Article
Biochemistry & Molecular Biology
Jowita Nowakowska-Golacka, Justyna Czapiewska, Hanna Sominka, Natalia Sowa-Rogozinska, Monika Slominska-Wojewodzka
Summary: EDEM1 is an important regulatory factor involved in APP metabolism, as it recognizes misfolded APP proteins and directs them to cytosol for degradation, leading to decreased secretion of Aβ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Qi Shen, Xiaolei Wu, Zhan Zhang, Di Zhang, Sihua Yang, Da Xing
Summary: The study found that inducing gamma oscillations with non-invasive light flicker can reduce Alzheimer's disease-related pathology. By increasing the anchoring of amyloid precursor protein (APP) to the plasma membrane for non-amyloidogenic processing and interacting with KCC2, it helps maintain surface GABA(A) receptor alpha 1 levels and reduce beta-amyloid (A beta) production. These findings highlight the importance of enhancing APP trafficking to the plasma membrane in the reduction of A beta load in Alzheimer's disease.
Article
Neurosciences
Heather M. Wilkins, Benjamin R. Troutwine, Blaise W. Menta, Sharon J. Manley, Taylor A. Strope, Colton R. Lysaker, Russell H. Swerdlow
Summary: This study reveals that mitochondrial function affects the localization of amyloid-beta protein precursor and its secretion. Enhanced mitochondrial activity promotes amyloid-beta secretion, while depressed mitochondrial activity reduces amyloid-beta secretion. These findings provide insights into the pathogenesis of Alzheimer's disease and the potential use of amyloid-beta secretion as a biomarker of mitochondrial function.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Jinhu Kim, Seungjoon Kim, Hyeonho Kim, In-Wook Hwang, Sungwon Bae, Sudeep Karki, Dongwook Kim, Roberto Ogelman, Geul Bang, Jin Young Kim, Tommi Kajander, Ji Won Um, Won Chan Oh, Jaewon Ko
Summary: Balanced synaptic inhibition is crucial for brain function. MDGA1 suppresses synaptic inhibition in mammalian neurons by interacting with APP, affecting GABAergic synaptic transmission in hippocampal CA1 neurons. Down-regulation of APP specifically suppresses GABAergic transmission strength and inputs in presynaptic interneurons. Overexpression of MDGA1 impairs novel object recognition memory in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Pascal Dominic Rem, Vita Sereikaite, Diego Fernandez-Fernandez, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salome Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Stromgaard, Bernhard Bettler
Summary: Amyloid-beta precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. A 17 amino acid peptide (APP17) derived from APP binds to the extracellular sushi domain 1 (SD1) of GABA(B) receptors (GBRs). However, APP17 does not influence GBR activity in heterologous cells, indicating that sAPP exerts its neuronal effects through receptors other than GBRs.
Review
Biochemistry & Molecular Biology
Vladimir Rudajev, Jiri Novotny
Summary: This article discusses the relationship between cholesterol and the development of Alzheimer's disease, as well as the influence of cholesterol on the production of amyloid beta (Aβ).
CELL AND BIOSCIENCE
(2023)
Article
Neurosciences
Yi Li, Jin-zhao Wang, Yue-ming Deng, Kun Wang, Li Yang, Cheng Long
Summary: This study suggests that A beta PP modulates neuronal firing and oscillatory activity in the hippocampus, and Kv1.4 may be involved in mediating the modulation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Kenji Yamamoto, Ryo Yamamoto, Nobuo Kato
Summary: In this study, it was found that specific antibodies can recover the activity of BK channels suppressed by Aβ oligomers in neurons of Alzheimer's disease model mice, suggesting an important role of APP in this process.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Alexandra A. Sandberg, Evan Manning, Heather M. Wilkins, Randall Mazzarino, Taylor Minckley, Russell H. Swerdlow, David Patterson, Yan Qin, Daniel A. Linseman
Summary: In this study, the potential of mitochondrial-targeted AICD to induce neuronal apoptosis and its mechanism of neurotoxicity were examined. The results showed that only when AICD was targeted to the mitochondria, significant neuronal apoptosis was induced. Furthermore, AICD induced apoptosis via a mechanism that is distinct from that of A beta.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Endocrinology & Metabolism
Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu
Summary: This article summarizes the regulatory effects of APP and its cleavage peptides on metabolism in the central nervous system and peripheral tissues, indicating that peptides generated by non-amyloidogenic processing can have positive effects on metabolism, while those produced by amyloidogenic processing may have negative impacts. Abnormal expression of APP is associated with metabolic diseases (such as diabetes, obesity, etc.) and cancer.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Cell Biology
Grant Pfundstein, Alexander G. Nikonenko, Vladimir Sytnyk
Summary: This review examines the interactions of cell adhesion molecules with APP and Aβ, and analyzes the critical role these proteins play in regulating APP metabolism and physiological function, as well as Aβ toxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Xi-Jun Song, He-Yan Zhou, Yu-Ying Sun, Han-Chang Huang
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of senile plaques, Aβ peptide, is derived from AβPP through cleaving by enzymes. Post-translational modifications like phosphorylation and glycosylation of AβPP may affect its trafficking and cleavage.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Livius d'Uscio, Zvonimir S. Katusic
Summary: The study revealed an age-related increase in APP expression in vascular endothelium, which is believed to be an adaptive response aimed at protecting and maintaining eNOS function. Endothelial dysfunction was exacerbated in aged eAPP(-/-) mice compared to age-matched WT mice, suggesting a crucial role of APP in controlling endothelial function during aging.
Article
Biochemistry & Molecular Biology
Ryota Suzuki, Haruka Takahashi, Chika Yoshida, Masafumi Hidaka, Tomohisa Ogawa, Eugene Futai
Summary: In this study, the APP mutation T714I, which is associated with familial Alzheimer's disease, was found to severely reduce the cleavage of A beta. Secondary mutations were identified that restored the cleavage of APP T714I and could modulate the production of A beta species in mammalian cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan
Summary: Decades of research have shown that amyloid-beta (Aβ) plays an undeniable role in the development of Alzheimer's disease (AD). However, the focus on the pathological effects of Aβ may overshadow the significance of its metabolic precursor, amyloid precursor protein (APP), in the occurrence and progression of AD. This review explores the various roles of APP in AD, including its structure, functions, enzymatic processing, and potential therapeutic approaches to targeting APP to ameliorate AD pathologies and halt disease progression.
Article
Behavioral Sciences
Houng-Wei Tsai, Yuan-Feen Tsai, Mei-Yun Tai, Kuei-Ying Yeh
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Neurosciences
Chris Armoskus, Debbie Moreira, Kayla Bollinger, Oliva Jimenez, Saori Taniguchi, Houng-Wei Tsai
Review
Physiology
Houng-Wei Tsai, Joyce C. Chen, Ktiei-Ying Yeh, Mei-Yun Tai, Yuan-Feen Tsai
CHINESE JOURNAL OF PHYSIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Houng-Wei Tsai, Patrick A. Grant, Emilie F. Rissman
Article
Behavioral Sciences
Karolina Bojkowska, Magdalena M. Hamczyk, Houng-Wei Tsai, Anna Riggan, Emilie F. Rissman
HORMONES AND BEHAVIOR
(2008)
Article
Geriatrics & Gerontology
Joyce C. Chen, Houng-Wei Tsai, Kuei-Ying Yeh, Mei-Yun Tai, Yuan-Feen Tsai
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2008)
Article
Developmental Biology
Michael Franklin, Chris Armoskus, Saori Taniguchi, Courtney Moder, Kathy Trang, Marilisa Santacruz, Allyson Milla, Houng-Wei Tsai
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
R. Berlemont, N. Winans, D. Talamantes, H. Dang, H-W. Tsai
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Houng-Wei Tsai, Vicky Y. Lin, Margaret A. Shupnik
Summary: This study investigates the transcriptional activity and protection mechanism of forskolin on estrogen receptors (ERs). It is found that forskolin can enhance the transcriptional activity of ERα through the ligand-binding domain and protect ERα and ERβ from degradation. Additionally, forskolin increases ubiquitination of ERα and ERβ. These findings provide insights into the mechanisms of forskolin on ERα and ERβ.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Neurosciences
Joyce C. Chen, Houng-Wei Tsai, Kuei-Ying Yeh, Mei-Yun Tai, Yuan-Feen Tsai
Article
Behavioral Sciences
HW Tsai, HA Shui, HS Liu, MY Tai, YF Tsai
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2006)
Article
Reproductive Biology
HW Tsai, PS LaPolt, AP Olcott, JKH Lu
BIOLOGY OF REPRODUCTION
(2004)
Article
Endocrinology & Metabolism
HW Tsai, JA Katzenellenbogen, BS Katzenellenbogen, MA Shupnik
Article
Reproductive Biology
HW Tsai, SJ Legan
BIOLOGY OF REPRODUCTION
(2002)