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Biochemistry & Molecular Biology
Qi Zhang, Xianming Wu, Yongheng Fan, Peipei Jiang, Yannan Zhao, Yaming Yang, Sufang Han, Bai Xu, Bing Chen, Jin Han, Minghan Sun, Guangfeng Zhao, Zhifeng Xiao, Yali Hu, Jianwu Dai
Summary: This study investigated the development of neurons and glial cells in the human spinal cord during embryonic and fetal stages, revealing stage-specific profiles and dynamics. Transitional glial cells expressing EGFR were identified, showing unique features and interactions with other neural cells during development. The research provides insights into neural cell development in the human spinal cord.
Article
Neurosciences
Shengming Wang, Yu Fu, Takaki Miyata, Sakiko Matsumoto, Tomoyasu Shinoda, Kyoko Itoh, Akihiro Harada, Shinji Hirotsune, Mingyue Jin
Summary: This study reveals the functional cooperation between aSyn and tau during brain development. Deletion of aSyn and tau alters the balance between progenitor cell proliferation and neurogenesis, resulting in an overproduction of early born neurons. Furthermore, there is a reduction in neural progenitor cells in the aSyn-/-tau-/- cortex, leading to diminished gliogenesis. Additionally, expansion and maturation of macroglial cells are suppressed in the aSyn-/-tau-/- postnatal brain, resulting in reduced brain size and cortical thickness.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Developmental Biology
Sami A. Leino, Sean C. J. Constable, Andrea Streit, David G. Wilkinson
Summary: In the development of the zebrafish hindbrain, Fgf signaling has different roles at different stages. Our study reveals the important role of the Zbtb16 transcription factor in coordinating the transition of Fgf signaling during hindbrain development.
Article
Multidisciplinary Sciences
Erika E. Paulson, Emily L. Fishman, Richard M. Schultz, Pablo J. Ross
Summary: MicroRNAs play a crucial role in preimplantation embryo development, with their expression increasing during the morula and blastocyst stages. Knockdown of DGCR8 inhibits the expression of embryonically expressed miRNAs and the morula-to-blastocyst transition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Deeptha Vasudevan, Yen-Chyi Liu, Joshua P. Barrios, Maya K. Wheeler, Adam D. Douglass, Richard Dorsky
Summary: Zebrafish are able to recover swimming behavior even after complete spinal cord transection, and the regenerated interneurons have the ability to integrate into existing locomotor circuitry.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Cell Biology
Feng-Shou Chen, Xiang-Yi Tong, Bo Fang, Dan Wang, Xiao-Qian Li, Zai-Li Zhang
Summary: This review summarizes the relationship between miRNAs and spinal cord ischemia/reperfusion injury, as well as potential therapeutic strategies, which is of great significance for the research of spinal cord ischemia/reperfusion injury.
NEURAL REGENERATION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Ruonan Li, Jiangyi Liu, Ping Yi, Xianli Yang, Jun Chen, Chenyang Zhao, Xingyun Liao, Xiaotang Wang, Zongren Xu, Huiping Lu, Hongshun Li, Zhi Zhang, Xianyang Liu, Junjie Xiang, Ke Hu, Hongbo Qi, Jia Yu, Peizeng Yang, Shengping Hou
Summary: Through single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing, the heterogeneity of retinal progenitor cells and their differentiation into seven major types of retinal cells is explored. Lineage-determining transcription factors are identified and their regulatory networks at the transcriptomic and epigenomic levels are refined. Treatment with the inhibitor of RE1 silencing transcription factor, X5050, induces more neurogenesis and reduces Muller glial cells. The signatures of major retinal cells and their correlation with pathogenic genes associated with ocular diseases are described, providing an integrated framework for exploring the single-cell developmental dynamics of the human primary retina.
Review
Cell & Tissue Engineering
Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li, Xue-wen Kang
Summary: SCI often leads to serious motor and sensory dysfunction of the limbs below the injured segment, causing physical, psychological harm and economic burden. MSC therapy for SCI has shown promise but faces challenges like low survival rate and immune rejection, while exosomes derived from MSCs have great potential in the treatment of SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Materials Science, Multidisciplinary
Weijian Kong, Ronghang Li, Peng Xia, Su Pan, Zhiping Qi, Chengliang Zhao, Chuan Fu, Xiaoyu Yang
Summary: This study investigated the therapeutic effect of AuNPs@PDAPLGA nanomembrane combined with electrical stimulation (ES) on spinal cord injury (SCI). The results showed that the nanomembrane combined with ES could promote the proliferation and differentiation of neural stem cells (NSCs), as well as the regeneration of new neurons and formation of neuronal synapses, contributing to the functional recovery of SCI.
MATERIALS & DESIGN
(2022)
Article
Biology
Yann Roussel, Stephanie F. Gaudreau, Emily R. Kacer, Mohini Sengupta, Tuan Bui
Summary: This study builds models of developing zebrafish spinal circuits and simulates the underlying mechanisms of swimming movements. The simulations reveal the relationships between neuronal firing patterns and developmental stages, highlighting some key features of zebrafish locomotion.
Review
Neurosciences
Chunjia Zhang, Zuliyaer Talifu, Xin Xu, Wubo Liu, Han Ke, Yunzhu Pan, Yan Li, Fan Bai, Yingli Jing, Zihan Li, Zehui Li, Degang Yang, Feng Gao, Liangjie Du, Jianjun Li, Yan Yu
Summary: Spinal cord injury (SCI) is a global medical problem with limited diagnosis and treatment methods. Gene expression, particularly microRNAs (miRNAs), plays an important role in regulating SCI repair. Secondary damage, such as oxidative stress, apoptosis, autophagy, and inflammation, contributes to poor functional recovery. Understanding the pathophysiological mechanism of miRNAs in secondary injury after SCI can provide new insights for clinical diagnosis and treatment, and miRNAs could potentially be used as biomarkers and therapeutic targets for spinal cord injuries.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Anatomy & Morphology
Tatsuya Yuikawa, Takehisa Sato, Masaaki Ikeda, Momo Tsuruoka, Kaede Yasuda, Yuto Sato, Kouhei Nasu, Kyo Yamasu
Summary: In this study, the involvement of the pou5f3 gene in spinal cord elongation and neurogenesis was confirmed through mutant analysis and gain-of-function experiments. The study also revealed that pou5f3 regulates retinoic acid (RA) levels, which contribute to neurogenesis in the posterior neural tube.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Neurosciences
Leonora Olivos-Cisneros, Jesus Ramirez-Santos, Gabriel Gutierrez-Ospina
Summary: The study highlights that the lengthening of cell cycle during the transition from neurogenesis to gliogenesis affects the differentiation potential of neural stem cells, while the decrease in proliferation rate does not impact this mechanism.
IBRO NEUROSCIENCE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Paula G. Slater, Miguel E. Dominguez-Romero, Maximiliano Villarreal, Veronica Eisner, Juan Larrain
Summary: Spinal cord injury (SCI) causes paralysis in many people worldwide, with no current full functional recovery therapies available. Mitochondria play a crucial role in cellular responses after SCI, such as cell death, immune response, axon regeneration, and neural stem cell self-renewal and differentiation. Further investigation into mitochondrial function and regulation is needed to identify potential targets for SCI therapeutic intervention.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury is a devastating injury to the central nervous system, and current therapies have not been successful. MiRNA plays a crucial role in CNS development and pathological processes after neural injury, making it a promising candidate for SCI therapy.
Article
Neurosciences
Q. Zhu, Z. Tan, S. Zhao, H. Huang, X. Zhao, X. Hu, Y. Zhang, C. B. Shields, N. Uetani, M. Qiu
Article
Neurosciences
Jie Jiang, Qiang Zhu, Tania F. Gendron, Shahram Saberi, Melissa McAlonis-Downes, Amanda Seelman, Jennifer E. Stauffer, Paymaan Jafar-nejad, Kevin Drenner, Derek Schulte, Seung Chun, Shuying Sun, Shuo-Chien Ling, Brian Myers, Jeffery Engelhardt, Melanie Katz, Michael Baughn, Oleksandr Platoshyn, Martin Marsala, Andy Watt, Charles J. Heyser, M. Colin Ard, Louis De Muynck, Lillian M. Daughrity, Deborah A. Swing, Lino Tessarollo, Chris J. Jung, Arnaud Delpoux, Daniel T. Utzschneider, Stephen M. Hedrick, Pieter J. de Jong, Dieter Edbauer, Philip Van Damme, Leonard Petrucelli, Christopher E. Shaw, C. Frank Bennett, Sandrine Da Cruz, John Ravits, Frank Rigo, Don W. Cleveland, Clotilde Lagier-Tourenne
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Developmental Biology
Qiang Zhu, Xiaofeng Zhao, Kang Zheng, Hong Li, Hao Huang, Zunyi Zhang, Teresa Mastracci, Michael Wegner, Yiping Chen, Lori Sussel, Mengsheng Qiu
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Neurosciences
Jun Cai, Qiang Zhu, Kang Zheng, Hong Li, Yingchuan Qi, Qilin Cao, Mengsheng Qiu
Article
Neurosciences
Qiang Zhu, Scott R. Whittemore, William H. Devries, Xiaofeng Zhao, Nicholas J. Kuypers, Mengsheng Qiu
Article
Neurosciences
Jinsil Park, Ben Liu, Tao Chen, Hong Li, Xuemei Hu, Jing Gao, Ying Zhu, Qiang Zhu, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng, Mengsheng Qiu
JOURNAL OF NEUROSCIENCE
(2008)
Article
Multidisciplinary Sciences
Xiaofeng Zhao, Yidan Chen, Qiang Zhu, Hao Huang, Peng Teng, Kang Zheng, Xuemei Hu, Binghua Xie, Zunyi Zhang, Maike Sander, Mengsheng Qiu
Article
Multidisciplinary Sciences
Clotilde Lagier-Tourenne, Michael Baughn, Frank Rigo, Shuying Sun, Patrick Liu, Hai-Ri Li, Jie Jiang, Andrew T. Watt, Seung Chun, Melanie Katz, Jinsong Qiu, Ying Sun, Shuo-Chien Ling, Qiang Zhu, Magdalini Polymenidou, Kevin Drenner, Jonathan W. Artates, Melissa McAlonis-Downes, Sebastian Markmiller, Kasey R. Hutt, Donald P. Pizzo, Janet Cady, Matthew B. Harms, Robert H. Baloh, Scott R. Vandenberg, Gene W. Yeo, Xiang-Dong Fu, C. Frank Bennett, Don W. Cleveland, John Ravits
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Cell Biology
Guanxiu Xiao, Junqing Du, Huihui Wu, Xinqi Ge, Xiaofeng Xu, Aifen Yang, Ying Zhu, Xuemei Hu, Kang Zheng, Qiang Zhu, Mengsheng Qiu
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2020)
Article
Neurosciences
Qiang Zhu, Jie Jiang, Tania F. Gendron, Melissa McAlonis-Downes, Lulin Jiang, Amy Taylor, Sandra Diaz Garcia, Somasish Ghosh Dastidar, Maria J. Rodriguez, Patrick King, Yongjie Zhang, Albert R. La Spada, Huaxi Xu, Leonard Petrucelli, John Ravits, Sandrine Da Cruz, Clotilde Lagier-Tourenne, Don W. Cleveland
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Inmaculada Sanjuan-Ruiz, Noe Govea-Perez, Melissa McAlonis-Downes, Stephane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W. Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Summary: The study demonstrates that introducing a wild-type FUS gene can rescue mice with abnormal Fus expression, improve motor deficits, and extend lifespan. Wild-type FUS decreases cytoplasmic FUS load, increases retention of introns 6 and 7 in endogenous mouse Fus mRNA, and reduces expression of mutant mRNA.
MOLECULAR NEURODEGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Q Zhu, HY Chang, Y Chen, F Fang, CY Xue, FH Zhang, MZ Qiu, HZ Wang, B Wang, Z Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2005)
Article
Biochemistry & Molecular Biology
L Tang, QY Zhu, E Qin, M Yu, ZF Ding, HY Shi, XJ Cheng, CP Wang, GH Chang, Q Zhu, F Fang, HY Chang, SL Li, XM Zhang, XS Chen, J Yu, J Wang, Z Chen
DNA AND CELL BIOLOGY
(2004)
Article
Anatomy & Morphology
Shufang Zhao, Xuemei Hu, Jinsil Park, Ying Zhu, Qiang Zhu, Hong Li, Chen Luo, Ruifa Han, Nigel Cooper, Mengsheng Qiu
DEVELOPMENTAL DYNAMICS
(2007)