Article
Food Science & Technology
Peng Zhang, Zhengqiang Jiang, Jia Lei, Qiaojuan Yan, Chang Chang
Summary: This study demonstrated the potential of hydrolysates from bromelain and Geobacillus stearothermophilus protease (GsProS8) in inhibiting xanthine oxidase (XO) activity. The hydrolysates contained high levels of tryptophan, glutamic acid, and glycine, leading to excellent XO inhibitory activity. Three novel XO inhibitory peptides, IVYPW, YPWTQ, and LITGLW, were identified and characterized. Molecular docking studies revealed important interactions between tyrosine residues in IVYPW and YPWTQ and key amino acids in XO, enhancing the inhibitory activity. This research provides a promising strategy for developing anti-hyperuricemic peptides and understanding the inhibition mechanisms for managing hyperuricemia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Psychology, Biological
David Torrents-Rodas, Stephan Koenig, Metin Uengoer, Harald Lachnit
Summary: This study aimed to provide evidence for a combined effect of two attentional mechanisms during associative learning. Results showed an attentional advantage for relevant cues in the first stage, followed by an increase in attention to both types of cues in the beginning of the second stage. These findings were reflected in dwell times and within-trial patterns of fixations, and were consistent with predictions from a hybrid model of attention.
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
P. Soar, A. Kao, N. Shevchenko, S. Eckert, G. Djambazov, K. Pericleous
Summary: The interdependence between structural mechanics and microstructure solidification plays a crucial role in determining macroscopic properties and casting defects. However, current numerical models often neglect this interaction, resulting in the inability to predict important mechanisms such as the development of misoriented grains. This paper proposes a numerical method that couples a finite volume structural mechanics solver to a cellular automata solidification solver, allowing for accurate predictions of microstructure development.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Energy & Fuels
Lu Liu, Wenlan Chen, Quan Zhu, Haisheng Ren
Summary: The addition of NH3 effectively inhibits soot formation and reduces the concentration of crucial precursors during n-decane pyrolysis, resulting in a decrease in the mass fractions of PAHs and soot particles. The growth of PAHs is influenced by N-PAHs and the formation of carbonitride species, while the formation of soot particles is inhibited by preventing the formation of key reactants.
Article
Economics
Yucheng Sun, Xianbo Zhou
Summary: This study uses a representative survey of middle school students in China to examine the impact of teachers holding administrative positions (AP) on students' academic performance. The findings reveal that headteachers holding an AP have a negative and significant effect on students, while the effect of subject teachers holding an AP may be positive. The negative impact is more prominent among 9th grade students, boys, rural students, students with parents working outside, and students with mothers having lower education levels. Further analysis suggests that headteachers with an AP invest less teaching effort, as measured by time spent on grading and frequency of using supplementary teaching tools.
CHINA ECONOMIC REVIEW
(2022)
Article
Multidisciplinary Sciences
Yue Zhang, Alexandre Lehmann, Mickael Deroche
Summary: Recent research has shown that pupillometry is effective in quantifying listening effort. However, interpreting pupillary responses in listening situations involving multiple cognitive functions at once is challenging. Additionally, it was found that task-evoked pupillary response differs significantly in complex listening conditions.
Article
Computer Science, Interdisciplinary Applications
Shadi Ghiasi, Alberto Greco, Luca Faes, Michal Javorka, Riccardo Barbieri, Enzo Pasquale Scilingo, Gaetano Valenza
Summary: This study proposed a novel modeling framework for quantifying heartbeat regulatory mechanisms driven by different neural routes, with experimental results showing that more than 70% of heartbeat regulatory dynamics is driven by physical stressors in combination with cognitive/emotional stressors.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Review
Pharmacology & Pharmacy
Jinlong Luo, Xin Zhao, Baolin Guo, Yong Han
Summary: This paper discusses the use of thermosensitive hydrogels as drug carriers. By selecting raw materials, thermal response mechanisms, and material forms, desired drug release patterns and profiles can be tailored. Industrial transformation of thermosensitive hydrogels as drug delivery platforms needs to meet certain important conditions.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study aimed to investigate the role of interhemispheric primary motor cortex (M1-M1) influences during selective stopping with proactive cueing. The results showed that increased stopping uncertainty led to slower response times and reduced stopping interference. Proactive response inhibition was characterized by a slower rate of rise and faster cancel time in electromyographical bursts during stopping. There was a reduction in muscle excitability when the left hand was cued to stop, but there was no reinstatement of interhemispheric inhibition between the motor cortices.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Physical
Shawn Irgen-Gioro, Yue Wu, Rafael Lopez-Arteaga, Suyog Padgaonkar, Jack N. Olding, Emily A. Weiss
Summary: This study investigates the emission characteristics of CdSe/CdS core/shell nanplatelets and finds that blinking primarily occurs on time scales from 100 ps to seconds, while spectral diffusion mainly occurs on time scales of approximately 1 second and slower. Shorter time scale blinking is attributed to an equilibrium between dark and bright states, while longer time scale blinking involves an equilibrium between two distinct emissive states.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Engineering, Environmental
Voon Huey Lim, Yuji Yamashita, Kazuyoshi Ogawa, Yasuhisa Adachi
Summary: This study investigated the inhibitory effects of different polyanions on polycationic flocculants used in solid-liquid separation in water treatment processes. The degree of inhibition was found to be related to the affinity of polyanions toward polycations and particles.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Neurosciences
Francisco M. Lopez, Andres Pomi
Summary: Laboratory data shows that different experimental conditions in conflict tasks lead to differences in response time distributions. Previous studies have successfully reproduced these results by incorporating temporal dependencies into evidence accumulation models. This work presents an alternative approach to modeling decision-making based solely on inhibitory dynamics within a dual-route architecture. The proposed Dual-Route Evidence Accumulation Model (DREAM) achieves similar performance to previous models in fitting experimental response time distributions, despite lacking time-dependent functions. DREAM can reproduce conditional accuracy functions and delta plots with both positive and negative slopes. The implications of these findings, as well as the interpretation of parameters and potential connections to perceptual representations, are discussed. Python code for fitting DREAM to experimental data is provided.
COGNITIVE NEURODYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Lan Zhang, Haocun Kong, Zhaofeng Li, Xiaofeng Ban, Zhengbiao Gu, Yan Hong, Li Cheng, Caiming Li
Summary: Inhibiting pancreatic a-amylase activity can decrease the release rate of glucose, thereby delaying postprandial blood glucose. This study aimed to investigate the physicochemical properties and porcine pancreatic a-amylase (PPA) inhibitory activities of five bacterial exopolysaccharides (EPSs), and analyze the differences of their inhibitory activities, exploring the inhibition mechanism between EPSs and PPA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wei Yang, Jingyuan Zhuang, Chen Li, Chen Bai, Guijuan Cheng, Istvan Simon, Csaba Magyar
Summary: This study investigated the inhibitory mechanisms of Azacytidine (AZA) and Zebularine (ZEB) on DNA methyltransferase 3 alpha (DNMT3A) through molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) simulations. The results showed that AZA might stop the methyl transfer process, while ZEB might get stuck in a methyl-transferred intermediate (IM3). The IM3 state fails the elimination due to missing the catalytic water chain caused by unique protein dynamics. This research provides atomic-level insights into the mechanisms of AZA and ZEB in DNMT3A, which are important for the new generation of drug design for DNMTs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Multidisciplinary Sciences
Wonchull Kang, Chi Chung Lee, Andrew J. jasniewski, Markus W. Ribbe, Yilin Hu
Summary: Peters and colleagues' claim of contradicting our findings on the dynamic structure of the nitrogenase metallocofactor during N-2 reduction is refuted by our biochemical and structural data, which conclusively demonstrate the binding of dinitrogen species to the nitrogenase cofactor.
Article
Neurosciences
Gerard Derosiere, Pierre Vassiliadis, Sophie Demaret, Alexandre Zenon, Julie Duque
Article
Neurosciences
Gerard Derosiere, Alexandre Zenon, Andrea Alamia, Julie Duque
Article
Neurosciences
Oleg Solopchuk, Andrea Alamia, Laurence Dricot, Julie Duque, Alexandre Zenon
Article
Biochemical Research Methods
Julien Grandjean, Gerard Derosiere, Pierre Vassiliadis, Louise Quemener, Ysaline de Wilde, Julie Duque
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Neurosciences
Caroline Quoilin, Emmanuelle Wilhelm, Pierre Maurage, Philippe de Timary, Julie Duque
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
M. Algoet, J. Duque, G. D. Iannetti, A. Mouraux
Article
Neurosciences
Pierre Vassiliadis, Julien Grandjean, Gerard Derosiere, Ysaline de Wilde, Louise Quemener, Julie Duque
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Neurosciences
Gerard Derosiere, Pierre-Alexandre Klein, Sylvie Nozaradan, Alexandre Zenon, Andre Mouraux, Julie Duque
JOURNAL OF NEUROSCIENCE
(2018)
Article
Clinical Neurology
Julien Grandjean, Caroline Quoilin, Julie Duque
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2019)
Article
Neurosciences
Andrea Alamia, Alexandre Zenon, Rufin VanRullen, Julie Duque, Gerard Derosiere
Article
Neurosciences
Pierre Vassiliadis, Gerard Derosiere, Julien Grandjean, Julie Duque
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Pierre Vassiliadis, Gerard Derosiere, Cecile Dubuc, Aegryan Lete, Frederic Crevecoeur, Friedhelm C. Hummel, Julie Duque
Summary: Reward can enhance motor skill learning by specifically potentiating reinforcement-related adjustments in the most relevant motor component for task success, which persists even in the absence of reward the following day.
Article
Biochemistry & Molecular Biology
Gerard Derosiere, David Thura, Paul Cisek, Julie Duque
Summary: This study found that under decision policies favoring speed over accuracy, the motor system in humans exhibits broad activity amplification and local suppression around the chosen representation. These findings contribute to our understanding of the neural mechanisms underlying decision-making behavior.
Article
Clinical Neurology
Emmanuelle Wilhelm, Caroline Quoilin, Gerard Derosiere, Susana Paco, Anne Jeanjean, Julie Duque
Summary: In Parkinson's disease, the lack of preparatory suppression in the primary motor cortex is associated with motor slowness and is related to disease duration and motor impairment. This finding suggests a potential marker for assessing motor preparation and impairment in Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Pierre Vassiliadis, Gerard Derosiere, Julie Duque