Article
Clinical Neurology
Ashley L. B. Raghu, John Eraifej, Nagaraja Sarangmat, John Stein, James J. FitzGerald, Stephen Payne, Tipu Z. Aziz, Alexander L. Green
Summary: This study demonstrates that modulation of the primary motor putamen-posterior internal pallidum limb of the cortico-basal ganglia loop is characteristic of successful deep brain stimulation treatment of cervical dystonia. Preoperative diffusion imaging contains additional information that predicts outcomes, implying utility for patient selection and/or individualized targeting.
Article
Biochemistry & Molecular Biology
Mate Feher, Zsombor Marton, Akos Szabo, Janos Kocsa, Viktoria Kormos, Agnes Hunyady, Laszlo Akos Kovacs, Balazs Ujvari, Gergely Berta, Jozsef Farkas, Nora Furedi, Tamas Gaszner, Bence Pytel, Dora Reglodi, Balazs Gaszner
Summary: In this study, the researchers examined the role of the PACAP/PAC1R system in neuroprotection and its involvement in the development and progression of Parkinson's disease using a rat model. The results further supported the importance of the PACAP/PAC1R system in neurodegenerative diseases such as Parkinson's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Weitang Liu, Renxing Zhang, Hu Feng, Jiamin Luo, Hongyan Zhu
Summary: Parkinson's disease (PD) is a common neurodegenerative disease in elderly people, characterized by motor disabilities. The study investigated the role of Nav1.6, the most abundant subtype of voltage-gated sodium channels in the brain, in the pathogenesis of motor deficits in PD rats. The results showed that increased Nav1.6 expression in reactive astrocytes of the GP played an important role in the development of motor dysfunction in the middle stage of PD rats, possibly through regulating astrocyte-neuron communication and abnormal electrical signals in the basal ganglia.
Article
Neurosciences
Rui Xu, Narcisse P. Bichot, Atsushi Takahashi, Robert Desimone
Summary: This study reveals the connectivity between the lateral prefrontal cortex (LPFC) and the rest of the cortex. The results show isomorphic mappings between LPFC and other major processing domains, suggesting LPFC's role in coordinating activity within and across these domains.
Article
Neurosciences
Bing Hu, Minbo Xu, Zhizhi Wang, Danhua Jiang, Dingjiang Wang, Dongmei Zhang
Summary: Excessive synchronous oscillation activities in the brain are a key pathological feature of Parkinson's disease, and the mechanism behind it is still unclear. This study uses a STN-GPe mean-field model to explore the onset mechanism of Parkinson's oscillation and finds that various oscillation frequency bands can appear in the network. In addition to coupling weight between STN and GPe, delay is also a critical factor affecting oscillatory activities.
COGNITIVE NEURODYNAMICS
(2021)
Article
Neurosciences
Luis Puelles, Thorsten Stuehmer, John L. R. Rubenstein, Carmen Diaz
Summary: This study reveals that the internal pallidum in rodents is not homologous to the globus pallidus (GP) in primates, but rather has independent dorsal and ventral parts. On the other hand, both rodents and primates have similar gene expression properties and connectivity between their respective pallidal and hypothalamic structures. This finding is important for understanding the function and evolution of these structures in different species.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Jin-Jin Yu, Yan Xue, Ying Wang, Cui Liu, Lei Chen
Summary: Endocannabinoids play a key role in central motor control, particularly in the globus pallidus (GP) where cannabinoid receptors CB1R and CB2R are expressed. Cannabinoids exert diverse electrophysiological effects in the GP, primarily through CB1R, and produce complex behavioral responses.
Article
Neurosciences
Marc Deffains, Tho Hai Nguyen, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Erwan Bezard, Thomas Boraud
Summary: The study recorded and examined the inhibition of pallidal neurons using DREADD technology in the NHP model, demonstrating its effectiveness in this context.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Multidisciplinary Sciences
Taku Hasegawa, Satomi Chiken, Kenta Kobayashi, Atsushi Nambu
Summary: In this study, we investigated the role of the subthalamic nucleus in stabilizing motor control. Chemogenetic inactivation of the subthalamic nucleus in monkeys resulted in increased spike train variability in the pallidum and prolonged movement time. Our findings suggest that the subthalamic nucleus plays a crucial role in stabilizing pallidal spike trains and achieving stable movements.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Neurosciences
Dingding Shen, Linghao Cao, Yun Ling, Dianyou Li, Kang Ren, Weikun Shi, Zhonglue Chen, Haiyan Zhou, Jun Liu
Summary: This study aimed to compare the motor effect of bilateral globus pallidus interna (GPi) deep brain stimulation on motor subtypes of Parkinson's disease patients and identify preoperative predictors of short-term motor outcome. The results showed that bilateral GPi DBS could effectively improve motor outcomes in PD patients, with prominent improvement in tremor for tremor-dominant and indeterminate patients. Preoperative evaluation of levodopa responsiveness and tremor symptoms could serve as predictors of motor improvement after GPi DBS.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Luke A. Johnson, Joshua E. Aman, Ying Yu, David Escobar Sanabria, Jing Wang, Meghan Hill, Rajiv Dharnipragada, Remi Patriat, Mark Fiecas, Laura Li, Lauren E. Schrock, Scott E. Cooper, Matthew D. Johnson, Michael C. Park, Noam Harel, Jerrold L. Vitek
Summary: Studies have shown that high-frequency oscillations in the internal globus pallidus (GPi) increase during movement in Parkinson's patients and are negatively correlated with bradykinesia. High-frequency oscillations were observed in monkeys after the induction of parkinsonism with the neurotoxin 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine. Spontaneous high-frequency oscillations in patients were significantly reduced when on medication.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Zhenghao Li, Yijie Lai, Jun Li, Naying He, Dianyou Li, Fuhua Yan, Yuyao Zhang, Chencheng Zhang, Bomin Sun, Hongjiang Wei
Summary: This study reveals the alterations in stimulation site-seeded functional connectivity induced by GPi-DBS and examines the frequency band effect in blood oxygen level-dependent (BOLD) signals related to DBS. The findings suggest that these alterations in functional connectivity and the changing pattern of functional connectivity within the BOLD frequency subbands are associated with the efficacy of GPi-DBS for Parkinson's disease.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biology
Behrad Noudoost, Kelsey Lynne Clark, Tirin Moore
Summary: This study shows that working memory directly influences the neural circuits that transform visual inputs into visually guided behavior.
Article
Computer Science, Artificial Intelligence
Elishai Ezra Tsur, Michal Rivlin-Etzion
Article
Neurosciences
Alexander Kaplan, Aviv D. Mizrahi-Kliger, Zvi Israel, Avital Adler, Hagai Bergman
NATURE NEUROSCIENCE
(2020)
Article
Cell Biology
Lea Ankri, Elishai Ezra-Tsur, Shir R. Maimon, Nathali Kaushansky, Michal Rivlin-Etzion
Review
Neurosciences
Alina Sophie Heukamp, Rebekah Anne Warwick, Michal Rivlin-Etzion
ANNUAL REVIEW OF VISION SCIENCE, VOL 6, 2020
(2020)
Article
Multidisciplinary Sciences
Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, Hagai Bergman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Amit Benady, Sean Zadik, Dan Eimerl, Sami Heymann, Hagai Bergman, Zvi Israel, Aeyal Raz
SCIENTIFIC REPORTS
(2020)
Article
Biology
Dan Valsky, Shai Heiman Grosberg, Zvi Israel, Thomas Boraud, Hagai Bergman, Marc Deffains
Review
Clinical Neurology
Yanan Sui, Ye Tian, Wai Kin Daniel Ko, Zhiyan Wang, Fumin Jia, Andreas Horn, Dirk De Ridder, Ki Sueng Choi, Ausaf A. Bari, Shouyan Wang, Clement Hamani, Kenneth B. Baker, Andre G. Machado, Tipu Z. Aziz, Erich Talamoni Fonoff, Andrea A. Kuhn, Hagai Bergman, Terence Sanger, Hesheng Liu, Suzanne N. Haber, Luming Li
Summary: Deep brain stimulation (DBS) is a key clinical therapy for neurological disorders with potential for neuroscience research. A recent international workshop discussed cutting-edge technological achievements and clinical applications, focusing on new approaches and challenges in DBS treatment for various conditions. Key developments include advancements in neuroimaging, novel DBS recording capabilities, and online-based programming technology for global healthcare connections.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Jing Guang, Halen Baker, Orilia Ben-Yishay Nizri, Shimon Firman, Uri Werner-Reiss, Vadim Kapuller, Zvi Israel, Hagai Bergman
Summary: This study investigates the cortico-basal ganglia neuronal network in nonhuman primates under different sedation states, revealing that ketamine and propofol increase high and low-frequency power respectively, unlike regular healthy sleep. The results show that brain spectral states under ketamine and propofol mimic different sleep stages, providing a promising step towards asleep DBS with nondistorted physiological navigation.
NPJ PARKINSONS DISEASE
(2021)
Article
Multidisciplinary Sciences
L. Iskhakova, P. Rappel, M. Deffains, G. Fonar, O. Marmor, R. Paz, Z. Israel, R. Eitan, H. Bergman
Summary: This study reveals a strong coupling between beta oscillation frequency and dopamine tone in both monkeys and humans, indicating that beta frequency, rather than power, coherence, phase-locking, or PAC, is likely the key property of pathological oscillations in cortical and basal ganglia networks.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Elishai Ezra-Tsur, Oren Amsalem, Lea Ankri, Pritish Patil, Idan Segev, Michal Rivlin-Etzion
Summary: Retinal direction selectivity, mediated by starburst amacrine cells (SACs), originates from their centrifugal preference in response to stimuli. Utilizing the Retinal Stimulation Modeling Environment (RSME), detailed simulations revealed that precise organization of input kinetics along SAC processes and reciprocal inhibition between SACs contribute to this centrifugal preference. Additionally, the contribution of SAC-SAC inhibitory connections and SAC centrifugal preference to direction selectivity in direction selective ganglion cells (DSGCs) was explored, enhancing our understanding of SACs' role in visual processing.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biology
Osnat Oz, Lior Matityahu, Aviv Mizrahi-Kliger, Alexander Kaplan, Noa Berkowitz, Lior Tiroshi, Hagai Bergman, Joshua A. Goldberg
Summary: The tonic activity of striatal cholinergic interneurons (CINs) is modified differentially by their afferent inputs, and the localization of active dendritic conductances in CIN dendrites may promote their differential responses to thalamic vs. cortical inputs.
Article
Biology
Alexander Kaplan, Aviv D. Mizrahi-Kliger, Pnina Rappel, Liliya Iskhakova, Gennadiy Fonar, Zvi Israel, Hagai Bergman
Summary: Integrated analysis of non-human primate data reveals that pauses in GPe firing are associated with pupil dilation, suggesting that GPe pauses may influence basal ganglia downstream structures and play a role in exploratory behavior.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Rebekah A. Warwick, Alina S. Heukamp, Serena Riccitelli, Michal Rivlin-Etzion
Summary: Dopamine has subtype-specific effects on retinal ganglion cells (RGCs) in the mouse retina. The non-selective dopamine receptor agonist apomorphine can either increase or decrease RGCs' surround strength depending on their subtype. D-1- and D-2-like receptor blockers have opposite effects on RGC subtypes, with D-2-R blocker reducing surround antagonism and D-1-R blocker leading to surround activation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Clinical Neurology
Nir Asch, Yehuda Herschman, Rotem Maoz, Carmel R. Auerbach-Asch, Dan Valsky, Muneer Abu-Snineh, David Arkadir, Eduard Linetsky, Renana Eitan, Odeya Marmor, Hagai Bergman, Zvi Israel
BRAIN COMMUNICATIONS
(2020)