Article
Physiology
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J. Homma, Shinji Yamaguchi
Summary: Serotonin is a neurotransmitter that plays an important role in regulating mental states and processing emotions in mammals. This study conducted a molecular dissection of serotonergic neurons in the brainstem of birds and found heterogeneity among these neurons. These findings contribute to a better understanding of the correspondence between bird and mammalian serotonergic neurons.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaume Lillo, Iu Raich, Laura Silva, David A. Zafra, Alejandro Lillo, Carlos Ferreiro-Vera, Veronica Sanchez de Medina, Jose Martinez-Orgado, Rafael Franco, Gemma Navarro
Summary: The study found that CBD acts on CB2-5HT(1A)-Hets and reduces the abnormal expression of the receptor-receptor complex under hypoxic and ischemic conditions, thereby exerting a therapeutic effect on neonatal hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Tyler C. Hillman, Ryan Idnani, Christopher G. Wilson
Summary: Understanding hypoxia/hyperoxia exposure requires precise control of gas concentrations. Current commercial chambers are expensive and limited in functionality. We developed a low-cost and customizable chamber controlled by open-source software, allowing for reproducible data acquisition and analysis for different exposure protocols.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ruth Mae McLeod, Ted S. Rosenkrantz, Roslyn Holly Fitch, Rachel R. Koski
Summary: Preterm infants are often given caffeine as a respiratory stimulant, but it has also been found to have neuroprotective potential. This study investigated the effects of caffeine on microglial activation in rodent brains after hypoxic ischemic injury. The results suggest that caffeine offers protective effects by reducing cell death, but the mechanism may be different between males and females.
Article
Biochemistry & Molecular Biology
Berenice Le Dieu-Lugon, Nicolas Dupre, Celine Derambure, Francois Janin, Bruno J. Gonzalez, Stephane Marret, Arnaud Arabo, Philippe Leroux
Summary: MgSO4 is widely used in preventing neurological disabilities in preterm infants, mainly by suppressing synaptogenesis and axonal development to reduce inflammation and innate immune responses. Additionally, MgSO4 affects neural development by inhibiting RNA polymerase II transcription and regulating mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Obstetrics & Gynecology
Mireille Guillot, Steven P. Miller
Summary: White matter injury is a common type of brain injury in preterm neonates, primarily caused by hypoxia-ischemia and inflammation. Predicting, imaging diagnosing, and understanding the pathophysiology of white matter injury are all crucial aspects of research.
SEMINARS IN PERINATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tayo Adeyemo, Ayodele Jaiyesimi, Jill G. Bumgardner, Charity Lohr, Aditi Banerjee, Mary C. McKenna, Jaylyn Waddell
Summary: Choline is a crucial nutrient for brain development and function. Early supplementation of choline can enhance neurite outgrowth, improve histological measures, and promote learning ability. However, it seems that choline does not benefit females and may exacerbate HI-induced changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Hatayama, Sydney Riddick, Fares Awa, Xiaodi Chen, Daniela Virgintino, Barbara S. Stonestreet
Summary: Exposure to hypoxic-ischemic insults in newborns can lead to severe neurological sequelae. This study investigated the changes in the neurovascular unit (NVU) after hypoxic-ischemic injury in neonatal rats. The findings showed increased vascular density, neurovascular remodeling, and changes in pericyte coverage and claudin-5 expression in different brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lorena Barata, Maria de Hoz-Rivera, Angela Romero, Maria Martinez, Laura Silva, Maria Villa, Leticia Campa, Laura Jimenez-Sanchez, Jose Martinez-Orgado
Summary: This study aimed to investigate the neuroprotective and behavioral effects of cannabidiol (CBD) on newborn piglets with hypoxic-ischemic (HI) brain injury, and to explore the role of serotonin 5-HT1A receptor (5HT(1A)R) in these effects. The results showed that CBD prevented mood disturbances induced by HI in piglets through the activation of 5HT(1A)R. However, 5HT(1A)R activation seems to be necessary for CBD neuroprotection only in the first hours after HI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Michael J. Stark, Tara M. Crawford, Nina M. Ziegler, Anthea Hall, Chad C. Andersen
Summary: Ibuprofen is preferred over indomethacin for treatment of PDA in preterm babies despite the lower risk of intraventricular haemorrhage associated with indomethacin. The different effects of each medication on cerebral oxygen kinetics may explain this difference, but the effect of ibuprofen on cerebral perfusion is uncertain.
FRONTIERS IN PEDIATRICS
(2022)
Article
Physiology
Elisa M. Fonseca, Carolina R. Noronha-de-Souza, Kenia C. Bicego, Luiz G. S. Branco, Luciane H. Gargaglioni
Summary: The study investigated the role of serotoninergic neurons in the medullary raphe of toads in respiratory control during hypercarbia and hypoxia, finding that these neurons play a role in chemoreflex responses to these conditions but not during rest. This evidence in anurans, along with data from mammals, provides insights into the evolution of brain sites involved in the ventilatory chemoreflex in vertebrates.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Neurosciences
Marissa C. Ciesla, Yasin B. Seven, Latoya L. Allen, Kristin N. Smith, Elisa J. Gonzalez-Rothi, Gordon S. Mitchell
Summary: This study found that daily AIH increased the area of serotonergic immunolabeling in the XII motor nuclei in rats, while CIH protocols did not have the same effect, indicating that different intermittent hypoxia protocols have differential effects on XII serotonergic innervation.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Behavioral Sciences
A. F. Macchione, V Trujillo, F. Anunziata, M. Sahonero, A. Anastasia, P. Abate, J. C. Molina
Summary: Early ethanol exposure alters neonatal breathing plasticity, affecting breathing rates and patterns of brain-stem nuclei. It induces breathing depressions under normoxia but an exacerbated hypoxic ventilatory response under hypoxia. These disruptions are associated with changes in neural activation and receptor expression in the brainstem.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Fusheng Gao, Xiaoxia Shen, Hongxi Zhang, Ruicheng Ba, Xiaolu Ma, Can Lai, Jiangyang Zhang, Yi Zhang, Dan Wu
Summary: The study investigates the clinical feasibility and value of t(d)-dependent diffusion MRI in neonatal hypoxic-ischemic encephalopathy (HIE). Results show that t(d)-dependent dMRI provides high sensitivity in detecting moderate-to-severe HIE and can offer more information on brain microstructure.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Liam M. Koehn, Kevin Nguyen, Xiaodi Chen, Andre Santoso, Richard Tucker, Yow-Pin Lim, Barbara S. Stonestreet
Summary: Targeting hypoxia-ischemia (HI)-related brain injury can effectively alleviate behavioral deficits and brain infarct volume in newborns, with no significant differences found in the efficacy of hIAIPs at different doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Julie A. Wixey, Kah Meng Lee, Stephanie M. Miller, Kate Goasdoue, Paul B. Colditz, S. Tracey Bjorkman, Kirat K. Chand
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Gastroenterology & Hepatology
Peter J. Lewindon, Mora Puertolas-Lopez, Louise E. Ramm, Charlton Noble, Tamara N. Pereira, Julie A. Wixey, Gunter F. Hartel, Diego A. Calvopina, Daniel H. Leung, Grant A. Ramm
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Developmental Biology
Kate Goasdoue, Kirat Kishore Chand, Stephanie Melita Miller, Kah Meng Lee, Paul Bernard Colditz, Julie Anne Wixey, Stella Tracey Bjorkman
DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Nursing
C. J. Andrews, D. Ellwood, P. F. Middleton, C. S. E. Homer, H. E. Reinebrant, N. Donnolley, F. M. Boyle, A. Gordon, M. Nicholl, J. Morris, G. Gardener, M. Davies-Tuck, E. M. Wallace, V. J. Flenady
Review
Public, Environmental & Occupational Health
Susannah Hopkins Leisher, Arin A. Balalian, Hanna Reinebrant, Stephanie Shiau, Vicki Flenady, Louise Kuhn, Stephen S. Morse
Summary: Studies have not provided enough evidence to determine whether there is a higher risk of foetal death in Zika-affected pregnancies, but suggest that the quality of reporting on foetal deaths needs improvement.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2021)
Review
Pediatrics
Elliot J. Teo, Lara E. Jones, Julie A. Wixey, Roslyn N. Boyd, Paul B. Colditz, S. Tracey Bjorkman
Summary: This study found that combined HTH-MSC therapy improves astrocyte optical density, but there is insufficient preclinical data to confirm its superiority over HTH alone. Further research is needed to establish the efficacy of HTH and MSCs on neuropathology and neurobehavior measures. Improved reporting standards using checklists such as SYRCLE or ARRIVE tools could enhance the quality of preclinical data in this area.
PEDIATRIC RESEARCH
(2022)
Editorial Material
Clinical Neurology
Bobbi Fleiss, Deidre M. Murray, S. Tracey Bjorkman, Julie A. Wixey
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Kirat K. Chand, Stephanie M. Miller, Gary J. Cowin, Lipsa Mohanty, Jany Pienaar, Paul B. Colditz, Stella Tracey Bjorkman, Julie A. Wixey
Summary: Inflammation plays a key role in the progression of brain impairment in FGR newborns, and ibuprofen may reduce NVU disruption and brain impairment in FGR piglets. Ibuprofen treatment decreases pro-inflammatory response, enhances astrocyte interaction with blood vessels, and restores NVU integrity, improving the FGR brain microenvironment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell & Tissue Engineering
Kirat K. Chand, Jatin Patel, S. T. Bjorkman, Seen-Ling Sim, Stephanie M. Miller, Elliot Teo, Lara Jones, Jane Sun, Paul B. Colditz, Kiarash Khosrotehrani, Julie A. Wixey
Summary: The study found that a dose of combined MSC-ECFC on the first day of life for FGR newborn piglets improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation, and improved adverse neuronal and white matter changes in the FGR newborn piglet brain. These effects were not observed with MSCs alone, indicating that cECFC treatment may act as a neuroprotectant for the FGR brain.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Developmental Biology
Kirat K. K. Chand, Kerstin Pannek, Paul B. B. Colditz, Julie A. A. Wixey
Summary: Fetal growth restriction (FGR) is associated with long-term neurodevelopmental disabilities, but the mechanisms are still unknown and there are no current therapies to protect the FGR newborn brain. Piglets, which naturally develop FGR, serve as an ideal animal model to study how perinatal insults affect brain structure and function without the need for surgical or chemical intervention. Findings from FGR piglet studies may provide critical information to develop neuroprotective interventions for newborn babies.
DEVELOPMENTAL NEUROSCIENCE
(2022)
Review
Pediatrics
Nathan J. Stevenson, Melissa M. Lai, Hava E. Starkman, Paul B. Colditz, Julie A. Wixey
Summary: This review explores the potential of electroencephalography (EEG) as a tool for assessing brain development in fetuses with growth restriction (FGR) or born small for gestational age (SGA). Findings suggest that FGR/SGA is associated with measurable changes in EEG immediately after birth and into childhood. Early manifestations in EEG include changes in spectral power, symmetry/synchrony, sleep-wake cycling, and continuity of EEG amplitude, while later manifestations include changes in spectral power, sleep architecture, and EEG amplitude. FGR/SGA infants also show poorer neurodevelopmental outcomes compared to those appropriate for gestational age (AGA). EEG has the potential to identify FGR/SGA infants and assess the functional correlates of neurological damage.
PEDIATRIC RESEARCH
(2022)
Review
Cell & Tissue Engineering
Kirat Chand, Rachel Nano, Julie Wixey, Jatin Patel
Summary: This review discusses the potential application of stem cell therapy for FGR newborns. FGR newborns suffer from chronic inflammation and vascular disruption, and stem cell therapy may serve as an effective intervention for treating their neurological impairments and long-term disabilities.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Developmental Biology
Hannah Musco, Kate Beecher, Kirat K. Chand, Paul B. Colditz, Julie A. Wixey
Summary: Fetal growth restriction (FGR) and small for gestational age (SGA) infants have increased risk of mortality and morbidity. Blood biomarkers may be a promising tool for early detection of brain injury risk in FGR and SGA neonates.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Cell Biology
Hanna E. Reinebrant, Julie A. Wixey, Kathryn M. Buller
NEURAL REGENERATION RESEARCH
(2020)
