Article
Physiology
Vaughan G. G. Macefield, Lyndon J. J. Smith, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Horacio Kaufmann
Summary: This review focuses on hereditary sensory and autonomic neuropathy type III (HSAN III).
EXPERIMENTAL PHYSIOLOGY
(2023)
Review
Biology
Eirini Dri, Evangelos Lampas, George Lazaros, Emilia Lazarou, Panagiotis Theofilis, Costas Tsioufis, Dimitris Tousoulis
Summary: Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and vasoconstriction, elevated reactive oxygen species (ROS), and inflammatory factors, as well as deficiency of nitric oxide (NO) bioavailability. Inflammatory modulators/biomarkers and adhesion molecules involved in atherosclerosis progression have been shown to predict cardiovascular diseases. Furthermore, several signaling pathways, such as NLRP3 inflammasome, are postulated to be new indicators for endothelial cell inflammation and its associated endothelial dysfunction.
Article
Multidisciplinary Sciences
Betka Sophie, Lukowska Marta, Silva Marta, King Joshua, Garfinkel Sarah, Critchley Hugo
Summary: The study investigated heartbeat perception in both time and spatial domains, as well as the relationship between the two. It found that heartbeat perception typically occurs around 250 ms after the ECG R-wave, with most perceptions coming from the left side of the chest, and participants were most confident in discriminating heartbeats at 0 ms. Additionally, spatial precision of heartbeat perception was related to state-anxiety scores.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Marc Duchesne, Isobel Okoye, Paige Lacy
Summary: This review discusses the mechanisms of IL-25, IL-33, and TSLP secretion from airway epithelium and their influence on allergic airway cascade. The interactions between alarmin-receptor/co-receptor are also reviewed, exploring their modulation of downstream allergic inflammation. Current strategies targeting alarmins, their efficacy, and inflammatory phenotypes are also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gloria Maria Pontes-Quero, Lorena Benito-Garzon, Juan Perez Cano, Maria Rosa Aguilar, Blanca Vazquez-Lasa
Summary: The study encapsulated three hydrophobic anti-inflammatory drugs into core-shell terpolymer nanoparticles, reducing drug cytotoxicity and improving biocompatibility, demonstrating potential for treating inflammatory processes associated with osteoarthritis.
Article
Chemistry, Analytical
Shahid Ullah Khan, Stanislav Trashin, Victoria Beltran, Yuliya S. Korostei, Marius Pelmus, Sergiu M. Gorun, Tatiana Dubinina, Sammy W. Verbruggen, Karolien De Wael
Summary: Dye-sensitized TiO(2) has applications in dye sensitized solar cells, solar-to-chemical energy conversion, and chemical sensors. An electrochemical system for testing dye-sensitized materials was reported, showing the impact of redox mediators and the type of TiO2 and phthalocyanines on photoelectrochemical activity.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Tibor Docsa, Adam Sipos, Charles S. Cox, Karen Uray
Summary: Feeding intolerance and ileus are common complications in critically ill, surgical, and trauma patients, leading to longer hospital stays, increased infections, readmission rates, and medical costs. Current medical treatment for ileus is ineffective and has serious side effects. Inflammatory mediators play a critical role in the development of ileus, but their direct effects on gastrointestinal cells are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Julio C. Ribeiro, Juliana G. Duarte, Grace A. O. Gomes, Leticia P. Costa-Guarisco, Isabela T. M. de Jesus, Carla M. C. Nascimento, Ariene A. Santos-Orlandi, Fabiana S. Orlandi, Fernando A. Vasilceac, Marisa S. Zazzetta, Henrique Pott-Junior, Marcia R. Cominetti
Summary: The study found a negative association between dynapenia and inflammatory markers in older adults, particularly more pronounced in the presence of obesity. Obesity and dynapenia are both strongly linked to chronic inflammation and associated with comorbidities such as diabetes and cardiovascular diseases.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Pharmacology & Pharmacy
Barbara Politynska, Olga Pokorska, Anna M. Wojtukiewicz, Magdalena Sawicka, Marta Mysliwiec, Kenneth V. Honn, Stephanie C. Tucker, Marek Z. Wojtukiewicz
Summary: Cancer patients have a higher risk of developing depression, which can lead to decreased quality of life, worse prognosis, and higher mortality. The underlying pathophysiological mechanism connecting depression and cancer is still unclear, but recent studies have implicated neuroinflammatory mechanisms in the etiology of depression. These mechanisms may result in chronic inflammation in the brain, contributing to the development of depression. Three major routes, involving proinflammatory mediators, are likely implicated in cancer-related depression: the activation of the kynurenine pathway, impairment of the hypothalamic-pituitary-adrenal axis, and glutamate excitotoxicity via the glutamatergic pathway. Understanding these dysregulated mechanisms and other emerging pathways may provide insights for therapeutic targeting and improve the care of cancer patients.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Article
Physics, Condensed Matter
N. Nouri, Z. Nourbakhsh, Gh. Rashedi
Summary: Using the multi-orbital (sp3) tight-binding (TB) model, the band structure of the Antimony monolayer with a hexagonal array of holes, known as Antimony antidot lattice (AAL), was obtained. The band structure depends on the size of embedded holes in the Antimony monolayer as points of the antidot lattice. Spin-orbit coupling significantly affects the band gap for the Antimony antidot lattice in different ranges of hole radius. The effect of distance between holes, as well as the variation of the band gap due to strain, and the influence of substrate on the electronical properties of Antimony monolayer with and without holes were also investigated.
PHYSICA B-CONDENSED MATTER
(2023)
Article
Biotechnology & Applied Microbiology
S. Marsh, T. Constantin-Teodosiu, V. Chapman, V. Sottile
Summary: The increasing prevalence of joint disease, especially osteoarthritis, requires new treatment strategies. Mesenchymal stem cells (MSCs) show promise for tissue repair, but their functional integration into host tissue may be affected by the inflammatory environment. This study evaluates the effects of inflammatory mediators on MSCs derived from bone marrow and provides insight into the impact of factors driving osteoarthritis pathology on the therapeutic potential of MSCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Huabing Li, Zhilin Zheng, Jing He, Akihide Nagao, Qingqing Sun, Shuai Wang
Summary: This study compared the change of dislocation structure in coarse-grained Cu in the presence and absence of hydrogen. It was found that hydrogen had minimal effect on the tensile property and dislocation evolution in coarse-grained Cu. Density functional calculation revealed that the electron structure interaction between Cu and H was the main factor inhibiting hydrogen accumulation around dislocations, thus contributing to the high resistance to hydrogen embrittlement in coarse-grained Cu.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Chemistry, Physical
Xiaobo Wang, Jinxia Huang, Zhiguang Guo
Summary: Superhydrophobic surfaces inspired by the lotus have excellent performances, but there are still some issues that can be avoided by liquid-infused surfaces inspired by Nepenthes. Lubricant-free slipper materials have attracted more attention due to their durability and lubrication performance. This paper summarizes the types of LIS lubricants, their applications, and discusses the future development prospects.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Immunology
Nathan Calzadilla, Shane M. M. Comiskey, Pradeep K. K. Dudeja, Seema Saksena, Ravinder K. K. Gill, Waddah A. A. Alrefai
Summary: Bile acids play a critical role in lipid and fat-soluble vitamin digestion and absorption, but they also act as signaling molecules. Disturbances in bile acid homeostasis can contribute to the development of Inflammatory Bowel Diseases (IBD). Studies have shown that different bile acids have different effects on the inflammatory response and intestinal permeability, suggesting a potential link between bile acid changes and the development of IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Andrea M. Harriott, Tsubasa Takizawa, David Y. Chung, Shih-Pin Chen
JOURNAL OF HEADACHE AND PAIN
(2019)
Article
Endocrinology & Metabolism
Tsubasa Takizawa, Tao Qin, Andreia Lopes de Morais, Kazutaka Sugimoto, Joon Yong Chung, Liza Morsett, Inge Mulder, Paul Fischer, Tomoaki Suzuki, Maryam Anzabi, Maximilian Boehm, Wen-sheng Qu, Takeshi Yanagisawa, Suzanne Hickman, Joseph El Khoury, Michael J. Whalen, Andrea M. Harriott, David Y. Chung, Cenk Ayata
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Review
Clinical Neurology
Andrea M. Harriott, Fahri Karakaya, Cenk Ayata
Article
Clinical Neurology
Mia T. Minen, Emily F. Law, Andrea Harriott, Elizabeth K. Seng, Jennifer Hranilovich, Christina L. Szperka, Rebecca Erwin Wells
Article
Clinical Neurology
Kazutaka Sugimoto, David Y. Chung, Maximilian Boehm, Paul Fischer, Tsubasa Takizawa, Sanem Aslihan Aykan, Tao Qin, Takeshi Yanagisawa, Andrea Harriott, Fumiaki Oka, Mohammad A. Yaseen, Sava Sakadzic, Cenk Ayata
Article
Clinical Neurology
Andrea M. Harriott, David Y. Chung, Aylin Uner, Refik O. Bozdayi, Andreia Morais, Tsubasa Takizawa, Tao Qin, Cenk Ayata
Summary: The study used a minimally invasive optogenetic method to induce SD and found that a single SD caused bilateral periorbital mechanical allodynia, while repeated SDs also produced bilateral periorbital mechanical allodynia that lasted for 4 days. Repeated SDs increased anxiety behavior and facial expression pain scores, but did not affect working memory.
ANNALS OF NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
David Y. Chung, Fumiaki Oka, Gina Jin, Andrea Harriott, Sreekanth Kura, Sanem A. Aykan, Tao Qin, William J. Edmiston, Hang Lee, Mohammad A. Yaseen, Sava Sakadzic, David A. Boas, Michael J. Whalen, Cenk Ayata
Summary: The study reveals that experimental SAH in mice leads to early and persistent cognitive deficits, as well as alterations in hemodynamically derived measures of RSFC.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Anesthesiology
Jane E. Hartung, Jamie K. Moy, Emanuel Loeza-Alcocer, Vidhya Nagarajan, Ruth Jostock, Thomas Christoph, Wolfgang Schroeder, Michael S. Gold
Summary: This study characterized the high voltage-activated calcium currents in human and rat sensory neurons, revealing differences between the two species. The results showed significant differences in current density, sensitivity, and inhibition between human and rat neurons.
Review
Clinical Neurology
Chia-Chun Chiang, Adnan H. Shahid, Andrea M. Harriott, Gretchen E. Tietjen, Luis E. Savastano, James P. Klaas, Giuseppe Lanzino
Summary: Headache in patients with moyamoya disease is often migraine-related, with most experiencing improvement after surgical revascularization. However, some may worsen or develop new headaches after surgery. Careful consideration of different medical therapies is necessary to enhance quality of life without increasing risk of adverse cerebrovascular events.
Article
Anesthesiology
Emanuel Loeza-Alcocer, Michael S. Gold
Summary: Pain in inflammatory bowel disease (IBD) is believed to be caused, in part, by a decrease in peripheral GABAA receptor (GAR)-mediated inhibition. Activating low-affinity GAR or blocking high-affinity GAR may be effective therapeutic strategies for managing IBD pain.
Review
Clinical Neurology
Claudio Tana, Enrico Bentivegna, Soo-Jin Cho, Andrea M. Harriott, David Garcia-Azorin, Alejandro Labastida-Ramirez, Raffaele Ornello, Bianca Raffaelli, Eloisa Rubio Beltran, Ruth Ruscheweyh, Paolo Martelletti
Summary: Headache is a common symptom occurring after COVID-19 and can be a worsening of preexisting headaches or a new headache that develops after the infection. Long COVID headache often presents with other symptoms such as hyposmia and can resemble migraine or tension-type headaches. Due to the lack of treatment studies, current treatment strategies are based on guidelines for primary headaches.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Clinical Neurology
Jasmin Harpe, Carolyn Bernstein, Andrea Harriott
Summary: This study examines the issues surrounding the treatment of infertility in patients with migraine. The research shows that migraine may have a negative impact on family planning and fertility, and it is also associated with an increased prevalence of endocrine disorders. Additionally, infertility treatments may cause mild headache as a side effect. However, there is limited research on the exacerbation of migraine headaches and other migraine-related health outcomes with infertility treatment.
Review
Biotechnology & Applied Microbiology
Zhong Alan Li, Shilpa Sant, Sung Kwon Cho, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Michael S. Gold, Hang Lin
Summary: Synovial joint disorders like osteoarthritis and rheumatoid arthritis are common worldwide, but current clinical management does not fully restore joint function. Organ-on-chip (OoC) technology, which can culture multiple human cell-derived tissues/organs, shows potential in developing better therapies for joint diseases.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Anesthesiology
Andreia Morais, Tao Qin, Cenk Ayata, Andrea M. Harriott
Summary: The study demonstrates the efficacy of inhibiting persistent sodium currents (INaP) in reducing optogenetic spreading depolarization (SD) induced nociceptive behavior. By using rodent models of migraine with aura, the researchers found that GS-458967, a preferential inhibitor of INaP, can suppress SD-induced periorbital allodynia and decrease susceptibility to SD. The findings suggest that INaP inhibition could be an antinociceptive strategy for the treatment of migraine.
Article
Engineering, Biomedical
Yingqiao Wang, Jane E. Hartung, Adam Goad, Matias A. Preisegger, Benjamin Chacon, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: This study investigates the biosafety of Ti3C2Tx-based photothermal modulation. It finds that culturing neurons on Ti3C2Tx films and illuminating them with laser pulses do not cause damage to the cell membrane, induce cellular stress, or generate oxidative stress. These findings provide important insights for the clinical translation of photothermal modulation.
ADVANCED HEALTHCARE MATERIALS
(2023)