Article
Genetics & Heredity
Peng Liu, Jialong Liang, Fengze Jiang, Wanshi Cai, Fang Shen, Jing Liang, Jianjun Zhang, Zhongsheng Sun, Nan Sui
Summary: Impairing reconsolidation can prevent relapse of morphine reward memories. DNA methyltransferases play a crucial role in the reconsolidation of opiate-associated memories, specifically in the basolateral amygdala (BLA), and DNA hypermethylation of certain genes is necessary for the reconsolidation of morphine reward memories.
Article
Neurosciences
Matteo Bernabo, Josue Haubrich, Karine Gamache, Karim Nader
Summary: The study found that NMDAR activation and proteasome activity can lead to a temporary reduction in PKM xi protein after memory retrieval, while new PKM xi protein is synthesized during memory reconsolidation to restore memory. Failure to synthesize new PKM xi during memory reconsolidation impairs memory, but continuous synthesis of PKM xi is not necessary for maintenance itself.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jessica A. Higginbotham, Rong Wang, Ben D. Richardson, Hiroko Shiina, Shi Min Tan, Mark A. Presker, David J. Rossi, Rita A. Fuchs
Summary: Systemic CB1R antagonism during cocaine-memory reconsolidation reduced drug context-induced cocaine-seeking behavior and inhibited cellular adaptations and synaptic physiology changes in the basolateral amygdala. These findings suggest that CB1R signaling modulates cellular and synaptic mechanisms in the BLA, potentially playing a crucial role in preventing relapse.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Maryam Nazari, Ali Rashidy-Pour, Abbas Ali Vafaei, Payman Raise-Abdullahi
Summary: This study investigated the role of glucocorticoid receptors in the basolateral amygdala in the late reconsolidation of fear memory. The results showed that corticosterone injection 12 hours after memory reactivation effectively impaired late memory reconsolidation. This impairment could be blocked by a glucocorticoid receptor antagonist in the amygdala. Additionally, the age of the memory also affected the impairing effect.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Neurosciences
Natividade de Sa Couto Pereira, Querusche Klippel Zanona, Marcelo Pastore Bernardi, Joelma Alves, Carla Dalmaz, Maria Elisa Calcagnotto
Summary: Maternal separation in male rats can lead to resistant memory labilization in adulthood. The desynchronization between the dorsal hippocampus and the basolateral amygdala during fear memory reactivation may be responsible for this impairment.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Neurosciences
Nicole C. Ferrara, Janine L. Kwapis, Sydney Trask
Summary: Following fear conditioning, behavior can be reduced through either multiple CS-alone presentations, known as extinction, or a few presentations with interference in subsequent memory reconsolidation. Although the procedures have similarities, the behavioral outcomes and neurobiological processes are distinct. This review explores the neural and behavioral mechanisms behind these different reductions, as well as factors determining the retrieval-dependent reconsolidation process or extinction process.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2023)
Article
Neurosciences
Despina Antypa, Aurore A. Perrault, Patrik Vuilleumier, Sophie Schwartz, Ulrike Rimmele
Summary: Evidence from a study suggests that in humans, when memories are reactivated and immediately followed by suppression of cortisol levels, reconsolidation processes change in a way that leads to the strengthening of the reactivated memories.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Alvaro Cabral Araujo, Nickolas Carui, Alia Garrudo Guirado, Daniela Schiller, Francisco Lotufo Neto, Felipe Corchs
Summary: Delivering ECT after retrieving traumatic memories can enhance the treatment efficacy in PTSD by reducing symptoms and reactivity. Regardless of memory retrieval, the sample as a whole experienced reduction in anxiety, mood symptoms, and physiological reactivity to traumatic memories.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Hotaka Fukushima, Yue Zhang, Satoshi Kida
Summary: Memory reconsolidation is believed to enhance original memories by activating gene expression in the amygdala, mPFC, and hippocampus. Interactions between the amygdala and mPFC as upstream regulators of the hippocampus play a crucial role in enhancing inhibitory avoidance memory. Blocking these regions post-memory retrieval inhibits memory enhancement and the induction of c-Fos, indicating their importance in reconsolidating memory.
Article
Neurosciences
Jobe L. Ritchie, Jennifer L. Walters, Justine M. C. Galliou, Robert J. Christian, Shuyi Qi, Marina Savenkova, Christopher K. Ibarra, Shayna R. Grogan, Rita A. Fuchs
Summary: The study found that CRFR1 signaling in the brain region BLA is crucial for regulating the strength of cocaine memories in rats, with potential sex differences in its effects.
Article
Neurosciences
Or Duek, Nachshon Korem, Yutong Li, Ben Kelmendi, Shelley Amen, Charles Gordon, Madison Milne, John H. Krystal, Ifat Levy, Ilan Harpaz-Rotem
Summary: NMDA receptor antagonists play a vital role in the processes of extinction, learning, and reconsolidation. In this pilot study, ketamine infusion followed by brief exposure therapy was tested for its potential to enhance post-retrieval extinction of PTSD trauma memories. Although both groups showed improvement in PTSD symptoms, ketamine recipients demonstrated lower activation and connectivity in the amygdala and hippocampus, suggesting that ketamine may enhance the extinction of traumatic memories in humans. These preliminary findings provide promising direction for further investigation of ketamine as a treatment for PTSD when combined with psychotherapy.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ding Rulan, Yang Zhenbang, Zhang Yipu, Gao Yuan, Ewa Galaj, Shi Xiaorui, Li Wenshuya, Luo Jiaqi, Zhang Yan, Yang Chang, Yin Xi, Song Li, Luo Yixiao, Shi Haishui
Summary: The study found that exogenous sulfur dioxide can affect the reconsolidation of drug reward memory rather than inhibiting the expression of drug reward memory. This suggests potential for sulfur dioxide in the treatment and prevention of substance-related and addictive disorders, warranting further investigation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Victor M. Tang, Kathleen Trought, Kristina M. Gicas, Mari Kozak, Sheena A. Josselyn, Zafiris J. Daskalakis, Daniel M. Blumberger, Daphne Voineskos, Yuliya Knyahnytska, Suvercha Pasricha, Yuan Chung, Young Zhou, Moshe Isserles, Albert H. C. Wong
Summary: This study aimed to test the use of ECT to disrupt the reconsolidation of traumatic memories as a potential treatment for PTSD. The results showed that pairing ECT with pre-treatment traumatic memory reactivation was not more effective for treating PTSD symptoms than ECT alone, but provided further support for the efficacy of ECT for improving symptoms of PTSD with comorbid depression.
Article
Cell Biology
BumJin Ko, Jong-Yeon Yoo, Taesik Yoo, Woochul Choi, Rumeysa Dogan, Kibong Sung, Dahun Um, Su Been Lee, Hyun Jin Kim, Sangjun Lee, Seung Tae Beak, Sang Ki Park, Se-Bum Paik, Tae-Kyung Kim, Joung-Hun Kim
Summary: The amygdala circuit encodes associations between conditioned and unconditioned stimuli and controls fear expression. However, the processing of non-threatening information for unpaired conditioned stimuli remains unknown. This study reveals the cellular and molecular mechanisms that regulate the consolidation of non-threatening memories, supporting fear discrimination.
Article
Multidisciplinary Sciences
Marie Lods, Emilie Pacary, Wilfrid Mazier, Fanny Farrugia, Pierre Mortessagne, Nuria Masachs, Vanessa Charrier, Federico Massa, Daniela Cota, Guillaume Ferreira, Djoher Nora Abrous, Sophie Tronel
Summary: The study found that adult-born neurons play a crucial role in memory reconsolidation, particularly immature adult-born neurons during learning are necessary for remote memory reconsolidation in rats.
NATURE COMMUNICATIONS
(2021)