Article
Plant Sciences
Wei Song, Ying Sun, Xiao-Chun Liang, Qian Zhang, Jun Xie, Chao Wang, Wei Liu
Summary: In this study, it was found that mechanical allodynia and peripheral nerve morphology in DPN rats deteriorated over time, but were notably improved after 12 and 16 weeks of JMT treatment. JMT significantly corrected the decreased MPZ level in DPN rats. Moreover, JMT was found to significantly up-regulate the suppressed Wnt/beta-catenin pathway in a time-dependent manner in the sciatic nerves of DPN rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alevtina Y. Y. Grishanova, Lyubov S. S. Klyushova, Maria L. L. Perepechaeva
Summary: As evolutionarily conserved signaling cascades, AhR and Wnt signaling pathways are crucial in controlling vital developmental and somatic processes. AhR integrates its signaling pathway into organ homeostasis and cellular functions, while the Wnt signaling pathway regulates cell proliferation and differentiation. Understanding the biological implications of the interaction between AhR and Wnt is important, as they are central to development and various pathological conditions. Recent studies have accumulated information about the crosstalk between AhR and Wnt signals, and this review focuses on assessing the complexity of their interaction.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alexandre Vallee, Yves Lecarpentier, Jean-Noel Vallee
Summary: Gliomas are the most common primary intraparenchymal brain tumor in the central nervous system, with molecular dysregulations being part of their definition. IDH1 mutations are associated with patient survival and involved in the malignancy process of gliomas through affecting HIF-1 alpha and the WNT/beta-catenin pathway.
Review
Immunology
Alexandre Vallee, Yves Lecarpentier, Jean-Noel Vallee
Summary: COVID-19 caused by the novel coronavirus SARS-CoV-2 has become a pandemic, with cytokine profiles showing significant changes and the upregulation of the WNT/beta-catenin pathway associated with inflammation, suggesting PPAR gamma agonists as potential drugs to regulate inflammation and the cytokine storm.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xue Hu, Qiang Zhang, Wanying Xing, Wan Wang
Summary: This mini-review discusses the modulation of the Wnt/beta-catenin signaling pathway in triple-negative breast cancer, focusing on the involvement of lncRNAs and miRNAs in its regulation and their impact on breast cancer pathogenesis, proliferation, migration, and malignancy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ozgun Ozalp, Ozge Cark, Yagmur Azbazdar, Betul Haykir, Gokhan Cucun, Ismail Kucukaylak, Gozde Alkan-Yesilyurt, Erdinc Sezgin, Gunes Ozhan
Summary: Nradd, a negative regulator of Wnt/beta-catenin signaling, suppresses Wnt-mediated patterning in zebrafish embryos and mammalian cells, highlighting its role in regulating cell growth and development through modulating Wnt signaling and apoptosis.
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Jianyun Zhu, Xiaoting Li, Chunhua Liang, Xu Zhou, Miaomiao Ge, Yue Chen, Jianliang Jin, Juan Yin, Haie Xu, Chunfeng Xie, Caiyun Zhong
Summary: The abnormal activation of Wnt/β-catenin signaling is critical in lung cancer development, and apatinib, a VEGFR2 inhibitor, shows efficient antitumor activity by targeting lung cancer stem cells (CSCs) and inhibiting CSC-like characteristics. Apatinib represses CSC traits by inhibiting beta-catenin and its downstream targets, while also inducing ROS production to suppress lung CSCs. Understanding these mechanisms is crucial for better application of apatinib in combating advanced lung cancer.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Kuangen Zhang, Rui Wu, Fang Mei, Yuhe Zhou, Lin He, Yanhua Liu, Xuyang Zhao, Jiangfeng You, Beiying Liu, Qingyang Meng, Fei Pei
Summary: LASS2 acts as a tumor-suppressor gene in prostate cancer by promoting beta-catenin degradation through physical interaction with specific proteins, and phosphorylation of LASS2 at a specific residue plays a crucial role in inhibiting cancer cell growth and metastasis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Farzad Rahmani, Abdulridha Mohammed Al-Asady, Reyhane Hanaie, Mehrdad Zandigohar, Homeira Faridnejad, Mahya Payazdan, Pegah Safavi, Mikhail Ryzhikov, Seyed Mahdi Hassanian
Summary: Brain cancers are aggressive malignancies with high mortality rates. The pathogenesis of brain cancers involves genetic mutations and activation of oncogenic signaling pathways like the Wnt/beta-catenin axis. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play important roles in regulating cell functions and their aberrant expression has been reported in various brain cancers. Understanding the expression and regulatory role of non-coding RNAs on the Wnt signaling pathway may provide novel approaches for the diagnosis, prognosis, and treatment of brain cancers.
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Review
Oncology
Amir Barzegar Behrooz, Amir Syahir
Summary: CD133 serves as a biomarker for cancer stem cells in Glioblastoma Multiforme (GBM), promoting tumor growth and recurrence, and being associated with the Wnt/beta-catenin and PI3K/AKT/mTOR signaling pathways. Studies have revealed that the crosstalk between CD133, Wnt/beta-catenin, and telomerase/TERT can enhance GBM stemness and lead to therapeutic resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Xianquan Feng, Jialiang Zhang, Lina Wu, Wanjing Lin, Zhihong Liu, Xin Zhou, Yang Qi, Zhenzhen Chen, Lingjun Zeng, Changqing Zheng, Xiaomu Hu, Qian Zhang, Hongtao Song
Summary: This study evaluates the role of drug self-delivery nanocubes (ATO/PpIX-SMN) combined with anti-PD-L1 in TNBC treatment. The nanocubes enhance photodynamic therapy-induced immunogenic cell death and downregulate tumor signaling. Combined with anti-PD-L1, they promote dendritic cell maturation, increase CTL infiltration, reduce regulatory T cells, and activate the host immune system, effectively treating primary and distal tumors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Medical Laboratory Technology
Suzan Boutary, Andoni Echaniz-Laguna, David Adams, Julien Loisel-Duwattez, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Summary: CMT1A, caused by a duplication on chromosome 17p11.2, is the most common form of CMT disease. Current treatments are symptomatic, but there is promising potential in PMP22-targeted small interfering RNA and antisense oligonucleotides.
TRANSLATIONAL RESEARCH
(2021)
Article
Neurosciences
Martine El-Etr, Yvette Akwa, Marion Rame, Michael Schumacher, Regine Sitruk-Ware
Summary: The study demonstrated that NES promotes oligodendrocyte progenitor cell proliferation and differentiation into mature OL by regulating the expression of transcription factors Olig2, Myt1, and Sox17, ultimately contributing to remyelination in a demyelination mouse model.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Yousra Laouarem, Abdelmoumen Kassoussi, Amina Zahaf, Tom Hutteau-Hamel, Amine Mellouk, Pierre Bobe, Claudia Mattern, Michael Schumacher, Elisabeth Traiffort
Summary: Hedgehog and androgen signals are coordinated in oligodendrocyte and myelin production, with persistent Hedgehog signaling potentially impeding myelin production, while testosterone has a significant pro-myelinating activity and AR controls neural stem cell commitment. The pathways functionally cooperate in accelerating myelin regeneration, leading to reduced neuroinflammation and functional improvement in demyelinating diseases, with unique effects on cytokines and immune cell populations.
Article
Biochemistry & Molecular Biology
Dalila N. J. Mancino, Maria Luz Leicaj, Analia Lima, Paulina Roig, Rachida Guennoun, Michael Schumacher, Alejandro F. De Nicola, Laura Garay
Summary: Progesterone and its metabolites may play a role in postnatal cerebellar myelination, with higher levels of progesterone observed in P18 and P35 mice, correlating with increased myelination during development.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Neurosciences
Agustina Lara, Ivan Esperante, Maria Meyer, Philippe Liere, Noelia Di Giorgio, Michael Schumacher, Rachida Guennoun, Gisella Gargiulo-Monachelli, Alejandro Federico De Nicola, Maria Claudia Gonzalez Deniselle
Summary: The study on the efficacy of testosterone in the ALS animal model Wobblers mice found that testosterone treatment can alleviate inflammatory responses in the degenerating spinal cord, protect neurons, slow down disease progression, and improve motor performance.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Behavioral Sciences
Regine Sitruk-Ware, Brooke Bonsack, Roberta Brinton, Michael Schumacher, Narender Kumar, Jea-Young Lee, Vanessa Castelli, Sydney Corey, Alexandreya Coats, Nadia Sadanandan, Bella Gonzales-Portillo, Matt Heyck, Alex Shear, Cozene Blaise, Henry Zhang, Michael Sheyner, Julian Garcia-Sanchez, Lisset Navarro, Martine El-Etr, Alejandro F. De Nicola, Cesar Borlongan
Summary: Hormone therapy using progesterone and progestins for CNS disorders shows promise in regenerative medicine, with Nestorone emerging as a potential candidate for diseases such as MS, ALS, SCI, and stroke. Researchers are working to optimize drug regimens and identify suitable patient populations to advance Nestorone to clinical application.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biology
Suzan Boutary, Marie Caillaud, Mevidette El Madani, Jean-Michel Vallat, Julien Loisel-Duwattez, Alice Rouyer, Laurence Richard, Celine Gracia, Giorgia Urbinati, Didier Desmaele, Andoni Echaniz-Laguna, David Adams, Patrick Couvreur, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Summary: The study introduces a treatment for CMT1A using siRNA conjugated to squalene nanoparticles, which resulted in the restoration of pathology and function, providing a potential therapeutic strategy for inherited peripheral neuropathies. This approach demonstrates the concept of precision medicine based on normalizing disease gene expression by using siRNA.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Alejandro F. De Nicola, Maria Meyer, Laura Garay, Maria Sol Kruse, Michael Schumacher, Rachida Guennoun, Maria Claudia Gonzalez Deniselle
Summary: Progesterone plays a crucial role in neuroprotection by improving neuropathology in the Wobbler mouse model, including reducing motoneuron vacuolization, enhancing mitochondrial respiratory complex activity, and decreasing nitric oxide synthase activity. Additionally, progesterone has differential effects on glial cells, such as increasing oligodendrocyte density and decreasing astrogliosis. These changes are associated with reduced expression of anti-inflammatory markers.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Claire-Marie Vacher, Helene Lacaille, Jiaqi J. O'Reilly, Jacquelyn Salzbank, Dana Bakalar, Sonia Sebaoui, Philippe Liere, Cheryl Clarkson-Paredes, Toru Sasaki, Aaron Sathyanesan, Panagiotis Kratimenos, Jacob Ellegood, Jason P. Lerch, Yuka Imamura, Anastas Popratiloff, Kazue Hashimoto-Torii, Vittorio Gallo, Michael Schumacher, Anna A. Penn
Summary: This study reveals that placental ALLO insufficiency alters neurodevelopment in a sex-linked manner, leading to cerebellar white matter abnormalities and autistic-like behavior in male offspring. Gender plays an important role in brain development.
NATURE NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Petra Bloms-Funke, Michael Schumacher, Song Liu, Diya Su, Jing Li, Philippe Liere, Rainer Rupprecht, Caroline Nothdurfter, Gregor Bahrenberg, Thomas Christoph, Christopher Habermann, Christa Kneip, Wolfgang Schroeder, Thomas M. Tzschentke, Derek Saunders
Summary: CNP, a chronic neuropathic pain, cannot be effectively prevented or reversed by opioids, necessitating the development of non-opioid options. GRT-X, a novel drug, acts on multiple mechanisms to enhance neuroprotection and neuroregeneration, showing potential as a treatment for CNP.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rainer Rupprecht, Christian H. Wetzel, Mario Dorostkar, Jochen Herms, Nathalie L. Albert, Jens Schwarzbach, Michael Schumacher, Inga D. Neumann
Summary: Efficient treatment of stress-related disorders remains challenging. Neurosteroids show rapid therapeutic effects, but long-term use is limited by tolerance and side effects. Promoting endogenous neurosteroidogenesis via TSPO could provide a new treatment option.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Amina Zahaf, Abdelmoumen Kassoussi, Tom Hutteau-Hamel, Amine Mellouk, Corentine Marie, Lida Zoupi, Foteini Tsouki, Claudia Mattern, Pierre Bobe, Michael Schumacher, Anna Williams, Carlos Parras, Elisabeth Traiffort
Summary: The neuroprotective, anti-inflammatory, and remyelinating properties of androgens have been well documented in demyelinated male mice and men with multiple sclerosis. However, the effects of androgens mediated by the androgen receptor (AR) in females with low androgen levels have been poorly studied. This study reveals a significant expression of AR in microglial cells in demyelinated lesions of female mice and women with multiple sclerosis, while AR expression is almost undetectable in lesions from male animals and men with multiple sclerosis. Additionally, androgens and estrogens act synergistically in female mice, with androgens driving microglial cell response towards regeneration. Transcriptomic comparisons of demyelinated mouse spinal cords show that androgens up-regulate genes related to neuronal function and myelin production, but down-regulate immune system genes in females and lipid catabolism genes in males. These findings highlight the importance of considering male-female differences in therapeutic approaches for demyelinating diseases as androgens are necessary for proper myelin regeneration in females.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Bin Bin Wang, Chao Guo, Sheng Qiao Sun, Xing Nan Zhang, Zhen Li, Wei Jie Li, De Zhi Li, Michael Schumacher, Song Liu
Summary: This study compared the effect of different peripheral nerve injury models on nerve regeneration through animal experiments. It was found that the regeneration speed was faster in the crush injury model, while it was slower in the transection injury model. This provides some reference for the selection of clinical research models.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Neike Fernandez, Anthony Petit, Antoine Pianos, Lena Haddad, Michael Schumacher, Philippe Liere, Rachida Guennoun
Summary: Ischemic stroke is a leading cause of disability and death, and aging is the main nonmodifiable risk factor. Neuroactive steroids play a key role in cerebroprotection. Older mice have decreased capacity to metabolize steroids toward the 5 alpha-reduction pathway compared to younger mice, which may contribute to worsened stroke outcomes.
Article
Neuroimaging
Miao Ling, Binbin Sui, Diya Su, Dezhi Li, Binbin Wang, Hong Wan, Michael Schumacher, Lanxin Ji, Song Liu
Summary: The study investigated the effects of hypoglossal nerve transfer on facial function restoration in patients with facial paralysis. Enhanced activation in motor cortices correlated with improved facial function, suggesting potential targets for adjuvant therapies in the central nervous system.
NEUROIMAGE-CLINICAL
(2021)