Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiyong Zhao, Huaying Cai, Manli Huang, Weihao Zheng, Tingting Liu, Di Sun, Guocan Han, Linhui Ni, Yi Zhang, Dan Wu
Summary: The study found that patients with PSD showed specific alterations in the transmission and reception of information in the hippocampal subfields, leading to decreases in inward information flow and increases in outward information flow. Additionally, there were significant correlations between cognitive scores and dFCs in the PSD group related to the hippocampal subfields. Furthermore, dFCs of the hippocampus and its subfields improved the classification between PSD and PSND patients compared to clinical and demographic parameters alone, with high accuracy, sensitivity, and specificity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Multidisciplinary Sciences
Wei-Tang Chang, Stephanie K. Langella, Yichuan Tang, Sahar Ahmad, Han Zhang, Pew-Thian Yap, Kelly S. Giovanello, Weili Lin
Summary: The hippocampus is crucial for learning and memory, and can be divided into anatomically-defined subfields. Research has shown that there are differences in functional connectivity patterns within the hippocampus during resting state, and data-driven approaches can provide valuable insights into hippocampal functional organization.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Junjie Wu, Syed S. S. Shahid, Qixiang Lin, Antoine Hone-Blanchet, Jeremy L. L. Smith, Benjamin B. B. Risk, Aditya S. S. Bisht, David W. W. Loring, Felicia C. C. Goldstein, Allan I. I. Levey, James J. J. Lah, Deqiang Qiu
Summary: This study investigated the morphometry, functional connectivity, and tissue microstructure of hippocampal subfields in cognitively normal adults and those with asymptomatic AD using multi-modal MRI. The findings suggest that the subiculum and CA1-3 are the most vulnerable in asymptomatic AD, and tau protein levels play a crucial role in driving these early changes.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Nahla M. H. Elsaid, Pierrick Coupe, Andrew J. Saykin, Yu-Chien Wu
Summary: This study aimed to introduce a new methodology for studying hippocampus-aging using sub-millimeter super-resolution hybrid diffusion imaging (HYDI) MRI. The findings showed reduced structural connectivity in the hippocampal subfields of older adults compared to younger adults, providing new insights into the relationship between hippocampal connectivity and different types of dementia.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Developmental
Kelsey L. Canada, Gregory R. Hancock, Tracy Riggins
Summary: The hippocampus shows differential development of subfields within the head and body across early- to mid-childhood. Changes in volume of certain subfields within specific age ranges are related to improvements in memory, highlighting the importance of considering subfields separately in the hippocampus. This study emphasizes the protracted development of subfields in vivo during childhood, the cooccurring development of brain and behavior, and the strength of longitudinal data and latent modeling in examining brain development.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Edmund T. Rolls, Gustavo Deco, Chu-Chung Huang, Jianfeng Feng
Summary: This study investigates the effective connectivity in the human hippocampal memory system, revealing the directionality and strength of the connections between different brain regions. By connecting different information streams with the hippocampus, the hippocampal function is optimized.
Article
Neurosciences
Jorge Bosch-Bayard, Rolando J. Biscay, Thalia Fernandez, Gloria A. Otero, Josefina Ricardo-Garcell, Eduardo Aubert-Vazquez, Alan C. Evans, Thalia Harmony
Summary: This study describes the maturation of EEG effective connectivity in healthy infants during the first year of life. The results show that initially, the highest indices of connectivity are in the subcortical nuclei and then expand to other brain regions, consistent with the myelination process. As age increases, connectivity mainly increases in the right hemisphere and decreases in the left hemisphere. There is an increase in connectivity in the right hemisphere for frequencies between 20 to 30 Hz. Theta and alpha connections show the greatest changes with age, consistent with behavioral development in infants.
Article
Neurosciences
Erwan Leprince, Robin F. Dard, Salome Mortet, Caroline Filippi, Marie Giorgi-Kurz, Romain Bourboulou, Pierre-Pascal Lenck-Santini, Michel A. Picardo, Marco Bocchio, Agnes Baude, Rosa Cossart
Summary: The adult CA1 region of the hippocampus produces coordinated neuronal dynamics with minimal reliance on its extrinsic inputs. Neonatal CA1, on the other hand, is tightly linked to externally generated sensorimotor activity, but the circuit mechanisms underlying early synchronous activity in CA1 remain unclear. In this study, researchers use a combination of in vivo and ex vivo circuit mapping, calcium imaging, and electrophysiological recordings in mouse pups to investigate the dynamics in the ventro-intermediate CA1. They find that these dynamics are influenced by both the entorhinal (EC) and thalamic (VMT) inputs, but movement-related population bursts are exclusively driven by the EC. The differential effects reflect the different intrahippocampal targets of these inputs, suggesting distinct contributions to the development of the hippocampal microcircuit and related cognitive maps.
Article
Neurosciences
Tiantian Qiu, Qingze Zeng, Yusong Zhang, Xiao Luo, Xiaopei Xu, Xiaodong Li, Zhujing Shen, Kaicheng Li, Chao Wang, Peiyu Huang, Minming Zhang, Shouping Dai, Fei Xie
Summary: Recent studies have shown that subtle cognitive changes in the preclinical phase of Alzheimer's disease (AD) can be detected using sensitive neuropsychological measures, leading to the concept of objectively-defined subtle cognitive decline (Obj-SCD). This study aimed to assess the functional alteration of hippocampal subfields in individuals with Obj-SCD and its association with cognition and pathological biomarkers.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Juliette Boscheron, Aurelie Ruet, Mathilde Deloire, Julie Charre-Morin, Aurore Saubusse, Bruno Brochet, Thomas Tourdias, Ismail Koubiyr
Summary: The study found a decline in verbal memory performances over time in early MS patients, while visuo-spatial memory performances remained stable. Hippocampal volumes decreased significantly, with an increase in hippocampal connections over time. The results suggest an important interplay between hippocampal-related structural and functional networks and memory performances in early stages of MS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Sydney Weber Boutros, Kat Kessler, Vivek K. Unni, Jacob Raber
Summary: The tight regulation of immediate early gene (IEG) expression is crucial for synaptic plasticity, learning, and memory. Recent research suggests that DNA double strand breaks (DSBs) may play a role in inducing IEG expression in post-mitotic cells. This study demonstrates that etoposide, a cancer treatment that induces DSBs, alters IEG expression and impairs hippocampus-dependent contextual fear memory.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yifeng Luo, Yu Liu, Zhao Qing, Li Zhang, Yifei Weng, Xiaojie Zhang, Hairong Shan, Lingjiang Li, Rongfeng Qi, Zhihong Cao, Guangming Lu
Summary: This study found that wives without PTSD who lost their only child had worse re-experiencing symptoms compared to their husbands, which was associated with alterations in functional connectivity between the hippocampal subregions and the thalamus. Among sexes, only female subjects showed marked differences in functional connectivity in certain brain regions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Caroline D. David, Brianna N. Wyrosdic, HoYin Wan, Hannah E. Lapp, Andrew A. Bartlett, Shewit Yitbarek, Jin Ho Park
Summary: In this study, it was found that castrated B6D2F1 hybrid males can retain some male reproductive behaviors, and the relationship between gonadal steroid-independent male sexual behavior and cognition was investigated. The results showed that the males with steroid-independent behavior performed better in spatial memory tasks compared to non-mating males.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Alvaro Deleglise, Patricio Andres Donnelly-Kehoe, Abraham Yeffal, Florencia Jacobacci, Jorge Jovicich, Edson Amaro Jr, Jorge L. Armony, Julien Doyon, Valeria Della-Maggiore
Summary: Recent research suggests that the hippocampus plays an important role in the reactivation and consolidation of motor memory, as indicated by tracking brain functional connectivity. The findings also highlight the relevance of the hippocampus in the early stages of motor memory consolidation.
Article
Anatomy & Morphology
G. L. Poirier, W. Huang, K. Tam, J. R. DiFranza, Jean A. King
BRAIN STRUCTURE & FUNCTION
(2017)
Review
Clinical Neurology
Matthew F. Thompson, Guillaume L. Poirier, Martha I. Davila-Garcia, Wei Huang, Kelly Tam, Maxwell Robidoux, Michelle L. Dubuke, Scott A. Shaffer, Luis Colon-Perez, Marcelo Febo, Joseph R. DiFranza, Jean A. King
JOURNAL OF PSYCHOPHARMACOLOGY
(2018)
Article
Clinical Neurology
Benjamin C. Nephew, Marcelo Febo, Wei Huang, Luis M. Colon-Perez, Laurellee Payne, Guillaume L. Poirier, Owen Greene, Jean A. King
JOURNAL OF AFFECTIVE DISORDERS
(2018)
Article
Behavioral Sciences
J. M. Gallagher, B. C. Nephew, G. Poirier, J. A. King, R. S. Bridges
HORMONES AND BEHAVIOR
(2019)
Article
Substance Abuse
Jean A. King, Benjamin C. Nephew, Asmita Choudhury, Guillaume L. Poirier, Arlene Lim, Pranoti Mandrekar
Article
Environmental Sciences
Benjamin C. Nephew, Alexandra Nemeth, Neelakshi Hudda, Gillian Beamer, Phyllis Mann, Jocelyn Petitto, Ryan Cali, Marcelo Febo, Praveen Kulkarni, Guillaume Poirier, Jean King, John L. Durant, Doug Brugge
ENVIRONMENTAL RESEARCH
(2020)
Article
Neurosciences
Andrew J. D. Nelson, Lisa Kinnavane, Eman Amin, Shane M. O'Mara, John P. Aggleton
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Bethany E. Frost, Sean K. Martin, Matheus Cafalchio, Md Nurul Islam, John P. Aggleton, Shane M. O'Mara
Summary: Lesions affecting the anterior thalamic nuclei may be responsible for diencephalic amnesia, similar to how hippocampal lesions cause temporal lobe amnesia. The core element of diencephalic amnesia seems to be the loss of information in hippocampal output regions following anterior thalamic pathology, possibly due to the direct connections between the two areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Eleonora Lomi, Mathias L. Mathiasen, Han Y. Cheng, Ningyu Zhang, John P. Aggleton, Anna S. Mitchell, Kate J. Jeffery
Summary: The study investigated the differences between two subregions of the retrosplenial cortex (RSC), finding that the granular RSC is more closely connected to the hippocampal formation and receives differential inputs from the anteroventral thalamus (AV) compared to the dysgranular RSC. The results suggest the existence of two distinct but interacting RSC subcircuits, one potentially part of the cognitive hippocampal system and the other linking hippocampal and perceptual regions.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Mathias L. Mathiasen, Andrew J. D. Nelson, Eman Amin, Shane M. O'Mara, John P. Aggleton
Summary: The nucleus reuniens and anterior thalamic nuclei have different patterns of cortical and hippocampal inputs, reflecting their distinct roles in learning and memory processes.
Review
Neurosciences
John P. Aggleton, Shane M. O'Mara
Summary: Standard models of episodic memory focus on hippocampal-parahippocampal interactions, but recent advances have shown that the anterior thalamic nuclei also play a significant role in memory.
NATURE REVIEWS NEUROSCIENCE
(2022)
Article
Neurosciences
Steliana Yanakieva, Mathias L. Mathiasen, Eman Amin, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton
Summary: This study compared collateral projections from different rostral thalamic nuclei terminating in different cortical areas. The results showed that these projections predominantly arise from separate populations of neurons with discrete cortical termination zones.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
John P. Aggleton, Seralynne D. Vann, Shane M. O'Mara
Summary: Understanding the neural basis of episodic memory requires an appreciation of the significance of the fornix. Through studying patients with colloid cysts, it was found that there is a consistent relationship between mammillary body volume and episodic memory recall. Additionally, a dissociation between recollective-based recognition and familiarity-based recognition was observed, highlighting the importance of the mammillary body-anterior thalamic nuclei axis and the hippocampus for episodic memory.
Article
Neurosciences
M. LaClair, M. Febo, B. Nephew, N. J. Gervais, G. Poirier, K. Workman, S. Chumachenko, L. Payne, M. C. Moore, J. A. King, A. Lacreuse
Article
Neurosciences
Lisa Kinnavane, Seralynne D. Vann, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton