期刊
JOURNAL OF NEUROSCIENCE
卷 31, 期 30, 页码 10811-10818出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0388-11.2011
关键词
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资金
- Institut National de la Sante et de la Recherche Medicale
- Agence Nationale de la Recherche [ANR-09-BLAN-0259-01]
- Ministere de l'Enseignement Superieur et de la Recherche
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0259] Funding Source: Agence Nationale de la Recherche (ANR)
Dentate granule cells, at the gate of the hippocampus, use coincidence detection of synaptic inputs to code afferent information under a sparse firing regime. In both human patients and animal models of temporal lobe epilepsy, mossy fibers sprout to form an aberrant glutamatergic network between dentate granule cells. These new synapses operate via long-lasting kainate receptor-mediated events, which are not present in the naive condition. Here, we report that in chronic epileptic rat, aberrant kainate receptors in interplay with the persistent sodium current dramatically expand the temporal window for synaptic integration. This introduces a multiplicative gain change in the input-output operation of dentate granule cells. As a result, their sparse firing is switched to an abnormal sustained and rhythmic mode. We conclude that synaptic kainate receptors dramatically alter the fundamental coding properties of dentate granule cells in temporal lobe epilepsy.
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