Article
Neurosciences
David Youssef, John H. Wittig Jr, Samantha Jackson, Sara K. Inati, Kareem A. Zaghloul
Summary: Microstimulation has complex effects on neuronal spiking and its impact on behavior is not well understood. This study used microelectrode arrays to investigate the spiking responses of individual neurons in the human anterior temporal lobe. The findings show that different stimulation sites can drive either excitation or inhibition in individual neurons, providing a potential method for controlling spiking activity at the single-neuron level. The proximity to the stimulation site influenced the type of spiking response, with inhibitory responses closer to the site and excitatory responses more spatially distributed.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Lorenzo Rocchi, Alessandro Di Santo, Katlyn Brown, Jaime Ibanez, Elias Casula, Vishal Rawji, Vincenzo Di Lazzaro, Giacomo Koch, John Rothwell
Summary: The study aims to measure the separate contributions of auditory and somatosensory stimulation caused by TMS, and assess their impact on the TEP waveform during motor cortex stimulation.
Auditory stimulation induces known responses in electrodes around the vertex, which can be suppressed by appropriate noise masking. Stimulation of the scalp alone generates nonspecific responses in central electrodes.
Article
Clinical Neurology
Duc T. Nguyen, Destiny E. Berisha, Elisa E. Konofagou, Jacek P. Dmochowski
Summary: This study aimed to investigate the relationship between pre-stimulation neural activity and the neuronal response to tFUS. The findings suggest that baseline brain rhythms significantly modulate the response to tFUS, with different levels of Delta, Theta, and Gamma power producing varying degrees of firing rate increases.
Article
Multidisciplinary Sciences
Ana B. Lao-Rodriguez, Karol Przewrocki, David Perez-Gonzalez, Artoghrul Alishbayli, Evrim Yilmaz, Manuel S. Malmierca, Bernhard Englitz
Summary: Prediction is crucial for survival, and cognitive studies indicate that the brain can make multilevel predictions. However, neuronal evidence for predictions has been difficult to find due to the challenge of separating neural activity related to predictions from stimulus responses. In this study, we recorded single-neuron activity from auditory regions in both anesthetized and awake animals and observed reliable responses to omitted tones, providing empirical evidence for the implementation of predictive processes.
Article
Behavioral Sciences
Sergejus Butovas, Cornelius Schwarz
Summary: The goal of cortical neuroprosthetics is to accurately implant sensory information into cortical networks. This study demonstrated that passive touch and active touch have different effects on the local field potential (LFP) responses to microstimulation in the barrel cortex. Active touch significantly suppressed the positive deflection of LFP responses. This finding suggests that the behavioral context should be considered when using neuroprostheses to stimulate cortical circuits.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Veronica Gomez Godinez, Vikash Morar, Christopher Carmona, Yingli Gu, Kijung Sung, Linda Z. Shi, Chengbiao Wu, Daryl Preece, Michael W. Berns
Summary: The study used laser-induced shockwaves and genetically encoded biosensors to investigate the response of cells, finding that both cortical neurons and Schwann cells exhibit a transient increase in Ca2+ regardless of extracellular Ca2+ conditions. This research method allows for simultaneous monitoring of the effects of shear stress on cells and cell damage and death in the vicinity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yulong Chen, Xinyuan Lv, Ruihan Liu, Xuefeng Cui, Fang Ye, Laifei Cheng
Summary: A novel SiCw/SiC-Si-Y composite was prepared by infiltrating silicon-yttrium alloy into a SiCw/C preform via reactive melt infiltration method. The obtained composite exhibited excellent mechanical properties and retained high strength and toughness after water-oxygen corrosion at high temperature. This composite material has great potential for aerospace applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Neurosciences
Lukas Konecny, Rafid Quadir, Abel Ninan, Adrian Rodriguez-Contreras
Summary: Understanding the role of neuronal activity in sensory development and its impact on angiogenesis and hypoxia-induced factors is crucial for the study of physiological and pathological responses to oxygen shortage. This article discusses the hypothesis that sensory neurons' spontaneous activity leads to intermittent tissue hypoxia, which in turn promotes the expression of hypoxia inducible transcription factors and the production of angiogenic factors. These findings have implications for understanding the mechanisms underlying oxygen-related conditions in the newborn brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Engineering, Biomedical
Alejandro Pascual-Valdunciel, Grace W. Hoo, Simon Avrillon, Filipe Oliveira Barroso, Jennifer G. Goldman, Julio C. Hernandez-Pavon, Jose L. Pons
Summary: Studies have shown that peripheral electrical stimulation can modulate tremor generation, providing new perspectives for short- and long-term tremor reduction. However, there are significant disparities in stimulation patterns, experimental designs, and tremor assessment methods across studies, highlighting the need for standardized experimental methodology.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Cell Biology
Phillip Wibisono, Shawndra Wibisono, Jan Watteyne, Chia-Hui Chen, Durai Sellegounder, Isabel Beets, Yiyong Liu, Jingru Sun
Summary: This study demonstrates that NMUR-1 regulates the expression of immune genes in C. elegans by modulating the activity of transcription factors involved in binding to RNA polymerase II regulatory regions. This finding provides a molecular basis for the specificity of C. elegans innate immunity and could potentially shed light on the specificity of innate immunity in other animals, including mammals.
Article
Biochemistry & Molecular Biology
Thu Nguyen Minh Pham, Natarajan Perumal, Caroline Manicam, Marion Basoglu, Stefan Eimer, Dominik C. Fuhrmann, Claus U. Pietrzik, Albrecht M. Clement, Hagen Koerschgen, Jana Schepers, Christian Behl
Summary: Misfolded proteins and calcium homeostasis disruption can cause endoplasmic reticulum stress, which is associated with neurodegenerative diseases. Investigating how neuronal cells adapt to chronic endoplasmic reticulum stress is important. In this study, clonal mouse hippocampal cell lines resistant to prolonged endoplasmic reticulum stress were established as in vitro models. The resistant cells showed increased vesicular and autophagosomal structures, with "giant lysosomes" particularly prominent. While autophagic activity increased, lysosomal function was slightly impaired. Enhanced ER-phagy was observed in both cell lines. Proteomic analysis revealed differential regulation of protein clusters and signaling pathways in response to chronic endoplasmic reticulum stress induced by thapsigargin or tunicamycin. Bioenergetic analysis showed a shift towards aerobic glycolysis and defective complex I of the oxidative phosphorylation machinery. ER stress-resistant cells activated the unfolded protein response pathways. These findings demonstrate the adaptive responses of neuronal cells to chronic ER stress. ER stress-resistant neuronal cells could be potential pharmacological targets for preventing neurodegeneration.
Article
Cell Biology
Hao Li, Xiaokun Li, Shouming Lv, Xuefang Peng, Ning Cui, Tong Yang, Zhendong Yang, Chun Yuan, Yang Yuan, Jiaying Yao, Zan Yuan, Jiachen Li, Xiaolei Ye, Xiaoai Zhang, Shu Zhu, Ke Peng, Wei Liu
Summary: The single-cell landscape of peripheral immune responses in SFTS patients is reprogrammed, with potential targets including intermediate monocytes and IFN-I-inducible plasmablasts. A retrospective clinical study showed no efficiency of IFN-α in treating SFTS, indicating the pivotal role of the IFN-I response in exacerbating hyperinflammation and lethal SFTS.
Article
Biophysics
Stephan J. Ihle, Sophie Girardin, Thomas Felder, Tobias Ruff, Julian Hengsteler, Jens Duru, Sean Weaver, Csaba Forro, Janos Voros
Summary: We present a paradigm to examine the behavior of multiple neuronal networks with controlled topology in vitro. Our approach enables simultaneous electrical stimulation and recording of neuronal activity from 60 independent networks over multiple weeks. We found that the network response pattern to a stimulus remains stable for at least 12 hours and continuous stimulation does not significantly change the stimulation-induced mean spiking frequency of a circuit. We also investigated the effect of stimulation amplitude and timing on the network response and demonstrated the capability of our setup to apply complex stimulation protocols.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biology
Sarah M. Lurie, James E. Kragel, Stephan U. Schuele, Joel L. Voss
Summary: Through experimental studies on patients with epilepsy, it is found that the receptivity of the hippocampus to input changes with the phase of theta rhythms, further confirming the proposed mechanism of neural oscillations modulating human hippocampal function.
Article
Biochemical Research Methods
Schnaude Dorizan, Kevin J. Kleczka, Admir Resulaj, Trevor Alston, Chris S. Bresee, Mitra J. Z. Hartmann
Summary: This article introduces a novel multi-whisker stimulator for assessing neural selectivity for the direction of global motion. The stimulator can generate repeatable, linear sweeps of tactile stimulation across the whisker array in any direction and with a range of speeds.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Multidisciplinary Sciences
Takahide Itokazu, Masashi Hasegawa, Rui Kimura, Hironobu Osaki, Urban-Raphael Albrecht, Kazuhiro Sohya, Shubhodeep Chakrabarti, Hideaki Itoh, Tetsufumi Ito, Tatsuo K. Sato, Takashi R. Sato
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
L. E. Dominguez-Rodriguez, K. Stecina, D. L. Garcia-Ramirez, E. Mena-Avila, J. J. Milla-Cruz, L. Martinez-Silva, M. Zhang, H. Hultborn, J. N. Quevedo
Article
Clinical Neurology
Simone Hjaeresen, Tobias Sejbaek, Marcus Axelsson, Helle Vinslov-Jensen, Sif Klovedal Mortensen, Gorm Pihl-Jensen, Lenka Novakova, Julie Damgaard Rosgaard Christensen, Christian Bonde Pedersen, Bo Halle, Frantz Rom Poulsen, Jette Lautrup Frederiksen, Mengliang Zhang, Eirikur Benedikz, Jan Lycke, Zsolt Illes, Asa Fex Svenningsen
Summary: This study found that levels of HTRA1 in cerebrospinal fluid significantly increased in multiple sclerosis patients, and disease modifying therapies were able to decrease these levels. ROC analysis showed that HTRA1 levels could distinguish healthy controls from MS patients, demonstrating potential biomarker value.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Sophie Laturnus, Adrian Hoffmann, Shubhodeep Chakrabarti, Cornelius Schwarz
Summary: The brainstem trigeminal nuclei were found to largely preserve the encoding properties of primary afferents, including local encoding and kinematic response fields. While Pr5 and Sp5i exhibited lower spike and information rates compared to TG, the information rate per spike was comparable. This suggests a commonality in transferring primary afferent information despite differences in assumed functions.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Liliana S. Carvalho, Helena M. Brito, Elena A. Lukoyanova, Gisela H. Maia, Daniil Sarkisyan, Olga Nosova, Mengliang Zhang, Nikolay Lukoyanov, Georgy Bakalkin
Summary: The study demonstrates that unilateral brain injury in pregnant rats could lead to postural asymmetry and impaired coordination in the offspring. The findings suggest that the lateralized effects of maternal brain injury may be transmitted to the fetus, indicating potential left-right side-specific mechanisms at play.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Hiroyuki Watanabe, Olga Nosova, Daniil Sarkisyan, Marlene Storm Andersen, Liliana Carvalho, Vladimir Galatenko, Igor Bazov, Nikolay Lukoyanov, Gisela H. Maia, Mathias Hallberg, Mengliang Zhang, Jens Schouenborg, Georgy Bakalkin
Summary: The study found that the spinal opioid system may mediate or counteract injury effects, and the effects of opioid antagonists are injury side-specific. Different types of opioid antagonists have specific effects on the injury side, suggesting a lateralized control mechanism by neuropeptides.
Article
Biology
Nikolay Lukoyanov, Hiroyuki Watanabe, Liliana S. Carvalho, Olga Kononenko, Daniil Sarkisyan, Mengliang Zhang, Marlene Storm Andersen, Elena A. Lukoyanova, Vladimir Galatenko, Alex Tonevitsky, Igor Bazov, Tatiana Iakovleva, Jens Schouenborg, Georgy Bakalkin
Summary: Brain injuries can lead to hindlimb postural asymmetry and asymmetric gene expression patterns in the spinal cord. These postural effects may be related to side-specific signaling of pituitary neurohormones.
Article
Neurosciences
Georgy Bakalkin, Olga Nosova, Daniil Sarkisyan, Mathias Hallberg, Mengliang Zhang, Jens Schouenborg, Niklas Marklund, Hiroyuki Watanabe
Summary: Traumatic brain injury and controlled cortical impact (CCI) caused asymmetry in posture in rats, with left side injuries unexpectedly resulting in flexion on the left hindlimb. The effects on hindlimb postural asymmetry were not mirror-symmetrical between the left and right CCI, suggesting differences in neural pathways between the two types of injuries.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Anatomy & Morphology
Jared B. Smith, Shubhodeep Chakrabarti, Todd M. Mowery, Kevin D. Alloway
Summary: The basal ganglia, claustrum, and pontocerebellar systems in rats and cats have evolved distinct patterns of sensorimotor cortical convergence.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Marlene Storm Andersen, Dilara Bedriye Guler, Jonas Larsen, Karen Kalhoj Rich, Asa Fex Svenningsen, Mengliang Zhang
Summary: This study investigated the effects of brain injury on limb postural changes and the expression of 5-HT2A and 2C receptors. The results showed that brain injury caused long-term motor deficits and postural asymmetry, but these deficits were not related to the expression of 5-HT2A and 2C receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Simone Hjaeresen, Tobias Sejbaek, Markus Axelsson, Sif Klovedal Mortensen, Helle Vinslov-Jensen, Gorm Pihl-Jensen, Lenka Novakova, Christian Bonde Pedersen, Bo Halle, Frantz Rom Poulsen, Mengliang Zhang, Eirikur Benedikz, Jette Lautrup Frederiksen, Jan Lycke, Zsolt Illes, Asa Fex-Svenningsen
Summary: The levels of macrophage migration inhibitory factor (MIF) in the cerebrospinal fluid (CSF) of patients with different subtypes of multiple sclerosis (MS) were investigated. MIF levels were found to be affected by gender and disease type. MIF levels were decreased in clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) patients, but elevated in secondary progressive MS (SPMS) patients. The expression of MIF in the human brain was localized to neurons, astrocytes, pericytes, and oligodendrocytes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yun-Fei Li, Rui-Xue Wei, Kai-Qi Yang, Gary D. Hack, Yan-Yan Chi, Wei Tang, Xue-Jun Sui, Meng-Liang Zhang, Hong-Jin Sui, Sheng-Bo Yu
Summary: The space between the inferior margin of the cerebellar vermis to the level of the foramen magnum has been defined as the cisterna magna, while an enlarged dorsal subarachnoid space at the occipito-cervical junction extending from the foramen magnum to the upper border of the C2 has been ignored. Recent studies have found that the myodural bridge complex drives the flow of cerebrospinal fluid via this region, leading to the introduction of the occipito-atlantal cistern (OAC) for a better understanding of this subarachnoid space.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Critical Care Medicine
Mengliang Zhang, Hiroyuki Watanabe, Daniil Sarkisyan, Jonas Thelin, Jens Schouenborg, Georgy Bakalkin
JOURNAL OF NEUROTRAUMA
(2018)
Article
Clinical Neurology
Mengliang Zhang, Hiroyuki Watanabe, Daniil Sarkisyan, Marlene Storm Andersen, Olga Nosova, Vladimir Galatenko, Liliana Carvalho, Nikolay Lukoyanov, Jonas Thelin, Jens Schouenborg, Georgy Bakalkin
BRAIN COMMUNICATIONS
(2020)
Article
Clinical Neurology
Hiroyuki Watanabe, Olga Nosova, Daniil Sarkisyan, Marlene Storm Andersen, Mengliang Zhang, Linda Rorick-Kehn, Fredrik Clausen, Kinga Gawel, Jan Kehr, Mathias Hallberg, Jens Schouenborg, Niklas Marklund, Georgy Bakalkin
BRAIN COMMUNICATIONS
(2020)