Review
Clinical Neurology
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueno, Jaime Ferrer-Lozano, Lucia Forero, Yolanda Higueras, Nieves Tellez Lara, Angela Vidal-Jordana, Francisco Carlos Perez-Miralles
Summary: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system triggered by unknown environmental factors in patients with genetic risk profiles. Prevention of neurological disability is essential, but mechanisms driving disease progression remain unknown. Lack of markers for early detection and varying definitions of disability progression complicate assessment in clinical practice.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Luca Prosperini, Matteo Lucchini, Serena Ruggieri, Carla Tortorella, Shalom Haggiag, Massimiliano Mirabella, Carlo Pozzilli, Claudio Gasperini
Summary: This study shows a trend of older age at onset for multiple sclerosis (MS) and a decrease in the interval between onset and diagnosis. Additionally, among patients aged 40 and above, there is a higher female-to-male ratio, more frequent spinal cord onset, and less frequent supratentorial onset.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Jack P. Antel, Timothy E. Kennedy, Tanja Kuhlmann
Summary: In this study, the authors investigate the potential of targeting the neuron-oligodendrocyte potassium shuttling as a neuroprotective strategy in multiple sclerosis. They examine disease models, evaluate the impact of pharmacologic intervention, and assess the status in tissues from MS patients. These findings serve as a template for defining a potential protective pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Maria Cellerino, Giacomo Boffa, Caterina Lapucci, Francesco Tazza, Elvira Sbragia, Elisabetta Mancuso, Nicolo Bruschi, Simona Minguzzi, Federico Ivaldi, Ilaria Poire, Alice Laroni, Gianluigi Mancardi, Elisabetta Capello, Antonio Uccelli, Giovanni Novi, Matilde Inglese
Summary: The study found that ocrelizumab is an effective and safe treatment for patients with RRMS and PMS, with better outcomes observed in treatment-naive patients and those with lower baseline disability levels. Depletion of CD8 + cells may be a key factor in the early therapeutic effects of ocrelizumab.
Article
Clinical Neurology
Sam Harding-Forrester, Izanne Roos, Ai-Lan Nguyen, Charles B. Malpas, Ibrahima Diouf, Nahid Moradi, Sifat Sharmin, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Dana Horakova, Eva Kubala Havrdova, Alexandre Prat, Marc Girard, Pierre Duquette, Francois Grand Maison, Marco Onofrj, Alessandra Lugaresi, Pierre Grammond, Serkan Ozakbas, Maria Pia Amato, Oliver Gerlach, Patrizia Sola, Diana Ferraro, Katherine Buzzard, Olga Skibina, Jeannette Lechner-Scott, Raed Alroughani, Cavit Boz, Vincent Van Pesch, Elisabetta Cartechini, Murat Terzi, Davide Maimone, Cristina Ramo-Tello, Bassem Yamout, Samia Joseph Khoury, Daniele La Spitaleri, Maria Jose Sa, Yolanda Blanco, Franco Granella, Mark Slee, Ernest Butler, Youssef Sidhom, Riadh Gouider, Roberto Bergamaschi, Rana Karabudak, Radek Ampapa, Jose Luis Sanchez-Menoyo, Julie Prevost, Tamara Castillo-Trivino, Pamela A. McCombe, Richard Macdonell, Guy Laureys, Liesbeth Van Hijfte, Jiwon Oh, Ayse Altintas, Koen de Gans, Recai Turkoglu, Anneke van der Walt, Helmut Butzkueven, Steve Vucic, Michael Barnett, Edgardo Cristiano, Suzanne Hodgkinson, Gerardo Iuliano, Ludwig Kappos, Jens Kuhle, Vahid Shaygannejad, Aysun Soysal, Bianca Weinstock-Guttman, Bart Van Wijmeersch, Tomas Kalincik
Summary: This study compared primary and secondary progressive multiple sclerosis (PPMS, SPMS), and found that SPMS has later onset of the progressive phase and slower disability accrual, but higher baseline disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Monica Guglielmetti, Wahidah H. Al-Qahtani, Cinzia Ferraris, Giuseppe Grosso, Simona Fiorini, Eleonora Tavazzi, Giacomo Greco, Alessandro La Malfa, Roberto Bergamaschi, Anna Tagliabue
Summary: Based on the available data, it is suggested that a balanced diet and healthy lifestyle may improve clinical parameters and quality of life for patients with multiple sclerosis (MS). This study aimed to investigate the relationship between dietary adherence to the Mediterranean Diet (MedDiet) and MS severity in Italian patients. The results showed that higher adherence to the MedDiet was associated with a higher probability of having a mild-to-moderate MS.
Article
Clinical Neurology
Ibrahima Diouf, Charles B. Malpas, Sifat Sharmin, Izanne Roos, Dana Horakova, Eva Kubala Havrdova, Francesco Patti, Vahid Shaygannejad, Serkan Ozakbas, Sara Eichau, Marco Onofrj, Alessandra Lugaresi, Raed Alroughani, Alexandre Prat, Pierre Duquette, Murat Terzi, Cavit Boz, Francois Grand'Maison, Patrizia Sola, Diana Ferraro, Pierre Grammond, Bassem Yamout, Ayse Altintas, Oliver Gerlach, Jeannette Lechner-Scott, Roberto Bergamaschi, Rana Karabudak, Gerardo Iuliano, Christopher McGuigan, Elisabetta Cartechini, Stella Hughes, Maria Jose Sa, Claudio Solaro, Ludwig Kappos, Suzanne Hodgkinson, Mark Slee, Franco Granella, Koen de Gans, Pamela A. McCombe, Radek Ampapa, Anneke van der Walt, Helmut Butzkueven, Jose Luis Sanchez-Menoyo, Steve Vucic, Guy Laureys, Youssef Sidhom, Riadh Gouider, Tamara Castillo-Trivino, Orla Gray, Eduardo Aguera-Morales, Abdullah Al-Asmi, Cameron Shaw, Talal M. Al-Harbi, Tunde Csepany, Angel P. Sempere, Irene Trevino Frenk, Elizabeth A. Stuart, Tomas Kalincik
Summary: This study compared the effectiveness of six commonly used therapies for relapsing-remitting multiple sclerosis (RRMS) over a 5-year period. The results showed that natalizumab, fingolimod, and dimethyl fumarate were more effective in reducing relapses than glatiramer acetate. Natalizumab also showed superior effects in reducing disability worsening and improving disability compared to other interventions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Brit Ellen Rod, Oivind Torkildsen, Kjell-Morten Myhr, Lars Bo, Stig Wergeland
Summary: Our study found minimal transfer of rituximab into breast milk in nursing mothers, and the levels of rituximab in infant serum were difficult to detect. The B cell counts in infants were unaffected.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, with up to 50% of patients experiencing depressive disorders. Major depression (MD) is a serious comorbidity of MS, potentially involving various dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jaume Sastre-Garriga, Alex Rovira, Aran Garcia-Vidal, Pere Carbonell-Mirabent, Manel Alberich, Angela Vidal-Jordana, Cristina Auger, Mar Tintore, Xavier Montalban, Deborah Pareto
Summary: This study aimed to test the existence of spinal cord (SC) reserve by using spinal canal area (SCaA) as a proxy. The results showed that a larger SCaA was significantly associated with lower scores on Patient Determined Disease Steps in multiple sclerosis (MS) patients, possibly supporting the existence of SC reserve.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Winston Dzau, Sifat Sharmin, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Serkan Ozakbas, Oliver Gerlach, Cavit Boz, Pierre Grammond, Murat Terzi, Maria Pia Amato, Daniele La Spitaleri, Cristina Ramo-Tello, Davide Maimone, Elisabetta Cartechini, Katherine Buzzard, Olga Skibina, Anneke van der Walt, Helmut Butzkueven, Gerardo Iuliano, Aysun Soysal, Tomas Kalincik
Summary: This study investigated the association between early progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) with the onset and disability accumulation of secondary progressive multiple sclerosis (SPMS). It found that early PIRA and RAW were associated with increased risk of SPMS, but not with the rate of disability progression during SPMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Oana Aurelia Vladacenco, Eugenia Roza, Radu-Stefan Perjoc, Daniel Mihai Teleanu
Summary: Multiple sclerosis (MS) is a chronic immune-mediated neurodegenerative disease of the central nervous system, which usually begins around the age of 20-30. However, in recent years, MS has been increasingly recognized among children, with distinct characteristics compared to adult-onset disease. The etiology and mechanisms of the disease are not well understood, leading to uncertain efficacy and safety of MS treatment options in pediatric patients. This review aims to provide insight into the progress in therapeutic strategies for children and adolescents with MS, discussing etiology, risk factors, comorbidities, diagnosis possibilities, treatment strategies, clinical trials, and emerging alternatives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Gavin Giovannoni, Veronica Popescu, Jens Wuerfel, Kerstin Hellwig, Ellen Iacobeus, Michael B. Jensen, Jose Manuel Garcia-Dominguez, Livia Sousa, Nicola De Rossi, Raymond Hupperts, Giuseppe Fenu, Benedetta Bodini, Hanna-Maija Kuusisto, Bruno Stankoff, Jan Lycke, Laura Airas, Cristina Granziera, Antonio Scalfari
Summary: This article challenges the view that multiple sclerosis is purely an inflammatory disease and proposes a more comprehensive pathological process. It also emphasizes the importance of considering systemic disease processes in the management of multiple sclerosis.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Clinical Neurology
Axel Petzold, Sharon Y. L. Chua, Anthony P. Khawaja, Pearse A. Keane, Peng T. Khaw, Charles Reisman, Baljean Dhillon, Nicholas G. Strouthidis, Paul J. Foster, Praveen J. Patel
Summary: The study tested the feasibility of using retinal optical coherence tomography (OCT) measures of retinal asymmetry as a diagnostic test for multiple sclerosis at the community level. The results showed that the inter-eye difference of inner retinal OCT data has potential diagnostic value for multiple sclerosis. The discriminatory power of diagnosing multiple sclerosis using these measures was higher compared to other methods and may be considered as supportive measurements for diagnostic criteria.
Article
Clinical Neurology
Isabel Lutfullin, Maria Eveslage, Stefan Bittner, Gisela Antony, Martina Flaskamp, Felix Luessi, Anke Salmen, Barbara Gisevius, Luisa Klotz, Catharina Korsukewitz, Achim Berthele, Sergiu Groppa, Florian Then Bergh, Brigitte Wildemann, Antonios Bayas, Hayrettin Tumani, Sven G. Meuth, Corinna Trebst, Uwe K. Zettl, Friedemann Paul, Christoph Heesen, Tania Kuempfel, Ralf Gold, Bernhard Hemmer, Frauke Zipp, Heinz Wiendl, Jan D. Luenemann
Summary: Obesity is associated with higher disease severity and poorer outcome in newly diagnosed patients with multiple sclerosis. The presence of obesity at disease onset is linked to higher disability at baseline and at follow-up periods of 2, 4, and 6 years. Obesity management could potentially improve the clinical outcome of multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Letter
Clinical Neurology
Stefania Kaninia, Anthony J. Edey, Nick A. Maskell, Claire M. Rice
JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Rheumatology
Jonathan Cleaver, Hamish Morrison, Shelley A. Renowden, Denize Atan, Mark Cossburn, Claire M. Rice
Article
Clinical Neurology
Pamela Sarkar, Juliana Redondo, Kelly Hares, Steven Bailey, Anastasia Georgievskaya, Kate Heesom, Kevin C. Kemp, Neil J. Scolding, Claire M. Rice
Summary: The study compared the secretome of MSC from control subjects and people with MS, showing that MSC from progressive MS have lower levels of mitochondrial fumarate hydratase. Exogenous mFH restored the neuroprotective potential of MS-MSC in vitro. Additionally, MS-MSC had reduced levels of fumarate hydratase with downstream effects on oxidative stress regulation.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Urology & Nephrology
Nadine A. M. van Merode, Shoba Dawson, Elizabeth Coulthard, Emily J. Henderson, Claire M. Rice, Jonathan Rees, Matthew Smith, Edward Strong, Nikki Cotterill, Alyson L. Huntley, Marcus J. Drake
Summary: This study conducted a systematic review of nocturia in neurological diseases and achieved expert consensus for management in clinics without neurologist input. The study found that there is a lack of robust evidence in this field and the need for guidance in the primary care context.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Multidisciplinary Sciences
Bhagteshwar Singh, Suzannah Lant, Sofia Cividini, Jonathan W. S. Cattrall, Lynsey C. Goodwin, Laura Benjamin, Benedict D. Michael, Ayaz Khawaja, Aline de Moura Brasil Matos, Walid Alkeridy, Andrea Pilotto, Durjoy Lahiri, Rebecca Rawlinson, Sithembinkosi Mhlanga, Evelyn C. Lopez, Brendan F. Sargent, Anushri Somasundaran, Arina Tamborska, Glynn Webb, Komal Younas, Yaqub Al Sami, Heavenna Babu, Tristan Banks, Francesco Cavallieri, Matthew Cohen, Emma Davies, Shalley Dhar, Anna Fajardo Modol, Hamzah Farooq, Jeffrey Harte, Samuel Hey, Albert Joseph, Dileep Karthikappallil, Daniel Kassahun, Gareth Lipunga, Rachel Mason, Thomas Minton, Gabrielle Mond, Joseph Poxon, Sophie Rabas, Germander Soothill, Marialuisa Zedde, Konstantin Yenkoyan, Bruce Brew, Erika Contini, Lucette Cysique, Xin Zhang, Pietro Maggi, Vincent van Pesch, Jerome Lechien, Sven Saussez, Alex Heyse, Maria Lucia Brito Ferreira, Cristiane N. Soares, Isabel Elicer, Laura Eugenin-von Bernhardi, Waleng Nancupil Reyes, Rong Yin, Mohammed A. Azab, Foad Abd-Allah, Ahmed Elkady, Simon Escalard, Jean-Christophe Corvol, Cecile Delorme, Pierre Tattevin, Kevin Bigaut, Norbert Lorenz, Daniel Hornuss, Jonas Hosp, Siegbert Rieg, Dirk Wagner, Benjamin Knier, Paul Lingor, Andrea Sylvia Winkler, Athena Sharifi-Razavi, Shima T. Moein, SeyedAhmad SeyedAlinaghi, Saeidreza JamaliMoghadamSiahkali, Mauro Morassi, Alessandro Padovani, Marcello Giunta, Ilenia Libri, Simone Beretta, Sabrina Ravaglia, Matteo Foschi, Paolo Calabresi, Guido Primiano, Serenella Servidei, Nicola Biagio Mercuri, Claudio Liguori, Mariangela Pierantozzi, Loredana Sarmati, Federica Boso, Silvia Garazzino, Sara Mariotto, Kimani N. Patrick, Oana Costache, Alexander Pincherle, Frederikus A. Klok, Roger Meza, Veronica Cabreira, Sofia R. Valdoleiros, Vanessa Oliveira, Igor Kaimovsky, Alla Guekht, Jasmine Koh, Eva Fernandez Diaz, Jose Maria Barrios-Lopez, Cristina Guijarro-Castro, Alvaro Beltran-Corbellini, Javier Martinez-Poles, Alba Maria Diezma-Martin, Maria Isabel Morales-Casado, Sergio Garcia Garcia, Gautier Breville, Matteo Coen, Marjolaine Uginet, Raphael Bernard-Valnet, Renaud Du Pasquier, Yildiz Kaya, Loay H. Abdelnour, Claire Rice, Hamish Morrison, Sylviane Defres, Saif Huda, Noelle Enright, Jane Hassell, Lucio D'Anna, Matthew Benger, Laszlo Sztriha, Eamon Raith, Krishna Chinthapalli, Ross Nortley, Ross Paterson, Arvind Chandratheva, David J. Werring, Samir Dervisevic, Kirsty Harkness, Ashwin Pinto, Dinesh Jillella, Scott Beach, Kulothungan Gunasekaran, Ivan Rocha Ferreira Da Silva, Krishna Nalleballe, Jonathan Santoro, Tyler Scullen, Lora Kahn, Carla Y. Kim, Kiran T. Thakur, Rajan Jain, Thirugnanam Umapathi, Timothy R. Nicholson, James J. Sejvar, Eva Maria Hodel, Catrin Tudur Smith, Tom Solomon
Summary: This study investigated the spectrum of neurological disease in hospitalized COVID-19 patients and analyzed the clinical outcomes and factors associated with poor outcomes. The study found that encephalopathy and cerebrovascular events were the most common diagnoses, with cerebrovascular event patients more likely to have poor outcomes. Specific risk factors for poor outcomes included breathlessness on admission and elevated D-dimer. Overall, neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources.
Article
Clinical Neurology
Claire M. Rice, Pamela Sarkar, Peter Walsh, Denise Owen, Clare Bidgood, Paul Smith, Nick M. Kane, Suhail Asghar, David I. Marks, Neil J. Scolding
Summary: This study demonstrates the safety and feasibility of repeated non-myeloablative autologous bone marrow-derived cell therapy in patients with progressive multiple sclerosis.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Editorial Material
Clinical Neurology
N. J. Scolding
PRACTICAL NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Thomas Minton, Kelly Hares, Kevin Kemp, Neil Scolding, Claire Rice
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Kevin C. Kemp, Anastasia Georgievskaya, Kelly Hares, Juliana Redondo, Steven Bailey, Claire M. Rice, Neil J. Scolding, Chris Metcalfe, Alastair Wilkins
Summary: This pilot study investigates the potential therapeutic effects of recombinant granulocyte-colony stimulating factor (G-CSF) administration in patients with Friedreich's ataxia (FA). The findings demonstrate that G-CSF treatment is safe in FA patients, and it leads to mobilization of hematopoietic stem cells (HSCs) comparable to that of healthy individuals. Moreover, G-CSF administration results in sustained increases in cellular frataxin concentrations and elevated expression of PGC-1 alpha and Nrf2, indicating its potential clinical impact in FA patients.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Gavin Brittain, Alasdair J. Coles, G. Giovannoni, Paolo Antonio Muraro, Jacqueline Palace, Jennifer Petrie, Elisa Roldan, N. J. Scolding, John A. Snowden, Basil Sharrack
Summary: In carefully selected patients, autologous HSCT is a safe and highly effective treatment for immune-mediated neurological disorders. Limited understanding has caused confusion, mistrust, and an increase in health tourism.
PRACTICAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Evangelia A. Fragkiadaki, Nikki E. Cotterill, Claire Rice, Jonathan Smith, Isabella Nizza
Summary: Multiple Sclerosis (MS) has diverse and complex symptoms that significantly impact patients' quality of life and relationships. Psychological interventions have shown moderate effects on various aspects of MS, but most current interventions are not tailored to the complexity and unpredictability of the disease.
Article
Clinical Neurology
Rosario Pascarella, Katherina Antonenko, Gregoire Boulouis, Hubert De Boysson, Caterina Giannini, Mirjam R. Heldner, Odysseas Kargiotis, Thanh N. Nguyen, Claire M. Rice, Carlo Salvarani, Antje Schmidt-Pogoda, Daniel Strbian, Salman Hussain, Marialuisa Zedde
Summary: The European Stroke Organisation (ESO) has developed guidelines on Primary Angiitis of the Central Nervous System (PACNS) using standard operating procedures and GRADE methodology. The guidelines provide recommendations for diagnosis and treatment, but the quality of evidence is generally low, resulting in ongoing uncertainty. The guidelines emphasize the limitations of current diagnostic criteria and suggest a multidisciplinary team approach in expert centers for managing PACNS.
EUROPEAN STROKE JOURNAL
(2023)
Review
Cell & Tissue Engineering
Juliana Redondo, Steven Bailey, Kevin C. Kemp, Neil J. Scolding, Claire M. Rice
Summary: This article reviews the role of the bone marrow microenvironment in immune-mediated inflammatory diseases (IMIDs), with a focus on MSCs. It predicts that further research on the bone marrow microenvironment will provide new insights into pathophysiology and aid in the identification of new drug targets and optimization of cell-based therapy in IMIDs.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Sam Olum, Charlotte Scolding, Venice Omona, Kansiime Jackson, Neil Scolding
Summary: Acute Flaccid Myelitis is a paralytic disease that mainly affects children and has similarities to poliomyelitis. It is an emerging, global, infectious neurological disease that has been rapidly spreading to different regions. However, it has been poorly studied in low- and middle-income countries due to a lack of research and neurological care services in these areas.
BRAIN COMMUNICATIONS
(2023)
