Article
Cell Biology
Bolu Zhou, Kristin E. Claflin, Kyle H. Flippo, Andrew I. Sullivan, Arvand Asghari, Satya M. Tadinada, Sharon O. Jensen-Cody, Ted Abel, Matthew J. Potthoff
Summary: The study reveals that FGF21 is not expressed in the hypothalamus, but in the retrosplenial cortex (RSC), and it enhances spatial memory in the hippocampus without regulating energy homeostasis or sugar intake.
Article
Geriatrics & Gerontology
Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Nozomu Masuyama, Ayaka Notoya, Shinya Ueno
Summary: The effects of chronic DZP administration differ between young and middle-aged mice. Memory retrieval performance impairment induced by chronic DZP in middle-aged mice is likely due to decreased LTP and dendritic spine density in hippocampal neurons in the CA3. Prophylactic exercise may mitigate the adverse effects of chronic DZP on LTP and spine maintenance in middle-aged mice.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Cell Biology
Xin Yang, Ru Gong, Linwei Qin, Yifei Bao, Yi Fu, Shan Gao, Hui Yang, Jinfei Ni, Ti-Fei Yuan, Wei Lu
Summary: NMDAR trafficking plays a crucial role in the modulation of synaptic functions and information processing. It can regulate the trafficking of AMPAR and AMPAR-mediated LTP, while AMPAR trafficking does not impact NMDAR-mediated LTP. Additionally, impaired NMDAR trafficking results in deficits in fear memory consolidation.
Article
Multidisciplinary Sciences
David Vandael, Yuji Okamoto, Peter Jonas
Summary: Post-tetanic potentiation (PTP) is a major form of plasticity at hippocampal mossy fiber synapses and is considered an entirely presynaptic phenomenon. The authors show that mossy fiber PTP not only lacks associativity, but rather shows anti-associative induction properties, implementing a brake on mossy fiber detonation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Linda D. Simmler, Yue Li, Lotfi C. Hadjas, Agnes Hiver, Ruud van Zessen, Christian Luscher
Summary: Ketamine does not induce synaptic plasticity in the nucleus accumbens despite eliciting dopamine transients, due to the rapid off-kinetics of the dopamine transients and NMDAR antagonism. However, it supports reinforcement through NMDAR antagonism in GABA neurons of the ventral tegmental area, which is quickly terminated by type-2 dopamine receptors on dopamine neurons.
Article
Multidisciplinary Sciences
Joanna Sikora, Sonia Di Bisceglie Caballero, David Reiss, Brigitte L. Kieffer, Pierre Paoletti, Pierre-Yves Jacob, Abdel-Mouttalib Ouagazzal
Summary: The study reveals that by eliminating zinc binding to GluN2A, spatial memory and contextual fear memory can be improved, leading to enhanced spatial cognition in mice.
Article
Multidisciplinary Sciences
Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukawa
Summary: Cholinergic activation and glutamatergic dysfunction in the hippocampus are closely related. The study shows the importance of hippocampal cholinergic neurostimulating peptide (HCNP) in acetylcholine synthesis and suggests that HCNP-pp KO mice can serve as genetic models for cholinergic functional impairment. The findings support the cholinergic hypothesis and suggest that the model mice may be potential partial pathological animal models for Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kunwei Wu, Wenyan Han, Wei Lu
Summary: Sleep is an essential process for memory consolidation, and this study reveals the daily rhythmic alterations of GABAergic synapses in hippocampal CA1 pyramidal neurons. Wake promotes tonic inhibition and inhibits phasic inhibition compared to sleep. The study also demonstrates that inhibitory inputs from parvalbumin-expressing interneurons contribute to dynamic iLTP during sleep and wake. Additionally, synaptic insertion of alpha 5-GABA(A) receptors is found to underlie the wake-specific enhancement of iLTP at parvalbumin synapses, independent of the time of the day.
Article
Clinical Neurology
Emma G. Duerden, Ting Guo, Cecil Chau, Vann Chau, Anne Synnes, Ruth E. Grunau, Steven P. Miller
Summary: Early exposure to benzodiazepines, specifically midazolam, in neonates may lead to reduced hippocampal volumes in preterm children, which can have long-lasting effects on learning and memory, particularly in boys.
Review
Medicine, Research & Experimental
Vahideh Zalouli, Hosnieh Rajavand, Mahdi Bayat, Jalil Khaleghnia, Fariborz Sharifianjazi, Farzad Jafarinazhad, Nima Beheshtizadeh
Summary: Physical exercise has positive effects on adult hippocampal neurogenesis (AHN) and cognitive processes. The effects of anaerobic resistance training and high-intensity interval training on AHN are not clear. Individual genetic diversity may play a role in the response to exercise on AHN. Exercise can improve health on average, but the benefits may vary due to genetic differences. This review discusses the capability of AHN for peripheral nervous system regeneration and central nervous system control through physical exercise, as well as the genes and factors involved.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Juan Pablo Damian, Lucia Vazquez Alberdi, Lucia Canclini, Gonzalo Rosso, Silvia Olivera Bravo, Mariana Martinez, Natalia Uriarte, Paul Ruiz, Miguel Calero, Maria Vittoria Di Tomaso, Alejandra Kun
Summary: CMT1 type 1 disease is caused by mutations in pmp22, with TrJ/+ mice serving as an animal model. Behavioral analysis showed increased anxiety levels in TrJ/+ mice, consistent with hippocampus-associated behaviors. Expression of pmp22/PMP22 in hippocampal neurons also differed between TrJ/+ and wild-type mice.
Article
Cell Biology
Ye Tao, Fang Wang, Zhaohui Xu, Xianfu Lu, Yanqing Yang, Jing Wu, Changyu Yao, Fangzheng Yi, Jiajia Li, Zhigang Huang, Yehai Liu
Summary: The study reveals that in peripheral nerve regeneration, GSDMD leads to the formation of foamy cells through pyroptosis. Inhibiting GSDMD can reduce the number of foamy cells, promote axon regeneration, and improve functional recovery.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Katherine E. Squires, Kyle J. Gerber, Matthew C. Tillman, Daniel J. Lustberg, Carolina Montanez-Miranda, Meilan Zhao, Suneela Ramineni, Christopher D. Scharer, Ramendra N. Saha, Feng-Jue Shu, Jason P. Schroeder, Eric A. Ortlund, David Weinshenker, Serena M. Dudek, John R. Hepler
Summary: The study reveals that genetic variants of the RGS14 gene can profoundly impact protein function and physiology, with the LR variant irreversibly accumulating in the nucleus and the RQ variant exhibiting a mixed phenotype. These variants affect physiological processes such as inhibiting long-term potentiation in unexpected ways.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Immunology
Marina Estrazulas, Raquel D. S. Freitas, Eduarda T. Kafer, Ana P. A. Dagnino, Maria M. Campos
Summary: This study investigated the impact of environmental enrichment (EE) on nociceptive and inflammatory responses in a mouse model of arthritis. The results showed that EE reduced acute paw edema formation and arthritis scores, decreased the immune response in the prefrontal cortex, and increased the expression of brain-derived nerve factor (BDNF) in the hippocampus.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)