Article
Biochemistry & Molecular Biology
Steven Hughes, Jessica K. Edwards, Ashleigh G. Wilcox, Carina A. Pothecary, Alun R. Barnard, Russell Joynson, Greg Joynson, Mark W. Hankins, Stuart N. Peirson, Gareth Banks, Patrick M. Nolan
Summary: Mutations in the transcription factor ZFHX3 have been shown to affect circadian rhythms in mice, with further investigation revealing its impact on retinal function, particularly in altered light responses and increased sensitivity to pupillary reflexes.
Article
Neurosciences
Jeremy M. Bohl, Jui Gope, Zachary J. Sharpe, Angela Shehu, Andrew Garrett, Christina C. Koehler, Chase B. Hellmer, Tomomi Ichinose
Summary: A looming visual stimulus triggers a consistent fear response in mice, resulting in freeze and flight. The retinal neural pathway responsible for this response is not fully understood. The study suggests that OFF starburst amacrine cells and the direction-selective pathway in the retina play a role in looming-induced fear behaviors.
Article
Biology
Giulio Bondanelli, Thomas Deneux, Brice Bathellier, Srdjan Ostojic
Summary: The study found that neural activity generates complex spatio-temporal patterns following the onset and offset of stimuli, especially in understanding the mechanisms generating OFF responses in cortical areas and recurrent interactions at the network level. By comparing single-cell and network models, it was revealed that the network model better explained the structural features of population responses.
Article
Economics
Ibrahim A. Tajudeen
Summary: The study found that the methods used for energy efficiency estimation have limitations in accurately ranking different countries' energy efficiency levels, and energy intensity is not a good proxy variable for energy efficiency. The impact of driving factors on energy efficiency in different countries shows similarities, while the results of asymmetric price responses in energy efficiency estimates vary slightly, with insignificant evidence of asymmetric effects of total energy price but asymmetric responses with energy-specific prices.
Article
Neurosciences
Mengting Liu, Fenghua Xie, Jinsheng Dai, Juan Zhang, Kexin Yuan, Ningyu Wang
Summary: The inferior colliculus (IC) is a central hub along the auditory pathway. It not only processes auditory information but also responds to multimodal stimuli. However, the sources of these non-auditory inputs are still unknown.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Perez-Lara, Consuelo Olivares-Yanez, Harm van Bakel, Luis F. Larrondo, Paulo Canessa
Summary: In this study, the transcriptomic differences between wild-type B. cinerea B05.10 and ? bcwcl1 were compared after a 60 min light pulse. The results showed that the deletion of the white-collar-1 gene caused a lack of response to light pulse in the mutant strain during its interaction with the plant. Additionally, the light-repressed genes in fungus-infected plants were enriched with biological functions associated with plant defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Shigeyuki Tamiya, Eisuke Yoshikawa, Koichiro Suzuki, Yasuo Yoshioka
Summary: The DBA/2 mouse strain shows higher bacterial load and enhanced Th1 and Th17 responses to Mycoplasma pneumoniae compared to other tested strains, making it a potentially valuable model for studying Mp infection and pathogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Engineering, Biomedical
Tamar Arens-Arad, Rivkah Lender, Nairouz Farah, Yossi Mandel
Summary: The study reveals that the light-adaptive state of the normal retina affects the responses to prosthetic retinal stimulation, which could have implications for AMD patients receiving a photovoltaic retinal implant and the design of prosthetic devices in general.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Zhenyue Chen, Irmak Gezginer, Mark-Aurel Augath, Yu-Hang Liu, Ruiqing Ni, Xose Luis Dean-Ben, Daniel Razansky
Summary: This article reports on the development of a fully hybridized system enabling concurrent functional magnetic resonance optoacoustic tomography (MROT) measurements of stimulus-evoked brain-wide sensory responses in mice. The results indicate that the BOLD signals are highly correlated, both spatially and temporally, with the total hemoglobin readings resolved with volumetric multi-spectral optoacoustic tomography. Furthermore, the differential oxygenated and deoxygenated hemoglobin optoacoustic readings exhibit superior sensitivity as compared to the BOLD signals when detecting stimulus-evoked hemodynamic responses.
Article
Food Science & Technology
Juliana Cavalli, Mariana A. Freitas, Elaine C. D. Gonsalves, Guilherme P. Fadanni, Adara A. Santos, Nadia R. B. Raposo, Rafael C. Dutra
Summary: Chia oil, rich in alpha-linolenic acid, demonstrates anti-inflammatory effects and shows promise in attenuating motor deficits and hyperalgesia in an EAE model. Further research is needed to assess the effects of chia oil in controlled clinical trials involving MS patients.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Neurosciences
Paola Vitale, Fabio Librizzi, Andrea C. Vaiana, Elisa Capuana, Maurizio Pezzoli, Ying Shi, Armando Romani, Michele Migliore, Rosanna Migliore
Summary: The fundamental role of neurons in a network is to transform complex input patterns into output spikes, and understanding species-specific differences in this process is important. This study compared the morphological and electrophysiological properties of mouse and rat neurons to determine the parameters underlying their differences and created computational models to further investigate these distinctions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Angus C. Burns, Andrew J. K. Phillips, Martin K. Rutter, Richa Saxena, Sean W. Cain, Jacqueline M. Lane
Summary: This study conducted a genome-wide gene-by-environment interaction study in a large cohort to identify genetic variants associated with light sensitivity and their impact on chronotype, sleep, and mental health. The researchers found a significant genetic variant that enhances the effect of daytime light exposure on individual time preference and is associated with gene expression in brain and retinal tissues. This study provides insights into the genetic architecture of human circadian light sensitivity and its implications for sleep and mental health.
Article
Neurosciences
R. L. Seilheimer, C. K. McClard, J. Sabharwal, S. M. Wu
Summary: Using MEA recording technique, we investigated the effects of glycinergic NFACs on GCs in dark-adapted mouse retinas. Strychnine application altered spike rates and receptive field characteristics of GCs, while not affecting temporal profiles. Strychnine also had limited actions on RF surrounds, possibly through NFAC-WFAC connections.
Article
Neurosciences
Ji-Jie Pang, Fan Gao, Samuel M. Wu
Summary: By analyzing the responses of over 100 retinal ganglion cells in dark-adapted mouse retina, we found at least 14 distinct types of RGCs based on their spike responses and ion currents. These cells can be grouped based on their spike response patterns to light, and all express glycine receptors and receive glycinergic inputs from amacrine cells. The modulation of RGCs is primarily mediated by bipolar cell inputs and shunting inhibition from amacrine cells. Moreover, narrow-field amacrine cells enhance the light-evoked bipolar cell inputs to RGCs through presynaptic synergistic addition and postsynaptic shunting inhibition.
Article
Multidisciplinary Sciences
Ethan O. Contreras, Carley G. Dearing, Crystal A. Ashinhurst, Betty A. Fish, Sajila N. Hossain, Ariana M. Rey, Primal D. Silva, Stewart Thompson
Summary: The study found that in different disease models of retinal degeneration, two responses to light could be affected in opposite ways, and changes in a specific response to light did not accurately represent the degree of pathology.
Article
Chemistry, Multidisciplinary
Oliya S. Abdullaeva, Frank Balzer, Matthias Schulz, Juergen Parisi, Arne Luetzen, Karin Dedek, Manuela Schiek
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Neurosciences
Lena Nemitz, Karin Dedek, Ulrike Janssen-Bienhold
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Stephan Tetenborg, Shubhash Chandra Yadav, Bianca Brueggen, Georg R. Zoidl, Sheriar G. Hormuzdi, Hannah Monyer, Geeske M. van Woerden, Ulrike Janssen-Bienhold, Karin Dedek
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Angelika Einwich, Karin Dedek, Pranav Kumar Seth, Sascha Laubinger, Henrik Mouritsen
SCIENTIFIC REPORTS
(2020)
Article
Behavioral Sciences
Petra Bolte, Angelika Einwich, Pranav K. Seth, Raisa Chetverikova, Dominik Heyers, Irina Wojahn, Ulrike Janssen-Bienhold, Regina Feederle, Peter Hore, Karin Dedek, Henrik Mouritsen
Summary: The magnetic compass of birds is based on light-dependent radical-pair processes in the eyes, with cryptochromes being the primary candidate proteins for magnetoreceptor molecules. A study on various bird species confirmed the localization of Cry1a in the UV/V cone outer segments, suggesting accumulation of Cry1a molecules in distinct spots. No significant difference in Cry1a immunoreactivity was observed between light- and dark-adapted retinae, indicating that a C-terminal antibody against Cry1a does not specifically label a light-activated form of the protein.
ETHOLOGY ECOLOGY & EVOLUTION
(2021)
Article
Neurosciences
Silke Haverkamp, Laszlo Albert, Vaishnavi Balaji, Pavel Nemec, Karin Dedek
Summary: In this study, various transcription factors were tested in two avian species, revealing their crucial role in the ganglion cells of birds. The markers established may serve as valuable tools for further detailed studies on the retinal circuitry of these highly visual animals.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Anja Guenther, Karin Dedek, Silke Haverkamp, Stephan Irsen, Kevin L. Briggman, Henrik Mouritsen
Summary: Research has found that double cones in avian retinas are highly interconnected with neighboring double cones and other photoreceptor cells through telodendria-to-terminal and telodendria-to-telodendria contacts. Additionally, 15 bipolar cell types have been identified in the chicken retina based on different criteria such as axonal stratifications, photoreceptor contact patterns, soma position, and dendritic and axonal field mosaics. This study reveals a more complex connectivity network in the outer plexiform layer of the avian retina than previously thought.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Physics, Condensed Matter
Timo Grothe, Tobias Boehm, Karim Habashy, Oliya S. Abdullaeva, Jennifer Zablocki, Arne Luetzen, Karin Dedek, Manuela Schiek, Andrea Ehrmann
Summary: Recent advances in optoelectronics are often based on thin-film organic semiconductors, such as squaraines, which show excitonic coupling with visible light. Coating squaraine films on electrospun nanofiber mats and nanomembranes made conductive by PEDOT:PSS can significantly alter the thin film formation and improve optical properties.
PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS
(2021)
Article
Neurosciences
Lena Nemitz, Karin Dedek, Ulrike Janssen-Bienhold
Summary: Early postnatal ablation of horizontal cells in the mouse retina leads to differential remodeling in the cone pathway, where new synapses are established between cones and OFF bipolar cells while connections with ON bipolar cells are lost.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Christian Behrens, Shubhash Chandra Yadav, Maria M. Korympidou, Yue Zhang, Silke Haverkamp, Stephan Irsen, Anna Schaedler, Xiaoyu Lu, Zhuohe Liu, Jan Lause, Francois St-Pierre, Katrin Franke, Anna Vlasits, Karin Dedek, Robert G. Smith, Thomas Euler, Philipp Berens, Timm Schubert
Summary: The study revealed the existence of two synaptic strata in the outer plexiform layer of the mouse retina, where horizontal cells provide global signaling to CBCs through bulbs and local, cone-specific feedback to cones through dendritic tips. This spatial arrangement of synaptic contacts allows for simultaneous different modes of signaling by horizontal cells.
Article
Behavioral Sciences
Angelika Einwich, Pranav Kumar Seth, Rabea Bartoelke, Petra Bolte, Regina Feederle, Karin Dedek, Henrik Mouritsen
Summary: Research has shown that Cry2 protein is located in different layers of cells in the retina of night-migratory European robins, homing pigeons, and domestic chickens, and at a subcellular level, it is present in both the cytoplasm and the nucleus of these cells.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2022)
Editorial Material
Neurosciences
Tamas Kovacs-Oller, Karin Dedek, Daniel Hillier
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Vaishnavi Balaji, Silke Haverkamp, Pranav Kumar Seth, Anja Guenther, Ezequiel Mendoza, Jessica Schmidt, Maike Herrmann, Leonie Lovis Pfeiffer, Pavel Nemec, Constance Scharff, Henrik Mouritsen, Karin Dedek
Summary: Visual signal processing starts at the first synapse, where different types of bipolar cells receive information from photoreceptors and feed it into different processing channels. This study systematically tested 12 antibodies for their ability to label individual bipolar cells in the bird retina and identified 8 suitable antibodies across different bird species and retinal regions. The catalog of bipolar cell markers provided in this study will greatly facilitate the analysis of retinal circuitry in birds on a larger scale.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Raisa Chetverikova, Glen Dautaj, Leonard Schwigon, Karin Dedek, Henrik Mouritsen
Summary: Through studying the retinas of European robins and domestic chickens, it has been found that their double cone photoreceptors are highly ordered, which may aid their function in light-dependent magnetoreception and/or polarized light sensing.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Multidisciplinary Sciences
Stephan Tetenborg, Helen Y. Wang, Lena Nemitz, Anne Depping, Alexsandra B. Espejo, Jaya Aseervatham, Mark T. Bedford, Ulrike Janssen-Bienhold, John O'Brien, Karin Dedek
SCIENTIFIC REPORTS
(2020)