Review
Behavioral Sciences
Deborah Chiabrando, Veronica Fiorito, Sara Petrillo, Francesca Bertino, Emanuela Tolosano
Summary: This study examines the relationship between heme and the pathophysiology of pain, highlighting the important regulatory role of heme in nociception and its association with pain-related diseases. However, the molecular mechanisms linking heme to pain pathways remain unclear at present.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Critical Care Medicine
Laiche Djouhri, Asad Zeidan, Mohammad Alzoghaibi, Mohammad F. Al Otaibi, Seham A. Abd El-Aleem
Summary: Peripheral neuropathic pain (PNP) is a major health issue with limited drug treatment options. Studies suggest that axotomized and uninjured neurons in animal models of PNP show distinct electrophysiological changes. Uninjured neurons exhibit faster action potential kinetics, potentially contributing to the development of PNP.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Pharmacology & Pharmacy
Indiara Brusco, Allisson Benatti Justino, Cassia Regina Silva, Rahisa Scussel, Ricardo Andrez Machado-de-Avila, Sara Marchesan Oliveira
Summary: Fibromyalgia is a chronic disease characterized by widespread pain, with mechanisms involving kinins and their receptors. ACE inhibitors can enhance pain symptoms by blocking peptide degradation and boosting kinin receptors signaling. In mice, ACE inhibitors enhanced mechanical allodynia induced by reserpine and this effect was prevented by kinin receptor antagonists.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Andrew Marshall
Summary: Recent research suggests that affective touch is transmitted through C-tactile afferents in the spinal cord, requiring the brain to decode information from convergent inputs and distributed spinal pathways. However, significant disparities between humans and mice raise questions about inter-species translation and the nature of affective touch itself.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2022)
Review
Physiology
Jianzheng He, Botong Li, Shuzhen Han, Yuan Zhang, Kai Liu, Simeng Yi, Yongqi Liu, Minghui Xiu
Summary: This article provides an overview of the conserved genetics and evaluation methods of nociceptive mechanisms, as well as the progress in developing anti-pain drugs using the fruit fly model.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Robert A. R. Drake, Kenneth A. Steel, Richard Apps, Bridget M. Lumb, Anthony E. Pickering
Summary: The loss of cortical control over the descending pain modulatory system after nerve injury contributes to the expression of neuropathic sensitisation.
Article
Multidisciplinary Sciences
Jonathan A. Shulgach, Dylan W. Beam, Ameya C. Nanivadekar, Derek M. Miller, Stephanie Fulton, Michael Sciullo, John Ogren, Liane Wong, Bryan L. McLaughlin, Bill J. Yates, Charles C. Horn, Lee E. Fisher
Summary: Vagus nerve stimulation (VNS) holds promise for affecting gastrointestinal function and treating diseases, but off-target effects can lead to major side effects. This study successfully demonstrated selective activation of vagal neurons using abdominal VNS in ferrets, and showed potential for controlling gastrointestinal function through this method.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Dorien Bamps, Anthony James Blockeel, Erwin Dreesen, Heleen Marynissen, Jolien Laenen, Anne Van Hecken, August Wilke, Shahram Shahabi, Kirk W. Johnson, Emily Catherine Collins, Lisa M. Broad, Keith G. Phillips, Jan de Hoon
Summary: The novel TRPA1 antagonist LY3526318 was found to inhibit the increase in dermal blood flow induced by cinnamaldehyde in both rats and humans, suggesting that dermal blood flow changes can serve as a biomarker for assessing TRPA1 activity.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Trevor Poitras, Vandana Singh, Ramanaguru S. Piragasam, Xiuling Wang, Atef M. Mannaa, Ambika Chandrasekhar, Jose Martinez, Richard Fahlman, Douglas W. Zochodne
Summary: MUPs have a suppressive effect on the plasticity of sensory neurons and interact with insulin signaling, improving experimental neuropathy. The actions of MUPs are similar to other members of the lipocalin family.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemical Research Methods
Luisa Zupin, Egidio Barbi, Raffaella Sagredini, Giulia Ottaviani, Sergio Crovella, Fulvio Celsi
Summary: This study found that PBMT at 800 and 970 nm wavelengths has a positive effect on nociceptive sensory neuronal cell line by reducing capsaicin-induced calcium flow, increasing ATP, and MMP hyperpolarization. Additionally, the 800 nm wavelength also increased ROS and O-2(-) levels.
JOURNAL OF BIOPHOTONICS
(2021)
Review
Cell Biology
Giulia Magni, Benedetta Riboldi, Stefania Ceruti
Summary: In the past decade, research on the interactions between the host microbiota and the central nervous system (CNS) has significantly advanced. Dysregulation of the bidirectional gut-brain crosstalk has been shown to contribute to the development of various pathological conditions, including chronic pain. Glial cell activation in both the central and peripheral nervous systems is also implicated in the pathogenesis and progression of pain and other neurodegenerative disorders. Recent studies suggest that the gut microbiota plays a critical role in regulating the morphology and function of glial cells, particularly microglia and astrocytes, possibly through the effects of microbial metabolites such as short-chain fatty acids (SCFAs). Altered microbiota composition has also been observed in CNS disorders characterized by glial cell activation. This review discusses the latest research on the role of the gut microbiota in modulating glial cell morphology and function, and proposes a potential role for glia-microbiota interactions in the development and maintenance of chronic pain.
Article
Behavioral Sciences
Roger Watkins
Summary: This study explores the presence of slow conducting, low threshold mechanoreceptive afferents in humans and non-human species, as well as the impact of genetic manipulation on affective behavior. Activation of C-LTMs induces positive affect, while disruption reduces social behavior and increases negative affect. Future research will further elucidate the roles and functions of the CT afferent system.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Hafner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boue-Grabot, Michael A. Kienzler, Guillaume Sandoz
Summary: By manipulating neuronal activity using optogenetics and photopharmacology, researchers have developed a light-activatable molecule called LAKI that can block pain-related potassium channels. This molecule has the potential to be a valuable tool for studying these channels, and it can also be used to remotely control pain in animal models without the need for genetic manipulations or viral infection. This non-invasive and reversible approach has applications in pain research and drug screening.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hai-Qian Zhou, Liu-Jing Zhuang, Hong-Qiang Bao, Sheng-Ju Li, Feng-Yan Dai, Ping Wang, Qian Li, Dong -Min Yin
Summary: Olfactory behavior is crucial for animal survival, and olfactory dysfunction is commonly seen in various diseases. This study reveals that mature olfactory sensory neurons (OSNs) express high levels of dopamine D2 receptor (Drd2), which can modulate odorant recognition response by inhibiting odor-induced signaling. Furthermore, nasal dopamine and DRD2 receptor are identified as potential peripheral targets for olfactory modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Multidisciplinary Sciences
Sachine Yoshida, Hiromasa Funato
Summary: Physical contact between infants and caregivers plays a crucial role in developing emotional attachment and a sense of security, altering behavior and mood through tactile sensation and emotional communication.
Editorial Material
Surgery
Dominik Promny, Jasmin Gruener, Theresa Hauck, Raymund E. Horch
HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
(2023)
Article
Cell Biology
Ravikumar Vaghela, Andreas Arkudas, Daniel Gage, Carolin Koerner, Stephan von Hoersten, Sahar Salehi, Raymund E. Horch, Maximilian Hessenauer
Summary: Due to limitations in current in vivo experimental designs, our understanding of vascular development and its implications for large-scale tissue engineering is limited. Thus, this study aimed to develop unique in vivo imaging chambers for live visualization of cellular processes in the arteriovenous (AV) loop model in rats. Two different types of chambers were developed and filled with modified gelatin hydrogel. Intravital microscopy (IVM) using fluorescein isothiocyanate (FITC)-labeled dextran and rhodamine 6G dye allowed visualization of leukocyte trafficking and examination of microvascular development in the AV loop for up to 21 days. The combination of these IVM chambers provides a comprehensive understanding of vascular development in the AV loop tissue engineering model.
Article
Health Care Sciences & Services
Justus Osterloh, Ingo Ludolph, Robert Gruetzmann, Alexander Meyer, Werner Lang, Raymund E. Horch, Katja Fechner, Andreas Arkudas
Summary: Soft-tissue sarcomas (STS) are rare malignancies occurring in various parts of the body, with the limbs being the most common site. Referral to a specialized sarcoma center is crucial for prompt and appropriate treatment. Interdisciplinary tumor boards should discuss STS treatment strategies, involving expertise from reconstructive surgeons for optimal outcomes. Evaluation of plastic reconstruction is necessary to avoid complications after extensive resection, and primary flap reconstruction may be preferable to secondary flap reconstruction for reducing complications.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Correction
Surgery
Markus Mulica, Raymund E. Horch, Andreas Arkudas, Aijia Cai, Wibke Mueller-Seubert, Theresa Hauck, Ingo Ludolph
FRONTIERS IN SURGERY
(2023)
Article
Surgery
N. Moellhoff, L. Prantl, B. Behr, J. P. Beier, A. Daigeler, A. Dragu, S. U. Eisenhardt, P. C. Fuchs, G. Germann, T. Hirsch, R. E. Horch, M. Infanger, R. Jakubietz, U. Kneser, S. Langer, M. Lehnhardt, H. G. Machens, P. Mailaender, B. Reichert, C. Radtke, D. J. Schaefer, F. Siemers, P. M. Vogt, H. Menke, R. E. Giunta
Summary: This research report presents the research performance of plastic surgeons in Germany for the period 2021/2022 and compares it with previous periods. The report shows that there has been an increase in the number of research applications and approvals in plastic surgery, and most participating centers have their own research infrastructure such as experimental laboratories and clinical trial centers.
HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
(2023)
Article
Biochemistry & Molecular Biology
Maike Hermann, Ajay Peddi, Alexander Gerhards, Rafael Schmid, Deborah Schmitz, Andreas Arkudas, Volker Weisbach, Raymund E. Horch, Annika Kengelbach-Weigand
Summary: Chronic wounds are a global epidemic and regenerative medicine is exploring the use of adipose-derived stem cells (ADSC) for new therapies. This study investigated the use of platelet lysate (PL) as a substitute for foetal bovine serum (FBS) to create an ADSC secretome containing cytokines for optimal wound healing conditions. The ADSC secretome was tested on keratinocytes for migrational behavior and viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Anna K. Becker, Alexandru Babes, Miriam M. Duell, Mohammad Khalil, Zoltan Kender, Jan Groener, Barbara Namer, Peter W. Reeh, Susanne K. Sauer
Summary: This study investigates the contribution of MGO to the development of pain and hyperalgesia in diabetic neuropathy. It found that TRPA1-expressing C-nociceptors play a crucial role in the development of spontaneous activity and sensitization in response to MGO.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Editorial Material
Oncology
R. E. Horch, M. R. Kesting, S. Kersting, S. Fichtner-Feigl, A. Arkudas
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Health Care Sciences & Services
Raymund E. Horch, Andreas Arkudas
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Celena A. Soergel, Aijia Cai, Rafael Schmid, Raymund E. Horch
Summary: Human skin is vulnerable to damaging influences, and severe skin defects often require surgical interventions. Bioprinting techniques offer an alternative approach by using biofabricated skin grafts to restore skin continuity and functions. Various bioprinting methods and strategies for graft vascularization can be employed to accelerate wound healing and reconstitute the physiological functions of the skin.
Article
Health Care Sciences & Services
Koblandy Khamitov, Wojciech Dudek, Andreas Arkudas, Mohamed Haj Khalaf, Chirag Parjiea, Mostafa Higaze, Raymund E. Horch, Horia Sirbu
Summary: In patients who underwent surgical resection for primary and secondary MCWTs, chest wall resections were found to be feasible with good perioperative outcomes. The overall survival rate was significantly higher in patients with primary MCWTs compared to those with secondary MCWTs.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Wibke Mueller-Seubert, Patrick Ostermaier, Raymund E. Horch, Luitpold Distel, Benjamin Frey, Ramona Erber, Andreas Arkudas
Summary: Different irradiation regimens have different effects on random-pattern flaps. A higher total dose of postoperative irradiation may increase flap necrosis, and irradiation can increase the expression of VEGF and HIF-1α.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jana Schulik, Sahar Salehi, Aldo R. Boccaccini, Stefan Schruefer, Dirk W. Schubert, Andreas Arkudas, Annika Kengelbach-Weigand, Raymund E. Horch, Rafael Schmid
Summary: This study compared the mechanical properties and the behavior of human umbilical vein endothelial cells (HUVECs) in three hydrogels (Alg/HA/Gel, ADA-GEL, and GelMA) for vascular tissue engineering. ADA-GEL and GelMA showed promising results for cell survival, migration, and sprouting, while Alg/HA/Gel did not provide a good environment for long-term survival of HUVECs.
BIOENGINEERING-BASEL
(2023)
Article
Surgery
Ingo Ludolph, Andreas Arkudas, Wibke Muller-Seubert, Aijia Cai, Raymund E. Horch
Summary: Lymphadenectomy is an essential part of surgical tumor therapy despite potential complications, and conservative or surgical treatments are available for secondary lymphedema.