Article
Endocrinology & Metabolism
Hilde van den Brink, Doeschka A. Ferro, Jeroen de Bresser, Esther E. Bron, Laurien P. Onkenhout, L. Jaap Kappelle, Geert Jan Biessels
Summary: Cerebral cortical microinfarcts (CMI) are common in patients with internal carotid artery (ICA) occlusion, particularly in the hemisphere of the occluded ICA. The burden of CMI was related to the severity of cervical arterial compromise, with a higher number of additional occluded or stenosed cervical arteries and lower cerebral blood flow observed in patients with CMI compared to those without.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, General & Internal
Piotr Kaszczewski, Michal Elwertowski, Jerzy Leszczynski, Tomasz Ostrowski, Joanna Kaszczewska, Zbigniew Galazka
Summary: This study explores the changes in blood flow volume in carotid artery occlusion (CAO) patients and finds that volumetric flow compensation may play an important predictive role in these patients.
Article
Medicine, General & Internal
Piotr Kaszczewski, Michal Elwertowski, Jerzy Leszczynski, Tomasz Ostrowski, Joanna Kaszczewska, Tomasz Brzezinski, Daniel Jarosz, Siavash Swieczkowski-Feiz, Zbigniew Galazka
Summary: This study aimed to assess cerebral blood flow in patients with internal carotid artery stenosis and focused on the circulation pathways and flow volume in extracranial arteries. The results showed that patients could compensate for the reduced blood flow through volumetric flow compensation, and this compensatory ability decreased with age.
Article
Cardiac & Cardiovascular Systems
Samuel P. Klein, Veerle De Sloovere, Geert Meyfroidt, Bart Depreitere
Summary: This study provides new insights into the quadriphasic physiology of cerebrovascular autoregulation (CA) and reveals substantial intersubject variability in the limits of CA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Randolph S. Marshall, David S. Liebeskind, John Huston III, Lloyd J. Edwards, George Howard, James F. Meschia, Thomas G. Brott, Brajesh K. Lal, Donald Heck, Giuseppe Lanzino, Navdeep Sangha, Vikram S. Kashyap, Clarissa D. Morales, Dejania Cotton-Samuel, Andres M. Rivera, Adam M. Brickman, Ronald M. Lazar
Summary: High-grade carotid artery stenosis may cause hemodynamic impairment and lead to cortical thinning in the ipsilateral hemisphere. A relative time-to-peak delay on MRI was found to be associated with cortical thinning in that hemisphere.
Article
Genetics & Heredity
Yasuo Murai, Eitaro Ishisaka, Atsushi Watanabe, Tetsuro Sekine, Kazutaka Shirokane, Fumihiro Matano, Ryuta Nakae, Tomonori Tamaki, Kenta Koketsu, Akio Morita
Summary: This study investigated the relationship between ICA saccular aneurysm and RNF213, finding that the association between the two was not correlated with the location of the ICA and bifurcation, presence of rupture, or multiplicity. However, when the etiology and location of aneurysms were more restricted, the incidence of RNF213 mutations in ICA-AN was higher than previously reported. This suggests that strict maternal vessel selection and pathological selection of aneurysm morphology may reveal an association between genetic mutations and ICA-AN development.
Article
Multidisciplinary Sciences
Zhensen Chen, Anders Gould, Duygu Baylam Geleri, Niranjan Balu, Li Chen, Baocheng Chu, Kristi Pimentel, Gador Canton, Thomas S. Hatsukami, Chun Yuan
Summary: The study aimed to explore the associations between intracranial vascular features extracted from NCE-MRA images and global cognition. The results showed that artery length and number of branches were positively associated with cognitive scores. These findings suggest that intracranial vascular features may serve as useful markers of cerebrovascular health and provide additional information in individuals with cognitive impairment.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Yunyun Liang, Pei Mo, Xinguang Yang, Yihua He, Weijin Zhang, Xianfan Zeng, Longchang Xie, Qingchun Gao
Summary: This study compared the estimation of cerebral critical closing pressure and resistance-area product using blood pressure measurements from the common carotid artery and radial artery, and found that the values obtained from both methods were consistent.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Endocrinology & Metabolism
Isabel N. Christie, Rowan Windsor, Henk J. M. M. Mutsaerts, Therese Tillin, Carole H. Sudre, Alun D. Hughes, Xavier Golay, Alexander Gourine, Patrick S. Hosford
Summary: This study examined the link between systemic arterial blood pressure and cerebral perfusion in a tri-ethnic study in the UK. Results showed a significant negative correlation between blood pressure, age, and cerebral blood flow. The group of hypertensive patients prescribed with anti-hypertensive drugs but with uncontrolled blood pressure recorded the lowest cerebral blood flow values. These findings highlight the importance of blood pressure control for maintaining brain blood flow.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Markus Fahlstrom, Johan Wikstrom, Ljubisa Borota, Per Enblad, Anders Lewen
Summary: Studies using multiple time points for CBF measurements post-ACZ challenge in patients with MMD show significant individual variations in CVR, with the maximum CBF increase typically occurring at 5 minutes post-injection but also seen at 15 or 25 minutes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Critical Care Medicine
Linda Xu, Jeffrey B. Ware, Junghoon J. Kim, Pashtun Shahim, Erika Silverman, Brigid Magdamo, Cian Dabrowski, Leroy Wesley, My Duyen Le, Justin Morrison, Hannah Zamore, Cillian E. Lynch, Dmitriy Petrov, H. Isaac Chen, James Schuster, Ramon Diaz-Arrastia, Danielle K. Sandsmark
Summary: Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. The study found that TBI participants had globally elevated CBF in both acute and chronic phases, with focal hypo- and hyperperfusion present in brain tissue. Furthermore, acute elevation in CBF post-TBI may play a reparative role and be associated with better clinical outcomes in the long term.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Piotr Kaszczewski, Michal Elwertowski, Jerzy Leszczynski, Tomasz Ostrowski, Zbigniew Galazka
Summary: This study aimed to estimate cerebral blood flow in Doppler ultrasonography and compare the flow volume in asymptomatic and symptomatic patients with carotid artery stenosis. The results showed that the percentage of patients with flow compensation increased with the severity of stenosis in symptomatic patients. Patients with flow compensation had a lower risk of ischemic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Stacey E. Aaron, Tsubasa Tomoto, Rong Zhang, John P. Thyfault, Eric D. Vidoni, Robert N. Montgomery, Jeffrey M. Burns, Sandra A. Billinger
Summary: This study aimed to assess the effects of statins on cerebral blood flow in older adults and explore the interaction between statin use and sex. The results showed that statin users had significantly higher cerebral blood flow velocity and cerebrovascular conductance, and lower pulsatility index. Female statin users also had lower cerebrovascular resistance compared to other groups. Targeting the cerebrovasculature with statins may be a promising prevention strategy for Alzheimer's disease and related dementia.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Clinical Neurology
Nicholas R. Evans, Jason M. Tarkin, Jessica Walsh, Mohammed M. Chowdhury, Andrew J. Patterson, Martin J. Graves, James H. F. Rudd, Elizabeth A. Warburton
Summary: The study demonstrated an independent association between atheroinflammation and the severity of cerebral small vessel disease, providing insights into the neurovascular interface and potential therapeutic strategies for managing systemic atherosclerosis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Wenjun Zhou, Oybek Kholiqov, Jun Zhu, Mingjun Zhao, Lara L. Zimmermann, Ryan M. Martin, Bruce G. Lyeth, Vivek J. Srinivasan
Summary: fiDWS is a technique that can rapidly monitor brain blood flow index and provide continuous wave absorption signals. Compared to other methods, fiDWS can achieve high-throughput measurements of optical BFI at a lower cost.
Article
Clinical Neurology
J. Joep van der Harst, Gert-Jan R. Luijckx, Jan Willem J. Elting, Thijs Lammers, Reinoud P. H. Bokkers, Walter M. van den Bergh, Omid S. Eshghi, Jan D. M. Metzemaekers, Rob J. M. Groen, Aryan Mazuri, Nic J. G. M. Veeger, J. Marc C. van Dijk, Maarten Uyttenboogaart
Summary: This study demonstrates that the CTA Vasospasm Score on day 5 can reliably identify patients with a high risk of developing (CI-)DCI and unfavorable outcome, providing valuable predictive information for aneurysmal subarachnoid hemorrhage patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Neurosciences
Kosmas I. Paraskevas, Dimitri P. Mikhailidis, Pier Luigi Antignani, Hediyeh Baradaran, Reinoud P. H. Bokkers, Richard P. Cambria, Alan Dardik, Alun H. Davies, Hans-Henning Eckstein, Gianluca Faggioli, Jose Fernandes e Fernande, Gustav Fraedrich, George Geroulakos, Peter Gloviczki, Jonathan Golledge, Mateja K. Jezovnik, Stavros K. Kakkos, Niki Katsiki, Michael Knoflach, M. Eline Kooi, Gaetano Lanza, Christos D. Liapis, Ian M. Loftus, Armando Mansilha, Antoine Millon, Andrew N. Nicolaides, Rodolfo Pini, Pavel Poredos, Jean-Baptiste Ricco, Thomas S. Riles, Peter Arthur Ringleb, Tatjana Rundek, Luca Saba, Felix Schlachetzki, Mauro Silvestrini, Francesco Spinelli, Francesco Stilo, Sherif Sultan, Jasjit S. Suri, Clark J. Zeebregts, Seemant Chaturvedi
Summary: International guidelines for the management of asymptomatic carotid stenosis (ACS) vary, and a multispecialty position statement aims to reconcile conflicting views. Several high-risk features associated with an increased risk of long-term ipsilateral ischemic stroke in ACS patients have been identified. Some guidelines recommend prophylactic carotid intervention in high-risk patients. The optimal management of ACS patients remains controversial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
F. Anne Pirson, Nikki Boodt, Josje Brouwer, Agnetha A. E. Bruggeman, Sanne J. den Hartog, Robert-Jan B. Goldhoorn, Lucianne C. M. Langezaal, Julie Staals, Wim H. van Zwam, Christiaan van der Leij, Rutger J. B. Brans, Charles B. L. M. Majoie, Jonathan M. Coutinho, Bart J. Emmer, Diederik W. J. Dippel, Aad van der Lugt, Jan-Albert Vos, Robert J. van Oostenbrugge, Wouter J. Schonewille
Summary: This study evaluates outcomes of a large cohort of posterior circulation stroke (PCS) patients treated with endovascular treatment (EVT) in clinical practice. The results show that despite high mortality, favorable clinical outcomes and successful reperfusion can be achieved with EVT for PCS. Patients treated in trial centers and nontrial centers had similar characteristics and outcomes.
Article
Clinical Neurology
Kars C. J. Compagne, Manon Kappelhof, Wouter H. Hinsenveld, Josje Brouwer, Robert-Jan B. Goldhoorn, Maarten Uyttenboogaart, Reinoud P. H. Bokkers, Wouter J. Schonewille, Jasper M. Martens, Jeannette Hofmeijer, H. Bart van der Worp, Rob T. H. Lo, Koos Keizer, Lonneke S. F. Yo, Geert J. Lycklama A. Nijeholt, Heleen M. den Hertog, Emiel J. C. Sturm, Paul J. A. M. Brouwers, Marianne A. A. van Walderveen, Marieke J. H. Wermer, Sebastiaan F. de Bruijn, Lukas C. van Dijk, Hieronymus D. Boogaarts, Ewout J. van Dijk, Julia H. van Tuijl, Jo P. P. Peluso, Paul L. M. de Kort, Boudewijn A. A. M. van Hasselt, Puck S. Fransen, Tobien H. C. M. L. Schreuder, Roel J. J. Heijboer, Sjoerd F. M. Jenniskens, Marieke E. S. Sprengers, Elias Ghariq, Ido R. van den Wijngaard, Stefan D. Roosendaal, Anton F. J. A. Meijer, Ludo F. M. Beenen, Alida A. Postma, Rene van den Berg, Albert J. Yoo, Pieter Jan van Doormaal, Marc P. van Proosdij, Menno G. M. Krietemeijer, Dick G. Gerrits, Sebastiaan Hammer, Jan Albert Vos, Jelis Boiten, Jonathan M. Coutinho, Bart J. Emmer, Ad C. G. M. van Es, Bob Roozenbeek, Yvo B. W. E. M. Roos, Wim H. van Zwam, Robert J. van Oostenbrugge, Charles B. L. M. Majoie, Diederik W. J. Dippel, Aad van der Lugt
Summary: This study evaluated data from stroke patients in the Netherlands who underwent endovascular treatment, and found that there has been an improvement in treatment time and successful reperfusion rates, leading to better clinical outcomes.
Article
Surgery
Simone F. Kleiss, Kirsten F. Ma, Mostafa El Moumni, Cagdas Unlu, Thomas S. Nijboer, Richte C. L. Schuurmann, Reinoud P. H. Bokkers, Jean-Paul P. M. de Vries
Summary: This study utilized hyperspectral imaging and thermal imaging to detect changes in perfusion during endovascular treatment in patients with peripheral arterial disease. The study found that changes in deoxyhemoglobin at the calves and feet were significantly different between limbs that showed clinical improvement and those that did not. These findings can help identify limbs that will benefit from the treatment.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Claire van der Riet, Richte C. L. Schuurmann, Reinoud P. H. Bokkers, Fenna A. van der Zijden, Ignace F. J. Tielliu, Cornelis H. Slump, Jean-Paul P. M. de Vries
Summary: This study validated the accuracy of flare geometric analysis and investigated intraobserver and interobserver variability. The results showed that flare geometric analysis can be used to determine the flare geometry of BECS.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Neuroimaging
Simone M. Uniken Venema, Jan Willem Dankbaar, Lennard Wolff, Adriaan C. G. M. van Es, Marieke Sprengers, Aad van der Lugt, Diederik W. J. Dippel, H. Bart van der Worp
Summary: This study found that collateral status is not associated with the probability of successful recanalization after EVT and does not modify the association between successful recanalization and functional outcome.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Yuanyuan Shen, Yanji Wei, Reinoud P. H. Bokkers, Maarten Uyttenboogaart, J. Marc C. Van Dijk
Summary: In this study, a numerical framework for modeling patient-specific cerebral blood flow was proposed. The framework utilized commonly available clinical datasets to extract arterial geometry parameters and employed flow information obtained from transcranial Doppler measurement for calibration. The results demonstrated that the proposed model could accurately reproduce blood flow in the circle of Willis for each patient, with the resistance at the distal end of each terminal branch being the primary parameter for flow distribution. This model holds promise as a useful tool for assessing cerebral hemodynamics in patients with cerebrovascular diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Health Care Sciences & Services
Kirsten F. Ma, Simone F. Kleiss, Richte C. L. Schuurmann, Thomas S. Nijboer, Mostafa El Moumni, Reinoud P. H. Bokkers, Jean-Paul P. M. de Vries
Summary: This study assessed the ability of the EPOS system to detect differences in tissue perfusion between healthy volunteers and patients with peripheral arterial disease (PAD). The results showed that the EPOS system can effectively differentiate patients with different severity of PAD after heating to 44 degrees C.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Wouter van der Steen, Nadinda A. M. van der Ende, Katinka R. van Kranendonk, Vicky Chalos, Robert J. van Oostenbrugge, Wim H. van Zwam, Yvo B. W. E. M. Roos, Pieter J. van Doormaal, Adriaan C. G. M. van Es, Hester F. Lingsma, Charles B. L. M. Majoie, Aad van der Lugt, Diederik W. J. Dippel, Bob Roozenbeek
Summary: This study aimed to identify determinants of symptomatic intracranial hemorrhage (sICH) occurrence and location. The study found that factors such as prior antiplatelet use, baseline systolic blood pressure, baseline plasma glucose levels, post-endovascular treatment modified treatment in cerebral ischemia score, and duration of procedure were associated with sICH occurrence. Additionally, determinants varied depending on the location of sICH, supporting the hypothesis of varying underlying mechanisms.
Review
Health Care Sciences & Services
Yuanyuan Shen, Rob Molenberg, Reinoud P. H. Bokkers, Yanji Wei, Maarten Uyttenboogaart, J. Marc C. van Dijk
Summary: This systematic review investigates the correlation between simulated hemodynamic indices of the circle of Willis (CoW) and intracranial aneurysm. Based on the analysis of three case reports, no firm conclusion can be drawn regarding the correlation between these hemodynamic parameters and aneurysmal formation or rupture. Further sensitive analysis and rigorous validations are required for personalized management.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Abdallah H. A. Zaid Al-Kaylani, Richte C. L. Schuurmann, Wouter D. Maathuis, Riemer H. J. A. Slart, Jean-Paul P. M. De Vries, Reinoud P. H. Bokkers
Summary: This systematic review provides an overview of flat-panel detector C-arm techniques for quantifying perfusion, their clinical applications, and their validation. The available literature is relatively scarce and heterogeneous, and larger-scale randomized prospective studies focusing on clinical outcomes and standardization are required for the full understanding and clinical implementation of these techniques.
Article
Medicine, General & Internal
Sabine A. Collette, Elke van de Ven, Gert-Jan R. F. Luijckx, Hester Lingsma, Pieter Jan van Doormaal, Adriaan C. G. M. R. van Es, Ido van den Wijngaard, Robert-Jan B. Goldhoorn, Jan Cees H. de Groot, Wim van Zwam, Charles B. L. M. Majoie, Diederik W. J. Dippel, Reinoud P. H. Bokkers, Maarten Uyttenboogaart
Summary: This study compared the outcomes of endovascular thrombectomy (EVT) through femoral access and alternative arterial access in patients with acute ischemic stroke. The results showed that EVT through alternative access was associated with worse functional outcomes, higher mortality, and more puncture-related complications, but had a higher rate of successful intracranial reperfusion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Raul Devia-Rodriguez, Maikel Derksen, Kristian de Groot, Issi R. Vedder, Clark J. Zeebregts, Reinoud P. H. Bokkers, Robert A. Pol, Jean-Paul P. M. de Vries, Richte C. L. Schuurmann
Summary: A validated method (LACS) for determining calcium load in the aorta and peripheral arteries using contrast-enhanced CT scans was developed. The LACS showed high correlation with noncontrast CT scans and had excellent interobserver agreement on contrast-enhanced CT scans. The slice thickness did not significantly affect the LACS results.
Article
Medicine, General & Internal
Berend G. C. Slijkhuis, David J. Liesker, Sherilyn A. C. Konter, Annet Possel-Nicolai, Reinoud P. H. Bokkers, Niek H. J. Prakken, Elisabeth Brouwer, Riemer H. J. A. Slart, Arie M. van Roon, Ben R. Saleem, Douwe J. Mulder
Summary: Inflammatory abdominal aortic aneurysms (iAAA) can be detected with ultrasound, and ruled out safely. The sensitivity and specificity of ultrasound in detecting iAAA were found to be 100% and 98.7% respectively. Additional CT imaging may still be necessary in cases where ultrasound shows positive results.
