Article
Multidisciplinary Sciences
Amy K. Sutton, Paulette B. Goforth, Ian E. Gonzalez, James Dell'Orco, Hongjuan Pei, Martin G. Myers, David P. Olson
Summary: The study reveals that VMH neurons expressing melanocortin 3 receptor (Mc3R) can sense glucose changes and promote glucose utilization by regulating blood glucose levels. Activation of these neurons can attenuate glucose fluctuations, while silencing them enhances blood glucose excursions following a glucose load.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Neurosciences
Zhihui Liu, Peng Cao
Summary: This study reports a new subpopulation of neurons, Cckar-expressing cells, located in the ventrolateral part of the ventromedial hypothalamus, and uncovers their roles in regulating female sexual behavior over reproductive cycles.
Review
Cell Biology
Yinqiong Huang, Xiahong Lin, Shu Lin
Summary: This research over the past decade has suggested that the pathogenic mechanisms of metabolic syndrome involve both peripheral tissues and central metabolic regulation imbalances. The hypothalamus, particularly the arcuate nucleus, is highlighted as the control center for metabolic homeostasis and energy balance, with Neuropeptide Y neurons playing a crucial role in integrating peripheral metabolic signals with the brain center. The manuscript aims to provide an overview of Neuropeptide Y's regulatory effects on metabolic syndrome and discuss clinical intervention strategies for neurometabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Article
Biochemistry & Molecular Biology
Polina A. Anfimova, Lydia G. Pankrasheva, Konstantin Yu Moiseev, Elizaveta S. Shirina, Valentina V. Porseva, Petr M. Masliukov
Summary: The hypothalamus plays a crucial role in regulating homeostasis, biological rhythms, adaptation, and aging. This study found the presence of Lin28-immunoreactive neurons in the ventromedial nucleus of the hypothalamus and their absence in other studied nuclei. The percentage of Lin28-positive neurons increases with age, peaks at 6 months and 1 year, and then declines. These neurons also colocalize components of insulin signaling, indicating their involvement in metabolic regulation. The findings suggest that Lin28 expression in the hypothalamus changes with development and signaling components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Berengere Coupe, Corinne Leloup, Kwame Asiedu, Julien Maillard, Luc Penicaud, Tamas L. Horvath, Sebastien G. Bouret
Summary: The study investigated the importance of the autophagy-related gene Atg7 in Sf1-expressing neurons of the ventromedial nucleus of the hypothalamus (VMH) under normal and fasting conditions. It was found that autophagy is nutritionally regulated in VMH neurons and participates in controlling energy homeostasis during fasting.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Anne-Sophie Sejling, Peili Wang, Wanling Zhu, Rawad Farhat, Nicholas Knight, Daniel Appadurai, Owen Chan
Summary: Repeated activation of noradrenergic receptors in the ventromedial hypothalamus increases local lactate levels, leading to a blunted counterregulatory hormone response to hypoglycemia.
Article
Biochemistry & Molecular Biology
Bailey Halter, Nicholas Ildari, Mark A. Cline, Elizabeth R. Gilbert
Summary: Ferulic acid (FA) was found to have transient appetite suppressing effects on food intake in chicks, possibly mediated through the hypothalamic arcuate nucleus (ARC) involving POMC. This effect did not impact defecation frequency or other behaviors in the chicks.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhigang Shi, Alyssa C. Bonillas, Jennifer Wong, Stephanie L. Padilla, Virginia L. Brooks
Summary: The study reveals that NPY in the hypothalamus suppresses sympathetic nerve activity in brown adipose tissue and influences heart rate and blood pressure via Y1R. Downstream pathways for BAT SNA may involve direct projections to the RPa and PVN.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mireia Medrano, Wissal Allaoui, Mathias Van Bulck, Sofie Thys, Leila Makrini-Maleville, Eve Seuntjens, Winnok H. De Vos, Emmanuel Valjent, Balazs Gaszner, Ann Van Eeckhaut, Ilse Smolders, Dimitri De Bundel
Summary: Neuromedin U (NMU) is an evolutionarily conserved neuropeptide that plays a role in various processes. A knock-in mouse model expressing Cre recombinase under the Nmu promoter has been generated, allowing a comprehensive characterization of NMU-expressing neurons in the brain. The model has been validated using multiple approaches, and the results suggest that it is a powerful and sensitive tool for studying the role of NMU neurons in mice.
Article
Multidisciplinary Sciences
Teodora Georgescu, Zin Khant Aung, David R. Grattan, Rosemary S. E. Brown
Summary: Aggressive behavior is observed in lactating female mice and is controlled by prolactin receptor in the ventromedial nucleus (VMN), which affects other brain regions involved in maternal behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Masaki Tanaka, Shunji Yamada, Yoshihisa Watanabe
Summary: Neuropeptide Y (NPY) plays a significant role in the brain, mainly mediating physiological and behavioral effects through Y1, Y2, and Y5 receptors in regions regulating various functions. The nucleus accumbens (NAc) has high levels of NPY concentration, contributing to functions like alcohol intake and emotional behavior. NPY in the NAc affects physiological and pathophysiological actions through neuroendocrine mechanisms and the autonomic nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
Shunji Yamada, Nienke van Kooten, Takuma Mori, Katsutoshi Taguchi, Atsushi Tsujimura, Masaki Tanaka
Summary: Neuropeptide Y (NPY) is widely distributed in the brain and plays various functions. This study clarified the anatomical connections of NPY neurons in the nucleus accumbens (NAc), showing that they project mainly to the lateral hypothalamus and receive direct synaptic connections from the midline thalamic nuclei and posterior basomedial amygdala. These findings provide new insights into the neural networks and functional roles of NAc NPY neurons.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Neurosciences
Xu Wang, Haohong Li
Summary: This study found that synaptic remodeling, lipid droplet accumulation, and synaptic dysfunction occur in feeding-related brain regions of obese mice induced by high-fat diet. These impairments are associated with energy homeostasis and reward regulation, which may contribute to overeating in obesity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Fumito Naganuma, Sathyajit S. Bandaru, Gianna Absi, Melissa J. Chee, Ramalingam Vetrivelan
BRAIN STRUCTURE & FUNCTION
(2019)
Review
Neurosciences
Elda Arrigoni, Melissa J. S. Chee, Patrick M. Fuller
Article
Endocrinology & Metabolism
Melissa J. Chee, Alex J. Hebert, Nadege Briancon, Stephen E. Flaherty, Pavlos Pissios, Eleftheria Maratos-Flier
MOLECULAR METABOLISM
(2019)
Article
Neurosciences
Kenichiro Negishi, Mikayla A. Payant, Kayla S. Schumacker, Gabor Wittmann, Rebecca M. Butler, Ronald M. Lechan, Harry W. M. Steinbusch, Arshad M. Khan, Melissa J. Chee
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Igor Melnick, Oleg A. Krishtal, William F. Colmers
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Neurosciences
Giovanne B. Diniz, Daniella S. Battagello, Marianne O. Klein, Bianca S. M. Bono, Jozelia G. P. Ferreira, Livia C. Motta-Teixeira, Jessica C. G. Duarte, Francoise Presse, Jean-Louis Nahon, Antoine Adamantidis, Melissa J. Chee, Luciane V. Sita, Jackson C. Bittencourt
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Endocrinology & Metabolism
Myriam P. Hoyeck, Rayanna C. Merhi, Hannah L. Blair, C. Duncan Spencer, Mikayla A. Payant, Diana I. Martin Alfonso, Melody Zhang, Geronimo Matteo, Melissa J. Chee, Jennifer E. Bruin
MOLECULAR METABOLISM
(2020)
Article
Nutrition & Dietetics
Melissa J. Chee, Nikita K. Koziel Ly, Hymie Anisman, Kimberly Matheson
Article
Behavioral Sciences
Mikayla A. Payant, Melissa J. Chee
Summary: Fructose consumption is linked to metabolic syndrome and obesity, potentially promoting obesity through various pathways such as overeating, increased visceral fat, hypertension, and insulin resistance. Emerging evidence suggests that dietary fructose can act on multiple brain systems to increase appetite drive, reduce time between meals, and decrease cognitive control, leading to overeating behaviors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Bianca S. Bono, Nikita K. Koziel Ly, Persephone A. Miller, Jesukhogie Williams-Ikhenoba, Yasmina Dumiaty, Melissa J. Chee
Summary: This study used in situ hybridization to label Klb mRNA and captured the distribution and levels of Klb in the mouse hypothalamus, hippocampal region, subiculum, and amygdala. The results showed heterogeneous expression of Klb in the hypothalamus and amygdala, suggesting novel roles for FGF15/19 or FGF21 signaling. These findings are consistent with the reported functions of Klb in metabolism, taste preference, and neuroprotection.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Kaylin G. Earnest, Erin M. McConnell, Eman M. Hassan, Mark Wunderlich, Bahareh Hosseinpour, Bianca S. Bono, Melissa J. Chee, James C. Mulloy, William G. Willmore, Maria C. DeRosa, Edward J. Merino
Summary: A DNA aptamer specific to AML cells was developed using SELEX technology in this study, showing specific binding to AML cells at a concentration of 37.5 nM, while displaying no binding to other cell types.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Neurosciences
Melissa J. Chee
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Endocrinology & Metabolism
Aditi S. Sankhe, Dillon Bordeleau, Diana I. Martin Alfonso, Gabor Wittman, Melissa J. Chee
Summary: Melanin-concentrating hormone (MCH) neurons in the hypothalamus are heterogeneous and can express other neuropeptides and transmitters. MCH neurons can release glutamate to directly innervate downstream neurons, potentially affecting glucose homeostasis, nutrient-sensing, energy balance, and mood disorders. By deleting the expression of vesicular glutamate transporter 2 (Vglut2) specifically in MCH neurons, researchers found that Mch-Vglut2-KO mice displayed anxiety-like behaviors and reduced exploratory activity, suggesting that glutamatergic signaling from MCH neurons, similar to MCH peptide, contributes to anxiety regulation and promotion.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Nikita K. Koziel Ly, Ladan Mohamud, Paul J. Villeneuve, Kimberly Matheson, Hymie Anisman, Melissa J. Chee
Summary: The COVID-19 pandemic has led to increased depression, anxiety, and stress. Physical activity during the pandemic has been found to be related to mental health outcomes, as it serves as a coping strategy to manage stress and promote resilience. This longitudinal study showed that a reduction in leisure-time physical activity was linked to subsequent feelings of depression, and individuals with lower levels of physical activity were more likely to appraise their COVID-19 situation as uncontrollable, which in turn was related to depressive feelings.
Meeting Abstract
Neurosciences
Mikayla A. Payant, Jenny Campbell, Alex J. Hebert, Eleftheria Maratos-Flier, Melissa J. Chee
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)