Article
Neurosciences
Wan-Ling Tsai, Chih-Ju Chang, Chih-Yang Wang, Tsung- Hsu, Ming-Yuan Chang, Yi-Hsin Wu, Pei-Shan Chang, Kai-Lun Lin, Jian-Ying Chuang, Artur Kania, Tzu-Jen Kao
Summary: The study demonstrates the essential role of paxillin in motor axon guidance in both chick and mouse embryos. Paxillin is involved in the Ephrin-Eph signaling pathway, influencing the trajectory selection of LMC axons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Lingdi Nie, Dongqing Ma, John P. Quinn, Minyan Wang
Summary: This study reveals that SFKs activity transmits P2X7 receptor signaling to facilitate CSD propagation via the glutamatergic pathway and promote neuroinflammation, which is particularly relevant to migraine.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Antonia S. Carroll, James Howells, Cindy S. Y. Lin, Susanna B. Park, Neil Simon, Mary M. Reilly, Steve Vucic, Matthew C. Kiernan
Summary: This study compares the excitability differences of motor and sensory axons in the main upper limb nerves and provides guidance for future research on human diseases. The results demonstrate that the excitability parameters are most comparable between the median and ulnar nerves.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Saad Javeed, Jacob K. Greenberg, Justin K. Zhang, Christopher F. Dibble, Jawad M. Khalifeh, Ying Liu, Thomas J. Wilson, Lynda J. Yang, Yikyung Park, Wilson Z. Ray
Summary: Accurate prediction of upper limb recovery following traumatic cervical spinal cord injury (SCI) is crucial for guiding reconstructive therapies. This study developed a clinical prediction rule to prognosticate upper limb functional recovery based on early neurological variables. The results showed that the prediction rule was effective in distinguishing dependent from independent patients and outperformed AIS grading.
Review
Biochemistry & Molecular Biology
Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Jishi Liu, Juan Tang
Summary: Src family kinases (SFKs) have been found to play a crucial role in acute kidney injury (AKI), making them potential therapeutic targets.
Article
Oncology
Ishwar N. Kohale, Jia Yu, Yongxian Zhuang, Xiaoyang Fan, Raven J. Reddy, Jason Sinnwell, Krishna R. Kalari, Judy C. Boughey, Jodi M. Carter, Matthew P. Goetz, Liewei Wang, Forest M. White
Summary: Breast cancer is the leading cause of cancer-related deaths in women globally, with triple negative breast cancer (TNBC) known for being highly aggressive and resistant to chemotherapy. In this study, the researchers identified Src family kinases (SFKs) as potential drug targets for chemotherapy-resistant TNBC. However, the prevalence of SFK-driven tumors was found to be low in human tumor tissue specimens. These findings highlight the importance of characterizing phosphotyrosine signaling profiles for patient stratification and therapeutic options.
Article
Neurosciences
Dandan Wang, Brian W. Howell, Eric C. Olson
Summary: The study found that alcohol exposure can induce tyrosine phosphorylation response in the fetal brain, affecting cortical development. This initial phosphorylation response activated by alcohol has the potential to disrupt multiple developmentally important signaling systems.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Han Qiu, Tianyang Qian, Tong Wu, Ting Gao, Qinghe Xing, Laishuan Wang
Summary: This study identified the pattern of p-Src expression after HI brain injury in immature rats and demonstrated its relationship with activated NMDA receptors. Inhibiting p-Src can ameliorate neuropathological changes and damage to neurological functions induced by HI injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Immunology
Nikolaos Koutras, Vasileios Morfos, Kyriakos Konnaris, Adamantia Kouvela, Athanasios-Nasir Shaukat, Constantinos Stathopoulos, Vassiliki Stamatopoulou, Konstantina Nika
Summary: This study reveals the ectopic function of SFKs in B cells and compares it to the predominant B cell SFK, Lyn. Our findings show substrate promiscuity displayed by these two SFKs, which is regulated by different mechanisms. Moreover, we demonstrate that signals generated by Lck and Lyn are sufficient to induce transcriptome alterations in B cells, resembling B cell activation. Additionally, we uncover a previously unknown role of SFKs in tipping the balance of cellular stress responses in B lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Xianzheng Zhang, Dan Mei, Lingling Zhang, Wei Wei
Summary: Autoimmune diseases encompass a spectrum of over 80 known disorders, with B cells playing a critical role in their development. Src family protein kinases (SFKs), including LYN, BLK, and Fyn, are important regulators in B lymphocytes, impacting the risk and progression of autoimmune disorders. Understanding the functions of these SFKs in autoimmune diseases could provide valuable insights for future therapeutic strategies.
Article
Neurosciences
Guangmin Xu, Zigang Huang, Jiajing Sheng, Xiang Gao, Xin Wang, Jason Q. Garcia, Guanyun Wei, Dong Liu, Jie Gong
Summary: The study revealed the crucial role of fgfbp3 in axonal morphogenesis and regeneration of motor neurons in zebrafish, with loss of fgfbp3 leading to defects that can be partially rescued by fgfbp3 mRNA injection and overexpression. Transcriptome sequencing identified drd1b and neurod6a as potential rescuers for motor neuron malformation in fgfbp3 knockout embryos.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Nathan Greiner, Beatrice Barra, Giuseppe Schiavone, Henri Lorach, Nicholas James, Sara Conti, Melanie Kaeser, Florian Fallegger, Simon Borgognon, Stephanie Lacour, Jocelyne Bloch, Gregoire Courtine, Marco Capogrosso
Summary: The study utilized a combination of computational modeling and experiments in non-human primates to investigate how epidural electrical stimulation (EES) can recruit upper-limb motor neurons and potentially improve arm and hand control in humans with quadriplegia.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Dingjin Yao, Yiran Deng, Si Zhang, Limiao Liang, Li Zhang, Shuqiang Weng, She Chen
Summary: This study aimed to thoroughly investigate the mutation status, expression level, prognostic value and relationship of Src family kinases (SFKs) in hepatocellular carcinoma (HCC). The study found that elevated mRNA expression levels of LYN, SRC, and SRM were observed in HCC tissues, whereas FYN was reduced. Approximately 10% genetic alterations rate of SFKs was observed in HCC. Dysregulated FYN and SRC expression in HCC were associated with poor prognosis and may be used as novel prognostic biomarkers in patients with HCC.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Review
Cell Biology
Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah, Leszek Kotula
Summary: Despite over a century of scientific inquiry since the discovery of v-SRC, there is still no final judgement on SRC function. However, Src family kinases have been defined as key players in tumor progression, invasion and metastasis. Understanding the role of SFKs in mediating invasion and metastasis processes has grown along with the evidence supporting epithelial-mesenchymal transition (EMT) in these processes. This article describes key mechanisms through which SFKs play critical roles in epithelial homeostasis and propagate invasive signals.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Samia Mohammed, Achraf A. Shamseddine, Benjamin Newcomb, Ronald S. Chavez, Tyler D. Panzner, Allen H. Lee, Daniel Canals, Chioma M. Okeoma, Christopher J. Clarke, Yusuf A. Hannun
Summary: Sublethal doses of Doxorubicin induce increased migration and invasion in cancer cells, independent of EMT and cancer stem cell population. Activation of SFKs, including Fyn, Yes, and Src, partly in a p53 and ATR-dependent manner, mediates these effects. Inhibiting SFKs with Dasatinib offers a potential therapeutic strategy to mitigate local invasion.
BREAST CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Veronica Murcia-Belmonte, Yaiza Coca, Celia Vegar, Santiago Negueruela, Camino de Juan Romero, Arturo Jose Valino, Salvador Sala, Ronan DaSilva, Artur Kania, Victor Borrell, Luis M. Martinez, Lynda Erskine, Eloisa Herrera
Article
Cell Biology
Hugues Petitjean, Farin B. Bourojeni, Deborah Tsao, Albena Davidova, Susana G. Sotocinal, Jeffrey S. Mogil, Artur Kania, Reza Sharif-Naeini
Article
Anesthesiology
Farin B. Bourojeni, Hanns Ulrich Zeilhofer, Artur Kania
Summary: Anterolateral system (AS) neurons relay nociceptive information from the spinal cord to the brain through canonical pathways, with disruption of this pathway leading to altered laterality of spinofugal projections and potential impacts on pain localization precision.
Biographical-Item
Neurosciences
Artur Kania, Laskaro Zagoraiou
Article
Neurosciences
Artur Kania
Summary: This overview discusses recent advances in the development of the components of the somatosensory system, including peripheral sensory neurons, central nervous system circuits, and higher structures like the somatosensory cortex. It also covers the role of neuronal activity in somatosensory development, formation of somatotopic maps, insights into human somatosensory development, and the connection between aberrant somatosensation and neurodevelopmental disorders.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Wan-Ling Tsai, Chih-Ju Chang, Chih-Yang Wang, Tsung- Hsu, Ming-Yuan Chang, Yi-Hsin Wu, Pei-Shan Chang, Kai-Lun Lin, Jian-Ying Chuang, Artur Kania, Tzu-Jen Kao
Summary: The study demonstrates the essential role of paxillin in motor axon guidance in both chick and mouse embryos. Paxillin is involved in the Ephrin-Eph signaling pathway, influencing the trajectory selection of LMC axons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Karina Chaudhari, Madhavi Gorla, Chao Chang, Artur Kania, Greg J. Bashaw
Summary: The study reveals that WRC is a direct effector of Robo signaling, with mutants of WRC enhancing defects caused by Robo1. The WIRS motif of Robo1 is essential for maintaining receptor activity, supporting an important conserved role for the WIRS-WRC interaction in Robo1-mediated axon repulsion.
Article
Anesthesiology
R. Brian Roome, Shima Rastegar-Pouyani, Amy Ker, Annie Dumouchel, Marie Kmita, Artur Kania
Summary: Projection neurons in the spinal cord dorsal horn transmit pain, itch, and temperature information to the brain through the anterolateral system. Recent research has shown that Phox2a, a transcription factor, is expressed in many developing neurons in this system and has provided insights into their development and wiring of nociceptive circuits. This study reveals that the loss of the axonal guidance and neuronal migration signal netrinl leads to impaired migration of Phox2a+ neurons in the spinal lamina I. Additionally, the absence of Dab1, an intracellular transducer of the neuronal migration signal reelin, impairs the migration of Phox2a+ neurons in the spinal lamina V and lateral spinal nucleus, consistent with deficits in nociception observed in mice with a loss of reelin signaling. Collectively, these findings provide evidence that netrinl and reelin control the development of spinal nociceptive projection neurons and offer a mechanistic explanation for studies linking sequence variations in human genes encoding these neurodevelopmental signals and abnormal pain sensation.
Article
Multidisciplinary Sciences
Wafa A. A. Alsulaiman, Raphaelle Quillet, Andrew M. Bell, Allen C. Dickie, Erika Polgar, Kieran A. Boyle, Masahiko Watanabe, R. Brian Roome, Artur Kania, Andrew J. Todd, Maria Gutierrez-Mecinas
Summary: Phox2a-positive cells in lamina I are ALS neurons, but the Phox2a::Cre line preferentially captures specific types of ALS cells.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Baruch Haimson, Yoav Hadas, Nimrod Bernat, Artur Kania, Monica A. Daley, Yuval Cinnamon, Aharon Lev-Tov, Avihu Klar
Summary: Peripheral and intraspinal feedback are crucial for shaping and updating spinal networks that control motor behavior. dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons, and are involved in local spinal circuits and lumbo-brachial coupling. Silencing these neurons results in destabilized stepping and wide-base walking gait in hatchlings, indicating their contribution to bipedal gait stabilization.
Article
Clinical Neurology
Samar Khoury, Marc Parisien, Scott J. Thompson, Etienne Vachon-Presseau, Mathieu Roy, Amy E. Martinsen, Bendik S. Winsvold, Hunt All-In Pain, Ingunn P. Mundal, John-Anker Zwart, Artur Kania, Jeffrey S. Mogil, Luda Diatchenko
Summary: Research has found that chronic multisite pain and chronic single-site pain have different genetic determinants. The genetic contributions are stronger for chronic multisite pain compared to chronic single-site pain. Functional genomics and brain imaging analysis suggest that axonogenesis plays a significant role in brain tissues and the gene DCC, which is associated with chronic multisite pain, is predominantly expressed in subcortical limbic regions and affects the microstructure of the uncinate fasciculus.
Article
Multidisciplinary Sciences
Shannon Tansley, Ning Gu, Alba Urena Guzman, Weihua Cai, Calvin Wong, Kevin C. Lister, Einer Munoz-Pino, Noosha Yousefpour, R. Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M. Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G. Gkogkas, James W. Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S. Mogil, Arkady Khoutorsky
Summary: After peripheral nerve injury, microglia degrade extracellular matrix structures (PNNs) in the spinal cord dorsal horn, enhancing the output of spinal nociceptive circuits and causing pain hypersensitivity.
Article
Neurosciences
Shima Rastegar-Pouyani, Timothy E. Kennedy, Artur Kania
Summary: Anterolateral system (AS) neurons are responsible for transmitting pain signals from the spinal cord to the brain. Research on DccPhox2a mice suggests that DCC signaling is important for the formation of somatotopically ordered maps in AS neurons, as well as their discriminatory function in recognizing noxious stimuli. Impairments in stimulus localization and topognosis are observed in these mice, while left-right discrimination and aversive responses remain largely unaffected.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Xinying Zhang, Magali Millecamps, Artur Kania
Summary: The development of chronic neuropathic pain states is influenced by abnormal function of peripheral sensory neurons, leading to central sensitization and maladaptive plasticity in the spinal dorsal horn. This eventually affects supraspinal areas and causes cognitive and affective co-morbidities such as anxiety and depression. The study focuses on the role of spinal projection neurons, specifically the Phox2a AS neurons, in the generation and maintenance of chronic neuropathic pain. The loss of Phox2a attenuated the development of cold hyperalgesia and anxio-depressive-like behaviors in mice, highlighting the critical role of Phox2a AS neurons in chronic pain.
Article
Cell Biology
R. Brian Roome, Farin B. Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, Annie Dumouchel, Charleen Salesse, W. Scott Thompson, Megan Brookbank, Yorick Gitton, Lino Tessarollo, Martyn Goulding, Jane E. Johnson, Marie Kmita, Alain Chedotal, Artur Kania