andrea Loreto, Michael P. Coleman, Peter Arthur-Farraj
Summary: Coculturing dissociated mouse Schwann cells (SCs) and dorsal root ganglion (DRG) neurons in microfluidic chambers can induce robust myelination and is a valuable technique for studying peripheral nervous system (PNS) myelination, injury, and regeneration. This model allows separate genetic manipulation of mouse SCs or neurons and can be used to complement in vivo mouse experiments. Live imaging of cocultures reveals that SCs are axo-protective and can clear axonal debris after traumatic axotomy.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Peng Yu, Guanhua Zhang, Bo Hou, Enpeng Song, Jiaming Wen, Yueyang Ba, Donglin Zhu, Gangwei Wang, Feng Qin
Summary: Complete myelination and formation of myelinated fibers are essential for functional nerve regeneration after peripheral nerve injury. Suboptimal myelin regeneration is common and can hinder ideal nerve regeneration. Therefore, closely monitoring and supporting myelin regeneration in patients with PNI is important for optimal outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinghui Xu, Bin Zhang, Jieyi Cai, Qianqian Peng, Junxia Hu, Parizat Askar, Jianghong Shangguan, Wenfeng Su, Changlai Zhu, Hualin Sun, Songlin Zhou, Gang Chen, Xiaoming Yang, Yun Gu
Summary: This study reveals that the transcriptional factor Stat1 plays a crucial role in myelination. Its deletion inhibits Schwann cell differentiation, leading to impaired myelination. Stat1 interacts with the promoter of Rab11fip1 to initiate Schwann cell differentiation. These findings uncover a novel function of Stat1 and provide a candidate molecule for clinical intervention in demyelinating diseases.
MOLECULAR MEDICINE
(2023)
Article
Biology
Dora Romhanyi, Kornelia Szabo, Lajos Kemeny, Endre Sebestyen, Gergely Groma
Summary: An increasing amount of evidence suggests the critical role of the cutaneous nervous system in the initiation and maintenance of psoriatic skin lesions through neurogenic inflammation. This study reanalyzed a psoriatic RNA sequencing dataset to identify molecular mechanisms affecting cutaneous neurons. The analysis revealed differential expression of transcripts related to nervous system development and functions, particularly those involved in neurite formation. These findings suggest that SEMA-PLXN and ROBO-DCC-UNC5, which regulate axonal growth and repulsion, are differentially affected in non-lesional and lesional skin samples. The study also identified expressional alterations in axonal guidance signaling ligands, including WNT5A, which may explain the abnormal cutaneous nerve filament formation observed in psoriatic skin. Furthermore, these processes also influence T-cell activation and infiltration, adding to the understanding of the crosstalk between the cutaneous nervous system and immune responses in psoriasis pathogenesis, alongside known neurogenic pro-inflammatory mediators.
Article
Neurosciences
Min You, Haizhu Xing, Ming Yan, Jie Zhang, Jiayi Chen, Yang Chen, Xiaoli Liu, Jing Zhu
Summary: Paclitaxel-induced peripheral neuropathy (PIPN) is a neurological disorder caused by paclitaxel (PTX) treatment in cancer patients. Schwann cell-derived exosomes (SC-EXOs) have been found to effectively improve PIPN both in vitro and in vivo. SC-EXOs alleviate PTX-induced mechanical nociceptive sensitization, ameliorate nerve fiber loss and DRG injury, and protect damaged neurons by upregulating miR-21 to repress the PTEN signaling pathway. These findings provide a novel strategy for the treatment of PIPN.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Rulan Yi, Huanyao Tang, Xiaoling Liang, Xu Wang, Ning Zhang, Fuwang Zhong, Tian Yu, Liang Zhou
Summary: This study found that GAS can restore myelination in the mPFC and alleviate depression-like behaviors induced by CRS. Treatment with GAS and CF in 'De' mice improved depression-like behaviors and restored myelination in the mPFC. GAS exerts its effects by inhibiting the activity of the Notch and 0-catenin pathways.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemical Research Methods
Allison Maker, Barry M. Gumbiner
Summary: This study reconstitutes the complete and full-length cadherin-catenin complex and observes it using nanodiscs and cryo-EM. The affinities of the binding interactions between alpha-catenin, beta-catenin, p120-catenin, and the E-cadherin cytoplasmic tail are analyzed. The results reveal the role of p120-catenin in adhesion activation.
PROTEIN EXPRESSION AND PURIFICATION
(2022)
Article
Biology
Amy Wang, Alexander R. Dunn, William Weis
Summary: Mechanotransduction at cell-cell adhesions is crucial for the structural integrity, organization, and morphogenesis of epithelia. The E-cadherin/beta-catenin/alpha E-catenin complexes can sense and transmit mechanical load by interacting with F-actin.
Correction
Biochemistry & Molecular Biology
Adrian Sanz-Moreno, David Fuhrmann, Armin Zankel, Herbert Reingruber, Lara Kern, Dies Meijer, Axel Niemann, Hans-Peter Elsaesser
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Hematology
Polynikis Kaimakis, Emma de Pater, Christina Eich, Parham Solaimani Kartalaei, Mari-Liis Kauts, Chris S. Vink, Reinier van der Linden, Martine Jaegle, Tomomasa Yokomizo, Dies Meijer, Elaine Dzierzak
Article
Neurosciences
Susanne Quintes, Bastian G. Brinkmann, Madlen Ebert, Franziska Froeb, Theresa Kungl, Friederike A. Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W. Sereda, Klaus-Armin Nave
NATURE NEUROSCIENCE
(2016)
Article
Neurosciences
Cristina Benito, Catherine M. Davis, Jose A. Gomez-Sanchez, Mark Turmaine, Dies Meijer, Valeria Poli, Rhona Mirsky, Kristjan R. Jessen
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Dick Jaarsma, Francois G. C. Blot, Bin Wu, Subramanian Venkatesan, Jan Voogd, Dies Meijer, Tom J. H. Ruigrok, Zhenyu Gao, Martijn Schonewille, Chris I. De Zeeuw
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Adrian Sanz-Moreno, David Fuhrmann, Armin Zankel, Herbert Reingruber, Lara Kern, Dies Meijer, Axel Niemann, Hans-Peter Elsaesser
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle, Toshika Ohkawa, Naoki Takahashi, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Keiji Imoto, Dies Meijer, Masahiko Watanabe, Masaki Fukata
Article
Biology
Daniel G. Booth, Alison J. Beckett, Ian A. Prior, Dies Meijer
Article
Multidisciplinary Sciences
Mert Duman, Adrien Vaquie, Gianluigi Nocera, Manfred Heller, Michael Stumpe, Devanarayanan Siva Sankar, Joern Dengjel, Dies Meijer, Teppei Yamaguchi, Patrick Matthias, Thomas Zeis, Nicole Schaeren-Wiemers, Antoinette Hayoz, Sophie Ruff, Claire Jacob
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Daniel G. Booth, Nina Kozar, Stephen Bradley, Dies Meijer
Summary: Disruption of axon-glia interactions in the peripheral nervous system is a major cause of arthrogryposis multiplex congenita (AMC), with LGI4 and ADAM22 being genes implicated in the condition. Mutations in LGI4 may result in reduced secretion of the protein, but do not appear to affect its binding to ADAM22 or its myelination-promoting function.
Article
Multidisciplinary Sciences
Michael Hamm, Pierre Sohier, Valerie Petit, Jeremy H. Raymond, Veronique Delmas, Madeleine Le Coz, Franck Gesbert, Colin Kenny, Zackie Aktary, Marie Pouteaux, Florian Rambow, Alain Sarasin, Nisamanee Charoenchon, Alfonso Bellacosa, Luis Sanchez-del-Campo, Laura Mosteo, Martin Lauss, Dies Meijer, Eirikur Steingrimsson, Goran B. Jonsson, Robert A. Cornell, Irwin Davidson, Colin R. Goding, Lionel Larue
Summary: BRN2 is a key transcription factor that regulates melanoma invasion, but its role in melanoma initiation was previously unclear. This study shows that BRN2 acts as a haplo-insufficient tumor suppressor that positively regulates PTEN expression, and in the context of BRAF mutation and heterozygous PTEN, loss of BRN2 promotes melanoma initiation and progression.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Norihiko Yokoi, Yuko Fukata, Kei Okatsu, Atsushi Yamagata, Yan Liu, Makoto Sanbo, Yuri Miyazaki, Teppei Goto, Manabu Abe, Hidetoshi Kassai, Kenji Sakimura, Dies Meijer, Masumi Hirabayashi, Shuya Fukai, Masaki Fukata
Summary: The percentage of protein function required to prevent disease symptoms is a crucial question in genetic disorders. This study found that dual phosphorylation of ADAM22 by PKA regulates high-affinity binding of ADAM22 to dimerized 14-3-3, protecting LGI1-ADAM22 from degradation. Results suggest that targeting PKA or 14-3-3 could increase LGI1-ADAM22 complexes beyond necessary levels for epilepsy treatment.
Article
Genetics & Heredity
Dana Marafi, Nina Kozar, Ruizhi Duan, Stephen Bradley, Kenji Yokochi, Fuad Al Mutairi, Nebal Waill Saadi, Sandra Whalen, Theresa Brunet, Urania Kotzaeridou, Daniela Choukair, Boris Keren, Caroline Nava, Mitsuhiro Kato, Hiroshi Arai, Tawfiq Froukh, Eissa Ali Faqeih, Ali M. AlAsmari, Mohammed M. Saleh, Filippo Pinto E. Vairo, Pavel N. Pichurin, Eric W. Klee, Christopher T. Schmitz, Christopher M. Grochowski, Tadahiro Mitani, Isabella Herman, Daniel G. Calame, Jawid M. Fatih, Haowei Du, Zeynep Coban-Akdemir, Davut Pehlivan, Shalini N. Jhangiani, Richard A. Gibbs, Satoko Miyatake, Naomichi Matsumoto, Laura J. Wagstaff, Jennifer E. Posey, James R. Lupski, Dies Meijer, Matias Wagner
Summary: The LGI family of genes, including LGI1-4, are highly expressed in the nervous systems of mammals. Variations in LGI1 and LGI4 are associated with neurological disorders, while no diseases have been reported to be associated with LGI2 or LGI3. This study identified individuals with deleterious variants in LGI3 and found that these variants cause a clinically recognizable PNHS trait characterized by developmental delay and intellectual disability.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Maria Eleni Kastriti, Louis Faure, Dorothea Von Ahsen, Thibault Gerald Bouderlique, Johan Bostroem, Tatiana Solovieva, Cameron Jackson, Marianne Bronner, Dies Meijer, Saida Hadjab, Francois Lallemend, Alek Erickson, Marketa Kaucka, Viacheslav Dyachuk, Thomas Perlmann, Laura Lahti, Jan Krivanek, Jean-Francois Brunet, Kaj Fried, Igor Adameyko
Summary: The study reveals the similarities between Schwann cell precursors (SCPs) and neural crest cells in terms of transcriptional profiles and cell fate. SCPs diverge from neural crest cells during lineage differentiation. Defects in SCPs may affect neural crest cells along peripheral nerves and are associated with certain tumor development.
Article
Cell Biology
Nina Kozar-Gillan, Atanaska Velichkova, George Kanatouris, Yael Eshed-Eisenbach, Gavin Steel, Martine Jaegle, Eerik Aunin, Elior Peles, Carole Torsney, Dies N. N. Meijer
Summary: This study reveals a novel molecular pathway involving LGI3/2-ADAM23 interactions that cluster and stabilize Shaker-type voltage-gated potassium channels (Kv1) in myelinated axons. These myelin concealed Kv1 channels play a significant role in modifying axonal physiology.
JOURNAL OF CELL BIOLOGY
(2023)