Article
Neurosciences
Yaxin Miao, Xuhao Chen, Feng You, Manli Jia, Ting Li, Ping Tang, Ruyi Shi, Shisi Hu, Liping Zhang, Jiang-Fan Chen, Ying Gao
Summary: Synapse pruning is crucial for brain development and the pathogenesis of neurodevelopmental disorders, but effective pharmacological regulation is currently lacking. A study showed that A(2A)R antagonist can promote synaptic pruning in the visual pathway, suggesting a potential novel pharmacological strategy for regulating synaptic pruning and treating neurodevelopmental disorders associated with pruning dysfunction.
Article
Neurosciences
Jianzhong He, Fan Zhang, Guoqiang Xie, Shun Yao, Yuanjing Feng, Dhiego C. A. Bastos, Yogesh Rathi, Nikos Makris, Ron Kikinis, Alexandra J. Golby, Lauren J. O'Donnell
Summary: This study compared four tractography methods and found that UKF-2T and iFOD1 produce the best results for RGVP reconstruction. The iFOD1 method can more accurately estimate the percentage of decussating fibers, while the UKF-2T method produces reconstructed RGVPs that better correspond to known anatomy.
HUMAN BRAIN MAPPING
(2021)
Article
Genetics & Heredity
Kiana Mohajeri, Rachita Yadav, Eva D'haene, Philip M. Boone, Serkan Erdin, Dadi Gao, Mariana Moyses-Oliveira, Riya Bhavsar, Benjamin B. Currall, Kathryn O'Keefe, Nicholas D. Burt, Chelsea Lowther, Diane Lucente, Monica Salani, Mathew Larson, Claire Redin, Olga Dudchenko, Erez Lieberman Aiden, Bjorn Menten, Derek J. C. Tai, James F. Gusella, Sarah Vergult, Michael E. Talkowski
Summary: The study highlighted the significant impact of MEF2C deletion on neuronal cells and characterized the complex interactions caused by structural variants disrupting three-dimensional genome organization. Deletion of MEF2C resulted in differential expression of genes associated with neurodevelopmental pathways and synaptic function, as well as a reduction in synaptic activity in neuronal cells. Buffering effects were observed following deletion of specific structural variants, but homozygous loss led to down-regulation of MEF2C expression and reduced electrophysiological activity.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Neurosciences
Ashish Bhandari, Thomas W. Ward, Jennie Smith, Matthew J. Van Hook
Summary: This study investigates the effects of loss of visual input on TC neurons utilizing various techniques such as patch-clamp electrophysiology, optogenetics, immunostaining, and single-cell dendritic analysis. The findings reveal that degeneration of retinal terminals and RG synapses induces structural and functional changes in TC neurons following enucleation.
Article
Multidisciplinary Sciences
Adel Parvizi-Fard, Mahmood Amiri, Deepesh Kumar, Mark M. Iskarous, Nitish Thakor
Summary: The study modeled three stages of the tactile pathway from the periphery to the cortex and explored the roles of sensory neurons, cuneate nucleus, and cortical neurons in sensing indentation and edge stimuli. By utilizing a biomimetic decoder, edge orientation can be detected more accurately, and it was observed that larger receptive fields convey more information about edge orientation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zhaoxia Jin, Qiyao Zhu, Yangyang Guo, Ronglian Xing, Yanyan Wang, Yue Zhang, Xiaoxiao Gao, Fang Yu
Summary: The functional characterization of homologous genes involved in plant secondary metabolism reveals functional divergence and redundancy. The study focused on the CYP450 gene family involved in the biosynthesis of Strychnos alkaloid scaffold. Through various analyses, including metabolite profiling, phylogenetic analyses, and biochemistry assays, the researchers identified and characterized five homologous genes. The results showed that certain homologs played a major role in the biosynthesis of specific metabolites, while others had little impact. This study expands our understanding of the functional diversity and divergence of genes involved in secondary metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Gioia De Franceschi, Tania Rinaldi Barkat
Summary: This study found that task engagement can modulate neuronal activity in the auditory system, changing the response patterns of most neurons. Ten distinct modulation patterns were identified, and different types of neurons were found to have varying sensitivity to specific task-related variables along the auditory pathway.
Article
Multidisciplinary Sciences
Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner
Summary: The study reveals that NEDD8 can be phosphorylated at S65, affecting its structural dynamics similar to Ub. Phosphorylated NEDD8 has a distinct interactome compared to unmodified Ub and NEDD8, and it can more effectively regulate HSP70 protein activity.
NATURE COMMUNICATIONS
(2021)
Article
Computer Science, Information Systems
Souvik Ray, Subrata Pal, Sumit Kumar Kar, Ayanendranath Basu
Summary: Divergence measures, such as density power divergence, have a strong association with statistical inference, machine learning, and information theory, and have led to many useful procedures that balance model efficiency with outlier stability. The logarithmic density power divergence has also been successful in producing efficient and stable inference procedures and has been applied in information theory. This article characterizes a new class of divergence measures, called functional density power divergence, which can be explored further for applications in statistical inference, machine learning, and information theory.
IEEE TRANSACTIONS ON INFORMATION THEORY
(2023)
Article
Biochemical Research Methods
Kuei-Yueh Ko, Cho-Yi Chen, Hsueh-Fen Juan, Hsuan-Cheng Huang
Summary: The hourglass model posits that developmental constraints in the middle of a developmental process are higher, and phenotypes are evolutionarily more conserved. Research found that network stochasticity follows an anti-hourglass trajectory, supporting Raff's hypothesis. Different species activate similar biological process groups during development, with higher interspecies correlations at mid-developmental stages.
Article
Genetics & Heredity
Lingyu Zhan, Jiajin Li, Brandon Jew, Jae Hoon Sul
Summary: Late-onset Alzheimer's disease, the most common type of dementia, is strongly associated with rare-variant effects in the cellular transportation pathway, impacting disease risk and progression. This study highlights the potential of rare variants in this pathway as valuable targets for future AD research and therapeutic strategies.
Review
Biochemistry & Molecular Biology
Hui Song, Yunpeng Cao, Longgang Zhao, Jiancheng Zhang, Shuai Li
Summary: WRKY transcription factors (TFs) are important for plant growth, development, and response to environmental changes. They have been detected in plant genomes, especially in Arabidopsis thaliana, and their functions and regulatory networks have been studied. However, the relationship between their function and classification, as well as the functional divergence of homologous WRKY TFs, remains unclear.
Article
Biochemical Research Methods
Chunmei Cui, Yuan Zhou, Qinghua Cui
Summary: The proposed functional divergence score (FDS) algorithm can effectively evaluate the functional differences between human and mouse orthologous genes, helping to uncover gene expression divergence and distinguish successful and failed drug targets.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Plant Sciences
Jun Cheng, Jingjing Ma, Xianbo Zheng, Honglin Lv, Mengmeng Zhang, Bin Tan, Xia Ye, Wei Wang, Langlang Zhang, Zhiqian Li, Jidong Li, Jiancan Feng
Summary: This study identified seven PpGA2ox genes in the peach genome, and overexpression of these genes in tobacco resulted in dwarf plants with altered growth. The analysis also revealed differences in response time and activity between the C-19-GA2ox and C-20-GA2ox subgroups, with the latter depleting GA levels more broadly. These findings suggest that the PpGA2ox gene family plays a role in fine-tuning endogenous GA levels and provide insights for controlling the growth of peach trees.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Cell Biology
Yohalie Kalukula, Andrew D. Stephens, Jan Lammerding, Sylvain Gabriele
Summary: The nucleus plays a critical role in determining cell fate and function in response to signals and stimuli. It is constantly exposed to mechanical forces that trigger changes in nuclear structure. Recent data suggest that the physical deformation of the nucleus modulates cellular and nuclear functions.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Neurosciences
Dajun Xing, Chun-I Yeh, Robert M. Shapley
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Chun-I Yeh, Dajun Xing, Robert M. Shapley
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Dajun Xing, Chun-I Yeh, Robert M. Shapley
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Dajun Xing, Yutai Shen, Samuel Burns, Chun-I Yeh, Robert Shapley, Wu Li
JOURNAL OF NEUROSCIENCE
(2012)
Article
Multidisciplinary Sciences
Chun-I Yeh, Dajun Xing, Patrick E. Williams, Robert M. Shapley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Dajun Xing, Chun-I Yeh, Samuel Burns, Robert M. Shapley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Multidisciplinary Sciences
Dajun Xing, Chun-I Yeh, James Gordon, Robert M. Shapley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Neurosciences
Yu-Chun Hsu, Chun- Yeh, Jian-Jia Huang, Chang-Hung Hung, Chou Po Hung, Yu-Cheng Pei
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Medicine, Research & Experimental
Chun- Yeh, Mei-Fang Cheng, Furen Xiao, Yi-Chieh Chen, Chien-Chu Liu, Hung-Yi Chen, Ruoh-Fang Yen, Yu-Ten Ju, Yilin Chen, Mohan Bodduluri, Pin-Huan Yu, Chau-Hwa Chi, Ngot Swan Chong, Liang-Hsiang Wu, John R. Adler, Michael Bret Schneider
Summary: This study demonstrates that focal metabolic changes can be induced in the brain through precise delivery of ionizing radiation, without causing brain lesions. The effects were significant at doses of 60 Gy or higher, with only 120 Gy resulting in visible ablation. This noninvasive approach may open new avenues for investigating neuromodulatory treatments for disorders involving dysfunctional brain circuits.
Article
Multidisciplinary Sciences
Yueh-Peng Chen, Chun-I Yeh, Tsung-Chi Lee, Jian-Jia Huang, Yu-Cheng Pei
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Yu-Po Cheng, Jian-Jia Huang, Chun- Yeh, Yu-Cheng Pei
Summary: The study investigated the manipulation of feature preferences in barrel cortical neurons using repetitive paired whisker deflection and optogenetic stimulation. It was found that neuron responses were enhanced in the nonpreferred direction only when the optogenetic stimulus preceded the mechanical stimulus, suggesting that repetitive paired optogenetic-mechanical stimulation can induce in vivo neuroplasticity in limited situations.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Biochemistry & Molecular Biology
Chuanliang Han, Tian Wang, Yi Yang, Yujie Wu, Yang Li, Weifeng Dai, Yange Zhang, Bin Wang, Guanzhong Yang, Ziqi Cao, Jian Kang, Gang Wang, Liang Li, Hongbo Yu, Chun- Yeh, Dajun Xing
Summary: The study found 3 narrowband gamma rhythms in the primary visual cortex (V1) that processed distinct spatial frequency signals and had different neural origins. These gamma rhythms showed better performance in discriminating the edge and surface of simple objects, reflecting the neural dynamics of processing different SF information in the visual system.
Article
Multidisciplinary Sciences
Daniel A. Butts, Chong Weng, Jianzhong Jin, Chun-I Yeh, Nicholas A. Lesica, Jose-Manuel Alonso, Garrett B. Stanley
Article
Neurosciences
Jianzhong Z. Jin, Chong Weng, Chun-I Yeh, Joshua A. Gordon, Edward S. Ruthazer, Michael P. Stryker, Harvey A. Swadlow, Jose-Manuel Alonso
NATURE NEUROSCIENCE
(2008)