Article
Neurosciences
Yuichi Utsumi, Makiko Taketoshi, Michiko Miwa, Yoko Tominaga, Takashi Tominaga
Summary: Non-clinical toxicology is a major cause of drug candidate attrition during development. This paper presents an in vitro seizure liability assay using voltage-sensitive dye (VSD) imaging techniques in hippocampal brain slices, offering a powerful alternative to traditional electrophysiological methods. By employing this approach, the authors investigated the in vitro drug-induced seizure liability of representative pro-convulsant compounds.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Shima Rashidi, Weilun Xu, Dian Lin, Andrew Turpin, Lars Kulik, Krista Ehinger
Summary: This paper presents a theory-based model for predicting eye movements in a foveated visual system, which can generalize to any set of natural images and targets without the need for large eye movement datasets. The model outperforms or performs comparably to data-driven models trained on human eye movement datasets.
PATTERN RECOGNITION
(2023)
Article
Multidisciplinary Sciences
Sirhan Al Batty, Sama M. Al-Jubouri, Mohammed Wali Hakami, Abdulla Sarief, Sk Manirul Haque
Summary: This study focused on extracting natural dyes from fruits for use in Dye-sensitized solar cells (DSSC). Among the four dyes studied, ber dye showed the highest solar cell efficiency, making it a promising candidate for eco-friendly and cost-effective DSSC development.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2022)
Article
Neurosciences
Rebecca W. Pak, Jeeun Kang, Emad Boctor, Jin U. Kang
Summary: In this study, a series of optimal tissue concentrations of VSD were established, maximizing the detection of membrane potential responses to external stimuli by varying the concentration of IR-780 perchlorate VSD in the brain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Ori Carmi, Adi Gross, Nadav Ivzan, Lamberto La Franca, Nairouz Farah, Zeev Zalevsky, Yossi Mandel
Summary: Neuronal activity magnitude localization and measurement are crucial for mapping and understanding neuronal systems. In this study, seven different methods for localizing cortical responses were evaluated, with Temporally Structured Component Analysis (TSCA) found to outperform others in generating high-resolution retinotopic maps.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Automation & Control Systems
Mengshi Zhang, Yu Cao, Jian Huang, Xinkai Chen
Summary: This paper proposes a novel cross-backstepping control strategy based on a composite error transformation for underactuated robotic systems with input coupling. The strategy aims to handle the complexities arising from input coupling and improve the stability and robustness of the system by constructing a unified form between multiple coupled states and a single actual control input.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Computer Science, Information Systems
Ahmed Shahin, Sayed Abulanwar, Abdelhady Ghanem, Mohammad E. M. Rizk, Fujin Deng, Serge Pierfederici, Islam Ismael
Summary: This paper proposes a one-loop sensorless controller based on the flatness technique for non-isolated power supply consisting of parallel inverters. The controller relies on a nonlinear online observer to estimate currents and voltages, and models system losses using equivalent voltage and current sources. The proposed controller achieves high dynamic performance, wide bandwidth, and low voltage THD.
Article
Automation & Control Systems
Santanu Kumar Dash, Pravat Kumar Ray
Summary: This article introduces a novel topology for a photovoltaic fed open unified power quality conditioner, which focuses on the requirement of voltage sensitive loads. By incorporating adaptive controllers, the system is able to increase robustness and adaptability to various grid conditions. Experimental results show satisfactory performance of the proposed controllers in laboratory settings.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2021)
Article
Automation & Control Systems
Bolin Li, Lijun Zhu, Zhiyong Chen
Summary: This article presents an improved fractional-order active disturbance rejection control scheme to approximate the open-loop transfer function of an uncertain system. The proposed controller improves the system's robustness and uses an improved fractional-order extended state observer for better estimation performance. Compared to conventional controllers, the proposed scheme has a simpler form, better transient performance, and more robustness against parameter variation.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Computer Science, Information Systems
Rajababu Durgam, Ramsha Karampuri, Shriram S. Rangarajan, Umashankar Subramaniam, E. Randolph Collins, Tomonobu Senjyu
Summary: This paper proposes a method to improve the performance of an isolated wind energy conversion system (WECS) by using the unified voltage SVPWM technique along with an adaptive voltage controller (AVC) and load current observer (LCO), which can improve transient behavior and reduce harmonic content.
Article
Computer Science, Interdisciplinary Applications
Weimin Zhou, Umberto Villa, Mark A. Anastasio
Summary: Medical imaging systems are often evaluated and optimized using objective measures of image quality, with the Bayesian Ideal Observer (IO) representing an upper limit for performance evaluation. A new MCMC method called MCMC-GAN, employing a GAN-based stochastic object model (SOM), shows promise in extending the applicability of MCMC methods for IO analyses of medical imaging systems.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Ophthalmology
Pierfrancesco Ambrosi, David Charles Burr, Guido Marco Cicchini
Summary: Continuous tracking is a newly developed technique that allows fast and efficient data acquisition by asking participants to track a stimulus varying in some property. It is a promising paradigm for investigating dynamic features of perception and is particularly useful for testing ecologically relevant situations. This study demonstrates the feasibility of tracking experiments with novel stimulus features and develops an ideal observer model that closely matches human results.
Article
Neurosciences
Katsushige Sato, Yoko Momose-Sato
Summary: This study utilized NK2761 absorption dye to perform multiple-site optical recordings in the embryonic chick olfactory system, and investigated the functional development of olfactory nerve-related circuits. It was found that NMDA receptor function played a significant role in sensory information transfer in these circuits. Additionally, the ventral circuit developed earlier than the dorsal circuit, and the neural circuits projecting from the periphery to the subpallium matured earlier compared to those projecting to the pallium.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Catalin-Paul Constantin, Mariana-Dana Damaceanu, Mihai Mihaila, Mihaela Kusko
Summary: The attachment of cyanoacrylic acid acceptor groups to the donor core leads to a negative shift in the molecular orbitals of the dye, affecting electron diffusion and electron interception by the electrolyte, resulting in a decrease in the open-circuit voltage of dye-sensitized solar cells.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Psychology, Clinical
Sophie Mohamed, Robin S. S. Kramer, Tracey Thornborrow, Thomas Pollet, Martin J. Tovee, Piers L. Cornelissen
Summary: The research used questionnaires and 3D modelling programs to measure men's concept of their bodies, and demonstrated the actual body features captured by the questionnaires by analyzing the relationship between questionnaire scores and muscle mass.
Article
Neurosciences
Christian Waiblinger, Caroline M. Wu, Michael F. Bolus, Peter Y. Borden, Garrett B. Stanley
JOURNAL OF NEUROSCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Linlin Lu, Xuefeng Fu, Yijuin Liew, Yongyi Zhang, Siyuan Zhao, Zheng Xu, Jingna Zhao, Da Li, Qingwen Li, Garrett B. Stanley, Xiaojie Duan
Article
Multidisciplinary Sciences
Katharina Schmidt, Bilal Bari, Martina Ralle, Clorissa Vvashington-Hughes, Abigael Muchenditsi, Evan Maxey, Svetlana Lutsenko
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Neurosciences
Bilal A. Bari, Cooper D. Grossman, Emily E. Lubin, Adithya E. Rajagopalan, Jianna Cressy, Jeremiah Y. Cohen
Article
Engineering, Biomedical
M. F. Bolus, A. A. Willats, C. J. Rozell, G. B. Stanley
Summary: The study achieved real-time feedback control of neuronal activity in the thalamocortical circuit of awake mice through optogenetic stimulation and a state-space optimal control framework. The model-based control scheme was effective for single-neuron feedback control in awake animals, and simulated multi-output feedback control showed better control of heterogeneous neuronal populations.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biochemical Research Methods
William M. Stoy, Bo Yang, Ali Kight, Nathaniel C. Wright, Peter Y. Borden, Garrett B. Stanley, Craig R. Forest
Summary: The new method utilizes the dependency on the distance between cell membrane and glass pipette to develop an autonomous synchronization method for high-yield whole-cell recordings in the deep brain of living mice. This synchronization nearly doubles the gigaseal yield and significantly improves whole-cell recording yield, making pan-brain whole-cell electrophysiology practical in the living mouse brain.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Yi Juin Liew, Aurelie Pala, Clarissa J. Whitmire, William A. Stoy, Craig R. Forest, Garrett B. Stanley
Summary: This study introduces a statistical framework for inferring synaptic connectivity based on experimentally recorded data, setting the stage for large-scale assessment of synaptic connectivity within and across brain structures. By identifying and assessing potential monosynaptic connectivity across neuronal circuits from population spiking activity, this framework will help us better understand the signaling within networks that underlies perception and behavior.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Clarissa J. Whitmire, Yi Juin Liew, Garrett B. Stanley
Summary: This study investigated the role of thalamic state on timing within the thalamocortical circuit, finding that thalamic state influences how neurons in the thalamus and cortex respond to sensory stimuli, impacting timing precision. These state-dependent changes propagate to the cortex, altering the encoding of sensory signals in the cortex.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Nathaniel C. Wright, Peter Y. Borden, Yi Juin Liew, Michael F. Bolus, William M. Stoy, Craig R. Forest, Garrett B. Stanley
Summary: Rapid sensory adaptation is a common phenomenon observed in all sensory systems, yet the mechanistic basis behind it is still poorly understood. Studies on awake mice suggest that cortical adaptation in primary somatosensory cortex is mainly driven by changes in thalamic input timing and differential impacts on cortical excitation and feed forward inhibition. This highlights the significant role of thalamic gating in rapid adaptation of primary sensory cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Eunyoung Kim, Bilal A. Bari, Jeremiah Y. Cohen
Summary: The study investigates the mechanisms behind persistent activity changes in the prefrontal cortex of mice during behaviors that involve reward predictions. The researchers found that reward-predictive persistent firing increases in specific layers and cell types, conveying information about internal state through synaptic mechanisms.
Article
Behavioral Sciences
Bilal A. Bari, Megan J. Moerke, Hank P. Jedema, Devin P. Effinger, Jeremiah Y. Cohen, Charles W. Bradberry
Summary: The study found that squirrel monkeys exhibited key behavioral characteristics similar to other species, and the reversal learning task validated their reliability as a model for behavioral flexibility.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Aurelie Pala, Garrett B. Stanley
Summary: Lateralization is a characteristic of somatosensory processing in the mammalian brain. This study reveals that ipsilateral tactile stimuli drive larger and more reliable responses in the secondary somatosensory cortex (S2) compared to the primary somatosensory cortex (S1). The cellular organization and functional role of these ipsilateral stimulus responses differ between S1 and S2, suggesting that higher cortical areas may integrate tactile inputs across larger portions of space.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Christian Waiblinger, Megan E. McDonnell, April R. Reedy, Peter Y. Borden, Garrett B. Stanley
Summary: Behavioral experience and flexibility are important for survival, but the neural mechanisms underlying them are not well explored. This study shows that the primary somatosensory cortex plays a crucial role in flexible behaviors, as neuronal signals shift from simply representing stimulus properties to facilitating adaptive behavior in an experience dependent manner.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Bilal A. Bari, Samuel J. Gershman
Summary: The matching law explains how agents tend to match their choice ratios to the ratios of rewards they receive when faced with multiple options. However, perfect matching is rare, and agents often exhibit undermatching or bias choices towards the poorer option. Overmatching is seldom observed. This article proposes that agents not only aim to maximize rewards but also minimize cognitive cost, measured as policy complexity. The theory suggests that capacity-constrained agents can only undermatch or perfectly match, consistent with empirical evidence.
JOURNAL OF NEUROSCIENCE
(2023)
Letter
Psychiatry
Fernando Espi Forcen, Bilal Bari, Kwadwo Owusu-Boaitey
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)