Article
Multidisciplinary Sciences
Gioele La Manno, Kimberly Siletti, Alessandro Furlan, Daniel Gyllborg, Elin Vinsland, Alejandro Mossi Albiach, Christoffer Mattsson Langseth, Irina Khven, Alex R. Lederer, Lisa M. Dratva, Anna Johnsson, Mats Nilsson, Peter Lonnerberg, Sten Linnarsson
Summary: A comprehensive single-cell transcriptomic atlas of the mouse brain between gastrulation and birth identifies hundreds of cellular states and reveals the spatiotemporal organization of brain development.
Article
Biology
Hind Baba Aissa, Romain W. Sala, Elena Laura Georgescu Margarint, Jimena Laura Frontera, Andres Pablo Varani, Fabien Menardy, Assunta Pelosi, Denis Herve, Clement Lena, Daniela Popa
Summary: The study found that in the DYT25 dystonia model, the excitability of the cerebello-thalamic pathways increased in the presymptomatic state, and asymptomatic mice after the first dystonic episode exhibited higher excitability, which persisted after cerebellar theta-burst stimulation. Stimulation administered during symptomatic states reduced cerebello-thalamic excitability and alleviated dystonic symptoms.
Article
Cell Biology
Gregg A. Wildenberg, Matt R. Rosen, Jack Lundell, Dawn Paukner, David J. Freedman, Narayanan Kasthuri
Summary: The study reveals that primate neurons receive fewer excitatory and inhibitory synapses compared to mouse neurons, leading to lower excitatory-to-inhibitory ratios in excitatory neurons. Inhibitory axons have consistent properties in both species, with local and specific innervation of excitatory neurons. Additionally, the penalty for creating and maintaining synapses in artificial neural networks results in a reduction of connections per node, similar to the pattern seen in primate neurons versus mice.
Article
Engineering, Biomedical
Xingran Wang, Jiaqing Yan, Huiran Zhang, Yi Yuan
Summary: This study demonstrates that UTS can directly induce neural activity in the thalamus and indirectly induce neural activity in the M1, with a strong connection relationship between thalamus and M1 under UTS. These findings have the potential to guide ultrasound treatment of thalamus-related diseases.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Neurosciences
Jacqueline M. Ehrman, Paloma Merchan-Sala, Lisa A. Ehrman, Bin Chen, Hee-Woong Lim, Ronald R. Waclaw, Kenneth Campbell
Summary: The projection neurons of the striatum can be categorized into the striatopallidal (indirect) pathway or the striatonigral (direct) pathway. Striatonigral axons pioneer the internal capsule and cerebral peduncle and provide guidance for corticofugal and thalamocortical axons. Defects in the striatonigral pathway can disrupt internal capsule formation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Josue M. Avecillas-Chasin, Simon Levinson, Taylor Kuhn, Mahmoud Omidbeigi, Jean-Philippe Langevin, Nader Pouratian, Ausaf Bari
Summary: The amygdala is important in emotion, learning, and memory, and is associated with behavioral disorders. Understanding the amygdala circuitry is crucial for developing new therapies. Using data from 200 healthy subjects, we created statistical maps of amygdala connectivity to brain regions involved in different circuits. Clustering analysis revealed three clusters of the amygdala based on its connectivity, showing a medial-to-lateral pattern.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Patricia R. Nano, Claudia V. Nguyen, Jessenya Mil, Aparna Bhaduri
Summary: The cerebral cortex derives its cognitive power from a modular network of specialized areas processing a multitude of information. Efforts to capture the gene networks which drive arealization have been hampered by the lack of tractable models of human neurodevelopment. Advancements in omics technologies have enabled breakthroughs into the molecular and structural characteristics of cortical areas, shaping our current understanding of cortical areas.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Steliana Yanakieva, Mathias L. Mathiasen, Eman Amin, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton
Summary: This study compared collateral projections from different rostral thalamic nuclei terminating in different cortical areas. The results showed that these projections predominantly arise from separate populations of neurons with discrete cortical termination zones.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Theo F. F. Marins, Maite Russo, Erika C. C. Rodrigues, Marina Monteiro, Jorge Moll, Daniel Felix, Julia Bouzas, Helena Arcanjo, Claudia D. D. Vargas, Fernanda Tovar-Moll
Summary: Cross-modal plasticity in blind individuals refers to the ability of their visual brain structures to process nonvisual information. However, the structural basis of this plasticity in congenitally blind individuals is not clear. This study investigates the thalamocortical connectivity and white matter integrity in 10 congenitally blind individuals and 10 sighted controls, revealing changes in connectivity between the thalamus and occipital and temporal cortices. The findings demonstrate a remapping of thalamocortical connections and provide insights into the functional adaptations in congenitally blind individuals.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Tolulope Adeyelu, Tanya Gandhi, Charles C. Lee
Summary: Researchers have identified a prominent contralateral corticothalamic projection originating in the insular cortex, which differs from the traditional unilateral thalamo-cortico-thalamic loops and suggests a unique bilateral mechanism for refining ascending sensory information.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Anatomy & Morphology
Levente Gellert, Heiko J. Luhmann, Werner Kilb
Summary: The functional connections between S1 and M1 or S2 are not confined to the same cortical area, but exist already at the day of birth between adjacent cortical areas. These connections play an important role in the development of sensorimotor integration.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Multidisciplinary Sciences
Houri Hintiryan, Ian Bowman, David L. Johnson, Laura Korobkova, Muye Zhu, Neda Khanjani, Lin Gou, Lei Gao, Seita Yamashita, Michael S. Bienkowski, Luis Garcia, Nicholas N. Foster, Nora L. Benavidez, Monica Y. Song, Darrick Lo, Kaelan Cotter, Marlene Becerra, Sarvia Aquino, Chunru Cao, Ryan P. Cabeen, Jim Stanis, Marina Fayzullina, Sarah Ustrell, Tyler Boesen, Amanda J. Tugangui, Zheng-Gang Zhang, Bo Peng, Michael S. Fanselow, Peyman Golshani, Joel D. Hahn, Ian R. Wickersham, Giorgio A. Ascoli, Li Zhang, Hong-Wei Dong
Summary: The authors used machine-learning based computational techniques to map the connectivity of the basolateral amygdalar complex, identifying distinct domains within the anterior BLA with target-specific projection neurons and morphological features. This study provides insights into the circuitry of BLA projection neurons and their connections to behavior networks within the brain.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Nathaniel C. Wright, Peter Y. Borden, Yi Juin Liew, Michael F. Bolus, William M. Stoy, Craig R. Forest, Garrett B. Stanley
Summary: Rapid sensory adaptation is a common phenomenon observed in all sensory systems, yet the mechanistic basis behind it is still poorly understood. Studies on awake mice suggest that cortical adaptation in primary somatosensory cortex is mainly driven by changes in thalamic input timing and differential impacts on cortical excitation and feed forward inhibition. This highlights the significant role of thalamic gating in rapid adaptation of primary sensory cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Salvatore Bertino, Gianpaolo Antonio Basile, Alessia Bramanti, Rosella Ciurleo, Adriana Tisano, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
Summary: Different parcellation pipelines were tested for identifying the treatment target Vim for drug refractory tremors, with higher-order signal modeling and threshold-based voxel classification criteria being the most reliable in terms of inter-subject variability. Connectivity parcels corresponding to Vim were primarily derived from precentral and dentate nucleus-thalamic connectivity, but showed significant differences compared to a ground truth model. Data quality and parcellation pipelines significantly influenced the volume of connectivity clusters, highlighting the need for caution in thalamic connectivity-based segmentation for stereotactic targeting.
Article
Neurosciences
Divesh Thaploo, Akshita Joshi, Charalampos Georgiopoulos, Jonathan Warr, Thomas Hummel
Summary: This study aims to investigate the number of fiber bundles between the piriform cortex and the orbitofrontal cortex (OFC) as well as the piriform cortex and the thalamus, and their correlations with trigeminal and olfactory chemosensory perceptions. The study found that the number of fiber bundles between the piriform cortex and the thalamus was higher in the left hemisphere, while the number of fiber bundles between the piriform cortex and the OFC was higher in the right hemisphere. Additionally, the fiber bundles between the piriform cortex and the thalamus were positively correlated with the intensity of irritating (trigeminal) odors, while the fiber bundles between the piriform cortex and the OFC were correlated with the threshold scores for these trigeminal odors.
Book Review
Clinical Neurology
Zoltan Molnar, Alasdair Coles
Article
Neurosciences
Chrysoula Giasafaki, Eleanor Grant, Anna Hoerder-Suabedissen, Shuichi Hayashi, Sheena Lee, Zoltan Molnar
Summary: This study investigates the gene expression changes in the dLGN after monocular enucleation at birth. The results show that monocular enucleation leads to downregulation of certain genes in dLGN, which are normally enriched in this region during development. Comparison with developmental gene expression patterns suggests immature and delayed gene expression in enucleated dLGN. Additionally, the study reveals that the induced layer 5 fibers that innervate enucleated dLGN originate from the primary visual cortex and retain increased synapse formation into adulthood.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Neurosciences
Godwin Sokpor, Beate Brand-Saberi, Huu Phuc Nguyen, Tran Tuoc
Summary: Cell delamination plays a crucial role in cortical development, and improper delamination can result in progenitor cell fate commitment and neuronal migration abnormalities. Many factors regulate cell attachment and delamination processes, and they are associated with neurodevelopmental disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Megan F. Veltri, Emily L. Durham, Kate M. Lesciotto, Abigail Coupe, Mizuho Kawasaki, Susan Motch-Perrine, Anastassia Stoykova, Tran C. Tuoc, Kazuhiko Kawasaki, Joan T. Richtsmeier
Meeting Abstract
Biochemistry & Molecular Biology
Abigail Coupe, Emily L. Durham, Kate M. Lesciotto, Megan F. Veltri, Mizuho Kawasaki, Susan Motch-Perrine, Anastassia Stoykova, Tran C. Tuoc, Kazuhiko Kawasaki, Joan T. Richtsmeier
Article
Behavioral Sciences
Peter A. Perrino, Renee Y. Chasse, Anthony P. Monaco, Zoltan Molnar, Antonio Velayos-Baeza, R. Holly Fitch
Summary: Developmental dyslexia is a common neurodevelopmental disorder characterized by difficulties in reading and writing. The gene KIAA0319 has been identified as a candidate risk gene for dyslexia. Studies using animal models have shown inconsistent results, but recent experiments on KIAA0319 knockout mice revealed auditory processing impairments and neuroanatomical changes in relevant brain structures. These findings support a role for KIAA0319 in the development of auditory processing functions critical to speech processing, language, and reading.
GENES BRAIN AND BEHAVIOR
(2022)
Review
Neurosciences
Heiko J. Luhmann, Patrick O. Kanold, Zoltan Molnar, Sampsa Vanhatalo
Summary: This article reviews the methods for assessing neuronal activity in both clinical and animal models, and discusses the urgent need for translational research, the challenges and possible solutions in translating biomedical research into clinical diagnostics or treatments.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Anna Hoerder-Suabedissen, Gabriel Ocana-Santero, Thomas H. Draper, Sophie A. Scott, Jesse G. Kimani, Andrew M. Shelton, Simon J. B. Butt, Zoltan Molnar, Adam M. Packer
Summary: Our study investigates the development of mouse claustrum neurons, including their birth time, location in the developing brain, and the formation of their connections to the cortex. We found that a specific protein distribution and a dense patch of cells are present in the claustrum from postnatal day 21, while most claustrum neurons are born around embryonic day 12.5. The claustrum's connectivity to different cortical regions matures at different times. This research establishes a timeline of claustrum development and provides insights into its unique connectivity.
Article
Microscopy
Shuichi Hayashi, Nobuhiko Ohno, Graham Knott, Zoltan Molnar
Summary: Recent advances in volume electron microscopy, especially in the combination with light microscopy, have enabled the study of brain structure at a detailed level. By using genetic tools and natural landmarks, immunostaining-free techniques have been developed, allowing for the investigation of brain development in live organisms.
Article
Biology
Janine Traut, Jose Prius Mengual, Elise J. Meijer, Laura E. McKillop, Hannah Alfonsa, Anna Hoerder-Suabedissen, Seo Ho Song, Kristoffer D. Feher, Dieter Riemann, Zoltan Molnar, Colin J. Akerman, Vladyslav V. Vyazovskiy, Lukas B. Krone
Summary: Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. In this study, we demonstrated that the commonly used DREADD actuator, clozapine-N-oxide (CNO), as well as a novel actuator, compound 21 (C21), can modulate sleep in mice not expressing DREADD receptors. Our findings suggest that back-metabolism to clozapine is not the sole mechanism underlying the sleep effects of chemogenetic actuators.
Article
Biology
Javier Gilbert-Jaramillo, Ujang Purnama, Zolta Molnar, William S. James
Summary: The replication of Zika virus (ZIKV) in cortical progenitor cells derived from human induced pluripotent stem cells (hiPSCs) is influenced by the metabolic patterns of these cells. ZIKV alters the transcription of metabolic genes and upregulates glycolytic capacity in early hi-NPCs, while affecting mitochondrial distribution and size in both early and late hi-NPCs. These findings suggest that alterations in cellular metabolism during ZIKV infection may contribute to different brain damage in each trimester.
Meeting Abstract
Clinical Neurology
J. Traut, J. Prius Mengual, E. J. Meijer, L. E. McKillop, H. Alfonsa, A. Hoerder-Suabedissen, S. M. Song, Z. Molnar, C. J. Akerman, V. V. Vyazovskiy, L. B. Krone
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
E. Meijer, S. Wilcox, A. Hoerder-Suabedissen, T. Yamagata, Z. Molnar, V. Vyazovskiy
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
J. Traut, J. P. Mengual, E. Meijer, L. E. McKillop, H. Alfonsa, A. Hoerder-Suabedissen, S. M. Song, Z. Molnar, C. J. Akerman, V. V. Vyazovskiy, L. Krone
Meeting Abstract
Anatomy & Morphology
Sara Bandiera, Zoltan Molnar
JOURNAL OF ANATOMY
(2022)