Article
Medicine, Research & Experimental
VyVy N. Young, Joseph Kidane, Grant E. Gochman, David J. Bracken, Yue Ma, Clark A. Rosen
Summary: This study is the first to objectively assess laryngopharyngeal sensation in AdLD. The findings demonstrate increased laryngopharyngeal sensation in AdLD patients compared to controls. The identification of increased laryngeal hypersensitivity in these patients may improve understanding of AdLD pathophysiology and identify future targets for intervention.
Article
Clinical Neurology
Lena C. O'Flynn, Kristina Simonyan
Summary: This study investigated the short-term and long-term effects of BoNT treatment on brain function in patients with LD. The results suggest that BoNT-treated patients who benefited from the treatment had reduced activity in the left precuneus compared to untreated patients and patients who did not benefit from the treatment. Additionally, BoNT-treated patients with adductor LD showed decreased activity in the right thalamus, while patients with abductor LD showed reduced activity in the left inferior frontal cortex. There were no significant differences in brain activity between patients with shorter and longer treatment durations. However, patients with intermediate treatment duration of 6-12 years showed reduced activity in the right cerebellum and right prefrontal cortex compared to patients with shorter treatment duration.
Review
Food Science & Technology
Winnie Yeung, Amanda L. Richards, Daniel Novakovic
Summary: Laryngeal dystonia is a chronic disorder affecting laryngeal movement, primarily interfering with phonation and speech, significantly diminishing patients' quality of life. Botulinum neurotoxin is the standard treatment for LD, with this article providing a comprehensive overview of its clinical application and therapeutic injection techniques in managing LD.
Review
Medicine, General & Internal
Maja Rogic Vidakovic, Ivana Gunjaca, Josipa Bukic, Vana Kosta, Josko Soda, Ivan Konstantinovic, Braco Boskovic, Irena Bilic, Nikolina Rezic Muzinic
Summary: This narrative review provides a summary of the patho-neuro-physiological and genetic background of focal laryngeal dystonia (LD), as well as the standard treatment options and potential future therapies. It also presents two LD cases and discusses the diagnostic procedures and achievements in treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Kristina Simonyan, Julie Barkmeier-Kraemer, Andrew Blitzer, Mark Hallett, John F. Houde, Teresa Jacobson Kimberley, Laurie J. Ozelius, Michael J. Pitman, Robert Mark Richardson, Nutan Sharma, Kristine Tanner
Summary: Research priorities for improving clinical management of laryngeal dystonia should focus on identifying disorder-specific biomarkers, elucidating critical nodes within neural networks, and fostering collaborations to facilitate rapid progress in understanding and treatment of this rare disorder.
Article
Audiology & Speech-Language Pathology
Amy Rutt, Kathleen D. Kennelly, Jhon F. Martinez-Paredes
Summary: This study explores nonbiological factors that can affect the patient experience during Laryngeal Botulinum Toxin injection (LBTX) therapy for Adductor Spasmodic Dysphonia. The study identifies preprocedure education, body position, pain, and stress sensation as potential factors influencing treatment outcomes.
Article
Otorhinolaryngology
Antonia Lagos-Villaseca, Neel K. Bhatt, Parirash Abdolhosseini, Leonel Quinonez, Marcus F. Paoletti, Grant Gochman, Michael M. Johns, Clark A. Rosen, Tzu-Cheg Kao, Tanya K. Meyer
Summary: This study found that despite insurance companies usually mandating a minimum 3-month interval for BoNT treatment injections, there are still many patients with LD and ETVT who choose to receive shorter interval injections to optimize their vocal function.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Otorhinolaryngology
Nupur Kapoor Nerurkar, Deeksha Agrawal, Dipali Joshi
Summary: The study revealed a significant association between patients of spasmodic dysphonia (SD) with an abductor component (ABSD and mixed SD) and vocal fold sulcus, possibly due to asymmetric adductor and abductor muscle stimulation in SD or the primary presence of a vocal fold sulcus contributing to altered sensory feedback resulting in SD. Further research is recommended to evaluate this association and study the vocal response to medialisation procedures for ABSD patients with sulcus.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Robert Brinton Fujiki, Caitlin K. Croegaert-Koch, Susan L. Thibeault
Summary: The study aimed to examine the impact of patient voice-related diagnosis, dysphonia severity, and rater's experience on the correlation between laryngeal oscillation ratings obtained from videostroboscopic and high-speed videoendoscopic (HSV) exams. The results indicated that the correlation between the ratings was stronger for patients with benign vocal fold lesions compared to those with adductor spasmodic dysphonia (ADSD). Differences between the two exams were more significant for various ratings in ADSD patients, especially for raters with less experience. The study suggests further research is needed to understand the clinical implications of these differences.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Maryam Naghibolhosseini, Stephanie R. C. Zacharias, Sarah Zenas, Farrah Levesque, Dimitar D. Deliyski
Summary: This study used laryngeal high-speed videoendoscopy (HSV) to measure the glottal attack time (GAT) and glottal offset time (GOT) during connected speech for normophonic and adductor spasmodic dysphonia (AdSD) voices. The results showed that the GAT was longer in the AdSD group compared to the normophonic group, and there was more variability in both GATs and GOTs in the AdSD group. The study suggested that GAT and GOT measures could be used as objective markers for characterizing AdSD and aiding in the accurate diagnosis of the condition.
APPLIED SCIENCES-BASEL
(2023)
Article
Otorhinolaryngology
Nikita Kohli, Michael Lerner, Jamie Rashty, Diana Kirke, Thomas Stewart, Andrew Blitzer
Summary: This study demonstrates the efficacy of incobotulinumtoxinA in the treatment of adductor spasmodic dysphonia and its potential as an alternative for non-responders to onabotulinumtoxinA.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Victoria Vanderaa, Lisa A. Vinney
Summary: The objective of this research was to determine whether there is an association between laryngeal exploration and the prevalence of self-reported upper respiratory infection (URI) at the time of SD onset. Individuals with and without SD were recruited to complete an online survey measure. Significant associations were found between ADSD and LH, mixed SD and LH, and URI at time of SD onset and increased severity of LH symptoms.
Article
Audiology & Speech-Language Pathology
Katherine L. Marks, Taylor F. Feaster, Sarah Baker, Manuel E. Diaz-Cadiz, Philip C. Doyle, Cara E. Stepp
Summary: Currently, there is a lack of clinically feasible objective measures specific to adductor laryngeal dystonia (LD). This study aimed to establish concurrent validity of a new automated acoustic outcome measure, SAHf(o), for tracking treatment progress of LD. The results provide evidence of its validity.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2022)
Article
Medicine, Research & Experimental
Arthur Thomas, Natasha Mirza, Steven J. Eliades
Summary: In this study, patients with spasmodic dysphonia showed increased sensitivity to altered auditory feedback during sustained phonation. They exhibited significantly higher vocal pitch compensation and greater variability compared to controls. However, vocal compensation did not show significant correlations with patient demographics, but did show a significant inverse correlation with VHI.
Article
Medicine, Research & Experimental
Grant E. Gochman, Christopher D. Dwyer, VyVy N. Young, Clark A. Rosen
Summary: This study aimed to assess patients' preferences among a selection of voice-related PROMs and investigate associations between selected instruments. The results showed that VHI-10 and CPIB-10 were the most preferred, while OMNI-VES and VAS were less favored. Patients of different age groups had different preferences for PROMs.
Review
Clinical Neurology
Christy L. Ludlow
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2015)
Review
Clinical Neurology
Christy L. Ludlow
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2015)
Article
Clinical Neurology
Ling Yan, Matt Hicks, Korey Winslow, Cynthia Comella, Christy Ludlow, H. A. Jinnah, Ami R. Rosen, Laura Wright, Wendy R. Galpern, Joel S. Perlmutter
PARKINSONISM & RELATED DISORDERS
(2015)
Article
Physiology
Sarah Hegyi Szynkiewicz, Rachel W. Mulheren, Kathryn W. Palmore, Cynthia R. O'Donoghue, Christy L. Ludlow
JOURNAL OF APPLIED PHYSIOLOGY
(2016)
Article
Neurosciences
Rachel W. Mulheren, Erin Kamarunas, Christy L. Ludlow
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
Seng Mun Wong, Rickie J. Domangue, Sidney Fels, Christy L. Ludlow
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Neurosciences
Kristina Simonyan, Christy L. Ludlow
Article
Otorhinolaryngology
Christy L. Ludlow
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2011)
Review
Physiology
Ralph F. Fregosi, Christy L. Ludlow
JOURNAL OF APPLIED PHYSIOLOGY
(2014)
Article
Medicine, Research & Experimental
Xin Feng, Tan Zhang, Evelyn Ralston, Christy L. Ludlow
Review
Clinical Neurology
H. A. Jinnah, Alfredo Berardelli, Cynthia Comella, Giovanni DeFazio, Mahlon R. DeLong, Stewart Factor, Wendy R. Galpern, Mark Hallett, Christy L. Ludlow, Joel S. Perlmutter, Ami R. Rosen
MOVEMENT DISORDERS
(2013)
Editorial Material
Clinical Neurology
Guida Landoure, Jeremy M. Sullivan, Janel O. Johnson, Clare H. Munns, Yijun Shi, Oumarou Diallo, J. Raphael Gibbs, Rachelle Gaudet, Christy L. Ludlow, Kenneth H. Fischbeck, Bryan J. Traynor, Barrington G. Burnett, Charlotte J. Sumner
Article
Neurosciences
Soren Y. Lowell, Richard C. Reynolds, Gang Chen, Barry Horwitz, Christy L. Ludlow
EXPERIMENTAL BRAIN RESEARCH
(2012)
Article
Audiology & Speech-Language Pathology
Christy L. Ludlow
SEMINARS IN SPEECH AND LANGUAGE
(2012)
Article
Behavioral Sciences
Kristina Simonyan, Xin Feng, Victor M. Henriquez, Christy L. Ludlow
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2012)