Recovery of Motoneuron Output Is Delayed in Old Men Following High-Intensity Fatigue

Dalton BH, Harwood B, Davidson AW, Rice CL. Recovery of motoneuron output is delayed in old men following high-intensity fatigue. J Neurophysiol 103: 977-985, 2010. First published December 23, 2009; doi:10.1152/jn.00908.2009. Despite an age-related slowing in the contractile properties of the triceps surae, inherently low maximal motor unit firing rates (MUFRs) in the soleus are unchanged. Fatigue following high-intensity contractions is characterized by contractile slowing in conjunction with a reduction in MUFRs in young adults. Here we exploit the ageing model of the soleus to assess changes in neuromuscular function during fatigue and short-term recovery. We hypothesize that a high-intensity sustained contraction will cause minimal reductions in MUFRs in young and old subjects but that recovery of MUFRs will be delayed in aged subjects. We compared the effects of a high-intensity sustained task on the MUFRs of the soleus and triceps surae contractile properties in six young (similar to 24 yr) and six old (similar to 75 yr) men. Various measures of the contractile function of the triceps surae were tested during two to six sessions via maximal voluntary isometric contractions (MVCs) and tibial nerve stimulation. Populations of MUFR trains were recorded from the soleus during brief (similar to 7 s) MVCs, a high-intensity (75% MVC) sustained fatiguing task, and brief MVCs following task failure at 1, 2, 5, and 10 min. Old men had greater time to task failure than the young (similar to 138 and similar to 100 s, respectively). Voluntary activation was near maximal (>99%) for all subjects but at task failure, decreased to similar to 89% in both groups. Maximal MUFRs, for both groups, were reduced by similar to 44% and twitch contraction duration slowed by similar to 30% following task failure. Contraction duration recovered equally for both groups within 2 min, but maximal MUFRs did not recover until 5 min in the old compared with 1 min for the young. The surprising fatigue-induced reduction in MUFRs was similar for both groups, but despite a similar recovery of contractile properties for both, recovery of MUFRs was impaired in the old subjects.