Article
Immunology
Hugo Akerstrand, Elena Boldrin, Giorgia Montano, Stijn Vanhee, Karin Olsson, Niklas Krausse, Stefano Vergani, Maciej Ciesla, Cristian Bellodi, Joan Yuan
Summary: The LIN28B RNA binding protein plays a crucial role in fetal and neonatal B lymphopoiesis by amplifying the CD19/PI3K/c-MYC pathway and promoting protein synthesis. Its impact on B cell development is stage-dependent, with IL-7 signaling masking its effect on Pro-B cells. Elevated protein synthesis, mediated by Lin28b, is a defining requirement for early-life B cell development. Impaired protein synthesis specifically affects neonatal B lymphopoiesis and the output of B-1a cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Da Chen, Osvaldo H. Campanella
Summary: In this study, pea protein hydrolysates were obtained through enzymatic hydrolysis, and their physicochemical properties and gelling capacity were investigated. The hydrolysates showed decreased fluorescence intensity and surface hydrophobicity compared to the original protein solution, indicating increased water accessibility and polarity. The hydrolysates were unstable at high temperatures but formed gels under specific conditions. Addition of certain substances decreased the gel strength, suggesting the involvement of electrostatic and hydrophobic interactions, as well as hydrogen and disulfide bonds in gelation.
FOOD HYDROCOLLOIDS
(2022)
Article
Mathematical & Computational Biology
Zhen Wang, Ramesh Ramamoorthy, Xiaojian Xi, Hamidreza Namazi
Summary: This study presents a mathematical modeling study on the synchronization among neurons connected by transient electrical synapses transformed to chemical synapses over time. The results show that the transient synapses lead to burst synchronization of the neurons while the neurons are resting when both synapses exist constantly. The period of the transitions and the time of presence of electrical synapses to chemical ones are effective on the synchronization.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Matthew L. Kraushar, Ferdinand Krupp, Dermot Harnett, Paul Turko, Mateusz C. Ambrozkiewicz, Thiemo Sprink, Koshi Imami, Manuel Guennigmann, Ulrike Zinnall, Carlos H. Vieira-Vieira, Theres Schaub, Agnieszka Muenster-Wandowski, Joerg Buerger, Ekaterina Borisova, Hiroshi Yamamoto, Mladen-Roko Rasin, Uwe Ohler, Dieter Beule, Thorsten Mielke, Victor Tarabykin, Markus Landthaler, Guenter Kramer, Imre Vida, Matthias Selbach, Christian M. T. Spahn
Summary: This study explores the architecture of ribosomes in the developing nervous system and identifies Ebp1 as a crucial factor in protein synthesis, playing a key role in cell morphology and the synthesis of membrane-targeted cell adhesion molecules. Ebp1 regulates ribosome occupancy of specific codons during different stages of protein synthesis in the neocortex, highlighting its importance in neuronal development.
Article
Fisheries
Satomi Takagi, Natsuki Hasegawa, Tsuyoshi Watanabe, Yuichi Sakai, Tatsuya Unuma
Summary: This study aimed to investigate the protein requirement for somatic growth and gonad production of the sea urchin Strongylocentrotus intermedius at different life stages. The results showed that the protein level did not significantly affect body weight growth, but it was correlated with the growth of gonads. Previous studies overestimated the protein requirement due to protein leaching during seawater immersion. Therefore, the protein content in sea urchin feed diets can be considerably reduced.
Article
Biotechnology & Applied Microbiology
Adewale Adeniyi, Ibrahim Bello, Taofeek Mukaila, Ewumbua Monono, Ademola Hammed
Summary: A mimicking process was developed to produce bio-ammonia solution by fermenting soybean and pepsin-hydrolysate using rumen microbes. The highest yield of bio-ammonia was obtained from pepsin-hydrolysate. Metagenomic analysis revealed the dominant presence of Klebsiella quasivariicola, Escherichia coli, and Enterobacter cloacae in the hyper-ammonia-producing bacteria population.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Neurosciences
Kelvin K. Hui, Maya Latif, Chesa Dojo Soeandy, Shudi Huang, Christopher E. Rodgers, Andrew J. Elia, Jeffrey T. Henderson
Summary: Cisplatin-induced cell death in the developing CNS is highly dependent on caspase-3, and a delayed form of necroptosis-like cell death occurs. These findings suggest a coordinated regulation of genotoxic stress response in vivo.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Henrique Melo da Silva, Andre Soares de Oliveira
Summary: Accurate prediction of protein requirements for maintenance and lactation is important for developing profitable diets and reducing environmental impact. A new factorial approach based on a meta-analysis of 223 N balance trials was developed to estimate net protein requirement for maintenance (NPM) and metabolizable protein efficiency for lactation (EMPL). The model showed a strong goodness-of-fit and outperformed several existing dairy cattle nutrition models in predicting protein requirements.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Zhen Luo, Zijian Wang, Zeyu Guan, Chao Ma, Letian Zhao, Chuanchuan Liu, Haoyang Sun, He Wang, Yue Lin, Xi Jin, Yuewei Yin, Xiaoguang Li
Summary: A high-performance synaptic device based on ferroelectric tunnel junction has been designed and established. This device exhibits ultrafast speed, low power consumption, and multiple non-volatile states. Experimental results show that this device achieves high online learning accuracy in recognizing fashion product images and demonstrates good robustness to input image noise.
NATURE COMMUNICATIONS
(2022)
Article
Toxicology
Sebastian Luna, Lorena P. Neila, Rodrigo Vena, Conrado Borgatello, Silvana B. Rosso
Summary: Glyphosate exposure has been shown to negatively impact behavioral and cognitive functions in rats, likely through affecting synaptic formation and maturation. In vitro and in vivo experiments demonstrated that Glyphosate reduces synaptic complexity and protein expression in hippocampus, leading to cognitive impairments and altered neuronal connectivity.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liubov Yakovlieva, Thomas M. Wood, Johan Kemmink, Ioli Kotsogianni, Franziska Koller, Juergen Lassak, Nathaniel I. Martin, Marthe T. C. Walvoort
Summary: The bacterial enzyme EarP recognizes a beta-hairpin loop when transferring rhamnose to a specific arginine residue. Its activity is sensitive to the method used for inducing cyclization and shows some tolerance to amino acid sequence variation.
Article
Cell Biology
Ana A. Jones, Elvira Diamantopoulou, Sarah Baxendale, Tanya T. Whitfield
Summary: Epithelial morphogenesis of the zebrafish inner ear depends on the production and localization of glycosaminoglycans, particularly hyaluronan and proteoglycans, which play critical roles in epithelial projection outgrowth and otolith development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Muhammad Naqi, Min Seok Kang, Na Liu, Taehwan Kim, Seungho Baek, Arindam Bala, Changgyun Moon, Jongsun Park, Sunkook Kim
Summary: This study demonstrates an artificial electronic synapse device based on a synthesized MoS2 memristor array that can emulate synaptic behavior in deep neural network learning. The proposed device exhibits excellent endurance and retention performance, as well as highly uniform memory performance. It shows close linear behavior in potentiation and depression and achieves high recognition accuracy in the emulation of an artificial neural network.
NPJ 2D MATERIALS AND APPLICATIONS
(2022)
Article
Biochemical Research Methods
Jennifer Crodelle, David W. McLaughlin
Summary: Gap junctions play important roles in the cortex during development and adulthood by influencing synchronous firing between neurons and the formation and development of chemical synapses. Gap junction-coupled cells that share orientation preferences during development are more likely to be connected by chemical synapses in adulthood. Synchronization among gap junction-coupled cells underlies their preference to form strong recurrent synapses and develop similar orientation preferences, which is influenced by the timing of synaptic development.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Chemistry, Physical
Xiaofei Dong, Wenbin Wei, Hao Sun, Siyuan Li, Jianbiao Chen, Jiangtao Chen, Xuqiang Zhang, Yun Zhao, Yan Li
Summary: A new design of memristive devices using kuramite Cu3SnS4 as the switching medium is demonstrated, showing stable bipolar resistive switching and excellent optoelectronic synaptic plasticity.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Physiology
Kaleen M. Lavin, Stuart C. Sealfon, Merry-Lynn N. Mcdonald, Brandon M. Roberts, Katarzyna Wilk, Venugopalan D. Nair, Yongchao Ge, Preeti Lakshman Kumar, Samuel T. Windham, Marcas M. Bamman
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Critical Care Medicine
Zhaoyu Wang, Caroline M. Wilson, Natalia Mendelev, Yongchao Ge, Hanga Galfalvy, Gregory Elder, Stephen Ahlers, Angela M. Yarnell, Matthew L. LoPresti, Gary H. Kamimori, Walter Carr, Fatemeh Haghighi
JOURNAL OF NEUROTRAUMA
(2020)
Review
Biochemistry & Molecular Biology
James A. Sanford, Christopher D. Nogiec, Malene E. Lindholm, Joshua N. Adkins, David Amar, Surendra Dasari, Jonelle K. Drugan, Facundo M. Fernandez, Shlomit Radom-Aizik, Simon Schenk, Michael P. Snyder, Russell P. Tracy, Patrick Vanderboom, Scott Trappe, Martin J. Walsh
Article
Physiology
Kaleen M. Lavin, Yongchao Ge, Stuart C. Sealfon, Venugopalan D. Nair, Katarzyna Wilk, Jeremy S. McAdam, Samuel T. Windham, Preeti Lakshman Kumar, Merry-Lynn N. Mcdonald, Marcas M. Bamman
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Psychiatry
Sharon Alter, Caroline Wilson, Shengnan Sun, Rachel E. Harris, Zhaoyu Wang, Amanda Vitale, Erin A. Hazlett, Marianne Goodman, Yongchao Ge, Rachel Yehuda, Hanga Galfalvy, Fatemeh Haghighi
Summary: This study investigated the role of childhood trauma, depression severity, impulsivity, hostility, and sleep quality in suicide risk. The results showed that childhood trauma had an indirect effect on sleep quality, MDD psychopathology, impulsivity, and hostility, and was directly associated with increased suicide risk in MDD veterans.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Critical Care Medicine
Andrew Letizia, Yongchao Ge, Sindhu Vangeti, Carl Goforth, Dawn Weir, Natalia Kuzmina, Corey Balinsky, Hua Chen, Dan Ewing, Alessandra Soares-Schanoski, Mary-Catherine George, William Graham, Franca Jones, Preeti Bharaj, Rhonda Lizewski, Stephen Lizewski, Jan Marayag, Nada Marjanovic, Clare Miller, Sagie Mofsowitz, Venugopalan Nair, Edgar Nunez, Danielle Parent, Chad Porter, Ernesto Ana, Megan Schilling, Daniel Stadlbauer, Victor Sugiharto, Michael Termini, Peifang Sun, Russell Tracy, Florian Krammer, Alexander Bukreyev, Irene Ramos, Stuart Sealfon
Summary: Young adults with SARS-CoV-2 antibodies have about one-fifth the risk of subsequent infection compared to those without antibodies. While antibodies from initial infection offer protection, they do not guarantee effective neutralization or immunity against future infection. These findings could impact mass vaccination strategies.
LANCET RESPIRATORY MEDICINE
(2021)
Letter
Critical Care Medicine
Andrew Letiziat, Darci Smith, Yongchao Ge, Irene Ramos, Rachel Sealfon, Carl Goforth, Ana Gonzalez-Reiche, Sindhu Vangeti, Dawn Weir, Hala Alshammary, Hua Chen, Mary-Catherine George, Alessandra Soares-Schanoski, Rhonda Lizewski, Stephen Lizewski, Jan Marayag, Clare Miller, Edgar Nunez, Chad Porter, Ernesto Ana, Megan Schilling, Victor Sugiharto, Peifang Sun, Michael Termini, Adriana van de Guchte, Olga Troyanskaya, Harm van Bakel, Stuart Sealfon
LANCET RESPIRATORY MEDICINE
(2021)
Article
Neurosciences
Zac Chatterton, Natalia Mendelev, Sean Chen, Walter Carr, Gary H. Kamimori, Yongchao Ge, Andrew J. Dwork, Fatemeh Haghighi
Summary: Researchers are constantly seeking new sources of real-time analysis to replace difficult and dangerous brain sampling and uncomfortable cerebrospinal fluid withdrawal. Using cell-free DNA derived from glia and neurons, wide-ranging neurological disease diagnosis and monitoring are possible.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Immunology
Irene Ramos, Carl Goforth, Alessandra Soares-Schanoski, Dawn L. Weir, Emily C. Samuels, Shreshta Phogat, Michelle Meyer, Kai Huang, Colette A. Pietzsch, Yongchao Ge, Brian L. Pike, James Regeimbal, Mark P. Simons, Michael S. Termini, Sindhu Vangeti, Nada Marjanovic, Stephen Lizewski, Rhonda Lizewski, Mary-Catherine George, Venugopalan D. Nair, Gregory R. Smith, Weiguang Mao, Maria Chikina, Christopher C. Broder, Eric D. Laing, Alexander Bukreyev, Stuart C. Sealfon, Andrew G. Letizia
Summary: This study investigated the serological responses following a SARS-CoV-2 outbreak in spring 2020 on a US Marine recruit training base. The results showed that young adults who experienced asymptomatic or mild SARS-CoV-2 infection developed comparable humoral responses, with no decrease in neutralizing activity at least up to 10 weeks after infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Venugopalan D. Nair, Mital Vasoya, Vishnu Nair, Gregory R. Smith, Hanna Pincas, Yongchao Ge, Collin M. Douglas, Karyn A. Esser, Stuart C. Sealfon
Summary: Chromatin accessibility influences gene expression, with tissue-specific differentially accessible regions predominantly located in intergenic and intron regions, related to differentially expressed genes enriched in distinct biological processes in each tissue. Enriched motifs in differentially accessible regions may predict binding sites for tissue-specific transcription factors, regulating the expression of target genes.
Article
Clinical Neurology
Andrea Mountney, Jennifer Blaze, Zhaoyu Wang, Michelle Umali, William Jesse Flerlage, Jacqueline Dougherty, Yongchao Ge, Deborah Shear, Fatemeh Haghighi
Summary: Traumatic brain injury (TBI) can lead to sleep disturbance and molecular changes affecting immune-related and sleep-related genes, potentially causing neurodegeneration, sleep disturbances, and mood disorders. Rodent models of TBI showed significant differences in sleep architecture, with injured animals spending more time in slow wave sleep and less time in REM sleep. Transcriptome-wide gene expression profiling identified these differences and their potential impact on post-TBI pathology and symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Lot D. de Witte, Zhaoyu Wang, Gijsje L. J. L. Snijders, Natalia Mendelev, Qingkun Liu, Marjolein A. M. Sneeboer, Marco P. M. Boks, Yongchao Ge, Fatemeh Haghighi
Summary: Transcriptome studies have revealed age-, disease-, and region-associated microglial phenotypes reflecting changes in microglial function during development, aging, central nervous system homeostasis, and pathology. The aim of this study was to characterize the DNA methylation landscape of human microglia and the factors that contribute to variations in the microglia methylome. We found that human microglial cells have a methylation profile distinct from bulk brain tissue and neurons, and age explained a considerable part of the variation. Additionally, we showed that interindividual factors had a much larger effect on the methylation landscape of microglia than brain region, which was also seen at the transcriptome level. In our exploratory analysis, we found various differentially methylated regions that were related to disease status (mood disorder vs. control).
BIOLOGICAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Venugopalan D. Nair, Mital Vasoya, Vishnu Nair, Gregory R. Smith, Hanna Pincas, Yongchao Ge, Collin M. Douglas, Karyn A. Esser, Stuart C. Sealfon
Summary: In this study, a modified Omni-ATAC protocol was developed for chromatin accessibility analysis in rat adipose and muscle tissues, achieving high data reproducibility. The improved technique allows for rapid analysis of frozen rat tissues and provides improved data quality compared to the original Omni-ATAC protocol.
Article
Medicine, Research & Experimental
Michelle Meyer, Yuan Wang, Darin Edwards, Gregory R. Smith, Aliza B. Rubenstein, Palaniappan Ramanathan, Chad E. Mire, Colette Pietzsch, Xi Chen, Yongchao Ge, Wan Sze Cheng, Carole Henry, Angela Woods, LingZhi Ma, Guillaume B. E. Stewart-Jones, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Sivakumar Periasamy, Pei-Yong Shi, Barney S. Graham, Ian N. Moore, Irene Ramos, Olga G. Troyanskaya, Elena Zaslavsky, Andrea Carfi, Stuart C. Sealfon, Alexander Bukreyev
Summary: The study demonstrates that the mRNA-1273 vaccine is effective in hamsters against SARS-CoV-2, inducing robust neutralizing antibodies and reducing disease severity. It also shows the impact of the vaccine on immune cell infiltration, lymphocyte proportion, and antiviral responses conducive to lung health.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Andrew G. Letizia, Yongchao Ge, Carl W. Goforth, Dawn L. Weir, Rhonda Lizewski, Stephen Lizewski, Alessandra Soares-Schanoski, Sindhu Vangeti, Nada Marjanovic, Stuart C. Sealfon, Irene Ramos
Summary: A study of US Marine recruits found that 9.0% tested positive for SARS-CoV-2 IgG antibodies. Hispanic and non-Hispanic Black participants, as well as those from states affected early in the pandemic, had higher seropositivity rates. This suggests the importance of targeted public health strategies for young adults at increased risk of infection.
EMERGING INFECTIOUS DISEASES
(2021)