Article
Neurosciences
Hayley M. Dorfman, Momchil S. Tomov, Bernice Cheung, Dennis Clarke, Samuel J. Gershman, Brent L. Hughes
Summary: The study found that reward prediction errors modulated by causal beliefs are represented in the dorsal striatum, while unmodulated reward prediction errors are represented in the ventral striatum. Further analysis revealed that beliefs about causal structure are represented in the anterior insula and inferior frontal gyrus. Structural equation modeling showed effective connectivity from the anterior insula to the dorsal striatum, suggesting a neural architecture in which causal beliefs are integrated with prediction error signals to update action values.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Masaya Harada, Vincent Pascoli, Agnes Hiver, Jerome Flakowski, Christian Luescher
Summary: The study reveals that compulsive individuals exhibit stronger neuronal activity in the DS during the cue predicting reward availability, even at the risk of punishment. An increased AMPA/NMDA ratio was observed selectively at orbitofrontal cortex to DS synapses, and spiny projection neurons in the DS showed an activity peak at the moment of signaled reward availability.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Dermatology
Jaewon You, Michael D. Reilly, Mahmoud Eljalby, Rohan Bareja, Maftuna Yusupova, Nikki S. Vyas, Jakyung Bang, Wanhong Ding, Garrett Desman, Lloyd S. Miller, Olivier Elemento, Richard D. Granstein, Jonathan H. Zippin
Summary: This study demonstrates the importance of soluble adenylate cyclase (sAC) in psoriasis pathogenesis and identifies it as a potential therapeutic target. The absence of Adcy10 gene significantly reduces the symptoms of psoriasiform dermatitis in mice and inhibits the differentiation and gene expression of Th17 cells. Moreover, topical application of sAC inhibitors shows promise in reducing psoriasiform dermatitis and IL17 gene expression in the skin, suggesting their potential as topical therapeutics for Th17-mediated skin diseases.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Immunology
Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou, Tengfei Ma
Summary: This study found that inhibition of the NLRP3 inflammasome can reduce alcohol intake and anxiety-like behavior by regulating glutamatergic transmission in corticostriatal circuits. These findings provide a potential anti-inflammatory target for treating alcohol use disorders.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Psychology, Clinical
David A. Copland, Sonia Brownsett, Kartik Iyer, Anthony J. Angwin
Summary: The corticostriatal circuits play a regulatory role in language functions, with evidence suggesting their involvement in responding to uncertainty and conflict. This role is dynamic and varies depending on the degree and form of cognitive control required, recruiting specific circuits and components organized in a cognitive hierarchy.
NEUROPSYCHOLOGY REVIEW
(2021)
Article
Psychiatry
Xavier Caubit, Paolo Gubellini, Pierre L. Roubertoux, Michele Carlier, Jordan Molitor, Dorian Chabbert, Mehdi Metwaly, Pascal Salin, Ahmed Fatmi, Yasmine Belaidouni, Lucie Brosse, Lydia Kerkerian-Le Goff, Laurent Fasano
Summary: The study provides evidence that TSHZ3 haploinsufficiency is linked to autism spectrum disorder (ASD) and identifies cortical projection neurons (CPNs) and striatal cholinergic interneurons (SCINs) as key players in the TSHZ3-linked ASD syndrome. Dysfunction in either CPNs or SCINs is associated with distinct ASD behavioral traits, providing novel insights into the implications of the corticostriatal circuitry in ASD.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Jun Xu, Nobuo Koizumi, Yusuke V. Morimoto, Ryo Ozuru, Toshiyuki Masuzawa, Shuichi Nakamura
Summary: Nucleotide second messengers play crucial roles in signal transduction in various organisms. A study has found that the swimming motility of the soil bacterium Leptospira kobayashii can be rapidly modulated by light stimulation. Through analysis of a loss-of-photoresponsivity mutant, a novel sensory gene was identified, and the light-dependent synthesis of cyclic adenosine monophosphate (cAMP) was elucidated. These findings reveal a new role for cAMP in controlling the flagella-dependent motility of Leptospira and highlight the global distribution of the newly discovered photoactivated cyclase among diverse microbial species.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Hidetoshi Urakubo, Sho Yagishita, Haruo Kasai, Yoshiyuki Kubota, Shin Ishii
Summary: In this study, a computational model of D2 signaling was built to determine the conditions for detecting DA dips. It was found that the detection of DA dip requires a delicate balance between D2R and RGS levels, which seem to be crucial for normal learning and memory. Imbalance between D2R and RGS, as seen in patients with schizophrenia and DYT1 dystonia, may disrupt long-term memory formation and lead to associated symptoms.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Cell Biology
Jonas Cornelius, Klemens Rottner, Martin Korte, Kristin Michaelsen-Preusse
Summary: The loss of cortactin in knockout mice leads to deficits in hippocampus-dependent spatial memory formation, prominent dysregulation of functional and structural plasticity, impaired long-term potentiation, and a complete absence of structural spine plasticity. This may be explained by alterations in the activity-dependent modulation of synaptic actin in cortactin-deficient neurons.
Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Chemistry, Multidisciplinary
Dong Yang, Xiangbo Wu, Weina Wang, Yanfen Zhou, Zhenshan Wang
Summary: This study found that ciliary AC3 regulates body weight in the mouse VMH by modulating autophagy, and knocking down AC3 or GABARAP leads to exacerbated HFD-induced obesity.
Article
Neurosciences
Yingchun Li, Jing Rong, Haiquan Zhong, Min Liang, Chunting Zhu, Fei Chang, Rong Zhou
Summary: Prenatal stress has a long-term adverse effect on motor behaviors and corticostriatal synaptic plasticity. Epigenetic DNA alterations may play a key role in mediating these effects, with changes in dopamine signaling and DNA methylation contributing to alterations in synaptic plasticity and behavioral development.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Maria Jesus Trujillo, Constanza Ilarraz, Fernando Kasanetz
Summary: Neuronal plasticity plays a significant role in the development and persistence of pathological pain. This study explores the involvement of layer 5 caudal anterior cingulate cortex (cACC) neurons projecting to the dorsomedial striatum (DMS) in aberrant neuronal plasticity associated with neuropathic pain (NP). The results demonstrate that NP affects cACC neurons projecting to the DMS, providing further evidence for the importance of maladaptive plasticity in the cortico-striatal pathway in sustaining pathological pain.
Article
Biochemistry & Molecular Biology
Eri Kitayama, Maki Kimura, Takehito Ouchi, Masahiro Furusawa, Yoshiyuki Shibukawa
Summary: This study investigated the dynamics of intracellular cAMP in cultured human odontoblasts to understand the detailed expression patterns and role of the intracellular cAMP signaling pathway. The results showed the presence of G(alpha)s protein and various receptors (IP, 5-HT4, D-1, A(2A), and VIP) in odontoblasts. Activation of these receptors increased intracellular cAMP levels by activating AC, and this increase was inhibited by an AC inhibitor and receptor antagonists.
Article
Cell Biology
Gwenaelle Laverne, Jonathan Pesce, Ana Reynders, Etienne Combrisson, Eduardo Gascon, Christophe Melon, Lydia Kerkerian-Le Goff, Nicolas Maurice, Corinne Beurrier
Summary: Striatal cholinergic interneurons (CINs) play an important regulatory role in cortico-striatal transmission and striatal-dependent motor-skill learning, which is dependent on the integrity of dopaminergic inputs.
Article
Neurosciences
Nicholas I. Woods, Fabio Stefanini, Daniel L. Apodaca-Montano, Isabelle M. C. Tan, Jeremy S. Biane, Mazen A. Kheirbek
Article
Multidisciplinary Sciences
Jennifer L. Scribner, Eric A. Vance, David S. W. Protter, William M. Sheeran, Elliott Saslow, Ryan T. Cameron, Eric M. Klein, Jessica C. Jimenez, Mazen A. Kheirbek, Zoe R. Donaldson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Phi T. Nguyen, Leah C. Dorman, Simon Pan, Ilia D. Vainchtein, Rafael T. Han, Hiromi Nakao-Inoue, Sunrae E. Taloma, Jerika J. Barron, Ari B. Molofsky, Mazen A. Kheirbek, Anna Molofsky
Article
Multidisciplinary Sciences
Danilo De Gregorio, Jelena Popic, Justine P. Enns, Antonio Inserra, Agnieszka Skalecka, Athanasios Markopoulos, Luca Posa, Martha Lopez-Canul, He Qianzi, Christopher K. Lafferty, Jonathan P. Britt, Stefano Comai, Argel Aguilar-Valles, Nahum Sonenberg, Gabriella Gobbi
Summary: Clinical studies have shown that LSD can enhance empathy and social behavior in humans. This study in male mice found that LSD promotes social behavior by potentiating glutamatergic neurotransmission in the medial prefrontal cortex through the 5-HT2A/AMPA receptors and mTOR signaling. The results suggest that activating these pathways with psychedelic drugs could be explored for treating mental disorders characterized by social behavior impairments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Christopher K. Lafferty, Thomas D. Christinck, Jonathan P. Britt
Summary: Improvements in all-optical techniques for monitoring and manipulating neural activity have led to the development of new approaches for studying psychiatric disease. By combining calcium imaging with optogenetics, researchers have created new disease models that link specific circuit abnormalities to distinct disease dimensions. These approaches have the potential to identify circuit manipulations that can normalize pathological network activity, leading to the development of more effective treatments.
Correction
Neurosciences
Mark M. Gergues, Kasey J. Han, Hye Sun Choi, Brandon Brown, Kelsey J. Clausing, Victoria S. Turner, Ilia D. Vainchtein, Anna V. Molofsky, Mazen A. Kheirbek
NATURE NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Michael C. Kern, Mazen A. Kheirbek
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Victoria S. Turner, Rachel O. O'Sullivan, Mazen A. Kheirbek
Summary: The ventral hippocampus is the emotional hippocampus that integrates internal and external cues to promote adaptive behavioral selection.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Editorial Material
Neurosciences
Milan D. D. Valyear, Jonathan Philip Britt
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Jeremy S. Biane, Max A. Ladow, Fabio Stefanini, Sayi P. Boddu, Austin Fan, Shazreh Hassan, Naz Dundar, Daniel L. Apodaca-Montano, Lexi Zichen Zhou, Varya Fayner, Nicholas I. Woods, Mazen A. Kheirbek
Summary: By tracking CA1 neurons during associative learning, Biane, Ladow et al. found that dorsal and ventral hippocampus have distinct contributions in encoding and updating task-related representations. Odor responses in dCA1 were robust initially, while in vCA1, they emerged after learning and contained information about the paired outcome. Population activity in both regions rapidly reorganized with learning and stored the learned odor representations for days. Stable and robust signals were observed in CA1 when mice anticipated outcomes under behavioral control.
NATURE NEUROSCIENCE
(2023)
Article
Psychiatry
Elad Lax, Sonia Do Carmo, Yehoshua Enuka, Daniel M. Sapozhnikov, Lindsay A. Welikovitch, Niaz Mahmood, Shafaat A. Rabbani, Liqing Wang, Jonathan P. Britt, Wayne W. Hancock, Yosef Yarden, Moshe Szyf
Summary: This study found that Mbd2 deficiency leads to deficits in cognitive, social, and emotional functions in mice. Mbd2 regulates the expression of hundreds of genes by binding to regulatory DNA regions of neuronal genes, and there is a significant overlap with gene expression changes in individuals with Autism Spectrum Disorder (ASD). The findings suggest that Mbd2 is a novel epigenetic regulator of genes associated with ASD.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Mark Gergues, Joshua Bratsch-Prince, Shazreh Hassan, Mona Li, Arsine Kolanjian, Victoria Turner, Mazen Kheirbek
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Frances Xia, Nina Vishwakarma, Valeria Fascianelli, Frances Ghinger, Stefano Fusi, Mazen Kheirbek
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Mazen Kheirbek
JOURNAL OF NEUROCHEMISTRY
(2022)
Meeting Abstract
Neurosciences
Mazen Kheirbek
BIOLOGICAL PSYCHIATRY
(2022)