Article
Ophthalmology
Matthew Nguyen, James Sullivan, Wen Shen
Summary: Abnormal vasculature in the retina is common in retinal degenerative diseases, but its formation and development are still poorly understood. This study characterized the pathological vasculature in two well-studied mouse models of retinal degenerative diseases and demonstrated vascular degeneration paralleled to photoreceptor degeneration in the diseased retinas. The quantitative analysis of vascular structural architecture provides valuable information on vascular remodeling in retinal degenerative disease.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Acoustics
Gengxi Lu, Xuejun Qian, Chen Gong, Jie Ji, Biju B. Thomas, Mark S. Humayun, Qifa Zhou
Summary: Ultrasound neuromodulation is an emerging technology that has shown promise in activating healthy and degenerated retinas. This review article summarizes pilot studies on ultrasound retinal stimulation, compares it with other neuromodulation technologies, and discusses the advantages and limitations of using high-frequency ultrasound for developing a noninvasive retinal prosthesis. Opportunities and challenges in this field are also highlighted.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Review
Neurosciences
Jiajia Wu, Corey M. Rountree, Sai-Siva Kare, Pradeep Kumar Ramkumar, John D. Finan, John B. Troy
Summary: This article reviews the progress in chemical retinal prosthesis research over the past decade, discussing its advantages, resolution, materials, and biocompatibility, while considering potential issues.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Debora Napoli, Martina Biagioni, Federico Billeri, Beatrice Di Marco, Noemi Orsini, Elena Novelli, Enrica Strettoi
Summary: The study reveals structural abnormalities in the RPE of RP patients, leading to dysfunction of the inner barrier. Findings also suggest a correlation between the extent of photoreceptor loss and interruption zones of ZO-1. Treatment with dexamethasone in RP mice not only rescues cones but also restores RPE structure, highlighting a potential feedback loop for simultaneous protection of cones and the RPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
James M. Begeng, Wei Tong, Blanca del Rosal, Michael Ibbotson, Tatiana Kameneva, Paul R. Stoddart
Summary: Patients with photoreceptor degeneration-caused blindness can partially regain vision through artificial stimulation of surviving retinal ganglion cells (RGCs). Nanoparticle-based optical sensors, specifically nanoparticle-enhanced infrared neural modulation (NINM), show potential in stimulating and inhibiting RGCs, which is important for modulating different types of RGCs. Gold nanorods with tunable absorption in the near-infrared range could be well-suited for retinal prosthesis applications but have not been demonstrated in RGCs before.
Article
Neurosciences
Hyeonhee Roh, Yanjinsuren Otgondemberel, Jeonghyeon Eom, Daniel Kim, Maesoon Im
Summary: This study investigates the electric response features of retinal ganglion cells (RGCs) in rd8 mice with retinal degeneration caused by Crb1 mutation. The results show that different types of RGCs have different electric response features in the early stage of RP, suggesting the importance of genotype- and RGC type-dependent analyses for retinal prosthetic research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Abirami Santhanam, Eyad Shihabeddin, Haichao Wei, Jiaqian Wu, John O'Brien
Summary: This study analyzed single-cell transcriptome data from zebrafish retina to understand the transcriptional changes in different cell types in a model of retinitis pigmentosa. The study found that oxidative stress is widespread throughout the retina, affecting various cell types and leading to an increase in oxidative metabolism and glycolysis. There was also evidence of synaptic remodeling and enhanced glutamatergic transmission in the inner retina. Additionally, changes in circadian rhythm regulation and the transcriptomic signatures of retinal progenitor cells and newly formed rods were identified.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Sasidhar S. Madugula, Ramandeep Vilkhu, Nishal P. Shah, Lauren E. Grosberg, Alexandra Kling, Alex R. Gogliettino, Huy Nguyen, Pawel Hottowy, Alexander Sher, Alan M. Litke, E. J. Chichilnisky
Summary: Inferring sensitivity to electrical stimulation from features of spontaneous electrical activity can be used for vision restoration, as demonstrated by large-scale stimulation and recording from retinal ganglion cells. This approach has the potential to significantly improve the function of future high-fidelity retinal implants.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Pedro Henrique Victorino, Camila Marra, Dumitru Andrei Iacobas, Sanda Iacobas, David C. Spray, Rafael Linden, Daniel Adesse, Hilda Petrs-Silva
Summary: Glaucoma is a complex neurodegenerative disease involving degeneration of retinal ganglion cells. A study on the transcriptome of rat retina post-optic nerve crush revealed changes in gene expression variability and coordination, particularly in pathways related to complement cascade and Notch signaling. This deep bioinformatic analysis provides novel insights into the molecular mechanisms underlying RGC degeneration and retinal remodeling after ONC.
Review
Neurosciences
Anwesha Bhattacharyya
Summary: Inherited and age-related retinal degeneration (RD) is the leading cause of blindness, resulting from the death of retinal photoreceptors. Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are two prevalent forms of RD. While several approaches have been developed to stimulate remaining retinal neurons, their efficacy is limited. This review focuses on discussing the morphological and functional changes in the visual cortex during RD in rodents and humans, with the aim of developing tools and strategies for restoring high-resolution vision in visually impaired patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Rebecca L. Pfeiffer, Bryan W. Jones
Summary: This article discusses the current state of retinal remodeling and its implications for vision-restoring therapeutics. It also explores the challenges and potential therapeutic strategies related to retinal remodeling, as well as the possibility of combining diffusible molecules with other vision-restoring therapies. Furthermore, it highlights the potential of the retina and retinal remodeling as a model system for understanding the progression of neurodegenerative diseases in the central nervous system.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Ophthalmology
Laurence M. Occelli, Bryan W. Jones, Taylor J. Cervantes, Simon M. Petersen-Jones
Summary: This study investigated retinal remodeling in CRXRdy cats and found that with time, migration and atrophy of different retinal cells occur. The findings suggest that targeting inner retinal cells may be effective in therapy before advanced stages of retinal remodeling and neuronal cell loss.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Cell Biology
Hui Gao, Xiaona Huang, Juncai He, Ting Zou, Xuan Chen, Haiwei Xu
Summary: Retina remodeling, characterized by photoreceptor degeneration, retinal cell reprogramming, and rewiring, limits the effectiveness of treatment strategies for retinal degeneration. Microglia, the dominant immune cells in the retina, play a critical role in synaptic pruning and clearance of synaptic elements during retinal degeneration. Understanding the mechanisms of microglia in retina remodeling is necessary for developing therapeutic strategies.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Ophthalmology
Hashem H. Ghoraba, Wataru Matsumiya, Christopher Or, Hasan Khojasteh, Prem Patel, Irmak Karaca, Jonathan Regenold, Moosa Zaidi, Jaclyn Hwang, Sherin Lajevardi, Negin Yavari, Ngoc Trong Tuong Than, Sung Who Park, Amir Akhavanrezayat, Gunay Uludag, Cigdem Yasar, Loh-Shan B. Leung, Quan Dong Nguyen
Summary: This study describes and correlates electroretinographic responses with clinical and angiographic findings in patients with retinal vasculitis (RV). The study found weak correlations between high FFA scores and vitreous haze grading and cone-generated ffERG responses.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Engineering, Biomedical
Wadood Haq, Sunetra Basavaraju, Achim Speck, Eberhart Zrenner
Summary: This study explores a biomimetic stimulation paradigm to improve visual perception in blind patients. By mimicking the saccadic-like stimulation pattern found in nature, the researchers were able to produce sustained retinal responses and enhance the spatiotemporal characteristics of artificial vision.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Ophthalmology
Ninel Z. Gregori, Natalia F. Callaway, Catherine Hoeppner, Alex Yuan, Aleksandra Rachitskaya, William Feuer, Hossein Ameri, J. Fernando Arevalo, Albert J. Augustin, David G. Birch, Gislin Dagnelie, Salvatore Grisanti, Janet L. Davis, Paul Hahn, James T. Handa, Allen C. Ho, Suber S. Huang, Mark S. Humayun, Raymond Iezzi, K. Thiran Jayasundera, Gregg T. Kokame, Byron L. Lam, Jennifer I. Lim, Naresh Mandava, Sandra R. Montezuma, Lisa Olmos de Koo, Peter Szurman, Lejla Vajzovic, Peter Wiedemann, James Weiland, Jiong Yan, David N. Zacks
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Engineering, Biomedical
Zhen Huan Zhang, Meng Xin Pan, Jia Tong Cai, James D. Weiland, Kinon Chen
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Engineering, Biomedical
Steven T. Walston, Robert H. Chow, James D. Weiland
JOURNAL OF NEURAL ENGINEERING
(2018)
Article
Electrochemistry
Curtis D. Lee, Eric M. Hudak, John J. Whalen, Artin Petrossians, James D. Weiland
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2018)
Article
Engineering, Biomedical
Yao-Chuan Chang, Dorsa Haji Ghaffari, Robert H. Chow, James D. Weiland
JOURNAL OF NEURAL ENGINEERING
(2019)
Review
Clinical Neurology
Lauren N. Ayton, Nick Barnes, Gislin Dagnelie, Takashi Fujikado, Georges Goetz, Ralf Hornig, Bryan W. Jones, Mahiul M. K. Muqit, Daniel L. Rathbun, Katarina Stingl, James D. Weiland, Matthew A. Petoe
CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Engineering, Biomedical
Elena della Valle, Elissa J. Welle, Cynthia A. Chestek, James D. Weiland
Summary: The study conducted PtIr electrodeposition on carbon fiber microelectrode arrays to improve interface properties, resulting in a PtIr coating with 70% Pt and 30% Ir composition and reduced impedance by 89% at 1 kHz.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Yu Huan, Jeffrey P. Gill, Johanna B. Fritzinger, Paras R. Patel, Julianna M. Richie, Elena Della Valle, James D. Weiland, Cynthia A. Chestek, Hillel J. Chiel
Summary: Carbon fiber electrodes (CFEs) show potential for stable intracellular stimulation and recording with good signal-to-noise ratios, allowing for multi-neuron recording simultaneously. Despite lower amplitudes compared to glass microelectrodes, CFEs provide a powerful new technology for studying neural circuit dynamics.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Joseph G. Letner, Paras R. Patel, Jung-Chien Hsieh, Israel M. Smith Flores, Elena della Valle, Logan A. Walker, James D. Weiland, Cynthia A. Chestek, Dawen Cai
Summary: This study demonstrates the importance of high electrode biocompatibility and precise localization of neurons in characterizing the relationship between neuron spiking and recorded signals. The findings suggest that minimally invasive electrodes have the potential to sample naturalistic neural populations.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Computer Science, Information Systems
Hojun Son, James Weiland
Summary: The deployment of a deep convolutional neural network on low compute devices is a crucial area of research. This article proposes a compact CNN for low compute devices, utilizing pixel shuffling for efficient inferences. The study demonstrates that the CNN performs exceptionally well in terms of accuracy and performance, establishing its potential for real-time applications on low compute devices.
Article
Engineering, Biomedical
Dorsa Haji Ghaffari, Akwasi Darkwah Akwaboah, Ehsan Mirzakhalili, James D. Weiland
Summary: Retinal prostheses aim to improve visual perception in patients with photoreceptor degeneration-induced blindness, but the current limitations in shape and letter perception are due to low spatial resolution. Research has shown that better patient outcomes are correlated with spatially separate phosphenes. By using an optimization algorithm to find optimal stimulation parameters for focal RGC activation, the time required for optimizing implant operation can be reduced.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Engineering, Biomedical
Kathleen E. Finn, Hans J. Zander, Robert D. Graham, Scott F. Lempka, James D. Weiland
IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY
(2020)
Proceedings Paper
Engineering, Biomedical
Elena della Valle, James D. Weiland
2019 9TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2019)
Article
Ophthalmology
Walid Abdallah, Wen Li, James Weiland, Mark Humayun, Hossein Ameri
JOURNAL OF CURRENT OPHTHALMOLOGY
(2018)
Article
Engineering, Biomedical
Elissa J. Welle, Paras R. Patel, Joshua E. Woods, Artin Petrossians, Elena della Valle, Alexis Vega-Medina, Julianna M. Richie, Cai Dawen, James D. Weiland, Cynthia A. Chestek
JOURNAL OF NEURAL ENGINEERING
(2020)
