期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 110, 期 2, 页码 279-285出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00834.2012
关键词
prenatal stress; norepinephrine; ventral hippocampus; LTP
资金
- Israeli Science Foundation
- German-Israeli Project Cooperation (DIP)
Long-term effects of stress during pregnancy on brain and behavior have been analyzed extensively in recent years. These effects include changes in emotional behavior, a reduction in learning capacity, and ability to generate long-term potentiation (LTP) in the offspring. In earlier studies, we and others have described a difference in ability to express LTP in dorsal and ventral sectors of the hippocampus (DH and VH, respectively) and its modification by prior stress. We now found that norepinephrine (NE) facilitated conversion of short-term potentiation to LTP in the normal DH but not in VH. Prenatal stress (PS) switched the locus of the facilitating action of NE from the DH to the VH. The effects of NE are likely to be mediated by activation of calcium stores. PS also facilitated (S)-3,5-dihydroxyphenylglycine hydrate (DHPG)-induced LTD in the VH, assumed to be mediated by release of calcium from stores. These observations have important implications for the role of the hippocampus in cognitive and emotional memories.
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