期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 73, 期 1, 页码 72-80出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0000000000000028
关键词
beta-amyloid; Neuropathogenesis; Alzheimer disease; Argyrophilic grains; Autopsy; Cerebral amyloid angiopathy; Leuko-araiosis; Lewy bodies; PET imaging; Plaques; TDP-43; Vascular dementia; White matter
资金
- NIA NIH HHS [P30 AG019610, P30 AG19610] Funding Source: Medline
- NINDS NIH HHS [U24 NS072026] Funding Source: Medline
Neuropathologic heterogeneity is often present among Alzheimer disease (AD) patients. We sought to determine whether amyloid imaging measures of AD are affected by concurrent pathologies. Thirty-eight clinically and pathologically defined AD and 17 nondemented patients with quantitative florbetapir F-18 (18F-AV-45) positron emission tomography (PET) imaging during life and postmortem histological beta-amyloid quantification and neuropathologic examination were assessed. AD patients were divided on the basis of concurrent pathologies, including those with Lewy bodies (LBs) (n = 21), white matter rarefaction (n = 27), severe cerebral amyloid angiopathy (n = 11), argyrophilic grains (n = 5), and TAR DNA binding protein-43 inclusions (n = 18). Many patients exhibited more than 1 type of concurrent pathology. The ratio of cortical to cerebellar amyloid imaging signal (SUVr) and immunohistochemical beta-amyloid load were analyzed in 6 cortical regions of interest. All AD subgroups had strong and significant correlations between SUVr and histological beta-amyloid measures (p mu 0.001). All AD subgroups had significantly greater amyloid measures versus nondemented patients, and mean amyloid measures did not significantly differ between AD subgroups. When comparing AD cases with and without each pathology, AD cases with LBs had significantly lower SUVr measures versus AD cases without LBs (p = 0.002); there were no other paired comparison differences. These findings indicate that florbetapir-PET imaging is not confounded by neuropathological heterogeneity within AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据