Longitudinal Expression Analysis of αv Integrins in Human Gliomas Reveals Upregulation of Integrin αvβ3 as a Negative Prognostic Factor

A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)

(2012) L. Burt Nabors et al.   CANCER

Defining the Role of Integrin αvβ6 in Cancer

(2012) A. Bandyopadhyay et al.   CURRENT DRUG TARGETS

PDGF-B-mediated downregulation of miR-21: new insights into PDGF signaling in glioblastoma

(2012) Pedro M. Costa et al.   HUMAN MOLECULAR GENETICS

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Matched rabbit monoclonal antibodies against  v-series integrins reveal a novel  v 3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors

(2012) S. L. Goodman et al.   Biology Open

Confirmation of R132H mutation of isocitrate dehydrogenase 1 as an independent prognostic factor in anaplastic astrocytoma

(2011) Jens Schittenhelm et al.   ACTA NEUROPATHOLOGICA

Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by  8 Integrin

(2011) J. H. Tchaicha et al.   CANCER RESEARCH

The Role of Integrins in Glioma Biology and Anti-Glioma Therapies

(2011) Ghazaleh Tabatabai et al.   CURRENT PHARMACEUTICAL DESIGN

Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies

(2011) David A Reardon et al.   Future Oncology

Pro-apoptotic role of integrin β3 in glioma cells

(2011) Jong-Heon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Application of Mutant IDH1 Antibody to Differentiate Diffuse Glioma From Nonneoplastic Central Nervous System Lesions and Therapy-induced Changes

(2010) David Capper et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Important role of integrins in the cancer biology

(2010) R. Rathinam et al.   CANCER AND METASTASIS REVIEWS

Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study

(2010) Tobias Bäuerle et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma

(2010) Roger Stupp et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells

(2010) W. Yan et al.   NEURO-ONCOLOGY

A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis

(2010) J H Tchaicha et al.   ONCOGENE

MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8

(2010) L Fang et al.   ONCOGENE

Targeting integrins in malignant glioma

(2010) Ghazaleh Tabatabai et al.   Targeted Oncology

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrin signaling and lung cancer

(2010) Francesca Caccavari et al.   Cell Adhesion & Migration

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Reduced Expression of Integrin αvβ8 Is Associated with Brain Arteriovenous Malformation Pathogenesis

(2009) Hua Su et al.   AMERICAN JOURNAL OF PATHOLOGY

Specific Cross-talk between Epidermal Growth Factor Receptor and Integrin αvβ5 Promotes Carcinoma Cell Invasion and Metastasis

(2009) Jill M. Ricono et al.   CANCER RESEARCH

 v 3/ v 5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma

(2009) N. Skuli et al.   CANCER RESEARCH

Unsupervised Analysis of Transcriptomic Profiles Reveals Six Glioma Subtypes

(2009) A. Li et al.   CANCER RESEARCH

Automated Analysis and Detailed Quantification of Biomedical Images Using Definiens Cognition Network Technology®

(2009) Martin Baatz et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

 8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain

(2009) A. K. Mobley et al.   JOURNAL OF CELL SCIENCE

Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research

(2009) S. Madhavan et al.   MOLECULAR CANCER RESEARCH

Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro

(2009) Gabriele D. Maurer et al.   NEURO-ONCOLOGY

Imaging of integrin αvβ3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography

(2009) Oliver Schnell et al.   NEURO-ONCOLOGY

Expression of Integrin αvβ3in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature

(2008) Oliver Schnell et al.   BRAIN PATHOLOGY

αvβ3 integrin and angiogenesis: a moody integrin in a changing environment

(2008) Kairbaan Hodivala-Dilke   CURRENT OPINION IN CELL BIOLOGY

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency

(2008) Tom Mikkelsen et al.   INTERNATIONAL JOURNAL OF CANCER