Article
Neurosciences
Maria Nazarova, Pavel Novikov, Ekaterina Ivanina, Ksenia Kozlova, Larisa Dobrynina, Vadim V. Nikulin
Summary: This study utilized nTMS for cortical mapping of hand muscles, revealing the spatial relationships and reliability of muscle representations in the brain. The overlap between MCRs of different muscles was found to be highly reliable, while shifts between MCR centers of gravity and hotspots were relatively unstable.
HUMAN BRAIN MAPPING
(2021)
Review
Neurosciences
Danny Adrian Spampinato, Jaime Ibanez, Lorenzo Rocchi, John Rothwell
Summary: Transcranial magnetic stimulation (TMS) is a non-invasive technique used to study the human brain. One outcome measure of TMS is the motor-evoked potential (MEP), which estimates changes in corticospinal excitability. This article summarizes the neural pathways and circuits contributing to MEP generation, discusses factors to consider when interpreting MEP amplitude in motor processing and neurological conditions, and explores how emerging technologies can enhance understanding of neural substrates influencing MEPs.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
S. N. Makarov, W. A. Wartman, G. M. Noetscher, K. Fujimoto, T. Zaidi, E. H. Burnham, M. Daneshzand, A. Nummenmaa
Summary: The optimized TMS inverse problem solutions improve the focality of the electric field induced by TMS and reduce the size of the field hot spot near the target. Additionally, uncertainties in coil position/orientation, conductivity, and head segmentation accuracy affect the performance of TMS-IP.
Article
Neurosciences
Mathew Yarossi, Dana H. Brooks, Deniz Erdogmus, Eugene Tunik
Summary: This study investigates the similarity of modularity in hand muscle responses to transcranial magnetic stimulation (TMS) of the motor cortex and that derived from voluntary hand movement, providing a basis for future work using TMS to investigate muscle activation modularity in the human motor system.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Review
Neurosciences
Rachel E. Sondergaard, Davide Martino, Zelma H. T. Kiss, Elizabeth G. Condliffe
Summary: The review examines the influence of six key motor mapping parameters on outcome measures, based on a detailed analysis of 132 out of 1,587 distinct records. The summary provides insights for designing and interpreting TMS mapping studies.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
M. Garcia-Pallero, Diana Cardona, Lola Rueda-Ruzafa, Miguel Rodriguez-Arrastia, Pablo Roman
Summary: Phantom limb pain is a difficult-to-treat chronic pain syndrome. Neurostimulation treatment shows potential as an effective option, although more research evidence is needed. Repetitive transcranial magnetic stimulation and transcranial direct current stimulation have been found to be effective in reducing pain perception and relieving anxiety and depression symptoms in phantom limb pain patients.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Emmanuelle Wilhelm, Caroline Quoilin, Gerard Derosiere, Susana Paco, Anne Jeanjean, Julie Duque
Summary: In Parkinson's disease, the lack of preparatory suppression in the primary motor cortex is associated with motor slowness and is related to disease duration and motor impairment. This finding suggests a potential marker for assessing motor preparation and impairment in Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Ole Numssen, Anna-Leah Zier, Axel Thielscher, Gesa Hartwigsen, Thomas R. Knosche, Konstantin Weise
Summary: Transcranial magnetic stimulation (TMS) is a useful tool for studying causal structure-function relationships in the human brain, but the complex distribution of induced electric fields makes it challenging to precisely identify the stimulated neuronal populations. This study proposes a method to rapidly and feasibly localize cortical regions at the individual subject level by combining experimental data and numerically modeled fields. By establishing a functional link between the induced electric field and the modulated effect, the research demonstrates a fundamental step towards fully exploiting the potential of TMS for practical and clinical applications.
Article
Clinical Neurology
Yu-Ting Hu, Xi-Wen Hu, Jin-Fang Han, Jian-Feng Zhang, Ying-Ying Wang, Annemarie Wolff, Sara Tremblay, Dusan Hirjak, Zhong-Lin Tan, Georg Northoff
Summary: This study compared the therapeutic efficacy of rTMS at the left motor cortex (lMC) and left dorsolateral prefrontal cortex (lDLPFC) in MDD patients. The results showed no significant difference in treatment outcomes and tolerability between the two groups. The findings suggest that lMC can be a potential and easily accessible rTMS target.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Jelena Trajkovic, Vincenzo Romei, Matthew F. S. Rushworth, Alejandra Sel
Summary: The ventral premotor cortex (PMv) is involved in cortico-cortical pathways that regulate the primary motor cortex (M1) function. Paired associative stimulation (ccPAS) can modulate the influence of PMv on M1, which is associated with changes in phase synchrony between these two areas. PMv-to-M1 ccPAS increases phase synchrony in alpha and beta bands, while reversed M1-to-PMv ccPAS decreases theta phase synchrony. These changes, observed at rest, are also predictive of oscillatory power changes during movement execution and inhibition, respectively.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Meng-Xin Wang, Aihaiti Wumiti, Yao-Wen Zhang, Xue-Sheng Gao, Zi Huang, Meng-Fei Zhang, Zhi-Yong Peng, Yoshitaka Oku, Zhi-Ming Tang
Summary: The aim of this study was to investigate the effect of transcutaneous cervical vagus nerve stimulation (tcVNS) on motor cortex excitability in healthy adults. The results showed that after real stimulation, the amplitude of motor-evoked potential (MEP) significantly increased, while MEP latency and rest motor threshold (rMT) significantly decreased. This suggests that tcVNS can improve motor cortex excitability.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Multidisciplinary Sciences
Peemongkon Wattananon, Khin Win Thu, Soniya Maharjan, Kanphajee Sornkaew, Hsing-Kuo Wang
Summary: Evidence suggests that patients with chronic low back pain have deficits in lumbar multifidus muscle activation and changes in cortical excitability. However, one-session of anodal transcranial direct current stimulation does not induce changes in cortical excitability and lumbar multifidus muscle activation. There is a moderate to strong correlation between peak-to-peak motor evoked potential amplitude and lumbar multifidus muscle activation.
SCIENTIFIC REPORTS
(2023)
Review
Geriatrics & Gerontology
Abdulhameed Tomeh, Abdul Hanif Khan Yusof Khan, Wan Aliaa Wan Sulaiman
Summary: Stroke is a major cause of disability and death among the elderly population. Restoring blood circulation in the early phase of stroke is crucial for protecting neurons. Rehabilitation techniques can help stroke survivors regain their affected functions, and transcranial magnetic stimulation (TMS) has emerged as a novel method to aid in this process. TMS can be used to assess and modulate cortical excitability non-invasively, and repetitive TMS (rTMS) of the primary motor cortex (M1) shows promising results in post-stroke motor rehabilitation. It has also been found to have potential therapeutic uses in treating other symptoms such as dysphagia, speech impairments, central post-stroke pain, depression, and cognitive dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Meyi Duleme, Stephane Perrey, Gerard Dray
Summary: This study examines the frequency band modulations underlying working memory load and the role of executive control using scalp EEG data. The results show that decoding accuracy is higher for combined frequency bands compared to isolated frequency bands, and that there are transient changes in frequency band clusters during specific time windows.
COGNITIVE NEUROSCIENCE
(2023)
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Patrick Levy, Sophia Schiza
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Physiology
Titouan P. Perrin, Jeremy Rossi, Hugo A. Kerherve, Guillaume Y. Millet
Summary: The study aimed to investigate the effect of longitudinal bending stiffness (LBS) on energy cost of uphill running. Twenty well-trained male runners participated in the study and it was found that LBS did not have a significant effect on the energy cost of uphill running. However, there was a large interindividual variability in response to LBS changes, suggesting that increasing shoe LBS may be beneficial for certain runners.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Letter
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Patrick Levy
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Physiology
Frederic Sabater-Pastor, Katja Tomazin, Gregoire P. Millet, Julien Verney, Leonard Feasson, Guillaume Y. Millet
Summary: This study aimed to determine the physiological predictors of performance in a 166-km trail-running race. The results showed that VO(2)max and velocity at VO(2)max are significant predictors of performance in this race, suggesting that ultratrail runners should focus on developing these qualities to optimize their performance.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Sport Sciences
Mathieu Marillier, Mathieu Gruet, Anne-catherine Bernard, Benoit Champigneulle, Samuel Verges, Onofre Moran-mendoza, J. alberto Neder
Summary: This study aimed to investigate the effects of O-2 supplementation on cerebral oxygenation and perceived fatigue during exercise in patients with fibrotic interstitial lung disease (F-ILD). The study found that O-2 supplementation improved cerebral oxygenation and reduced fatigue in patients, suggesting that reversing cerebral hypoxia may have positive effects on patients' disablement.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Sport Sciences
Loic Espeit, Eric Luneau, Callum G. Brownstein, Julien Gondin, Guillaume Y. Millet, Vianney Rozand, Nicola A. Maffiuletti, Thomas Lapole
Summary: Comparing conventional and wide-pulse NMES, the study found no significant difference in evoked torque. All NMES protocols induced objective fatigability and peripheral alterations, but had no effect on CNS excitability. The results suggest that the chronic effects and treatment effectiveness of conventional and wide-pulse NMES may be comparable.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
Franck Le Mat, Mathias Gery, Thibault Besson, Cyril Ferdynus, Nicolas Bouscaren, Guillaume Y. Millet
Summary: By analyzing a large dataset of trail running races, this study shows that the gap in endurance performance between men and women decreases as the distance increases. It also reveals that the difference in endurance between sexes is smaller among top performers.
Letter
Respiratory System
Mathieu Marillier, Mathieu Gruet, Anne-Catherine Bernard, Samuel Verges, Onofre Moran-Mendoza, J. Alberto Neder
Letter
Hematology
Gaetano Cairo, Benoit Champigneulle, Margherita Correnti, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Anne-Kristine Meinild Lundby, Ivan Hancco, Carole Chirica, Dorra Guergour, Laura Oberholzer, Emeric Stauffer, Carsten Lundby, Aurelien Pichon, Julien Brugniaux, Stephane Doutreleau, Samuel Verges, Paul Robach
Article
Physiology
Rafael de Almeida Azevedo, Pablo R. Fleitas-Paniagua, Mackenzie Trpcic, Danilo Iannetta, Guillaume Y. Millet, Juan M. Murias
Summary: The aim of this study is to investigate the effects of different ramp-incremental (RI) slopes on fatigability and recovery in females and males. The results showed that gender had no significant effect on performance fatigability and recovery, and different RI slopes did not alter the level of performance fatigability at task failure.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Neurosciences
Ludovic Molle, Alexandre Coste, Charles-Etienne Benoit, Gerard Derosiere, Stefan Janaqi, Stephane Perrey, Arnaud Dupeyron
Summary: The emergence of consciousness is a biological mystery, and little is known about the physiological mechanisms underlying subjective experience. Recent research suggests that the breathing phase can modulate attention, with inhalation improving perceptual awareness and decision-making speed. This study tested this hypothesis and found that inhalation enhances perceptual awareness and speeds up objective decision-making.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Sport Sciences
Lenaic Borot, Benjamin Pageaux, Davy Laroche, Gregoire Vergotte, Romuald Lepers, Stephane Perrey
Summary: Compared to concentric exercise, eccentric exercise has a higher mental demand and activates the frontoparietal network, especially when the exercise intensity is fixed by torque.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Sport Sciences
Nicolas J. A. Berger, Russ Best, Andrew W. Best, Andrew M. Lane, Guillaume Y. Millet, Martin Barwood, Samuele Marcora, Patrick Wilson, Shawn Bearden
Summary: This paper reviews the major limitations in ultra-endurance running (UER) and discusses factors such as thermoregulation, oxygen delivery and utilization, running economy and biomechanics, fatigue, digestive system, and psychology. It provides guidance and suggestions for practitioners and future research in these areas.