Article
Multidisciplinary Sciences
Stephane Pages, Nicolas Chenouard, Ronan Chereau, Vladimir Kouskoff, Frederic Gambino, Anthony Holtmaat
Summary: The organization and plasticity of cortical sensory maps depend on experience, particularly on the role of higher-order thalamocortically mediated plateau potentials in whisker map plasticity. Blocking the plateau potentials can restore the typical organization of sensory maps.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Daniel Udvary, Philipp Harth, Jakob H. Macke, Hans-Christian Hege, Christiaan P. J. de Kock, Bert Sakmann, Marcel Oberlaender
Summary: The wiring specificity in the cerebral cortex is not only determined by synapse formation mechanisms, but also by the morphological properties of the neurons. The morphologically determined wiring specificity is reflected in the axo-dendritic projection patterns, packing density, and cellular diversity of the neurons. These factors determine whether the network topology is recurrent or feedforward.
Article
Computer Science, Interdisciplinary Applications
Chao Huang, Fleur Zeldenrust, Tansu Celikel
Summary: The study utilized a network model of cortical columns for simulations, finding that the simulated network replicated properties of touch representations and changes in synaptic strength. The simulations revealed the importance of the history of membrane potential in synaptic integration.
Article
Neurosciences
Sebastian M. Frank, Alexandra Otto, Gregor Volberg, Peter U. Tse, Takeo Watanabe, Mark W. Greenlee
Summary: This study demonstrates that tactile learning can transfer to untrained body parts that are coactivated with the trained body part. The researchers found that the transfer of tactile learning was greater from the trained foot to the untrained hand compared to the other way around. The results suggest that the neural mechanisms underlying tactile learning involve somatotopic representation in the primary somatosensory cortex.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Christina Georgiou, Vassilis Kehayas, Kok Sin Lee, Federico Brandalise, Daniela A. Sahlender, Jerome Blanc, Graham Knott, Anthony Holtmaat
Summary: This study identifies a subset of superficial multipolar inhibitory interneurons expressing VIP with high dynamics, located in layer 1 of the cortex, and exhibiting the electrophysiological characteristics of bursting cells. The structural plasticity of these neurons is distinct from that of excitatory neurons.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Hui-Xin Qi, Jamie L. Reed, Feng Wang, Christopher L. Gross, Xin Liu, Li Min Chen, Jon H. Kaas
Summary: The study demonstrates significant post-lesion behavioral recovery and cortical reactivation in squirrel monkeys with dorsal column lesions, particularly showing higher magnitude of fMRI responses in the specific training group. The use of specific kinematic measures in hand movements predicts recovery time better than overall task performance success. CBV scans may provide stronger signals for studying cortical reactivation process after sensory deprivations. The reactivation by digit 2 stimulation correlates best with overall behavioral recovery.
Article
Neurosciences
Kia M. Washington, Mario G. Solari, Rami R. Zanoun, Ernest E. Kwegyir-Afful, An-Jey A. Su, George E. Carvell, W. P. Andrew Lee, Daniel J. Simons
Summary: This study examines the cortical reintegration outcomes following hemifacial vascularized composite allograft (VCA) in a small animal model. The results suggest that there are changes in the somatosensory system and topographic organization in the barrel-cortex system after hemifacial VCA. The findings also indicate subcortical changes in the thalamus and/or brainstem may play a role in cortical plasticity following hemifacial transplantation.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julie Fourneau, Marie-Helene Canu, Erwan Dupont
Summary: This study investigated the synaptic plasticity process in the somatosensory primary cortex during a period of sensorimotor perturbation and recovery. The results showed that changes in the presynaptic compartment occurred as early as D7 during SMP, followed by changes in the postsynaptic compartment at D14, and these changes persisted at least until 24 hours of recovery. Proteins related to synapse structure were mildly affected, primarily at D14.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth, Sergiu P. Pasca
Summary: This study demonstrates the potential of transplanting self-organizing neural organoids derived from human stem cells into the somatosensory cortex of rats to develop mature cell types and integrate into sensory and motivation-related circuits. The transplanted cortical neurons exhibit more complex properties than their in vitro counterparts and can drive reward-seeking behavior when optogenetically activated. This approach has the potential to detect circuit-level phenotypes in patient-derived cells that cannot be uncovered using other methods.
Article
Biology
Hang Hu, Rachel E. Hostetler, Ariel Agmon, Eunji Cheong
Summary: Oscillations of extracellular voltage in the mammalian brain play important yet not fully understood roles in normal and abnormal brain function. This study reports the discovery of ripplets, fast oscillations at around 400 Hz, in the thalamorecipient layer of the mouse somatosensory cortex. Ripplets are an intrinsic cortical response to synchronized thalamocortical activity and could provide increased bandwidth for sensory information encoding and transmission.
Review
Neurosciences
Min Zhuo
Summary: Consciousness is a challenging topic in neuroscience, and our understanding of it is still limited. Recent studies have identified the basic brain networks involved in consciousness, which include projections, feedback, and feedforward circuits from the thalamus to the cortex. These circuits are capable of maintaining consciousness even in the presence of certain brain injuries, and synaptic plasticity plays a crucial role in shaping high-level consciousness.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Su Z. Hong, Lukas Mesik, Cooper D. Grossman, Jeremiah Y. Cohen, Boram Lee, Hey-Kyoung Lee, Johannes W. Hell, Alfredo Kirkwood
Summary: The induction and conversion of eligibility traces by neuromodulators potentiates and depresses visual responses, and this process is crucial for ocular dominance plasticity.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Aniello Lombardi, Qiang Wang, Maik C. Stuettgen, Thomas Mittmann, Heiko J. Luhmann, Werner Kilb
Summary: This study investigates the role of short-term synaptic plasticity (STP) in excitatory and inhibitory synapses in the cortical layer 2/3 of mice. The results show that burst stimulation leads to short-term depression (STD) in both excitatory and inhibitory synapses, with stronger depression observed in inhibitory synapses and longer decay time.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Klas Kullander, Lisa Topolnik
Summary: The passage discusses the concept of a dynamic excitation/inhibition balance tuned by circuit disinhibition, and the different subtypes of GABAergic inhibitory interneurons in cortical circuits. It highlights the central role of a subpopulation of GABAergic cells expressing VIP in disinhibitory modulation, as well as the multiple layers of disinhibition across cortical circuits regulating behavior and maintaining an excitation/inhibition balance.
TRENDS IN NEUROSCIENCES
(2021)
Article
Multidisciplinary Sciences
Mariel Muller, Cyriel M. A. Pennartz, Conrado Bosman, Umberto Olcese
Summary: Understanding the neural mechanisms of sensory processing has been a key objective for neuroscientists in the past decades. While many studies have focused on the rodent whisker system as a model for tactile processing, it remains unclear to what extent these findings are applicable to the human somatosensory system. To address this, researchers developed a restrained vibrotactile detection task involving the limb system in mice. The mice were able to learn the task with satisfactory performance and short training times, making this a versatile method for studying tactile processing at the neuron level in a different system.
Article
Behavioral Sciences
Brendan B. McAllister, Simon C. Spanswick, Payal P. Patel, Alison A. Barneto, Richard H. Dyck
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(2015)
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Pediatrics
Taryn B. Bemister, Brian L. Brooks, Richard H. Dyck, Adam Kirton
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Neurosciences
V. Kiryanova, S. J. Meunier, H. A. Vecchiarelli, M. N. Hill, R. H. Dyck
Article
Neurosciences
Veronika Kiryanova, Victoria M. Smith, Richard H. Dyck, Michael C. Antle
PSYCHOPHARMACOLOGY
(2017)
Review
Behavioral Sciences
Brendan B. McAllister, Richard H. Dyck
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2017)
Article
Multidisciplinary Sciences
Daniel J. Dennis, Grey Wilkinson, Saiqun Li, Rajiv Dixit, Lata Adnani, Anjali Balakrishnan, Sisu Han, Christopher Kovach, Nicole Gruenig, Deborah M. Kurrasch, Richard H. Dyck, Carol Schuurmans
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Editorial Material
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Brendan B. McAllister, David K. Wright, Ryan C. Wortman, Sandy R. Shultz, Richard H. Dyck
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Veronika Kiryanova, Sara J. Meunier, Richard H. Dyck
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Sarah E. Thackray, Brendan B. McAllister, Richard H. Dyck
BEHAVIOURAL BRAIN RESEARCH
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