期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 16, 页码 4201-4209出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0582-08.2008
关键词
Parkinson's disease; positron emission tomography; glucose metabolism; cerebral blood flow; levodopa treatment; STN DBS
资金
- NCRR NIH HHS [M01 RR018535-020004, M01 RR018535-030004, M01 RR018535-047117, M01 RR018535, M01 RR018535-056239] Funding Source: Medline
- NINDS NIH HHS [R01 NS035069-06, R01 NS035069-08, R01 NS035069-07, R01 NS035069-04, R01 NS035069, R01 NS035069-05A1] Funding Source: Medline
- PHS HHS [R01 35069] Funding Source: Medline
We compared the metabolic and neurovascular effects of levodopa (LD) therapy for Parkinson's disease (PD). Eleven PD patients were scanned with both [O-15]-H2O and [F-18]-fluorodeoxyglucose positron emission tomography in the unmedicated state and during intravenous LD infusion. Images were used to quantify LD-mediated changes in the expression of motor-and cognition-related PD covariance patterns in scans of cerebral blood flow (CBF) and cerebral metabolic rate for glucose (CMR). These changes in network activity were compared with those occurring during subthalamic nucleus (STN) deep brain stimulation (DBS), and those observed in a test-retest PD control group. Separate voxel-based searches were conducted to identify individual regions with dissociated treatment-mediated changes in local cerebral blood flow and metabolism. We found a significant dissociation between CBF and CMR in the modulation of the PD motor-related network by LD treatment (p < 0.001). This dissociation was characterized by reductions in network activity in the CMR scans (p < 0.003) occurring concurrently with increases in the CBF scans (p < 0.01). Flow-metabolism dissociation was also evident at the regional level, with LD-mediated reductions in CMR and increases in CBF in the putamen/globus pallidus, dorsal midbrain/pons, STN, and ventral thalamus. CBF responses to LD in the putamen and pons were relatively greater in patients exhibiting drug-induced dyskinesia. In contrast, flow-metabolism dissociation was not present in the STN DBS treatment group or in the PD control group. These findings suggest that flow-metabolism dissociation is a distinctive feature of LD treatment. This phenomenon may be especially pronounced in patients with LD-induced dyskinesia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据