Article
Biochemistry & Molecular Biology
Feifei Ge, Ping Mu, Rong Guo, Li Cai, Zheng Liu, Yan Dong, Yanhua H. Huang
Summary: Chronic REM sleep disturbance enhances neural activity in the medial habenula possibly through compromised TASK-3 function, suggesting a key molecular substrate for affect regulation changes.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Emily A. Mankin, Zahra M. Aghajan, Peter Schuette, Michelle E. Tran, Natalia Tchemodanov, Ali Titiz, Guldamla Kalender, Dawn Eliashiv, John Stern, Shennan A. Weiss, Dylan Kirsch, Barbara Knowlton, Itzhak Fried, Nanthia Suthana
Summary: The study found that stimulation of the right entorhinal white matter during visual memory tasks had a beneficial effect on subsequent memory, while other stimulation methods were ineffective. This highlights the importance of precise stimulation site on modulation of human hippocampal-dependent memory.
Article
Psychology, Biological
Salman E. Qasim, Uma R. Mohan, Joel M. Stein, Joshua Jacobs
Summary: In this study, the impact of emotion on memory was investigated using direct brain recording and deep brain stimulation. The findings show that emotional events have a significant influence on memory storage, with the brain prioritizing emotional information. Additionally, individuals with depression were found to have deficits in emotion-mediated memory and brain activity.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Clinical Neurology
Alberto Benussi, Valentina Cantoni, Mario Grassi, Lucie Brechet, Christoph M. Michel, Abhishek Datta, Chris Thomas, Stefano Gazzina, Maria Sofia Cotelli, Marta Bianchi, Enrico Premi, Yasmine Gadola, Maria Cotelli, Marta Pengo, Federica Perrone, Maria Scolaro, Silvana Archetti, Eino Solje, Alessandro Padovani, Alvaro Pascual-Leone, Barbara Borroni
Summary: This study found that non-invasive brain stimulation with transcranial alternating current stimulation at gamma-frequency (gamma-tACS) applied over the precuneus can improve episodic memory and modulate cholinergic transmission in early Alzheimer's disease. The response to gamma-tACS was dependent on genetic factors and disease stage.
ANNALS OF NEUROLOGY
(2022)
Article
Behavioral Sciences
Petra Ludowicy, Pedro M. Paz-Alonso, Thomas Lachmann, Daniela Czernochowski
Summary: Testing enhances long-term memory retention, and memory retrieval improves when correct-answer feedback is provided. Explicit positive or negative feedback further enhances memory performance beyond the effect of testing.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Maya Geva-Sagiv, Emily A. Mankin, Dawn Eliashiv, Shdema Epstein, Natalie Cherry, Guldamla Kalender, Natalia Tchemodanov, Yuval Nir, Itzhak Fried
Summary: The study found that delivering brief prefrontal pulses synchronized with MTL slow-wave active periods during human sleep can enhance sleep oscillation coupling and memory accuracy. This demonstrates the crucial role of hippocampal-thalamocortical synchronization in memory consolidation during sleep.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Spencer Bowles, Jordan Hickman, Xiaoyu Peng, W. Ryan Williamson, Rongchen Huang, Kayden Washington, Dane Donegan, Cristin G. Welle
Summary: Vagus nerve stimulation is a neuromodulation therapy that influences specific neural circuits through widespread brain activation, enhancing behavioral learning. By investigating neuronal activity in mice during a reach task, researchers found that VNS modulates neurons in the motor cortex through cholinergic signaling, accelerating motor refinement.
Article
Neurosciences
Barour H. Joensen, Daniel Bush, Umesh Vivekananda, Aidan J. Horner, James A. Bisby, Beate Diehl, Anna Miserocchi, Andrew W. McEvoy, Matthew C. Walker, Neil Burgess
Summary: In this study, the researchers investigated the predictive role of hippocampal theta activity during encoding on subsequent associative memory performance. They found that theta power in the hippocampus increased during encoding and that this increase was related to successful retrieval of pairs in the memory task. These findings help to clarify the role of theta oscillations in associative memory formation and suggest that results from epilepsy patients undergoing intracranial electroencephalography recordings can be extended to healthy participants undergoing magnetoencephalography recordings.
Article
Neurosciences
Anna-Lisa Schuler, Giovanni Pellegrino
Summary: This study found that the noise of the scanner can affect autonomic activity, with an increase in parasympathetic nervous system activity and a decrease in sympathetic nervous system activity. This influence should be taken into account when conducting fMRI experiments.
Article
Biotechnology & Applied Microbiology
Kui Zhang, Yaoyao Liu, Yilin Song, Shihong Xu, Yan Yang, Longhui Jiang, Shutong Sun, Jinping Luo, Yirong Wu, Xinxia Cai
Summary: To overcome the limitations of traditional MEAs in studying retinal ganglion cells (RGCs), researchers have developed a 3D MEA based on the planar MEA platform. The 3D MEA showed improvements in impedance, phase delay, charge storage capacity, and signal-to-noise ratio compared to planar MEA. Using the advanced 3D MEA, researchers investigated the encoding characteristics of RGCs under multi-modal stimulation, revealing different response patterns, response times, and encoding properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michael K. Schuhmann, Lena Papp, Guido Stoll, Robert Blum, Jens Volkmann, Felix Fluri
Summary: The research suggests that high-frequency stimulation of the mesencephalic locomotor region (MLR) may trigger anti-inflammatory processes within the perilesional area by modulating the cholinergic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Kritika Anand, Carolina L. Z. Vieira, Eric Garshick, Veronica Wang, Annelise Blomberg, Diane R. Gold, Joel Schwartz, Pantel Vokonas, Petros Koutrakis
Summary: This study investigated the association between solar and geomagnetic activity (SGA) and pulmonary function, as well as the potential enhanced effects of particulate pollution on pulmonary function. The results suggest that increased SGA may directly contribute to impaired pulmonary function and enhance the effects of particulate pollution.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Surgery
Yan Dong, Yiling Zhang, Shiying Li, Jiande D. Z. Chen
Summary: Intestinal electrical stimulation (IES) reduces postprandial blood glucose by enhancing the release of GLP-1 and GIP mediated via the cholinergic mechanism.
Article
Endocrinology & Metabolism
Emmani B. M. Nascimento, Michiel P. B. Moonen, Carlijn M. E. Remie, Karim Gariani, Johanna A. Jorgensen, Gert Schaart, Joris Hoeks, Johan Auwerx, Wouter D. van Marken Lichtenbelt, Patrick Schrauwen
Summary: NR supplementation reduced adipocyte cell size in BAT of HFD-fed mice, and enhanced in vitro norepinephrine-stimulated mitochondrial uncoupling in adipocytes derived from human BAT. However, NR supplementation in human volunteers did not alter BAT activity or cold-induced thermogenesis. Further research needs to be done to understand the differences in NAD+ metabolism between mice and humans.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Guney Bademci, Maria Lachgar-Ruiz, Mangesh Deokar, Mohammad Faraz Zafeer, Clemer Abad, Muzeyyen Yildirim Baylan, Neil J. Ingham, Jing Chen, Claire J. Sineni, Nirmal Vadgama, Ioannis Karakikes, Shengru Guo, Duygu Duman, Nitu Singh, Gaurav Harlalka, Shirish P. Jain, Barry A. Chioza, Katherina Walz, Karen P. Steel, Jamal Nasir, Mustafa Tekin
Summary: The discovery and understanding of deafness genes, like MINAR2, have greatly contributed to our knowledge of hearing and its disorders. This study found DNA variants in MINAR2 in families with autosomal recessive nonsyndromic deafness, highlighting the importance of this gene in hearing.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Clinical Neurology
Hang Zeng, Siyi Chen, Gereon R. Fink, Ralph Weidner
Summary: This review examines critical aspects of interareal information exchange in the brain, including structural connectivity, information exchange between cortical areas using the visual system as an example, and theories underlying neural communication principles. It also discusses open questions in the study of the neural mechanisms underlying interareal information exchange.
Article
Clinical Neurology
Lukas Hensel, Fabian Lange, Caroline Tscherpel, Shivakumar Viswanathan, Jana Freytag, Lukas J. Volz, Simon B. Eickhoff, Gereon R. Fink, Christian Grefkes
Summary: This study assessed the contributions of the ipsilesional and contralesional anterior intraparietal cortex (aIPS) for hand motor function in stroke patients and found increased resting-state connectivity in patients with good motor outcome. Interhemispheric connectivity was also found to be correlated with better motor performance.
Article
Clinical Neurology
Ann-Katrin Schild, Yasemin Goereci, Daniel Scharfenberg, Kim Klein, Joachim Luelling, Dix Meiberth, Finja Schweitzer, Sophie Stuermer, Philip Zeyen, Derya Sahin, Gereon R. Fink, Frank Jessen, Christiana Franke, Oezguer A. Onur, Josef Kessler, Clemens Warnke, Franziska Maier
Summary: The aim of this study was to assess the neuropsychological profile of patients with asymptomatic to mild/moderate acute COVID-19 disease. The study found that approximately 60% of participants reported cognitive deficits, particularly in the domains of learning/memory and executive functions. These deficits were associated with daytime sleepiness but not with depression, anxiety, sleep quality, general health status, or fatigue.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Marie Madlener, Christine Strippel, Franziska S. Thaler, Kathrin Doppler, Klaus P. Wandinger, Jan Lewerenz, Marius Ringelstein, Rosa Roessling, Til Menge, Jonathan Wickel, Christoph Kellingshaus, Sigrid Mues, Andrea Kraft, Andreas Linsa, Simone C. Tauber, Florian Then Berg, Stefan T. Gerner, Asterios Paliantonis, Alexander Finke, Josef Priller, Ingo Schirotzek, Marie Suesse, Kurt W. Suehs, Christian Urbanek, Makbule Senel, Claudia Sommer, Tania Kuempfel, Harald Pruess, Gereon R. Fink, Frank Leypoldt, Nico Melzer, Michael P. Malter
Summary: This study investigated 101 patients with suspected autoimmune neurological syndromes (AINS) associated with glutamic acid decarboxylase (GAD) antibodies. The results showed that immunotherapy had moderate effectiveness in these patients, and serum GAD antibody levels and intrathecal GAD antibody synthesis did not predict clinical characteristics or treatment outcomes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Serge Pinto, Adelheid Nebel, Jorn Rau, Robert Espesser, Pauline Maillochon, Oliver Niebuhr, Paul Krack, Tatiana Witjas, Alain Ghio, Marie-Charlotte Cuartero, Lars Timmermann, Alfons Schnitzler, Helke Hesekamp, Niklaus Meier, Julia Muellner, Thomas D. Haelbig, Bettina Moeller, Steffen Paschen, Laura Paschen, Jens Volkmann, Michael T. Barbe, Gereon R. Fink, Johannes Becker, Paul Reker, Andrea A. Kuehn, Gerd-Helge Schneider, Valerie Fraix, Eric Seigneuret, Andrea Kistner, Olivier Rascol, Christine Brefel-Courbon, Fabienne Ory-Magne, Christian J. Hartmann, Lars Wojtecki, Anne Fradet, David Maltete, Philippe Damier, Severine Le Dily, Friederike Sixel-Doering, Petra Benecke, Daniel Weiss, Tobias Waechter, Marcus O. Pinsker, Jean Regis, Stephane Thobois, Gustavo Polo, Jean-Luc Houeto, Andreas Hartmann, Karina Knudsen, Marie Vidailhet, Michael Schuepbach, Gunther Deuschl
Summary: This study compared speech intelligibility assessment and other outcomes between subthalamic nucleus deep brain stimulation (STN-DBS) and best medical treatment (BMT) in early-stage Parkinson's disease patients over a 2-year period. The results showed no significant differences in speech intelligibility and patient-reported outcomes between the STN-DBS and BMT groups, but there was a trend towards worsening in both groups.
MOVEMENT DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Norbert Galldiks, Philipp Lohmann, Gereon R. Fink, Karl-Josef Langen
Summary: For decades, amino acid PET tracers have been used to optimize diagnostics in brain tumor patients, with clinical indications including differentiation of neoplasm from nonneoplastic etiologies, delineation of tumor extent for further diagnostic and treatment planning, differentiation of treatment-related changes, and assessment of response to anticancer therapy. This article focuses on the diagnostic value of amino acid PET for patients with glioblastoma or metastatic brain cancer.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Aline Seger, Anja Ophey, Wiebke Heitzmann, Christopher E. J. Doppler, Marie-Sophie Lindner, Corinna Brune, Johanna Kickartz, Haidar S. Dafsari, Wolfgang H. Oertel, Gereon R. Fink, Stefanie T. Jost, Michael Sommerauer
Summary: This study aimed to optimize the identification of subjects with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) from the general population. An accurate questionnaire-based algorithm was developed to improve recruitment efficiency in research. The algorithm displayed high diagnostic accuracy and could be a convenient tool in research and clinical settings.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Christian Schneider, Meike K. K. Wassermann, Martin K. R. Svacina, Gilbert Wunderlich, Gereon R. R. Fink, Helmar C. C. Lehmann
Summary: In this study, the subclinical motor involvement in the upper extremity muscles of patients with lower limb-predominant nonsystemic vasculitic neuropathy (NSVN) was investigated using the MScanFit method. The results showed that the number of motor units and peak CMAP amplitudes were significantly reduced in patients with NSVN. However, there was no evidence of significant reinnervation, and the number of motor units did not correlate with clinical scores.
Letter
Oncology
Jan-Michael Werner, Michael M. Wollring, Caroline Tscherpel, Elena K. Rosen, Lisa Werr, Isabelle Stetter, Daniel Ruess, Maximilian Ruge, Anna Brunn, Abdulkader Al Shughri, Christoph Kabbasch, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Article
Geriatrics & Gerontology
Julian Dronse, Anna Ohndorf, Nils Richter, Gerard N. Bischof, Ronja Fassbender, Qumars Behfar, Hannes Gramespacher, Kim Dillen, Heidi I. L. Jacobs, Juraj Kukolja, Gereon R. Fink, Oezguer A. Onur
Summary: A study found that elevated cortisol levels are associated with memory decline in Alzheimer's disease patients, as well as hippocampal atrophy and memory impairment in healthy seniors.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Jan Goetz, Frederique Wieters, Veronika J. Fritz, Olivia Kaesgen, Aref Kalantari, Gereon R. Fink, Markus Aswendt
Summary: Stroke patients have some degree of spontaneous functional recovery, but it is not enough to prevent long-term disability. Characterizing the dynamics of stroke recovery genes in the lesion and distant areas is a promising approach. In this study, adult mice were induced with sensorimotor cortex lesions and gene expression was analyzed at different time points post-stroke. The results highlight the expression dynamics and spatial variability of genes involved in cAMP pathway, plasticity, and axonal sprouting, challenging existing theories of neural plasticity.
Article
Clinical Neurology
Claudia C. Schmidt, Elisabeth I. S. Achilles, Katharina Bolte, Nina N. Kleineberg, Monika K. Richter, Natalie Schloss, Gereon R. Fink, Peter H. Weiss
Summary: The study investigated the association between subcortical gray matter lesions and apraxic deficits in LH stroke patients, finding that lesions in the caudate nucleus were significantly related to apraxic deficits, while lesions in the globus pallidus were associated with a lower likelihood of apraxia. Other subcortical structures did not show significant differences in lesion load between apraxic and nonapraxic patients.
Article
Clinical Neurology
Lothar Burghaus, Marie Madlener, Felix Kohle, Emanuel F. Bruno, Volker Limmroth, Gereon R. Fink, Michael P. Malter
Summary: Status epilepticus (SE) is a neurological emergency characterized by prolonged seizure activity. Prehospital management of SE is crucial, and this study investigated the impact of different treatment strategies, specifically focusing on levetiracetam. The results showed that the use of levetiracetam in the prehospital setting did not have a significant additional effect on SE parameters.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Neuroimaging
Janusz L. Koob, Shivakumar Viswanathan, Maike Mustin, Imon Mallick, Sebastian Krick, Gereon R. Fink, Christian Grefkes, Anne K. Rehme
Summary: This study aims to investigate the factors in the early post-acute stage that may increase the risk of depression symptoms in stroke patients. The results show that more severe motor impairment promotes reward-dependent motor engagement, while depression and corticostriatal lesions may disrupt incentive motivational behavior, thereby increasing the risk of chronic depressive symptoms.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Hendrik Theis, Stephane Prange, Gerard N. Bischof, Merle C. Hoenig, Marc Tittgemeyer, Lars Timmermann, Gereon R. Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimeren
Summary: Impulsive-compulsive behavior (ICB) is frequently observed in early Parkinson's disease after starting dopamine replacement therapy, while apathy occurs even before treatment initiation. This study explored the relationship and underlying factors between these two behavioral conditions. The severity of ICB was positively correlated with the severity of apathy, and apathy and the Ser9Gly polymorphism of DRD3 were interactive risk factors for ICB severity.
NPJ PARKINSONS DISEASE
(2023)