Article
Pharmacology & Pharmacy
Xiao-Li Zhang, Qi Sun, Zhu-Sheng Quan, Liang Wu, Zi-Ming Liu, Yan-Qi Xia, Qian-Yi Wang, Yue Zhang, Jin-Xia Zhu
Summary: This study found that dopamine promotes the secretion of colonic glial cell-derived neurotrophic factor (GDNF) via D1 receptors on cholinergic neurons, while high concentrations of dopamine inhibit GDNF secretion via D2 receptors on enteric glial cells (EGCs) and/or cholinergic neurons.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Ji-chun Zhang, Wei Yao, Kenji Hashimoto
Summary: The N-methyl-D-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has been shown to have rapid and sustained antidepressant effects in treatment-resistant patients with major depressive disorder and other psychiatric disorders. However, recent studies suggest that the (R) enantiomer of ketamine may have even stronger and longer-lasting antidepressant effects than the (S) enantiomer. Additionally, the (R) enantiomer has fewer side effects. Ongoing clinical trials aim to further investigate the potential of (R)-ketamine in the treatment of treatment-resistant depression.
Article
Chemistry, Analytical
Pavel A. Markin, Natalia E. Moskaleva, Svetlana A. Lebedeva, Sergey V. Kozin, Ekaterina M. Grigorevskikh, Larisa G. Kolik, Tatyana A. Gudasheva, Svetlana A. Appolonova
Summary: The study characterizes a novel dipeptide mimetic of the 2nd BDNF loop named GTS-201, which crosses the blood-brain barrier and affects serotonin and dopamine levels in the brain. GTS-201 exhibits psycho-tropic properties and potential therapeutic effects in anxiety and alcohol dependence.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Medicine, General & Internal
Yaling Zhang, Dejian Chen, Daojuan Wang, Lei Wang, Yajing Weng, Hongwei Wang, Xiaoke Wu, Yong Wang
Summary: This study investigates the effects of moderate aerobic exercise on follicle development in PCOS-like rats. The results show that aerobic exercise not only reverses the PCOS phenotype, but also activates the BDNF-TrkB pathway to inhibit apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Review
Neurosciences
Olesja Bondarenko, Mart Saarma
Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Oscar Marcelo Lazo, Giampietro Schiavo
Summary: Neurons process real-time information by encoding inputs from distal axons as a stream of endocytic organelles, called signalling endosomes, targeted to the soma. The sorting mechanism of TrkB to signalling endosomes is unknown. In this study, we identify Rab10 as critical for TrkB sorting and propagation of BDNF signalling from axon terminals to the soma, providing insights into neurodegenerative diseases.
Article
Substance Abuse
Daniil Grinchii, Matar Levin-Greenwald, Noa Lezmy, Tamar Gordon, Ruslan Paliokha, Talah Khoury, Matej Racicky, Leonie Herburg, Claudia Grothe, Eliyahu Dremencov, Segev Barak
Summary: Altering the FGF2-FGFR1 pathway may reduce alcohol consumption by modifying the activity of dopaminergic neurons in the mesolimbic and nigrostriatal systems.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Biochemistry & Molecular Biology
Samuel Hogarth, Emily J. Jaehne, Xiangjun Xu, Quenten Schwarz, Maarten van den Buuse
Summary: The aim of this study was to investigate the role of BDNF and dopamine D3 receptors in the effects of chronic methamphetamine on prepulse inhibition (PPI), an endophenotype of psychosis. The results showed that chronic methamphetamine disrupted PPI regulation in male mice with BDNF haploinsufficiency, regardless of D3 receptor knockout. However, there were no effects of BDNF heterozygosity or D3 knockout on PPI regulation in female mice. These findings suggest a significant involvement of BDNF in the long-term effects of methamphetamine on PPI, particularly in male mice.
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiaobei Li, Yiping Huang, Yineng Han, Qiaolin Yang, Yunfei Zheng, Weiran Li
Summary: This study reveals that lncPVT1 positively regulates the osteogenic differentiation of PDLCs through miR-10a-5p and BDNF, providing a promising target for enhancing the osteogenic potential of PDLCs.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Article
Neurosciences
Shristi Khanal, Eugene Bok, Jaekwang Kim, Gyu Hwan Park, Dong-Young Choi
Summary: Parkinson's disease (PD) is a common neurodegenerative disease without known cure or therapy. Inosine, a purine nucleoside, can protect neuroblastoma cells and dopaminergic neurons through brain-derived neurotrophic factor (BDNF) upregulation and activation of its downstream signaling pathway. Adenosine receptors A1 and A2A play critical roles in mediating the neuroprotective effects of inosine. Inosine shows therapeutic potential in treating dopaminergic neurodegeneration in PD.
Article
Multidisciplinary Sciences
Andre Kleinridders, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William R. Collins, Sara G. Vienberg, Emmanuel N. Pothos, C. Ronald Kahn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Endocrinology & Metabolism
Silvana Obici, I. Jack Magrisso, Armen S. Ghazarian, Alireza Shirazian, Jonas R. Miller, Christine M. Loyd, Denovan P. Begg, Kimberly A. Krawczewski Carhuatanta, Michael K. Haas, Jon F. Davis, Stephen C. Woods, Darleen A. Sandoval, Randy J. Seeley, Laurie J. Goodyear, Emmanuel N. Pothos, Joram D. Mul
MOLECULAR METABOLISM
(2015)
Article
Medicine, Research & Experimental
Weikang Cai, Chang Xue, Masaji Sakaguchi, Masahiro Konishi, Alireza Shirazian, Heather A. Ferris, Mengyao E. Li, Ruichao Yu, Andre Kleinridders, Emmanuel N. Pothos, C. Ronald Kahn
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Cell Biology
Gina M. Leinninger, Darren M. Opland, Young-Hwan Jo, Miro Faouzi, Lyndsay Christensen, Laura A. Cappellucci, Christopher J. Rhodes, Margaret E. Gnegy, Jill B. Becker, Emmanuel N. Pothos, Audrey F. Seasholtz, Robert C. Thompson, Martin G. Myers
Article
Medicine, Research & Experimental
Hsien-yang Lee, Junko Nakayama, Ying Xu, Xueliang Fan, Maha Karouani, Yiguo Shen, Emmanuel N. Pothos, Ellen J. Hess, Ying-Hui Fu, Robert H. Edwards, Louis J. Ptacek
JOURNAL OF CLINICAL INVESTIGATION
(2012)
Article
Biochemistry & Molecular Biology
Tohru Kitada, Antonio Pisani, Maha Karouani, Marian Haburcak, Giuseppina Martella, Anne Tscherter, Paola Platania, Bei Wu, Emmanuel N. Pothos, Jie Shen
JOURNAL OF NEUROCHEMISTRY
(2009)
Article
Neurosciences
B. M. Geiger, M. Haburcak, N. M. Avena, M. C. Moyer, B. G. Hoebel, E. N. Pothos
Article
Psychology, Biological
Erin N. Umberg, Emmanuel N. Pothos
PHYSIOLOGY & BEHAVIOR
(2011)
Editorial Material
Psychology, Biological
Emmanuel N. Pothos
PHYSIOLOGY & BEHAVIOR
(2012)
Review
Psychology, Biological
Patricia J. Allen, Payal Batra, Brenda M. Geiger, Tara Wommack, Cheryl Gilhooly, Emmanuel N. Pothos
PHYSIOLOGY & BEHAVIOR
(2012)
Article
Multidisciplinary Sciences
Puspha Sinnayah, Erin E. Jobst, Joseph A. Rathner, Angela D. Caldera-Siu, Luciana Tonelli-Lemos, Aaron J. Eusterbrock, Pablo J. Enriori, Emmanuel N. Pothos, Kevin L. Grove, Michael A. Cowley
Article
Multidisciplinary Sciences
Youren Tong, Antonio Pisani, Giuseppina Martella, Maha Karouani, Hiroo Yamaguchi, Emmanuel N. Pothos, Jie Shen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Materials Science, Biomaterials
Will Collins, Nicolas Rouleau, Mattia Bonzanni, Kevin Kapner, Alex Jeremiah, Chuang Du, Emmanuel N. Pothos, David L. Kaplan
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Nutrition & Dietetics
Andre Kleinridders, Emmanuel N. Pothos
CURRENT NUTRITION REPORTS
(2019)