Article
Anatomy & Morphology
Sabrina Pitzalis, Fadila Hadj-Bouziane, Giulia Dal Bo, Carole Guedj, Francesca Strappini, Martine Meunier, Alessandro Farne, Patrizia Fattori, Claudio Galletti
Summary: The sensitivity of V6 and CSv to egomotion compatible optic flow shows differences between humans and macaques. While CSv in macaques displays selectivity to egomotion compatible optic flow, V6 does not. However, V6 in monkey brain shows high selectivity for coherently moving fields of dots, demonstrating similarities in V6 activation across humans and monkeys.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Seo Yoon Park, Sang Seok Yeo, Sung Ho Jang, In Hee Cho, Seunghue Oh
Summary: This study found a positive correlation between FA of PIVC on the affected side and FAC, as well as a negative correlation between FA of PIVC on the unaffected side and MI. The evaluation results of MI and FAC showed significant differences during the recovery process. Early detection of the projection pathway for PIVC injury using DTI may be helpful in predicting the prognosis of patients with PIVC injury.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Fu Zeng, Adam Zaidel, Aihua Chen, Christopher R. Fetsch
Summary: The adult brain shows remarkable plasticity by recalibrating its perceptual estimates based on information from multiple sensory sources. In this study, single-neuron activity was recorded in monkeys' brains, revealing that early multisensory cortices participate in unsupervised recalibration, while the VIP area reflects a global shift in vestibular space.
Review
Clinical Neurology
Bingyu Liu, Jiayu Shan, Yong Gu
Summary: The vestibular system plays a crucial role in various cognitive functions, and recent studies have shed light on its neural mechanisms. However, the complex spatiotemporal dynamics of vestibular signals pose challenges in integrating them with other modalities.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Luxin Zhou, Yong Gu
Summary: Accurate self-motion perception is crucial for survival, and it involves multiple sensory cues such as optic flow and inertial motion. Recent studies challenge previous conventional thoughts about the cortical mechanisms underlying visuo-vestibular integration and propose that different temporal component signals may mediate different functions in multisensory self-motion perception.
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Grace F. DiRisio, Yongsoo Ra, Yinghui Qiu, Akiyuki Anzai, Gregory C. DeAngelis
Summary: Smooth eye movements are essential for natural visual processes, and they can be guided by both visual cues and extraretinal signals. This study focuses on how the brain processes and integrates these signals during smooth pursuit eye movements. The researchers investigate the responses of neurons in the MSTd area of rhesus monkeys and find that most neurons have preferences for the direction of eye rotation based on both visual and extraretinal signals. This suggests that area MSTd plays a crucial role in integrating these signals and representing the velocity of smooth eye movements.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Qihao Zheng, Luxin Zhou, Yong Gu
Summary: The study investigates the integration of optic flow and vestibular cues in precise heading perception, finding that adjusting visual stimuli to lead vestibular cues can improve heading performance. This alignment is associated with nonlinear gain modulation effects, facilitating cue integration in certain brain areas.
Review
Biology
Zhao Zeng, Ce Zhang, Yong Gu
Summary: Multi-sensory decision making (MSDM) is crucial for making accurate decisions in complex environments. Recent research in computational theory, psychophysical behavior, and neurophysiology has made significant progress in understanding MSDM. By studying a visuo-vestibular heading model system, researchers have uncovered the complex temporal dynamics of vestibular signals in various brain regions, challenging the brain's ability to integrate cues across time and sensory modalities. Moreover, new evidence from higher-level decision-related areas has revised our understanding of how signals from different sensory modalities are processed and accumulated to form a unified perceptual decision.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Neurosciences
Sepiedeh Keshavarzi, Mateo Velez-Fort, Troy W. Margrie
Summary: Despite its involvement in key functions of the cerebral cortex, the vestibular sense is rarely conscious, but recent studies suggest that its integration with vision improves the cortical representation and perceptual accuracy of self-motion and orientation. This suggests that the cortex constantly updates and uses vestibular-visual integration to enhance sensory perception and make rapid navigation-related decisions.
ANNUAL REVIEW OF NEUROSCIENCE
(2023)
Review
Biology
Steven J. Jerjian, Devin R. Harsch, Christopher R. Fetsch
Summary: In order to navigate and guide adaptive behaviour in a dynamic environment, animals need to accurately estimate their own motion relative to the external world. This process involves the integration of visual, vestibular and kinesthetic inputs. Recent research has shown that time and certainty are crucial for self-motion perception and decision-making in navigation. By extending current models, researchers have been able to study confidence in heading discrimination and explore the connection between self-motion perception and navigation. Overall, this study offers promise for a deeper understanding of spatial perception and decision-making in behaving animals.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Michiaki Nagai, Verena Scheper, Thomas Lenarz, Carola Y. Foerster
Summary: The insular cortex is crucial in regulating the central autonomic nervous system in emotional stress and also functions as a vestibular area. Studies suggest the insular cortex plays a pivotal role in vestibular-cardiovascular integration.
CLINICAL AUTONOMIC RESEARCH
(2021)
Review
Clinical Neurology
Megan J. Kobel, Andrew R. Wagner, Daniel M. Merfeld, Jameson K. Mattingly
Summary: Vestibular perceptual thresholds have shown promise in detecting characteristic changes in vestibular pathologies and sub-clinical declines in vestibular function. Further research is needed to explore the potential applications and limitations in the diagnosis of vestibular disorders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Alexandra J. Ng, Lindsay K. Vincelette, Jiayi Li, Bridget H. Brady, John P. Christianson
Summary: Behaviors associated with distress can influence the anxiety-like states in observers and shape social interactions among stressed individuals. Serotonin and its receptors, particularly the 5-HT2C receptor, play a crucial role in modulating social affective decision-making and are involved in the social reactions to stressed individuals. Furthermore, these effects are not influenced by gender.
Article
Clinical Neurology
Elena Calzolari, Mariya Chepisheva, Rebecca M. Smith, Mohammad Mahmud, Peter J. Hellyer, Vassilios Tahtis, Qadeer Arshad, Amy Jolly, Mark Wilson, Heiko Rust, David J. Sharp, Barry M. Seemungal
Summary: Vestibular dysfunction is common in patients with TBI and requires a multi-level assessment due to the varied areas of damage. Patients with vestibular agnosia experience more severe imbalance, potentially linked to direct and indirect effects of white matter tract damage in the brain.
Article
Multidisciplinary Sciences
Caitlin S. Mallory, Kiah Hardcastle, Malcolm G. Campbell, Alexander Attinger, Isabel I. C. Low, Jennifer L. Raymond, Lisa M. Giocomo
Summary: Neural circuits in the medial temporal lobe construct a map-like representation of space that supports navigation by integrating multiple sensory cues and cues related to the individual's movement through the environment. The medial entorhinal cortex (MEC) encodes three-dimensional head movement, eye position, and velocity, alongside other self-motion signals in individual neurons, such as body position, running speed, and azimuthal head direction.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Eric Avila, Kaushik J. Lakshminarasimhan, Gregory C. DeAngelis, Dora E. Angelaki
Article
Neurosciences
Ramon Nogueira, Nicole E. Peltier, Akiyuki Anzai, Gregory C. DeAngelis, Julio Martinez-Trujillo, Ruben Moreno-Bote
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Shaun L. Cloherty, Jacob L. Yates, Dina Graf, Gregory C. DeAngelis, Jude F. Mitchell
Article
Neurosciences
Kaushik J. Lakshminarasimhan, Eric Avila, Erin Neyhart, Gregory C. DeAngelis, Xaq Pitkow, Dora E. Angelaki
Article
Neurosciences
Ryo Sasaki, Akiyuki Anzai, Dora E. Angelaki, Gregory C. DeAngelis
NATURE NEUROSCIENCE
(2020)
Article
Ophthalmology
Nicole E. Peltier, Dora E. Angelaki, Gregory C. DeAngelis
Article
Neurosciences
Aihua Chen, Fu Zeng, Gregory C. DeAngelis, Dora E. Angelaki
Summary: The activity in the parieto-insular vestibular cortex (PIVC) reflects a dynamically changing combination of sensory and choice signals, with a more balanced representation compared to other regions. Interestingly, there is a negative correlation between heading and choice signals in PIVC during the middle portion of the stimulus epoch.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Zhe-Xin Xu, Gregory C. DeAngelis
Summary: There are two sources of retinal image motion: objects moving in the world and observer movement. Neurons in the middle temporal (MT) area combine eye velocity and retinal velocity, potentially through a partial coordinate transformation or a multiplicative gain interaction, to compute head-centered object motion and depth information.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Adam Zaidel, Jean Laurens, Gregory C. DeAngelis, Dora E. Angelaki
Summary: This study found that adult rhesus macaques show little neural plasticity in the lower-level multisensory cortical area MSTd, but exhibit neural plasticity in the higher-level multisensory area VIP. The systematic shifts in VIP tuning curves were observed, reflecting the decision-related component of the population response. The results demonstrate neuronal calibration in single sessions, laying the foundation for understanding multisensory neural plasticity in maintaining accuracy for sensorimotor tasks.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
HyungGoo R. Kim, Dora E. Angelaki, Gregory C. DeAngelis
Summary: The detection of object motion in a scene during self-motion is not well understood. Neurons in the macaque middle temporal area have been found to have incongruent depth tuning for binocular disparity and motion parallax cues, and they play a role in predicting perceptual decisions during the detection of moving objects.
Article
Multidisciplinary Sciences
Ranran L. French, Gregory C. DeAngelis
Summary: An important function of the visual system is to represent 3D scene structure from 2D images. Motion parallax provides depth information, but object motion relative to the scene can complicate depth computation. Our study found that scene-relative object motion can confound depth perception.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Grace F. DiRisio, Yongsoo Ra, Yinghui Qiu, Akiyuki Anzai, Gregory C. DeAngelis
Summary: Smooth eye movements are essential for natural visual processes, and they can be guided by both visual cues and extraretinal signals. This study focuses on how the brain processes and integrates these signals during smooth pursuit eye movements. The researchers investigate the responses of neurons in the MSTd area of rhesus monkeys and find that most neurons have preferences for the direction of eye rotation based on both visual and extraretinal signals. This suggests that area MSTd plays a crucial role in integrating these signals and representing the velocity of smooth eye movements.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Adam D. Danz, Dora E. Angelaki, Gregory C. DeAngelis
Review
Physiology
Ranran L. French, Gregory C. DeAngelis
CURRENT OPINION IN PHYSIOLOGY
(2020)
Article
Neurosciences
L. Caitlin Elmore, Ari Rosenberg, Gregory C. DeAngelis, Dora E. Angelaki