Review
Behavioral Sciences
Tianrui Zhang, Mingqian Zhang, Shuang Cui, Wulin Liang, Zhanhong Jia, Fanfan Guo, Wenjing Ou, Yonghong Wu, Shuofeng Zhang
Summary: This review investigates the neuropathic pain caused by nervous system injury or dysfunction and highlights the crucial role played by the crosstalk among microglia, astrocytes, and neurons in maintaining this pain state. The activation of the microglia P2X4 receptor seems to be the key target in this process.
BRAIN AND BEHAVIOR
(2023)
Review
Neurosciences
Sana Chintamen, Fatima Imessadouene, Steven G. Kernie
Summary: Microglia play a crucial role in regulating neuronal development at different developmental stages and in specific environments of the adult brain. They modulate adult hippocampal neurogenesis by secreting factors that maintain a balance between cell proliferation and cell death, actively pruning synapses and engulfing excess neurons to shape the nervous system. Aberrant microglial activity in neurodegenerative diseases can impede the development of appropriate functional properties of adult born granule cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Kai Sun, Hao Zhang, Ting Zhang, Nan Sun, Jingru Hao, Zhiping Wang, Can Gao
Summary: Neuropathic pain is often accompanied by psychiatric comorbidities and lacks effective treatment. This study reveals that HDAC6 plays a crucial role in the development and maintenance of neuropathic pain through neuronal activation and neuroinflammatory responses. HDAC6 may be a promising target for treating neuropathic pain.
Article
Biology
Hui Peng, Brock T. Harvey, Christopher I. Richards, Kimberly Nixon
Summary: This study investigated the role of neuron-derived extracellular vesicles (NDEVs) in regulating microglial activity and inflammation. The findings suggest that NDEVs play a critical role in improving microglial viability, inhibiting activation markers expression, and reducing proinflammatory responses in microglia. Neuron-glia communication via EVs may be a key mechanism for neuroimmune regulation in the central nervous system.
Article
Biochemistry & Molecular Biology
Ji Hwan Lee, Jong Hee Choi, Jaihwan Kim, Tai Wan Kim, Ji-Young Kim, Geehoon Chung, Ik-Hyun Cho, Dae Sik Jang, Sun Kwang Kim
Summary: This study investigated the causal relationship between spinal microglial activation and oxaliplatin-induced peripheral neuropathy (OIPN) and explored the analgesic effects of syringaresinol on OIPN symptoms. Results showed that oxaliplatin treatment activated microglia, leading to inflammatory responses and pain induction. Syringaresinol treatment significantly ameliorated pain and suppressed microglial inflammatory responses.
Review
Immunology
Erliang Kong, Yongchang Li, Mengqiu Deng, Tong Hua, Mei Yang, Jian Li, Xudong Feng, Hongbin Yuan
Summary: Neuropathic pain is characterized by hyperalgesia and allodynia. Inflammation plays a role in the development of neuropathic pain, affecting synaptic transmission and regulated by glial cells. Glycometabolism reprogramming in inflammatory cells, specifically impaired oxidative phosphorylation and enhanced glycolysis, promotes neural inflammation in peripheral and central nervous system. Further research is needed to explore the role of glycometabolism in glial cells in neuropathic pain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka, Norikazu Kiguchi
Summary: The study focuses on investigating the sex-dependent roles of microglia in pain hypersensitivity, highlighting the importance of understanding the molecular aspects of spinal microglia regulation in pain. The results showed that chemogenetic activation of spinal microglia resulted in pain hypersensitivity in male mice, with sex differences observed in the upregulation of reactive microglia-dominant molecules and response to microglia depletion using pexidartinib.
Article
Biotechnology & Applied Microbiology
Yufu Xin, Xinrong Song, Qingye Ge
Summary: The study found that circSMEK1 promotes inflammation and microglia M1 polarization in NP by modulating the miR-216a-5p/TXNIP axis, providing a new molecular target for the future treatment of NP.
Article
Pharmacology & Pharmacy
Bingjin Li, Wei Yang, Tongtong Ge, Yao Wang, Ranji Cui
Summary: This article discusses the candidate mechanisms by which stress can lead to dysregulated microglia, which in turn contribute to the pathogenesis of depressive disorders. It suggests that changes in microglial function can strongly influence neuronal network activity through dysregulated cytokine secretion and increased release of neurotoxic metabolites, thereby contributing to pathological outcomes in response to stress.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Michelle Monje, Akiko Iwasaki
Summary: This article reviews the impact of persistent neurological and neuropsychiatric symptoms on the central nervous system after COVID-19 and discusses the possible neurobiological basis for the cognitive symptoms experienced by COVID-19 survivors.
Review
Cell Biology
Xin-Jin Su, Bei-Duo Shen, Kun Wang, Qing-Xin Song, Xue Yang, De-Sheng Wu, Hong-Xing Shen, Chao Zhu
Summary: The neuron-restrictive silencer factor (NRSF) is a zinc finger transcription factor that plays a crucial role in the development and function of the nervous system. NRSF can both silence and activate gene transcription, and its dysregulation has been implicated in various brain disorders and tumorigenesis. Targeting NRSF and its co-repressors may hold promise as a therapeutic strategy for neural disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ping Li, Chao Yu, Fan-Shuo Zeng, Xiaoyan Fu, Xiao-Jing Yuan, Qin Wang, Cundong Fan, Bao-Liang Sun, Qiang-San Sun
Summary: The study found that Lic-A significantly attenuated CCI-induced neuropathic pain by inhibiting microglia activation and inflammatory response. This suggests that Lic-A may be a potential drug for treating neuropathic pain.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Wenyao Wu, Xianwei Zhang, Shuo Wang, Tian Li, Quanshui Hao, Shiyong Li, Wenlong Yao, Rao Sun
Summary: The cGAS-STING pathway may be a potential therapeutic target for treating neuropathic pain by suppressing microglial M1 polarization. Activation of the cGAS-STING pathway occurs mainly in neurons and microglia, and inhibition of the pathway can suppress microglial M1 polarization and improve mechanical allodynia.
Review
Endocrinology & Metabolism
Seungyup Sun, Nicklaus H. Diggins, Zachary J. Gunderson, Jill C. Fehrenbacher, Fletcher A. White, Melissa A. Kacena
Review
Endocrinology & Metabolism
Luke G. McVeigh, Anthony J. Perugini, Jill C. Fehrenbacher, Fletcher A. White, Melissa A. Kacena
CURRENT OSTEOPOROSIS REPORTS
(2020)
Editorial Material
Medicine, General & Internal
Melissa A. Kacena, Fletcher A. White
Review
Cell Biology
Xingjuan Chen, Gagandeep Sooch, Isaac S. Demaree, Fletcher A. White, Alexander G. Obukhov
Article
Clinical Neurology
Kelly M. Naugle, Christopher Carey, Eric Evans, Jonathan Saxe, Ryan Overman, Fletcher A. White
JOURNAL OF HEADACHE AND PAIN
(2020)
Editorial Material
Cell Biology
Priya R. Kirtley, Gagandeep S. Sooch, Fletcher A. White, Alexander G. Obukhov
Article
Oncology
Tatsuo Okui, Masahiro Hiasa, Shoji Ryumon, Kisho Ono, Yuki Kunisada, Soichiro Ibaragi, Akira Sasaki, G. David Roodman, Fletcher A. White, Toshiyuki Yoneda
Summary: Bone pain caused by breast cancer metastasis is a common complication and a major factor in increased mortality. Studies suggest that HMGB1 secreted by breast cancer cells induces BCABP through binding to RAGE on sensory neurons.
JOURNAL OF BONE ONCOLOGY
(2021)
Article
Clinical Neurology
Xingjie Ping, Zhi Chai, Weiping Wang, Cungen Ma, Fletcher F. A. White, Xiaoming Jin
Summary: Blocking RAGE and TLR4 signaling pathways significantly increased seizure threshold, reduced spontaneous seizure events, increased neuronal and inhibitory interneuron densities in the lesioned cortex, and decreased astrocyte and microglia densities in the treatment groups, suggesting a potential strategy for preventing posttraumatic epilepsy.
Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Review
Clinical Neurology
Andreea Radulescu, Fletcher A. White, Chantal Chenu
Summary: Progress has been made in bone fracture repair research, but pain scoring and management in rodent fracture models remain challenging. Animal models for fracture pain provide a quantitative evaluation and study of new therapeutic approaches.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Eun Jin Ahn, Fletcher A. White, Ye Jin Cho, Chong Wha Baek, Yong Hun Jung, Ji Wung Kwon
Summary: This study evaluated the efficacy of immature Rubus occidentalis extract (iROE) on acid-induced hyperalgesia and investigated the mechanism involved. The antihyperalgesic effect of immature and mature ROEs was compared.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Neurosciences
Kelly M. Naugle, Sam Corrona, Jared A. Smith, Tyler Nguyen, Jonathan Saxe, Fletcher A. White
Summary: Lower levels of physical activity in the first month after mild TBI predict decreased conditioned pain modulation and greater pain catastrophizing in patients with mild TBI. Conversely, greater self-reported physical activity, especially moderate PA, 1 to 2 weeks after injury, predicted better pain inhibitory capacity on the CPM test at 1 month after injury in patients with mTBI. Additionally, greater sedentary behavior was associated with worse pain inhibition on the CPM test and greater pain catastrophizing at 1 month after injury.
Review
Medicine, General & Internal
Hyun Jin Min, Kyung Soo Kim, Geun Joo Choi, Hyun Kang, Fletcher A. White
Summary: The study aimed to evaluate the concentrations of high-mobility group box 1 and heat-shock protein 70 in the upper and lower airways of healthy individuals through meta-analysis. Results showed significant heterogeneity in the concentrations of these proteins in different airway locations and age groups. Heat-shock protein 70 had significantly higher concentrations in the upper airway compared to the lower airway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
Yohance Allette, Youngsook Kim, Jared Smith, Matthew Ripsch, Fletcher White
Meeting Abstract
Endocrinology & Metabolism
Melissa Kacena, Zachary Gunderson, Aamir Tucker, Natalie Taylor-Nguyen, Peter Malicky, Rachel Blosser, Fletcher White
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
