Article
Biology
Mai Ahmed, Yutaka Kojima, Ichiro Masai
Summary: In this study, the importance of Strip1 in inner retina development is explored. Loss of Strip1 results in defects in the formation of the inner plexiform layer and dramatic cell death of retinal ganglion cells in zebrafish. Strip1 interacts with its STRIPAK partner, Striatin 3, and both play overlapping roles in RGC survival. Additionally, Strip1 is required for RGC dendritic patterning, contributing to proper inner plexiform layer formation.
Article
Multidisciplinary Sciences
Nange Jin, Lian-Ming Tian, Iris Fahrenfort, Zhijing Zhang, Friso Postma, David L. Paul, Stephen C. Massey, Christophe P. Ribelayga
Summary: This study utilized rod- or cone-specific gene knockout mice to investigate the functionality of the secondary rod pathway and the additive contribution of different pathways to retinal output.
Article
Ophthalmology
Jing Zhao, Graydon B. Gonsalvez, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: In this study, the absence of S1R within optic nerve head astrocytes was found to have a negative effect on the growth and survival of retinal ganglion cells. The data suggest that S1R may enhance ganglion cell survival via glia-mediated mechanisms.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Biology
Isabella Boccuni, Richard Fairless
Summary: Disturbances in glutamate homeostasis can result in glutamate excitotoxicity, leading to degeneration of retinal neurons. The NMDA receptor plays a major role in the neurodegenerative mechanisms induced by glutamate.
Article
Multidisciplinary Sciences
Philip E. Wagstaff, Anneloor L. M. A. ten Asbroek, Jacoline B. ten Brink, Nomdo M. Jansonius, Arthur A. B. Bergen
Summary: Genetically complex ocular neuropathies like glaucoma are a major global cause of visual impairment with no effective treatment available. Retinal organoids are increasingly used for experimental therapies, but current methods may take a long time to develop and mature.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Xiaohuan Zhao, Mengqiao Xu, Zhenzhen Zhao, Yimin Wang, Yang Liu, Ting Zhang, Xiaoling Wan, Mei Jiang, Xueting Luo, Yao Shen, Lei Chen, Minwen Zhou, Feng Wang, Xiaodong Sun
Summary: This study found that the probiotic Bifidobacterium can promote the survival of retinal ganglion cells and optic nerve regeneration. This effect is achieved by inhibiting microglia activation and promoting Muller cell activation, leading to a reduction in the risk of optic nerve injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Dimokratis Karamanlis, Tim Gollisch
Summary: The study found that while some cells in the early visual system can be accurately predicted using linear receptive field models, many others show pronounced sensitivity to fine spatial contrast and local signal rectification. This highlights the diversity of receptive field nonlinearities as a crucial component for understanding early sensory encoding.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Michael D. Flood, Erika D. Eggers
Summary: The retina must adapt to a wide range of light intensities, with dopamine playing a crucial role in this process by activating D1 and D4 receptors. Activation of these receptors decreases excitation in ON-sustained ganglion cells, with both D1Rs and D4Rs affecting spontaneous activity.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ciriaco Corral-Domenge, Pedro de la Villa, Alicia Mansilla, Francisco Germain
Summary: The retina, as part of the central nervous system, is crucial for understanding the health and functioning of both the retina itself and the entire central nervous system. The neurons known as ganglion cells are responsible for processing and transmitting light information, and the degeneration of these cells can lead to irreversible blindness or impaired vision. Research into the subtypes of these ganglion cells and the identification of cell death pathways is essential for understanding degenerative processes and developing prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yichen Ge, Xushen Chen, Nan Nan, Jonathan Bard, Fuguo Wu, Donald Yergeau, Tao Liu, Jie Wang, Xiuqian Mu
Summary: This study investigates the epigenetic landscape changes during retinal cell differentiation using single-cell ATAC sequencing (scATAC-seq) and identifies enhancers, enriched motifs, and potential interacting transcription factors associated with cell state/type-specific gene expression. Using CUT&Tag, the study also identifies enhancers directly bound by four key transcription factors and reveals the sequential and combinatorial interactions of these factors with the epigenetic landscape to control gene expression along retinal cell lineages. The results provide insights into the collaborative and competitive regulation of distinct retinal cell types from multipotent retinal progenitor cells (RPCs) by transcription factors.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud
Summary: The study identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells, protecting the small intestine from bile acid toxicity and inflammation. Activation of CAR in T-eff cells infiltrating the small intestine induced large-scale transcriptional reprogramming and promoted the expression of the anti-inflammatory cytokine IL-10.
Article
Pharmacology & Pharmacy
Federica Conti, Giovanni Luca Romano, Chiara Maria Eandi, Mario Damiano Toro, Robert Rejdak, Giulia Di Benedetto, Francesca Lazzara, Renato Bernardini, Filippo Drago, Giuseppina Cantarella, Claudio Bucolo
Summary: The study demonstrated that brimonidine effectively protected the function of RGCs in mouse eyes and regulated the inflammatory biomarkers induced by retinal ischemia reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Michael L. Risner, Silvia Pasini, Nolan R. McGrady, David J. Calkins
Summary: Bax contributes to RGC dendritic degeneration and distinguishes the proximal and distal neurodegenerative programs involved during the progression of glaucoma.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xi Chen, Shanshan Li, Xiaoli Liu, Jingjie Zhao, Lanting Wu, Ran You, Yanling Wang
Summary: This study investigates the role of endogenous c-kit(+) cells in retinal degeneration. Stimulation of these cells by stem cell factor (SCF) provides protection against retinal degeneration. SCF administration improves visual function and prevents the loss of retinal ganglion cells. Transcriptome analysis reveals that SCF-induced changes are closely correlated with eye development-related pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Vittorio Porciatti, Tsung-Han Chou
Summary: This study introduces a framework to identify progressive and potentially reversible stages of RGC dysfunction leading to cell death in mouse models of glaucoma and other optic neuropathies. Mathematical equations are provided to describe state-transitions and modifiable parameters that can be used for hypothesis testing and fitting experimental PERG data. PERG dynamics are also utilized to differentiate phenotypic and altered RGC response dynamics, assess susceptibility to stressors, and evaluate reversible dysfunction with pharmacological treatment.
Article
Neurosciences
Tchoudomira M. Valtcheva, Christopher L. Passaglia
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Engineering, Biomedical
Simon A. Bello, Sharad Malavade, Christopher L. Passaglia
ANNALS OF BIOMEDICAL ENGINEERING
(2017)
Review
Ophthalmology
Gonzalo Ortiz, J. Vernon Odom, Christopher L. Passaglia, Radouil T. Tzekov
DOCUMENTA OPHTHALMOLOGICA
(2017)
Article
Neurosciences
Xiaolan Tang, Radouil Tzekov, Christopher L. Passaglia
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Ophthalmology
Christopher L. Passaglia, Tia Arvaneh, Erin Greenberg, David Richards, Brian Madow
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2018)
Article
Physiology
Andrew Wellman, Bradley A. Edwards, Scott A. Sands, Robert L. Owens, Shamim Nemati, James Butler, Chris L. Passaglia, Andrew C. Jackson, Atul Malhotra, David P. White
JOURNAL OF APPLIED PHYSIOLOGY
(2013)
Article
Neurosciences
Gloria J. Partida, Anna Fasoli, Alex Fogli Iseppe, Genki Ogata, Jeffrey S. Johnson, Vithya Thambiaiyah, Christopher L. Passaglia, Andrew T. Ishida
JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Andrew R. Stothert, Amirthaa Suntharalingam, Xiaolan Tang, Vincent M. Crowley, Sanket J. Mishra, Jack M. Webster, Bryce A. Nordhues, Dustin J. E. Huard, Christopher L. Passaglia, Raquel L. Lieberman, Brian S. J. Blagg, Laura J. Blair, John Koren, Chad A. Dickey
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Kayla R. Ficarrotta, Christopher L. Passaglia
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Multidisciplinary Sciences
Kayla R. Ficarrotta, Youssef H. Mohamed, Christopher L. Passaglia
SCIENTIFIC REPORTS
(2020)
Article
Ophthalmology
M. Christina Nicou, Aditi Pillai, L. Christopher Passaglia
Summary: This research aimed to investigate the dynamics of intraocular pressure (IOP) in conscious animals in response to stressors, common anesthetics, tonometry, and temperature manipulations. The study found that IOP fluctuates spontaneously by several mmHg, even in idle and anesthetized animals, demonstrating that IOP is dynamically modulated by internal and external factors. Wireless telemetry indicated that animal interaction induces startle and stress responses that raise IOP, but anesthesia blocks these responses, allowing for better tonometry estimates of resting IOP when body temperature is controlled.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Youssef Mohamed, Christopher L. Passaglia
Summary: Intraocular pressure (IOP) is influenced by trabecular outflow pathways. Eye cannulation is the standard method for measuring outflow resistance but is invasive. A new technology using a smart portable micropump allows for autonomous measurement of outflow facility in conscious rats. The micropump can adjust flow rate to maintain IOP at a target level. The device offers a unique tool for long-term monitoring of ocular health.
Article
Ophthalmology
Kayla R. Ficarrotta, Simon A. Bello, Youssef H. Mohamed, Christopher L. Passaglia
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Article
Engineering, Biomedical
Simon A. Bello, Christopher L. Passaglia
ANNALS OF BIOMEDICAL ENGINEERING
(2017)
Proceedings Paper
Engineering, Biomedical
Tchoudomira M. Valtcheva, Christopher L. Passaglia
29TH SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE (SBEC 2013)
(2013)