Correction
Mathematical & Computational Biology
Qiang Zhang, Yue Dai
Summary: The authors discovered several printing errors in the equations in the final versions online and in print proof, but there were no such errors in the submitted proof.
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Grant P. Higerd-Rusli, Sidharth Tyagi, Christopher A. Baker, Shujun Liu, Fadia B. Dib-Hajj, Sulayman D. Dib-Hajj, Stephen G. Waxman
Summary: Inflammation causes pain by altering the ionic currents in nociceptors, resulting in increased excitability. NaV1.7 and KV7.2 channels play opposing roles in nociceptor excitability. This study used live-cell imaging to investigate the mechanisms by which inflammatory mediators regulate the abundance of these channels at axonal surfaces. The results revealed a cell biological mechanism for inflammatory pain and suggested NaV1.7 trafficking as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Irina Ignatova, Roman Frolov, Soile Nymark
Summary: Recent studies have found voltage-activated Na+ channels in the retinal pigment epithelium (RPE), which are important for the phagocytosis of photoreceptor outer segments and maintaining retinal homeostasis.
Article
Cell Biology
Zhongming Ma, Usha Paudel, J. Kevin Foskett
Summary: The intensity of taste is strongly influenced by temperature, but there is a lack of comprehensive understanding about the physiological, hedonic, and commercial implications of this relationship. This study used patch-clamp electrophysiology to investigate the effects of temperature on taste-bud cell electrical excitability, revealing that temperature significantly affects the electrical activity of type II taste-bud cells. These findings provide a mechanism for understanding how temperature influences taste sensitivity and perception.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cell Biology
Paola Alberti, Sara Semperboni, Guido Cavaletti, Arianna Scuteri
Summary: Neurons are permanent cells that rely on finely tuned homeostasis for proper function, with microtubules playing a key role in cellular equilibrium by mobilizing molecular cargos. Alterations in cytoskeletal dynamics can impact neuronal excitability, highlighting the importance of understanding these processes in human diseases and neuronal functioning. Microscopic approaches for visualizing and assessing the cytoskeleton, particularly in mitochondrial trafficking, are essential for further research in this area.
Article
Neurosciences
Muhammad Moustafa, Mohamed H. Mousa, Mohamed S. Saad, Tamer Basha, Sherif M. Elbasiouny
Summary: The newly developed multi-compartment model allows for bifurcation analysis in XPPAUT, facilitating the study of neuronal excitability in health and disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Juan J. Nogueira
Summary: Mous et al. have recently reported the molecular mechanism of chloride transport through a light-activated pumping rhodopsin, highlighting its significance in cellular functions and its potential for advancements in photopharmacology and computational modeling.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Carlos Ancaten-Gonzalez, Ignacio Segura, Rosangelina Alvarado-Sanchez, Andres E. Chavez, Ramon Latorre
Summary: BK channels are large conductance potassium channels that play crucial roles in regulating neuronal excitability and synaptic communication in the brain. Their dysfunction has been implicated in various neurological disorders. Here, we discuss the physiological importance of BK channels and their contribution to the pathophysiology of different neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Callum G. Brownstein, Melanie Metra, Frederic Sabater Pastor, Robin Faricier, Guillaume Y. Millet
Summary: This study compared the effects of running and cycling on neuromuscular function. The results showed that despite similar reductions in knee extensor strength after both types of exercise, the mechanisms responsible for force loss differed. Running exercise was associated with greater impairments in nervous system function, particularly at the spinal level, while cycling exercise resulted in greater impairments in contractile function. This may be due to differences in the mechanical and metabolic demands imposed on the quadriceps during these two forms of exercise.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Neurosciences
Jane Yang, Steven A. Prescott
Summary: Neurons maintain homeostasis by adjusting ion channel expression levels through negative feedback. Degeneracy and pleiotropy play important roles in homeostatic regulation, where degeneracy enables compensatory changes in multiple channels and pleiotropy complicates regulation by affecting multiple properties. Understanding feedback loops and their interactions provides insight into the failure modes of homeostatic regulation, which can aid in developing more effective treatments for chronic neurological disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Kees McGahan, James Keener
Summary: Mechanistic mathematical modeling is used to describe cellular processes and understand ion channel kinetics. In this study, a novel mathematical model for heteromeric voltage gated potassium ion channels is presented. The model accurately captures the number and type of protein subunits in each channel. The model's validity is supported by comparing with experimental data and it is used to predict the effect of genetic mutations on channel formation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Physiology
Paula Q. Barrett, Nick A. Guagliardo, Douglas A. Bayliss
Summary: Excessive aldosterone plays a role in hypertensive disorders, with mutations in ion channels contributing to the activation of zona glomerulosa cells. While dispersed ZG cells exhibit electrically quiescent behavior, ZG cells in native rosette structures are electrically excitable, generating periodic voltage spikes and bursts of Ca2+ oscillations. Understanding how a variety of conductances underlie these oscillations and how the rosette orchestrates the behavior of a functional network to control aldosterone secretion is a challenge for future research.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Physiology
Clara Pfenninger, Nathan Grosboillot, Guillaume Digonet, Thomas Lapole
Summary: This study aims to investigate the acute effects of prolonged local vibration on central nervous system excitability. The results suggest that vibration applied to the muscle, whether in a relaxed or contracted state, can decrease motoneuronal excitability and increase cortical excitability.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Sonja J. Stutz, Aditi, Jacob Porter, Komi Gbedande, Brendan Prideaux, Thomas A. Green, Erin H. Seeley, Parimal Samir, Kelley T. Dineley, Gracie Vargas, Jia Zhou, Irma Cisneros, Robin Stephens, Fernanda Laezza
Summary: The study investigates the impact of TNF on neuronal excitability in hyperinflammatory cerebral malaria (eCM) and identifies the signaling network involving TNFR1, JAK2, FGF14, and Nav1.6. Plasmodium chabaudi infection increases Nav1.6 channel conductance in CA1 pyramidal neurons through the TNFR1-JAK2-FGF14-Nav1.6 pathway, leading to hyperexcitability. Targeting FGF14 may serve as a potential therapeutic strategy for mitigating TNF-mediated neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Samuel K. Powell, Callan O'Shea, Kayla Townsley, Iya Prytkova, Kristina Dobrindt, Rahat Elahi, Marina Iskhakova, Tova Lambert, Aditi Valada, Will Liao, Seok-Man Ho, Paul A. Slesinger, Laura M. Huckins, Schahram Akbarian, Kristen J. Brennand
Summary: Rapid and efficient induction of dopaminergic neurons can be achieved through transient overexpression of lineage-promoting transcription factors combined with stringent selection. These induced dopaminergic neurons provide a critical tool for modeling midbrain dopaminergic neuron development and dysfunction in psychiatric disease.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Brent Fedirchuk, Katinka Stecina, Kasper Kyhl Kristensen, Mengliang Zhang, Claire F. Meehan, David J. Bennett, Hans Hultborn
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Review
Neurosciences
Katinka Stecina, Brent Fedirchuk, Hans Hultborn
JOURNAL OF PHYSIOLOGY-LONDON
(2013)
Article
Neurosciences
Kevin E. Power, Kevin P. Carlin, Brent Fedirchuk
EXPERIMENTAL BRAIN RESEARCH
(2012)
Article
Neurosciences
Ke Chen, Renkai Ge, Yi Cheng, Yue Dai
EXPERIMENTAL BRAIN RESEARCH
(2019)
Article
Neurosciences
Yi Cheng, Qiang Zhang, Yue Dai
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Neurosciences
Renkai Ge, Ke Chen, Yi Cheng, Yue Dai
EXPERIMENTAL BRAIN RESEARCH
(2019)
Article
Mathematical & Computational Biology
Qiang Zhang, Yue Dai
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2020)
Article
Neurosciences
Renkai Ge, Yue Dai
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Correction
Mathematical & Computational Biology
Qiang Zhang, Yue Dai
Summary: The authors discovered several printing errors in the equations in the final versions online and in print proof, but there were no such errors in the submitted proof.
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Yi Cheng, Nan Song, Renkai Ge, Yue Dai
Summary: In this study, the biophysical and modulatory properties of persistent inward currents (PICs) in serotonergic neurons in the medulla were investigated using patch-clamp technique. The study revealed that different components of PICs contribute to the upregulation of excitability in these neurons, and serotonin enhances this effect, leading to facilitated repetitive firing in serotonergic neurons. The findings shed light on the channel mechanisms responsible for serotonergic modulation of serotonergic neurons in the brainstem.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Ke Chen, Xing Ge, Yue Dai
Summary: This study demonstrated that ACh potentiated PICs in 5-HT neurons of the brainstem by activating muscarinic M3 receptor.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Ke Chen, Yue Dai
Summary: This study investigated the adaptability of lamina X neurons in mice after 3-week treadmill exercise and found that exercise enhanced excitability by increasing persistent inward currents and dendritic length. These findings provide insight into the cellular and channel mechanisms underlying the adaptation of the spinal motor system to exercise.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Yi Cheng, Renkai Ge, Ke Chen, Yue Dai
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2019)