Article
Neurosciences
Chunguang Chu, Naying He, Kristina Zeljic, Zhen Zhang, Jiang Wang, Jun Li, Yu Liu, Youmin Zhang, Bomin Sun, Dianyou Li, Fuhua Yan, Chencheng Zhang, Chen Liu
Summary: The subthalamic nucleus (STN) and globus pallidus internus (GPi) are common targets for deep brain stimulation (DBS) treatment of Parkinson's disease. This study used resting-state fMRI data to investigate the changes in brain network topology associated with stimulation of these targets. The results showed that the stimulation had similar effects on motor brain regions for both targets, but target-specific effects were observed in non-motor brain regions.
Article
Clinical Neurology
Takashi Tsuboi, Marc Charbel, David T. Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R. Zeilman, Robert S. Eisinger, Kelly D. Foote, Lela Okromelidze, Sanjeet S. Grewal, Michael S. Okun, Erik H. Middlebrooks
Summary: This study aimed to identify anatomical regions related to stimulation-induced dyskinesia (SID) in PD patients after pallidal DBS and analyze the connectivity associated with SID. The results showed that SID VTAs were primarily located in the dorsal GPi/GPe and had higher structural connectivity to certain cortical regions compared to non-SID VTAs. Differences in connectivity between motor-related cortices and subcortical regions may explain the presence or absence of SID.
MOVEMENT DISORDERS
(2021)
Correction
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: A correction to this paper has been published.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: Our study reveals the potential effectiveness of GPi-DBS in treating camptocormia in PD patients, showing significant improvement in patients' postural deformity. Pre-surgical TCC angle, levodopa responsiveness of the TCC angle, and structural connectivity from volume of tissue activated to somatosensory cortex are closely associated with improvement in the TCC angle.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Lennard I. Boon, Wouter V. Potters, Thomas J. C. Zoon, Odile A. van den Heuvel, Naomi Prent, Rob M. A. de Bie, Maarten Bot, P. Richard Schuurman, Pepijn van den Munckhof, Gert J. Geurtsen, Arjan Hillebrand, Cornelis J. Stam, Anne-Fleur van Rootselaar, Henk W. Berendse
Summary: The severity of apathy significantly increased in PD patients treated with DBS, which may not be solely due to dose reductions of dopaminergic medication, but also potentially attributed to the stimulation itself. Additionally, stimulation location in the left hemisphere and changes in functional connectivity of the dorsolateral prefrontal cortex were associated with the increase in apathy severity.
Article
Behavioral Sciences
Nasya Thompson, Michael MacAskill, Maddie Pascoe, Tim Anderson, Campbell Le Heron
Summary: This study investigates the multidimensional pattern of apathy in individuals with Parkinson's disease (PD) using the Apathy Motivation Index (AMI), which explores behavioral, emotional, and social aspects of apathy. The results show that individuals with PD exhibit higher levels of behavioral and social apathy, but lower levels of emotional apathy. The study also demonstrates the connection between apathy and other non-motor comorbidities such as depression and anxiety. The findings highlight the importance of considering apathy as a multidimensional construct in clinical and research settings.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Lee-Anne Morris, Samuel J. Harrison, Tracy R. Melzer, John C. Dalrymple-Alford, Tim J. Anderson, Michael R. MacAskill, Campbell J. Le Heron
Summary: Morris et al. found that apathy in Parkinson's disease is associated with changes in functional connectivity and structural changes in the nucleus accumbens and anterior cingulate cortex, providing a potential causal pathway to loss of motivation. Their study demonstrates that disruption to key nodes within a network involved in motivated behavior may lead to the development of apathy. These findings suggest the possibility of identifying individuals at risk for apathy before the onset of motivational deficits.
Article
Clinical Neurology
Wei Wei, Xingyang Yi, Jianghai Ruan, Xiaodong Duan, Hua Luo
Summary: The study revealed that stimulating the right DLPFC with HF-rTMS can improve emotional processing in both apathetic and non-apathetic PD patients, but with differing sensitivities and distinct neurophysiological characteristics.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Multidisciplinary
Joshua A. Wilt, Amanda R. Merner, Jaclyn Zeigler, Michelle Montpetite, Cynthia S. Kubu
Summary: Deep Brain Stimulation (DBS) is a safe and effective treatment for Parkinson's Disease (PD) in improving motor symptoms, but concerns about its effects on patients' personality remain. Research shows that while there is little evidence of changes in dispositional traits following DBS, there is some positive progress in characteristic adaptations. Further research is needed in exploring the impact on narrative identity after DBS treatment for PD.
FRONTIERS IN PSYCHOLOGY
(2021)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Neurosciences
Zixiao Yin, Yin Jiang, Timon Merk, Wolf-Julian Neumann, Ruoyu Ma, Qi An, Yutong Bai, Baotian Zhao, Yichen Xu, Houyou Fan, Quan Zhang, Guofan Qin, Ning Zhang, Jun Ma, Hua Zhang, Huanguang Liu, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Jianguo Zhang
Summary: This study found that the oscillatory pattern of the pallidum in multiple movement disorders changes during sleep, and these changes can be used to differentiate sleep stages. Machine learning approaches can classify sleep stages in patients with different diseases based on the pallidal oscillatory features. These findings have broad translational prospects for the development of adaptive deep brain stimulation systems targeting sleep problems.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Francesco Bove, Danilo Genovese, Martina Petracca, Tommaso Tufo, Danila Pisani, Maria Rita Lo Monaco, Anna Rita Bentivoglio, Paolo Calabresi, Carla Piano
Summary: This study aimed to assess the incidence rate and risk factors for sialorrhea in long-term follow-up of patients with advanced Parkinson's disease. The findings indicate that deep brain stimulation (DBS) does not increase the risk of developing sialorrhea.
NPJ PARKINSONS DISEASE
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
M. Lenard Lachenmayer, Melina Murset, Nicolas Antih, Ines Debove, Julia Muellner, Maelys Bompart, Janine-Ai Schlaeppi, Andreas Nowacki, Hana You, Joan P. Michelis, Alain Dransart, Claudio Pollo, Guenther Deuschl, Paul Krack
Summary: A meta-analysis of deep brain stimulation in the globus pallidus internus and subthalamic nucleus for Parkinson's disease showed that STN-DBS had superior outcomes in improving motor function and quality of life, while GPi-DBS also showed efficacy in alleviating symptoms. Further studies are needed to validate recent changes in target selection preference for elderly patients with cognitive deficits and psychiatric comorbidities.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Emily Sanrey, Valerie Macioce, Victoria Gonzalez, Laura Cif, Fabienne Cyprien, Emilie Chan Seng, Philippe Coubes, Gaetan Poulen
Summary: HD is a neurodegenerative disorder associated with motor, psychiatric and cognitive deterioration. This study found that GPi continuous electrical neuromodulation had a positive impact on global cognitive function in HD patients, maintaining stability during the first 3 years of treatment despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Damien Benis, Claire Haegelen, Philippe Voruz, Jordan Pierce, Valerie Milesi, Jean-Francois Houvenaghel, Marc Verin, Paul Sauleau, Didier Grandjean, Julie Peron
Article
Clinical Neurology
Renaud Lopes, Clement Bournonville, Gregory Kuchcinski, Thibaut Dondaine, Anne-Marie Mendyk, Romain Viard, Jean-Pierre Pruvo, Hilde Henon, Marios K. Georgakis, Marco Duering, Martin Dichgans, Charlotte Cordonnier, Xavier Leclerc, Regis Bordet
Summary: The study found that a machine learning model based on the PSCI network can accurately predict long-term cognitive outcomes after stroke, particularly in memory, attention, visuospatial, and language functions. The left superior frontal cortex was shown to be involved in these cognitive functions, and cortical thickness 6 months poststroke was found to be unrelated to cognitive function 36 months poststroke.
Article
Clinical Neurology
Audrey Riou, Jean-Francois Houvenaghel, Thibaut Dondaine, Sophie Drapier, Paul Sauleau, Dominique Drapier, Joan Duprez, Murielle Guillery, Florence Le Jeune, Marc Verin, Gabriel Robert
Summary: The study revealed the involvement of the cerebellum in nonmotor domains of PD, with differential but overlapping patterns of metabolic correlations, suggesting the involvement of cerebello-thalamo-striatal-cortical loops.
Article
Multidisciplinary Sciences
Leonardo Ceravolo, Sascha Fruhholz, Jordan Pierce, Didier Grandjean, Julie Peron
Summary: This study aimed to characterize the role of subcortical brain regions, such as the basal ganglia and cerebellum, in vocal emotion processing. The results indicate crucial contributions of the basal ganglia, especially the putamen, external globus pallidus, subthalamic nucleus, and various cerebellar lobules and nuclei, in efficiently decoding and responding to vocal emotions.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Melanie Genetti Gatfield, Julie Peron, Friedrich Medlin, Jean-Marie Annoni, Ettore A. Accolla
Summary: This study explores neurological evidence of compulsions without obsession in a patient following a stroke in the left subcortical regions, highlighting the significant role of compulsions in OCD pathology. Additionally, comprehensive neuropsychological findings revealed specific alterations in executive and emotional domains. MRI analyses further demonstrated a strong decrease in connectivity following the subcortical stroke, indicating large network alterations.
Article
Multidisciplinary Sciences
Philippe Voruz, Jordan Pierce, Kevin Ahrweiller, Claire Haegelen, Paul Sauleau, Sophie Drapier, Dominique Drapier, Marc Verin, Julie Peron
Summary: This study investigated the impact of motor symptom asymmetry in Parkinson's disease on cognitive performance and quality of life after deep brain stimulation (DBS). The results showed that patients with predominantly left-sided motor symptoms experienced a decline in cognitive performance post-DBS, while patients with predominantly right-sided motor symptoms maintained their cognitive performance, except for a verbal executive task.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Marine Thomasson, Damien Benis, Philippe Voruz, Arnaud Saj, Marc Verin, Frederic Assal, Didier Grandjean, Julie Peron
Summary: There is growing evidence that both the basal ganglia and the cerebellum play functional roles in emotion processing, either directly or indirectly, through their connections with cortical and subcortical structures. However, the lateralization of this complex processing in emotion recognition remains unclear. This study investigated emotional prosody recognition in individuals with Parkinson's disease or cerebellar stroke patients, as well as in matched healthy controls. Results showed that a right hemispheric dysfunction was likely to induce greater deficits than a left one, and deficits following left hemispheric dysfunction were only observed in cerebellar stroke patients. Additional analyses revealed a worsening of performances in patients with predominantly right-sided lesions over time.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Thibaut Dondaine, Florine Ruthmann, Fanny Vuotto, Louise Carton, Patrick Gele, Karine Faure, Dominique Deplanque, Regis Bordet
Summary: Cognitive and emotional disorders are common in patients recovering from COVID-19, with hypoxia potentially exacerbating these issues. Fatigue, anxiety, and depression are prevalent in all patients, while attentional and memory impairments are more severe in inpatients.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Patrice H. Lalive, Karl O. Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jean-Luc Reny, Jerome Pugin, Idris Guessous, Radek Ptak, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van De Ville, Frederic Assal, Julie A. Peron
Summary: The neuropsychological deficits and brain damage following SARS-CoV-2 infection have been investigated in this study. 116 patients with different disease severities were tested for neuropsychological performance, olfactory function, completed questionnaires, and underwent functional magnetic resonance imaging. Severe patients showed poorer verbal episodic memory, while moderate patients had reduced mental flexibility. Neuroimaging revealed different patterns of functional brain connectivity alterations. The severity of the infection in the acute phase predicted the neuropsychological performance six to nine months later. SARS-CoV-2 infection causes long-term memory and executive dysfunctions related to functional brain connectivity alterations.
HUMAN BRAIN MAPPING
(2023)
Article
Behavioral Sciences
Philippe Voruz, Ioana Medeleine Constantin, Julie Anne Peron
Summary: The longitudinal trajectories of cognitive-neuropsychiatric symptoms in Parkinson's disease vary depending on the motor symptom asymmetry at disease onset. Further investigation is needed to explore the relationship with biomarkers.
Review
Neurosciences
Jordan E. Pierce, Marine Thomasson, Philippe Voruz, Garance Selosse, Julie Peron
Summary: The role of the cerebellum in affective processing is important and involves both the lateral hemispheric lobules and the vermis. The activation of the cerebellum differs between explicit and implicit emotion tasks, with some overlapping clusters and some distinct clusters.
Article
Psychology, Clinical
P. Voruz, I. Jacot de Alcantara, A. Nuber-Champier, A. Cionca, G. Allali, L. Benzakour, P. H. Lalive, K-O Loevblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J-L Reny, J. Pugin, I Guessous, R. Ptak, B. N. Landis, F. Assal, J. A. Peron
Summary: The study shows that moderate and severe forms of COVID-19 cause greater long-term neuropsychological deficits compared to a normative population, indicating the long-term effects of SARS-CoV-2 on cognitive function independent of the severity of the initial infection.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Letter
Psychiatry
L. Benzakour, P. Voruz, F. Lador, I. Guerreiro, A. Kharat, F. Assal, J. A. Peron
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)
Article
Clinical Neurology
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Marine Thomasson, Patrice H. Lalive, Karl-Olof Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jerome Pugin, Idris Guessous, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van de Ville, Frederic Assal, Julie A. Peron
Summary: Lack of awareness of cognitive impairment, specifically anosognosia, plays a key role in distinguishing between different phenotypes of post-COVID-19 conditions. The prevalence of anosognosia for memory impairment varies based on the severity of the infection. Anosognosic patients show different cognitive and psychiatric profiles compared to nosognosic patients, and there are differences in brain functional connectivity between the two groups.
BRAIN COMMUNICATIONS
(2022)
Article
Neuroimaging
Marine Thomasson, Damien Benis, Arnaud Saj, Philippe Voruz, Roberta Ronchi, Didier Grandjean, Frederic Assal, Julie Peron
Summary: Recent studies have shown that the cerebellum plays a significant role in emotion processing, with cerebellar stroke patients demonstrating difficulties in emotional prosody recognition. Patients with right cerebellar lesions, especially for neutral or negative prosody, showed more misattributions, with emotional misattributions correlating with lesions in specific areas such as right Lobules VIIb and VIII and right Crus I and II. Acoustic features including pitch, loudness, and spectral aspects explained a significant proportion of variance in the misattribution of emotions. These findings suggest bilateral posterior cerebellar involvement in both sensory and cognitive processing of emotions.
NEUROIMAGE-CLINICAL
(2021)