Article
Zoology
Xinsong Guo, Shan Li, Xuejie Yu, Tingting Wu, Penglai Liu, Yufeng Shao, Anan Li
Summary: The article introduces a new odor stimulation system that can precisely present odors in freely moving mice. The system can be combined with neural recordings and olfactory behavioral tests to investigate how neurons in the brain represent odor information during individual olfactory behaviors.
INTEGRATIVE ZOOLOGY
(2023)
Article
Engineering, Biomedical
Xudong Lin, Tianying Sun, Minghui Tang, Anqi Yang, Richard Yan-Do, Da Chen, Yaobin Gao, Xin Duan, Ji-Jung Kai, Feng Wang, Peng Shi
Summary: A hierarchical upconversion device is reported, which enables spatially selective and combinatory optogenetics in behaving rodent animals. This device can deliver dynamic light palettes based on excitation wavelength and allows remote optical control of different brain circuits.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Multidisciplinary Sciences
P. Wijdenes, K. Haider, C. Gavrilovici, B. Gunning, M. D. Wolff, T. Lijnse, R. Armstrong, G. C. Teskey, J. M. Rho, C. Dalton, Naweed Syed
Summary: This study presents a fully configurable neural microelectrode that can be used for both in-vitro and in-vivo applications, demonstrating high signal-to-noise ratio and diagnostic potential for neurological disorders. The microelectrodes enable the study of brain activity under normal and pathological conditions, aiding in the development of drug screening and neuromodulation systems.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Analytical
Kaoru Ide, Susumu Takahashi
Summary: Simultaneous monitoring of animal behavior and neuronal activity allows us to investigate the neural basis of behaviors. Traditional tethered recording systems have limitations in terms of animal movement and application to humans. However, the development of wireless neurologgers has overcome these challenges and provided new insights into studying behavior in natural environments.
Article
Biotechnology & Applied Microbiology
Dylan T. Berry, Joanne Choi, Calla A. Dexheimer, Morgan A. Verhaalen, Amir Javan-Khoshkholgh
Summary: The development of an implantable system for studying the electrophysiology of the GI tract is crucial for understanding functional GI disorders and motility dysfunctions. This system allows monitoring and modulation of the bioelectrical activity of the gastric system in freely behaving rodents, providing insights into the relationship between GI disorders and gastric dysrhythmias and the potential of electroceutical therapies for motility dysfunctions in clinical settings.
BIOENGINEERING-BASEL
(2022)
Article
Clinical Neurology
Olga Bukhtiyarova, Sylvain Chauvette, Josee Seigneur, Igor Timofeev
Summary: By studying the sleep and wake states of common marmosets, the researchers found that their distribution and electrographic patterns closely resemble those of humans. This suggests that marmosets are an excellent animal model to study the origin of human electrographical rhythms and brain states.
Article
Cell Biology
Mary R. Schreck, Liujing Zhuang, Emma Janke, Andrew H. Moberly, Janardhan P. Bhattarai, Jay A. Gottfried, Daniel W. Wesson, Minghong Ma
Summary: The central gating mechanism for olfactory processing during sleep remains uncertain. This study found increased neural activity in the olfactory pathway during sleep compared to wakefulness, suggesting a lack of central gating. Additionally, slower and shallower breathing during sleep may suggest a partial peripheral gating mechanism.
Article
Chemistry, Multidisciplinary
Yehhyun Jo, Sang-Mok Lee, Taesub Jung, Gijae Park, Chanhee Lee, Geun Ho Im, Seongju Lee, Jin Soo Park, Chaerin Oh, Geon Kook, Hyunggug Kim, Seongyeon Kim, Byung Chul Lee, Greg S. B. Suh, Seong-Gi Kim, Jeongyeon Kim, Hyunjoo J. Lee
Summary: This study presents a general-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents. The system, utilizing microelectromechanical systems (MEMS) technology, includes a small and lightweight artifact-free transducer for stimulation and neural recording.
Article
Chemistry, Physical
Jung-uk Lee, Wookjin Shin, Yongjun Lim, Jungsil Kim, Woon Ryoung Kim, Heehun Kim, Jae-Hyun Lee, Jinwoo Cheon
Summary: m-Torquer is a magnetic toolkit that mimics magnetoreception in nature, providing precise stimulation to cells and reliable neuromodulation in animals like mice. Its versatility allows for a wide range of applications, potentially even in large animals such as primates.
Review
Biochemistry & Molecular Biology
Changliang Guo, Aimin Wang, Heping Cheng, Liangyi Chen
Summary: In recent years, novel optical imaging tools have been developed to study neuronal activities using fluorescent indicators with brighter expression and higher sensitivity. Miniature microscopes offer a revolutionary approach to imaging large populations of neurons in freely behaving animals, allowing for exploration of the neural basis of behaviors. This review summarizes the historical development of two-photon miniature microscopy techniques and discusses their potential for neuroscientific inquiries. It also addresses the progress in mesoscale single-photon miniature microscopy and the registration of single cells from two-photon and large field-of-view miniature microscopy data. Furthermore, the potential future evolution of these techniques is presented.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jokubas Ausra, Mingzheng Wu, Xin Zhang, Abraham Vazquez-Guardado, Patrick Skelton, Roberto Peralta, Raudel Avila, Thomas Murickan, Chad R. Haney, Yonggang Huang, John A. Rogers, Yevgenia Kozorovitskiy, Philipp Gutruf
Summary: Wireless, battery-free, and fully subdermally implantable optogenetic tools have the potential to revolutionize neurobiological research in freely moving animals, but current devices still have issues with invasive stimulus delivery causing damage during implantation, as well as power delivery constraints limiting the size of operational arenas.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Renate Kat, Berry van den Berg, Matthijs J. L. Perenboom, Maarten Schenke, Arn M. J. M. van den Maagdenberg, Hilgo Bruining, Else A. Tolner, Martien J. H. Kas
Summary: This study developed and validated an EEG-based method to investigate visual deviance detection in freely behaving mice. It was found that deviant detection was evident as bi-phasic negativity in the difference waveform, along with deviance-associated oscillatory responses. The results showed good repeatability in an independent measurement.
Article
Optics
Arutyun Bagramyan, Loic Tabourin, Ali Rastqar, Narges Karimi, Frederic Bretzner, Tigran Galstian
Summary: This study introduces a novel miniature single-photon microscope with an electrically tunable liquid crystal lens for imaging in-depth fine neuronal structures in the brains of freely moving mice. The microscope is compact, lightweight, offers fast acquisition, high magnification, and high resolution, allowing for imaging of calcium activity during a wide range of behavioral tasks.
PHOTONICS RESEARCH
(2021)
Article
Engineering, Biomedical
Jinyong Zhang, Ryan N. Hughes, Namsoo Kim, Isabella P. Fallon, Konstantin Bakhurin, Jiwon Kim, Francesco Paolo Ulloa Severino, Henry H. Yin
Summary: A miniaturized one-photon endoscope integrating digital micromirrors allows for simultaneous optogenetic stimulation and calcium imaging of identified neurons in freely behaving mice.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Neurosciences
Kang Huang, Qin Yang, Yaning Han, Yulin Zhang, Zhiyi Wang, Liping Wang, Pengfei Wei
Summary: Measuring eye movement is important in cognitive science, and this study introduces a novel system that combines hardware and algorithms to analyze complex and dynamic eye-tracking data in freely-moving animals. This system provides a feasible approach to understanding the neural substrates of cognitive function.
NEUROSCIENCE BULLETIN
(2022)
Article
Multidisciplinary Sciences
Tatsuo S. Okubo, Emily L. Mackevicius, Hannah L. Payne, Galen F. Lynch, Michale S. Fee
Article
Neurosciences
Galen F. Lynch, Tatsuo S. Okubo, Alexander Hanuschkin, Richard H. R. Hahnloser, Michale S. Fee
Review
Neurosciences
Michale S. Fee
CURRENT OPINION IN NEUROBIOLOGY
(2014)
Article
Neurosciences
Jesse H. Goldberg, Michael A. Farries, Michale S. Fee
JOURNAL OF NEUROPHYSIOLOGY
(2012)
Article
Neurosciences
Benjamin B. Scott, Timothy Gardner, Ni Ji, Michale S. Fee, Carlos Lois
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Jesse H. Goldberg, Michale S. Fee
NATURE NEUROSCIENCE
(2012)
Article
Multidisciplinary Sciences
Dmitriy Aronov, Michale S. Fee
Article
Multidisciplinary Sciences
Yael Mandelblat-Cerf, Michale S. Fee
Review
Neurosciences
Jesse H. Goldberg, Michael A. Farries, Michale S. Fee
TRENDS IN NEUROSCIENCES
(2013)
Article
Biology
Yael Mandelblat-Cerf, Liora Las, Natalia Denissenko, Michale S. Fee
Article
Biology
Emily L. vi Mackevicius, Andrew H. Bahle, Alex H. Williams, Shijie Gu, Natalia I. Denisenko, Mark S. Goldman, Michale S. Fee
Article
Multidisciplinary Sciences
Emily L. Mackevicius, Michael T. L. Happ, Michale S. Fee
NATURE COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Philipp J. Schubert, Sven Dorkenwald, Michal Januszewski, Jonathan Klimesch, Fabian Svara, Andrei Mancu, Hashir Ahmad, Michale S. Fee, Viren Jain, Joergen Kornfeld
Summary: SyConn2 is an open-source toolkit for inferring and analyzing the connectomes in brain tissue using machine learning. It supports large datasets, provides a visualization interface, and allows for complex queries.
Article
Biochemical Research Methods
Joseph R. R. Scherrer, Galen F. F. Lynch, Jie J. J. Zhang, Michale S. S. Fee
Summary: We present a fluorescence microscope light path that allows imaging of thousands of neurons in mice and hundreds of neurons in juvenile songbirds during free behavior. The light path eliminates traditional illumination optics, resulting in head-mounted microscopes that are lighter and have a larger field of view (FOV). Two microscopes were designed using this light path: one optimized for FOV (approximately 4 mm FOV; 1.4 g), and the other optimized for weight (1.0 mm FOV; 1.0 g).
Article
Biology
Emily L. Mackevicius, Shijie Gu, Natalia I. Denisenko, Michale S. Fee
Summary: Behaviors emerge through the combination of experience and innate predispositions. The maturation of the brain leads to significant changes in cellular, network, and functional properties influenced by sensory experience and developmental processes. Tutor experience is not necessary for the formation of neural sequences, but it can influence the association between pre-existing sequences and new learned syllables. Delaying exposure to a tutor affects the ability of birds to learn new syllables.