Article
Neurosciences
Anhui Wang, Xiangchao Shi, Ruoyang Yu, Bao Qiao, Runan Yang, Changshui Xu
Summary: This study found that in DNP, the P2X(7) receptor is involved in modulating DNP hypersensitivity by decreasing the expression of TRPV1 and the phosphorylation levels of p38 and ERK1/2.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jiliang Wen, Zhenghao Chen, Si Wang, Mengmeng Zhao, Shaoyong Wang, Shengtian Zhao, Xiulin Zhang
Summary: As animals age, the electrical properties of bladder afferents undergo differential changes, with a decrease in excitability potentially contributing to reductions in bladder sensory function.
Article
Cell Biology
Hyun-jeong Pyo, Xue An, Hana Cho
Summary: This study identifies a new pathway for the modulation of TRPA1 and TRPV1 channels, which are involved in inflammatory and neuropathic pain. The findings show that endogenous anti-inflammatory lipid mediators can selectively inhibit the activity of these channels through specific signaling pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Junfan Fang, Sisi Wang, Jie Zhou, Xiaomei Shao, Haiju Sun, Yi Liang, Xiaofen He, Yongliang Jiang, Boyi Liu, Xiaoming Jin, Jianqiao Fang, Junying Du
Summary: The study demonstrated that the PKCε-TRPV1 signaling pathway plays a crucial role in pain transition. Electroacupuncture treatment was found to regulate the high expression of PKCε and TRPV1, increasing pain threshold. Moreover, EA could prevent the transition from acute to chronic pain during the early stages of acute pain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yesul Kim, Young-Hoon Jung, Seung-Bin Park, Heekee Kim, Jae-young Kwon, Hae-kyu Kim, Hyeon-Jeong Lee, Soeun Jeon, Eunsoo Kim
Summary: The study showed that TMI-1 partially protects against paclitaxel-induced neurotoxicity by reversing the upregulation of TRPV1 and decreasing levels of inflammatory cytokines, including TNF-alpha, IL-1 beta, and IL-6 in neuronal cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xiuqi Xu, Ziqi Yuan, Shijia Zhang, Guang Li, Guangqin Zhang
Summary: This study observed the changes in the TRPV1 channel in MSU-induced gouty arthritis and found that TRPV1 plays an important role in mediating mechanical hyperalgesia in gouty arthritis. This suggests that TRPV1 could be a potential new target for the clinical treatment of gouty arthritis.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
I-Han Hsiao, Hsien-Yin Liao, Chao-Min Cheng, Chia-Ming Yen, Yi-Wen Lin
Summary: In this study, a paper-based enzyme-linked immunosorbent assay method was used to examine the changes in acupoint environment. The results showed that levels of neurotransmitters and cytokines were increased after electroacupuncture (EA) treatment. Further investigations revealed the involvement of TRPV1 and its associated molecules in these changes. The findings provide novel insights into acupuncture mechanisms and clinical targeting.
Article
Biochemistry & Molecular Biology
Liying Dong, Qiqi Zhou, Qianqian Liang, Zhen Qiao, Yani Liu, Liming Shao, Kewei Wang
Summary: In this study, a novel TRPV1 agonist CPIPC was identified and shown to have analgesic activity in mice.
Article
Neurosciences
Junfan Fang, Junying Du, Xuaner Xiang, Xiaomei Shao, Xiaofeng He, Yongliang Jiang, Boyi Liu, Yi Liang, Jianqiao Fang
Summary: The study found that the expression and function of TRPV1 and P2X3 in the dorsal root ganglia (DRGs) differ at various stages in the CFA and SNI models, suggesting that these ion channels play distinct roles in inflammatory and neuropathic pain in the chronic stage.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Takehiro Yajima, Tadasu Sato, Hiroshi Hosokawa, Teruyoshi Kondo, Hiroyuki Ichikawa
Summary: This study demonstrates the expression and distribution of TRPM7 in rat lumbar dorsal root ganglion (DRG) neurons, highlighting its association with other TRP channels and involvement in peripheral targets. The findings suggest that TRPM7 is involved in response to noxious stimulation and that nerve injury can decrease TRPM7 expression in DRG neurons.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Pharmacology & Pharmacy
Mircea Iftinca, Manon Defaye, Christophe Altier
Summary: TRPV1 is a significant channel in pain perception and its agonists are being studied for chronic pain management. While TRPV1 antagonists have limited clinical use due to side effects, capsaicin offers a potential avenue for long-lasting pain relief by defunctionalising nociceptors. The development of TRPV1-targeted drugs could provide a new generation of analgesics for various pain conditions.
Article
Biochemistry & Molecular Biology
Elena Lucarini, Luisa Seguella, Martina Vincenzi, Carmen Parisio, Laura Micheli, Alessandra Toti, Chiara Corpetti, Alessandro Del Re, Silvia Squillace, Daniela Maftei, Roberta Lattanzi, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Giuseppe Esposito
Summary: This study investigated changes in the neuron-glial networks controlling visceral perception along the gut-brain axis during colitis and assessed the effects of peripheral glial manipulation. Modulation of peripheral glia activity emerges as a promising strategy for counteracting visceral pain induced by colitis.
Article
Biochemistry & Molecular Biology
Jenny Wilzopolski, Manfred Kietzmann, Santosh K. Mishra, Holger Stark, Wolfgang Baeumer, Kristine Rossbach
Summary: The study found that both TRPV1 and TRPA1 channels play important roles in the transmission of histamine-induced itch, with TRPV1 inhibition reducing itch induced by both H1R and H4R, while TRPA1 inhibition only reduced H4R-induced itch. In vitro experiments showed that inhibition of TRPV1 and TRPA1 led to reduced Ca2+ influx into sensory neurons.
Article
Pharmacology & Pharmacy
Yann Chappe, Pauline Michel, Alexandre Joushomme, Solene Barbeau, Sandra Pierredon, Luc Baron, Andre Garenne, Florence Poulletier De Gannes, Annabelle Hurtier, Stanislas Mayer, Isabelle Lagroye, Jean-Francois Quignard, Thomas Ducret, Vincent Compan, Christelle Franchet, Yann Percherancier
Summary: This study evaluated the bioluminescence resonance energy transfer (BRET) technique as a new high-throughput screening method for ion-channel studies by using intra- and intermolecular BRET probes targeting the TRPV1 ion channel. The results compared with reference techniques highlighted the potential of BRET probes in ion-channel drug screening campaigns.
MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lu Qin, Qin Li, Jianhua Li
Summary: The study investigated the mechanism of exercise pressor reflex (EPR) mediated by ASIC3 and P2X3 receptors in muscle afferent nerves in PAD. The results showed that ASIC3 KO attenuated the exaggerated P2X3-mediated pressor response in PAD rats, suggesting a potential new therapeutic approach for PAD.
Article
Biochemistry & Molecular Biology
Ho Shin Kim, Van-Hai Hoang, Mannkyu Hong, Kyung Chul Kim, Jihyae Ann, Cong-Truong Nguyen, Ji Hae Seo, Hoon Choi, Jun Yong Kim, Kyu-Won Kim, Woong Sub Byun, Sangkook Lee, Seungbeom Lee, Young-Ger Suh, Jie Chen, Hyun-Ju Park, Tae-Min Cho, Ji Young Kim, Jae Hong Seo, Jeewoo Lee
BIOORGANIC & MEDICINAL CHEMISTRY
(2019)
Article
Oncology
Tae-Min Cho, Ji Young Kim, Yoon-Jae Kim, Daeil Sung, Eunhye Oh, Seojin Jang, Lee Farrand, Van-Hai Hoang, Cong-Truong Nguyen, Jihyae Ann, Jeewoo Lee, Jae Hong Seo
Article
Biochemistry & Molecular Biology
Larry Pearce, Jihyae Ann, Peter M. Blumberg, Jeewoo Lee
BIOMOLECULES & THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Mariana Cooke, Victoria Casado-Medrano, Jihyae Ann, Jeewoo Lee, Peter M. Blumberg, Martin C. Abba, Marcelo G. Kazanietz
SCIENTIFIC REPORTS
(2019)
Article
Pharmacology & Pharmacy
Ha-Rim Lee, Jeewoo Lee, Hyun-Jung Kim
PHARMACOLOGICAL RESEARCH
(2019)
Article
Chemistry, Medicinal
Hobin Lee, Songyeon Ahn, Jihyae Ann, Heejin Ha, Young Dong Yoo, Young Ho Kim, Ji-Young Hwang, Kwang-Hyun Hur, Choon-Gon Jang, Larry V. Pearce, Timothy E. Esch, Nancy E. Lewin, Peter M. Blumberg, Jeewoo Lee
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Jihyae Ann, Ho Shin Kim, Shivaji A. Thorat, Hee Kim, Hee-Jin Ha, Kwanghyun Choi, Young-Ho Kim, Minseok Kim, Sun Wook Hwang, Larry Pearce, Timothy E. Esch, Noe A. Turcios, Peter M. Blumberg, Jeewoo Lee
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Songyeon Ahn, Yong Soo Kim, Myeong Seup Kim, Jihyae Ann, Heejin Ha, Young Dong Yoo, Young Ho Kim, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph, Jeewoo Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Pharmacology & Pharmacy
Nils Damann, Gregor Bahrenberg, Hannelore Stockhausen, Christopher J. Habermann, Bernhard Lesch, Robert Frank-Foltyn, Jeewoo Lee, Jihyae Ann, Thomas Christoph
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ha-Rim Lee, Jin Mi Kang, Young Min Kim, Sagang Kim, Jihyae Ann, Jeewoo Lee, Hyun-Jung Kim
Article
Chemistry, Medicinal
Juyoung Jung, Jinsun Kwon, Soojung Hong, An-Na Moon, Jinah Jeong, Sungwook Kwon, Jeong-ah Kim, Myoungjae Lee, Hongsub Lee, Jin Hee Lee, Jeewoo Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Medicinal
Cong-Truong Nguyen, Jihyae Ann, Raghaba Sahu, Woong Sub Byun, Sangkook Lee, Gibeom Nam, Hyun-Ju Park, Soeun Park, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo, Jeewoo Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Medicinal
Jin Mi Kang, Sun Ok Kwon, Jihyae Ann, Peter M. Blumberg, Heejin Ha, Young Dong Yoo, Robert Frank-Foltyn, Bernhard Lesch, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph, Jeewoo Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Letter
Biochemistry & Molecular Biology
Jung Min Park, Yoon-Jae Kim, Soeun Park, Minsu Park, Lee Farrand, Cong-Truong Nguyen, Jihyae Ann, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article
Chemistry, Multidisciplinary
Phuong-Thao Tran, Van-Hai Hoang, Jeewoo Lee, Tran Thi Thu Hien, Nguyen Thanh Tung, Son Tung Ngo