Article
Developmental Biology
Hui Wang, Chengdong Wang, Qi Long, Yuan Zhang, Meiling Wang, Jie Liu, Xufeng Qi, Dongqing Cai, Gang Lu, Jianmin Sun, Yong-Gang Yao, Wood Yee Chan, Wai Yee Chan, Yi Deng, Hui Zhao
Summary: Kindlin2 is essential for neural crest formation in Xenopus embryos independently of integrins, and it regulates the FGF pathway to promote the stability of FGF receptor 1.
Article
Cell Biology
Alexander M. Lovely, Timothy J. Duerr, Qingchao Qiu, Santiago Galvan, S. Randal Voss, James R. Monaghan
Summary: The study shows that the Wnt signaling pathway plays a similar role in both limb development and limb regeneration in axolotl salamanders. This provides new insights into the interaction of Wnt signaling with other signaling pathways during salamander limb development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hang Zhou, Zhongzheng Ma, Zhiqi Wang, Shuo Yan, Dan Wang, Jie Shen
Summary: Appendage regeneration in Harmonia axyridis, a model organism with advantages of short life cycle and strong regeneration capacity, involves upregulation of multiple signaling pathways such as Dpp, Wg, Ds/Ft/Hippo, Notch, Egfr, and Hh. The canonical Hh signaling and its auxiliary receptor Lrp2 are crucial for proper patterning and growth of the regenerative leg, while genes related to leg development are regulated by Hh and Lrp2, contributing to both leg length and pattern formation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Huong Nguyen, Godwin Sokpor, Arpan Parichha, Linh Pham, Nidhi Saikhedkar, Yuanbin Xie, Pauline Antonie Ulmke, Joachim Rosenbusch, Mehdi Pirouz, Ruediger Behr, Anastassia Stoykova, Beate Brand-Saberi, Huu Phuc Nguyen, Jochen F. Staiger, Shubha Tole, Tran Tuoc
Summary: The BAF chromatin remodeling complex has been found to regulate the spatiotemporal patterning of the mouse dorsal telencephalon. Deletion of the BAF complex resulted in abnormal expansion of forebrain patterning, causing disruptions in the development of the hippocampal primordium and cortical identity. The BAF complex interacts with the transcription factor LHX2 to drive the transcriptional program essential for dorsal telencephalon patterning.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Ayan T. Ray, Philippe Soriano
Summary: Loss of FGF signaling leads to defects in salivary gland branching. Disruption of Fgfr1 and Fgfr2 expression in salivary gland epithelial cells reveals their coordinated function in regulating branching. Non-canonical FGF signaling mechanisms involving cell-cell and cell-matrix adhesion play a role in salivary gland branching morphogenesis.
Article
Developmental Biology
Lena Deuper, Max Meuser, Hauke Thiesler, Ulrich W. H. Jany, Carsten Rudat, Herbert Hildebrandt, Mark-Oliver Trowe, Andreas Kispert
Summary: The coordinated development of mesenchymal and epithelial progenitors in the murine ureter is regulated by diverse signaling activities. Epithelial FGFR2 signaling enhances epithelial stratification and differentiation through increased expression of Shh, SHH, and BMP4. FGFR1 and FGFR2 in the mesenchyme regulate mesenchymal patterning and differentiation by modulating the SHH/BMP4 signaling axis.
Article
Biochemistry & Molecular Biology
Sunanjay Bajaj, Joshua A. Bagley, Christoph Sommer, Abel Vertesy, Sakurako Nagumo Wong, Veronica Krenn, Juergen A. Knoblich
Summary: The study identified key roles of neurotransmitter signaling pathways in guiding the migratory behavior of human cortical interneurons, showing that different modes of interneuron migration depend on distinct neurotransmitter signaling pathways, linking transcriptional maturation of interneurons with their migratory behavior.
Article
Cell Biology
Matthew J. White, Kyle A. Jacobs, Tania Singh, Lakyn N. Mayo, Annie Lin, Christopher S. Chen, Young-wook Jun, Matthew L. Kutys
Summary: This study uses a 3D model to demonstrate that Notch1 influences epithelial morphogenesis through a mechanism independent of transcriptional signaling. Notch1 cortical signaling directly regulates epithelial cell architecture and proliferation by stabilizing adherens junctions and cortical actin. These findings provide new insights into Notch1 signaling and regulation and suggest a coordination between transcriptional and cell adhesive programs.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Liping Liu, Mengnan Chai, Youmei Huang, Jingang Qi, Wenhui Zhu, Xinpeng Xi, Fangqian Chen, Yuan Qin, Hanyang Cai
Summary: Inflorescence architecture is regulated by the inflorescence meristem and pedicel length. SDG2 genetically interacts with the SWR1-ER signaling pathways to influence inflorescence growth, potentially mediated by auxin. SWR1 and ER signaling are necessary for H2A.Z histone variant enrichment, while SDG2 regulates SDG2-mediated H3K4me3 histone modification at auxin-related genes and H2A.Z histone variant enrichment, affecting auxin hormone signaling pathways.
Article
Multidisciplinary Sciences
Inbal Maidan, Anat Mirelman, Jeffrey M. Hausdorff, Yaakov Stern, Christian G. Habeck
Summary: The study found that cortical thickness patterns are differently associated with various mobility domains, affecting simple walking but not complex aspects of mobility. This suggests that functional connectivity may play a larger role in complex mobility tasks.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Qiang Guo, Yanjun Jing, Yuan Gao, Yitong Liu, Xiaofeng Fang, Rongcheng Lin
Summary: Light signals are perceived by photoreceptors, triggering a developmental transition in dark-germinated seedlings. This process is regulated by Phytochrome-interacting factors (PIFs). In this study, it is shown that histone acetylation is involved in the regulation of phytochrome-PIFs signaling in Arabidopsis. The interaction between histone deacetylase HDA19 and PIF1/PIF3, as well as the Mediator subunit MED25, leads to transcriptional repression through reduction in histone acetylation and chromatin accessibility. Additionally, MED25 forms liquid-like condensates and its puncta increase in darkness, potentially explaining the distinct transcriptional activity of PIF proteins.
Article
Gastroenterology & Hepatology
Shichao Zhu, Xiyun Rao, Yude Qian, Jinbiao Chen, Renhua Song, Huili Yan, Xi Yang, Junhao Hu, Xiaohong Wang, Zhiming Han, Yi Zhu, Renjing Liu, Justin Jong-Leong Wong, Geoffrey W. McCaughan, Xiangjian Zheng
Summary: In this study, the role of Heg in mammalian liver development and functional maintenance was examined. It was found that endothelial Heg is essential for the 3-dimensional patterning of the liver vascular and indirectly regulates biliary networks and proper liver zonation. The changes induced by endothelial Heg in liver metabolic zonation and metabolic enzyme expression in hepatocytes were functionally relevant to xenobiotic metabolism and drug-induced liver toxicity.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Neurosciences
Vahid Esmaeili, Keita Tamura, Samuel P. Muscinelli, Alireza Modirshanechi, Marta Boscaglia, Ashley B. Lee, Anastasiia Oryshchuk, Georgios Foustoukos, Yanqi Liu, Sylvain Crochet, Wulfram Gerstner, Carl C. H. Petersen
Summary: This study used a combination of calcium imaging, electrophysiology, and optogenetics to track the cortical activity sequence in mice from whisker stimulation to delayed licking. It found that enhanced activity in the secondary whisker motor cortex and transient reduction in orofacial sensorimotor cortex played important roles in completing the task, while sustained activity in the frontal cortex was crucial for licking during the response period.
Article
Cell & Tissue Engineering
Madeline G. Andrews, Clara Siebert, Li Wang, Matthew L. White, Jayden Ross, Raul Morales, Megan Donnay, Gradi Bamfonga, Tanzila Mukhtar, Arpanaarjun Mckinney, Kaila Gemenes, Shaohui Wang, Qiuli Bi, Elizabeth E. Crouch, Neelroop Parikshak, Georgia Panagiotakos, Eric Huang, Aparna Bhaduri, Arnold R. Kriegstein
Summary: The differentiation of outer radial glia (oRG) cells and the production of inhibitory interneurons (INs) in the cerebral cortex are regulated by leukemia-inhibitory factor (LIF) signaling.
Article
Cell Biology
Gokul Kesavan, Florian Raible, Mansi Gupta, Anja Machate, Dilara Yilmaz, Michael Brand
Summary: The study reveals the complex role of Ism1 in regulating extracellular signals during early embryonic development in zebrafish, with genetic interactions with both Fgf and nodal signaling pathways. Misexpression of Ism1 deletion constructs disrupts embryonic patterning in zebrafish, but CRISPR/Cas9-engineered Ism1 mutants did not show obvious developmental defects, suggesting a nuanced role for Ism1 in the developmental process.
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Melissa Barber, Yoko Arai, Yoshihiro Morishita, Lisa Vigier, Frederic Causeret, Ugo Borello, Fanny Ledonne, Eva Coppola, Vincent Contremoulins, Frank W. Pfrieger, Fadel Tissir, Subashika Govindan, Denis Jabaudon, Veronique Proux-Gillardeaux, Thierry Galli, Alessandra Pierani
Article
Multidisciplinary Sciences
Valentina Poletti, Alessia Delli Carri, Guidantonio Malagoli Tagliazucchi, Andrea Faedo, Luca Petiti, Emilia Maria Cristina Mazza, Clelia Peano, Gianluca De Bellis, Silvio Bicciato, Annarita Miccio, Elena Cattaneo, Fulvio Mavilio
Article
Biochemistry & Molecular Biology
Luis Puelles, Loreta Medina, Ugo Borello, Isabel Legaz, Anne Teissier, Alessandra Pierani, John L. R. Rubenstein
JOURNAL OF CHEMICAL NEUROANATOMY
(2016)
Article
Multidisciplinary Sciences
Andrea Faedo, Angela Laporta, Alice Segnali, Maura Galimberti, Dario Besusso, Elisabetta Cesana, Sara Belloli, Rosa Maria Moresco, Marta Tropiano, Elisa Fuca, Stefan Wild, Andreas Bosio, Alessandro E. Vercelli, Gerardo Biella, Elena Cattaneo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Neurosciences
Valentina Castiglioni, Andrea Faedo, Marco Onorati, Vittoria Dickinson Bocchi, Zhen Li, Raffaele Iennaco, Romina Vuono, Gaetano P. Bulfamante, Luca Muzio, Gianvito Martino, Nenad Sestan, Roger A. Barker, Elena Cattaneo
Article
Multidisciplinary Sciences
P. Conforti, D. Besusso, V. D. Bocchi, A. Faedo, E. Cesana, G. Rossetti, V. Ranzani, C. N. Svendsen, L. M. Thompson, M. Toselli, G. Biella, M. Pagani, E. Cattaneo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Cell Biology
Ugo Borello, Henry Kennedy, Colette Dehay
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2018)
Article
Neurosciences
Ugo Borello, Barbara Berarducci, Edwige Delahaye, David J. Price, Colette Dehay
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Neurosciences
Ugo Borello, Mayur Madhavan, Ilya Vilinsky, Andrea Faedo, Alessandra Pierani, John Rubenstein, Kenneth Campbell
Article
Neurosciences
Mary L. Arcila, Marion Betizeau, Xiaolu A. Cambronne, Elmer Guzman, Nathalie Doerflinger, Frantz Bouhallier, Hongjun Zhou, Bian Wu, Neha Rani, Danielle S. Bassett, Ugo Borello, Cyril Huissoud, Richard H. Goodman, Colette Dehay, Kenneth S. Kosik
Article
Multidisciplinary Sciences
Susan J. Harrison-Uy, Julie A. Siegenthaler, Andrea Faedo, John L. R. Rubenstein, Samuel J. Pleasure
Article
Cell & Tissue Engineering
Alessia Delli Carri, Marco Onorati, Valentina Castiglioni, Andrea Faedo, Stefano Camnasio, Mauro Toselli, Gerardo Biella, Elena Cattaneo
STEM CELL REVIEWS AND REPORTS
(2013)
Article
Multidisciplinary Sciences
Vittoria Dickinson Bocchi, Paola Conforti, Elena Vezzoli, Dario Besusso, Claudio Cappadona, Tiziana Lischetti, Maura Galimberti, Valeria Ranzani, Raoul J. P. Bonnal, Marco De Simone, Grazisa Rossetti, Xiaoling He, Kenji Kamimoto, Ira Espuny-Camacho, Andrea Faedo, Federica Gervasoni, Romina Vuono, Samantha A. Morris, Jian Chen, Dan Felsenfeld, Giulio Pavesi, Roger A. Barker, Massimiliano Pagani, Elena Cattaneo
Summary: This research uncovers the cellular hierarchies governing the lineage commitment of MSNs. It found that D1 and D2 medium spiny neurons arise from a common progenitor and lineage commitment is established during the postmitotic transition. Cell type-specific gene regulatory networks were identified and validated through in silico perturbation, while human-specific lincRNAs contributing to the phylogenetic divergence of this structure in humans were also discovered.
Article
Multidisciplinary Sciences
Jia Feng, Wen-Hsin Hsu, Denis Patterson, Ching-San Tseng, Hsiang-Wei Hsing, Zi-Hui Zhuang, Yi-Ting Huang, Andrea Faedo, John L. Rubenstein, Jonathan Touboul, Shen-Ju Chou
Summary: The development of cortical regions with precise boundaries relies on the patterning transcription factor COUP-TFI, which can expand the medial entorhinal cortex (MEC) and create protrusions and disconnected ectopic tissue. A mathematical model predicts that neuronal specification and differential cell affinity contribute to boundary sharpness. High COUP-TFI expression induces MEC cell fate and protocadherin 19 expression, highlighting the importance of a subtle interplay between transcription factors and cell affinity in boundary formation.