Article
Cell Biology
Danna Jia, Pan Gao, Yuexia Lv, Yuwen Huang, James Reilly, Kui Sun, Yunqiao Han, Hualei Hu, Xiang Chen, Zuxiao Zhang, Pei Li, Jiong Luo, Xinhua Shu, Zhaohui Tang, Fei Liu, Mugen Liu, Xiang Ren
Summary: Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. In this study, using a zebrafish model, it was found that loss of TULP1 leads to defects in cilia structure and opsin trafficking, which further increases the death of photoreceptors. These findings offer important insights into the pathogenesis and clinical treatment of early-onset retinal degeneration.
CELL DEATH & DISEASE
(2022)
Review
Medicine, Research & Experimental
Juan Carlos Martinez-Morales, K. Helivier Solis, M. Teresa Romero-Avila, Guadalupe Reyes-Cruz, J. Adolfo Garcia-Sainz
Summary: G protein-coupled receptors (GPCRs) are membrane proteins that function as sensors and play significant roles in various physiological and pathological processes. This review provides an overview of the current understanding of the structure, signaling, internalization, and recycling of GPCRs.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Immunology
Di Huang, Xueman Chen, Xin Zeng, Liyan Lao, Jiaqian Li, Yue Xing, Yiwen Lu, Qian Ouyang, Jianing Chen, Linbin Yang, Fengxi Su, Herui Yao, Qiang Liu, Shicheng Su, Erwei Song
Summary: Effective tumor control relies on inflammatory helper and cytotoxic T cells. The protein RGS1 negatively regulates effector T cell homing to tumors, leading to tumor immune evasion and decreased patient survival. Targeting RGS1 may offer a new strategy for tumor immunotherapy.
Article
Neurosciences
Chad Yee, Katharina Goertemaker, Rieke Wellpott, Karl-Wilhelm Koch
Summary: The cone photoreceptor cells of night-migratory songbirds have the ability to process both vision and magnetoreception. Recent studies have shown a link between a putative magnetoreceptor and a cone specific G-protein in European robins. This research investigates the interaction between the G protein and the cytoplasmic regions of long wavelength opsin in European robins and identifies a critical binding interface. The results suggest that the G protein binding to the magnetoreceptor can compete with the interaction with non-photoexcited long wavelength opsin.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Rikard Frederiksen, Ala Morshedian, Sonia A. Tripathy, Tongzhou Xu, Gabriel H. Travis, Gordon L. Fain, Alapakkam P. Sampath
Summary: Rod photoreceptors can become saturated by bright background light, but recent experiments have shown that they can also recover sensitivity and maintain responses even under prolonged exposure to bright light. The reduction of translocation of G protein transducin in transgenic mice may affect the recovery ability, and a novel mechanism of visual-pigment regeneration within the rod itself enables them to remain responsive. This allows rods to avoid extended closure of transduction channels, which could lead to photoreceptor degeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Miriam Ryl, Alexander Urbasik, Kaspar Gierke, Norbert Babai, Anneka Joachimsthaler, Andreas Feigenspan, Renato Frischknecht, Nina Stallwitz, Anna Fejtova, Jan Kremers, Julia von Wittgenstein, Johann Helmut Brandstaetter
Summary: The study investigated the impact of mutations in the Bassoon protein on the synaptic function and structure of photoreceptor cells in mice. Results showed that the synaptic defects were more severe in Bsn(gt/gt) mice, while expression of the Bsn(gt) allele led to cone photoreceptor death and neurite sprouting in the outer retina.
Article
Neurosciences
Ashley A. Farre, Chi Sun, Margaret R. Starostik, Samuel S. Hunter, Milton A. English, Audrey Duncan, Abirami Santhanam, Eyad Shihabeddin, John O'Brien, Anand Swaroop, Deborah L. Stenkamp
Summary: This study aimed to investigate the transcriptional heterogeneity and regulation of differentially expressed tandemly-replicated opsins using zebrafish as a model. The results showed additional transcriptional differences beyond opsin expression between LWS1 and LWS2 cones, which are likely controlled by multiple signals.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Min Zeng, Min Li, Zhihui Fei, Fang-Xiang Wu, Yaohang Li, Yi Pan, Jianxin Wang
Summary: A deep learning framework is proposed to automatically learn biological features, which enhances the identification of essential proteins by utilizing techniques and features at different levels, and outperforms traditional centrality methods and existing machine learning-based methods according to experimental results.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Cell Biology
Richard J. McDowell, Jessica Rodgers, Nina Milosavljevic, Robert J. Lucas
Summary: Melanopsin in mammals can signal through multiple pathways, with variations in signaling selectivity observed between species.
JOURNAL OF CELL SCIENCE
(2022)
Article
Infectious Diseases
Jinglan Wang, Laura Alvarez, Silvia Bulgheresi, Felipe Cava, Tanneke den Blaauwen
Summary: Peptidoglycan is crucial for bacterial survival and cell shape maintenance. Research on the gamma proteobacterium Candidatus Thiosymbion oneisti reveals its unique PG composition with high peptide cross-linkage and short glycan chains, as well as the involvement of endopeptidase PBP4 in septum formation. PBP4 shows different beta-lactam selectivity and potential allosteric binding site, suggesting a role in PG cleavage during longitudinal cell division and adaptation to a symbiotic lifestyle.
Article
Biology
Sergi Junyent, Joshua C. Reeves, James L. A. Szczerkowski, Clare L. Garcin, Tung-Jui Trieu, Matthew Wilson, Jethro Lundie-Brown, Shukry J. Habib
Summary: The Wnt-pathway interacts with AMPA/Kainate-type ionotropic glutamate receptors during cell recruitment, dynamics, and spindle orientation. AMPA receptors are crucial for segregating cell fate components in asymmetric cell division. The Wnt co-receptor Lrp6 plays a specific role in cytoneme formation and ACD, along with Lrp5 and β-catenin.
Review
Oncology
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Mahdi Mohaqiq, Hamed Shoorei, Aria Baniahmad, Mohammad Taheri, Elena Jamali
Summary: The PDCD family of proteins plays important roles in regulating apoptosis and its dysregulation is associated with a variety of diseases. Recent studies have discovered interactions between non-coding RNAs and members of the PDCD family. Specifically, microRNAs such as miR-21 and miR-183, as well as long non-coding RNAs such as MALAT1, MEG3, SNHG14, and LINC00473 have been found to interact with PDCDs in different contexts, particularly in the context of neoplasia.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicole Ahrens, Dana Elbers, Helena Greb, Ulrike Janssen-Bienhold, Karl-Wilhelm Koch
Summary: The study revealed diverse properties of recoverin and opsin kinase in zebrafish retina due to differential expression and interaction profiles, indicating distinct roles of different recoverin paralogs in rod and cone cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biology
Kelvin Yeung, Komal Kumar Bollepogu Raja, Yoon-Kyung Shim, Yumei Li, Rui Chen, Graeme Mardon
Summary: This study presents single cell transcriptomic data on the adult Drosophila eye, identifying cell type specific marker genes and revealing that the clustering of R7 and R8 photoreceptors is determined by the expression of specific Rhodopsin proteins. These transcriptomic data provide valuable insights into the mechanisms of the adult fly eye as a model system.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna S. Stroppel, Ngadhnjim Latifi, Alfred Hanswillemenke, Rafail Nikolaos Tasakis, F. Nina Papavasiliou, Thorsten Stafforst
Summary: The study demonstrates precise and efficient A-to-I RNA editing using the SNAP-ADAR tool in cell culture, and extends the platform by combining it with the HALO-tag to recruit additional effectors for optimal editing. By recruiting different deaminase activities, selective and concurrent editing of multiple RNA bases inside living cells can be achieved with moderate global off-target effects.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Genetics & Heredity
Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, Gregory J. Pazour
Article
Neurosciences
Ali S. Sharif, Dongmei Yu, Stuart Loertscher, Richard Austin, Kevin Nguyen, Pranav D. Mathur, Anna M. Clark, Junhuang Zou, Ekaterina S. Lobanova, Vadim Y. Arshavsky, Jun Yang
JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Ekaterina S. Lobanova, Stella Finkelstein, Jing Li, Amanda M. Travis, Ying Hao, Mikael Klingeborn, Nikolai P. Skiba, Raymond J. Deshaies, Vadim Y. Arshavsky
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
Rolf Herrmann, Ekaterina S. Lobanova, Timothy Hammond, Christopher Kessler, Marie E. Burns, Laura J. Frishman, Vadim Y. Arshavsky
JOURNAL OF NEUROSCIENCE
(2010)
Article
Multidisciplinary Sciences
Ekaterina S. Lobanova, Stella Finkelstein, Nikolai P. Skiba, Vadim Y. Arshavsky
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Neurosciences
Ekaterina S. Lobanova, Kai Schuhmann, Stella Finkelstein, Tylor R. Lewis, Martha A. Cady, Ying Hao, Casey Keuthan, John D. Ash, Marie E. Burns, Andrej Shevchenko, Vadim Y. Arshavsky
JOURNAL OF NEUROSCIENCE
(2019)
Article
Oncology
Lei Xu, Susan N. Bolch, Clayton P. Santiago, Frank M. Dyka, Omar Akil, Ekaterina S. Lobanova, Yuchen Wang, Kirill A. Martemyanov, William W. Hauswirth, W. Clay Smith, James T. Handa, Seth Blackshaw, John D. Ash, Astra Dinculescu
JOURNAL OF PATHOLOGY
(2020)
Article
Cell Biology
Stella Finkelstein, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, Ekaterina S. Lobanova
Article
Biochemistry & Molecular Biology
Lei Xu, Emily E. Brown, Clayton P. Santiago, Casey J. Keuthan, Ekaterina Lobanova, John D. Ash
Review
Biochemistry & Molecular Biology
Gyening Kofi Yeboah, Ekaterina S. Lobanova, Richard S. Brush, Martin-Paul Agbaga
Summary: Lipids, specifically VLC-PUFA and VLC-SFA synthesized by the enzyme ELOVL4, play critical roles in maintaining cellular function in tissues such as the retina and brain. ELOVL4 and its products are essential for life, with mutations affecting fatty acid biosynthesis leading to various tissue-specific human disorders. This review highlights the importance of ELOVL4 and its products in cellular function and the need for further research in understanding their roles.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xiajie Ma, Emily R. Sechrest, Diego Fajardo, Ping Zhu, Frank Dyka, Yixiao Wang, Ekaterina Lobanova, Shannon E. Boye, Wolfgang Baehr, Wen-Tao Deng
Summary: The study demonstrates that AAV-mediated gene augmentation therapy can rescue cone structure and function in a mouse model with a congenital opsin deletion, emphasizing the importance of early intervention for successful therapy.
HUMAN GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
Yixiao Wang, Claudio Punzo, John D. Ash, Ekaterina S. Lobanova
Summary: Activation of the mTORC1 pathway can increase proteasomal activity, improve photoreceptor survival, and delay vision loss. Chronic activation of mTORC1 may stimulate the UPS in degenerating photoreceptor neurons. Further research can aid in the development of therapeutic approaches to diseases related to impaired proteasomal degradation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yixiao Wang, Aaron Snell, Frank M. Dyka, Elizabeth R. Colvin, Cristhian Ildefonso, John D. Ash, Ekaterina S. Lobanova
Summary: Proteasomes play a crucial role in breaking down damaged and abnormal proteins in human cells. Stimulating proteasomal activity has been explored as a strategy to enhance cellular resistance to various types of protein stress. In this study, the overexpression of the Nfe2l1 transcription factor was shown to stimulate proteasome biogenesis and activity, improving clearance of ubiquitin-proteasomal reporter and delaying photoreceptor neuron loss in a mouse model of protein misfolding-induced blindness. These findings highlight Nfe2l1 as a potential therapeutic target for neurodegenerative diseases associated with protein misfolding.
Article
Neurosciences
Paige M. Dexter, Ekaterina S. Lobanova, Stella Finkelstein, Vadim Y. Arshavsky
Article
Neurosciences
Paige M. Dexter, Ekaterina S. Lobanova, Stella Finkelstein, William J. Spencer, Nikolai P. Skiba, Vadim Y. Arshavsky