Article
Cell Biology
Melodi A. Bowman, Jorge A. Gomez, Nathan C. Mitchell, Anne M. Wells, Melissa Vitela, Kyra M. Clarke, Rebecca E. Horton, Wouter Koek, Lynette C. Daws
Summary: Selective serotonin reuptake inhibitors (SSRIs) are less effective in treating depression in children than in adults. This may be due to the upregulation of organic cation transporter 3 (OCT3) and plasma membrane monoamine transporter (PMAT) in juveniles, leading to faster serotonin clearance and specific blocker's antidepressant-like effects.
Article
Neurosciences
Jamie L. Scholl, Rajeshwari R. Solanki, Michael J. Watt, Kenneth J. Renner, Gina L. Forster
Summary: In rats, withdrawal from chronic amphetamine increases OCT3 expression in specific brain regions, and corticosterone can increase OCT3 expression in the ventral hippocampus independently of glucocorticoid receptors (GRs). Mifepristone, a GR antagonist, does not block the effects of corticosterone on OCT3 expression and anxiety-like behavior.
Article
Cell Biology
Benjamin K. Lau, Ciaran Murphy-Royal, Manpreet Kaur, Min Qiao, Jaideep S. Bains, Grant R. Gordon, Stephanie L. Borgland
Summary: The overconsumption of highly palatable, energy-dense food is considered a key driver of the obesity pandemic. This study reveals that obesity disrupts astrocytes in the OFC, leading to a decrease in inhibitory GABA transmission between neurons.
Article
Multidisciplinary Sciences
Abida Shaheen, Syed Mahboob Alam, Fahad Azam, Salman Ahmad Saleem, Moosa Khan, Syed Saud Hasan, Afrose Liaquat
Summary: The present study investigated the influence of OCTN1 genetic variants on the therapeutic efficacy and safety of gabapentinoids in Pakistani patients with neuropathic pain. The results showed that there was no significant association between OCTN1 SNPs and clinical response to gabapentinoids. These findings suggest that renal functions play a role in predicting the interindividual variability to therapeutic responsiveness of gabapentinoids.
Article
Behavioral Sciences
Hector Miguel Mancha-Gutierrez, Erika Estrada-Camarena, Lilian Mayagoitia-Novales, Elena Lopez-Pacheco, Carolina Lopez-Rubalcava
Summary: Chronic social defeat during early adolescence leads to depression-like behaviors, cognitive deficits, and neuroendocrine abnormalities, with long-term effects causing persistent psychological and physiological impacts.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Tristan J. Philippe, Lexia Bao, Maya E. Koblanski, Victor Viau
Summary: This study found that male and female rats showed region-specific changes in 5-HT 1A receptor function after repeated restraint, which may be explained by changes in receptor availability.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hana Horackova, Rona Karahoda, Veronika Vachalova, Helena Turkova, Cilia Abad, Frantisek Staud
Summary: The human placenta plays a crucial role in the transport of neurotransmitters dopamine and norepinephrine during fetal development. This study investigates the mechanisms involved in the uptake of these monoamines across the placental membranes. The findings provide insights into the physiological aspects of dopamine and norepinephrine transport and have pharmacological relevance for the safe use of neuroactive drugs during pregnancy.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jun Xie, Yongchao Han, Yufeng Liang, Lei Peng, Tao Wang
Summary: In this study, a specific transporter called HisT was identified through in vitro screening, which can transport histamine into cells. The results demonstrated the critical role of HisT in histamine transport and synaptic transmission, as well as its important physiological function in maintaining histamine pools and sustaining visual transmission when histamine synthesis is reduced.
Article
Biochemistry & Molecular Biology
Joanna Bak, Bartosz Bobula, Grzegorz Hess
Summary: This study compared the effects of repeated restraint stress and corticosterone injections on the neuronal functions of the dorsal raphe nucleus (DRN) in rats. The results showed that both stress and corticosterone injections increased neuronal excitability in the DRN, but only corticosterone injections affected synaptic kinetics and inhibitory transmission. Blocking the 5-HT7 receptor partially alleviated the effects of stress on DRN neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zainonesa Abrahams-October, Rabia Johnson, Mongi Benjeddou, Ruben Cloete
Summary: This study predicted the three-dimensional protein structure of SLC22A2 and investigated the effects of five haplotypes on the transport function of Metformin and other drugs. The results suggest that haplotypes 4 and 5 have a stronger preference for binding large inhibitor molecules, potentially leading to reduced clearance of Metformin during co-administration of drugs.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Sook Wah Yee, Kathleen M. Giacomini
Summary: The SLC22 family consists of membrane proteins that play important roles in the transport of solutes. They are involved in the absorption and disposition of prescription drugs, and mutations in some members can lead to rare monogenic disorders. Genetic polymorphisms in SLC22 transporters are associated with common human diseases and drug response. Three new members have recently been identified and their physiological and pharmacological roles need further investigation.
DRUG METABOLISM AND DISPOSITION
(2022)
Review
Pharmacology & Pharmacy
Antonio J. Lopez Quinones, Leticia Salvador Vieira, Joanne Wang
Summary: This article focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response, and toxicity. Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131I-mIBG while minimizing toxicity in normal tissues.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Oncology
Mahesh R. Nepal, Hanieh Taheri, Yang Li, Zahra Talebi, Muhammad Erfan Uddin, Yan Jin, Duncan F. DiGiacomo, Alice A. Gibson, Maryam B. Lustberg, Shuiying Hu, Alex Sparreboom
Summary: Duloxetine has been found to inhibit OCT2 and prevent OIPN without compromising the pharmacokinetics and antitumor properties of oxaliplatin, suggesting its potential as a therapeutic candidate for preventing OIPN.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Samina Bano, Humaira Sharif, Faiza Sajid, Sumaiya Binte Hamid, Abdulla A-B Badawy
Summary: Deletion of the TDO2 gene induces an anxiolytic-like behaviour in mice, while TDO inhibition by allopurinol elicits an antidepressant-like effect in rats exposed to restraint stress. Chronic nicotine administration inhibits TDO activity, enhances brain serotonin synthesis, and exerts anxiolytic- and antidepressant-like effects in rodent models. The present study aimed to examine the relationship between anxiety and depression measures and liver TDO activity, brain tryptophan concentration, and serotonin synthesis in rats treated chronically with nicotine. Our findings support the association between liver TDO activity and measures of anxiety and depression, but provide little evidence for sex differences in the behavioral response to nicotine.
BEHAVIOURAL PHARMACOLOGY
(2023)