期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 120, 期 4, 页码 1914-1922出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00398.2018
关键词
activity; circuit assembly; connexin; development; dye coupling; electrotonic coupling; gap junctions; innexin
资金
- Wellcome Trust-DBT India Alliance Intermediate Fellowship
- Department of Biotechnology, Government of India
- Science and Engineering Research Board, Department of Science and Technology, Government of India
- Department of Atomic Energy, Government of India
- Council for Scientific and Industrial Research-UGC Fellowship
Neurons communicate with each other via electrical or chemical synaptic connections. The pattern and strength of connections between neurons are critical for generating appropriate output. What mechanisms govern the formation of electrical and/or chemical synapses between two neurons? Recent studies indicate that common molecular players could regulate the formation of both of these classes of synapses. In addition, electrical and chemical synapses can mutually coregulate each other's formation. Electrical activity, generated spontaneously by the nervous system or initiated from sensory experience, plays an important role in this process, leading to the selection of appropriate connections and the elimination of inappropriate ones. In this review, we discuss recent studies that shed light on the formation and developmental interactions of chemical and electrical synapses.
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