Article
Clinical Neurology
Giorgi Kuchukhidze, Iris Unterberger, Elisabeth Schmid, Laura Zamarian, Christian Michael Siedentopf, Florian Koppelstaetter, Elke Gizewski, Martin Kronbichler, Gerhard Luef, Hennric Jokeit, Eugen Trinka
Summary: In this study, we found that unilateral mesial TLE and ipsilateral AE could lead to dysfunction in emotion recognition. Patients with right-side mTLE had more impaired perception and recognition of emotions compared to those with left-side mTLE. Patients also showed deficits in emotion recognition compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Kamalesh Chakravarty, Sucharita Ray, Parampreet S. Kharbanda, Vivek Lal, Jitupam Baishya
Summary: Temporal lobe epilepsy with enlargement of the amygdala is a distinct clinical entity with contrasting clinical features compared to TLE with hippocampal sclerosis. Patients with AE tend to have an older age of onset, less febrile seizures, and similar aura and automatism types as TLE with HS but with lower prevalence.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Mani Ratnesh S. Sandhu, Mauricio Mandel, Hari McGrath, Layton Lamsam, Pue Farooque, Richard A. Bronen, Dennis D. Spencer, Eyiyemisi C. Damisah
Summary: This study investigated temporal lobe encephaloceles (TLENs) and found that they are one of the causes of medically refractory epilepsy. The study results showed a close relationship between intracranial electrophysiology and imaging findings with TLEN, and surgical resection had good outcomes. After surgery, patients did not exhibit significant neuropsychological deficits.
JOURNAL OF NEUROSURGERY
(2022)
Article
Genetics & Heredity
Yishu Wang, Jing Peng, Shuwei Bai, Haojun Yu, Hong He, Chunxiang Fan, Yong Hao, Yangtai Guan
Summary: Temporal lobe epilepsy (TLE), the most common form of refractory epilepsy in adults, may require surgery to alleviate seizures. Research suggests that a mutation in the PIK3R2 gene may play a significant role in the development of TLE.
FRONTIERS IN GENETICS
(2021)
Article
Clinical Neurology
Zhen Fan, Bing Sun, Li-qin Lang, Jie Hu, N. U. Farrukh Hameed, Zi-xuan Wei, Qi-yuan Zhuang, Jia-jun Cai, Feng-tao Liu, Yi-ting Mao, Rui Feng, Li Pan
Summary: In this study, the role of amygdala enlargement in TLE without ipsilateral mesial temporal sclerosis was explored using various presurgical workup tools. The results showed that resective surgeries encompassing the amygdala led to favorable outcomes, with HD-ESI providing accurate estimates of the epileptogenic focus.
NEUROLOGICAL SCIENCES
(2021)
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Article
Medicine, General & Internal
Pablo Cabezudo-Garcia, Nicolas L. Ciano-Petersen, Natalia Mena-Vazquez, Jesus Ortega-Pinazo, Maria J. Postigo-Pozo, Guillermina Garcia-Martin, Helena Antoli-Martinez, Violeta Sanchez-Sanchez, Pablo Quiroga-Subirana, Pedro J. Serrano-Castro, Guillermo Estivill-Torrus
Summary: The study revealed a high prevalence of neural autoantibodies in adult patients with drug-resistant temporal lobe epilepsy of unknown etiology, indicating a possible autoimmune mechanism. The presence of bitemporal, independent, interictal epileptiform discharges and a history of status epilepticus may serve as markers for autoimmune-associated epilepsy in drug-resistant temporal lobe epilepsy of unknown etiology. Further validation of the proposed ARTE score in larger independent cohorts is warranted.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Arthur Cukiert, Cristine Mella Cukiert, Jose Augusto Burattini, Pedro Paulo Mariani
Summary: The study investigated the outcomes of hippocampal deep brain stimulation (Hip-DBS) in patients with refractory temporal lobe epilepsy. The findings showed that Hip-DBS significantly reduced seizure frequency in patients with both focal aware and focal with impaired awareness seizures, suggesting it as a promising therapeutic option for patients who are not suitable for resective surgery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Zhang, Kai Xu, Haiyan Zhang, Jingyun Sha, Hongyu Yang, Houliang Zhao, Nan Chen, Kuncheng Li
Summary: This study investigated the recovery of the glymphatic system (GS) function in patients with temporal lobe epilepsy (TLE) after anterior temporal lobectomy (ATL) using diffusion tensor image analysis. The results revealed a significant decrease in GS function before surgery in TLE patients compared to healthy controls, but a significant increase after successful ATL. Furthermore, the GS index was significantly correlated with disease duration.
EUROPEAN RADIOLOGY
(2023)
Article
Behavioral Sciences
Ayako Motoki, Naoki Akamatsu, Tomoyuki Fumuro, Ayako Miyoshi, Hideaki Tanaka, Koichi Hagiwara, Shinji Ohara, Takashi Kamada, Hiroshi Shigeto, Hiroyuki Murai
Summary: Patients with temporal lobe epilepsy exhibit significant olfactory dysfunction, especially in those with bilateral seizure foci and older age of onset. Temporal lobectomy for hippocampal sclerosis does not lead to significant decline in olfactory function after long-term recovery.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Leonardo Favi Bocca, Thiago Pereira Rodrigues, Thiago Bortholin, Elza Marcia Targas Yacubian, Henrique Carrete Jr, Mirian Guaranha, Ricardo Silva Centeno
Summary: Sotos syndrome is a genetic disorder caused by NSD1 gene haploinsufficiency, with some patients experiencing epilepsy, including drug-resistant seizures. A 47-year-old female patient with Sotos syndrome had focal-onset seizures in the left temporal lobe, left-side hippocampal atrophy, and cognitive impairment. After undergoing left-side temporal lobe resection, the patient achieved complete awake seizure control and significant improvement in quality-of-life during the 3-year follow-up. Resective surgeries may be beneficial for improving seizure control and quality of life in selected patients with Sotos syndrome.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
John M. Stern, Norman M. Spivak, Sergio A. Becerra, Taylor P. Kuhn, Alexander S. Korb, David Kronemyer, Negar Khanlou, Samuel D. Reyes, Martin M. Monti, Caroline Schnakers, Patricia Walshaw, Inna Keselman, Mark S. Cohen, William Yong, Itzhak Fried, Sheldon E. Jordan, Mark E. Schafer, Jerome Engel Jr., Alexander Bystritsky
Summary: The study examined the safety and efficacy of Transcranial Focused Ultrasound (tFUS) neuromodulation in patients with refractory temporal lobe epilepsy undergoing surgery. Results showed that tFUS at intensities up to 5760 mW/cm(2) may be safe, with no detectable tissue damage and minimal changes in neuropsychological testing. Further research is needed due to methodological limitations and inconclusive findings.
Article
Endocrinology & Metabolism
Rick H. G. J. van Lanen, Roel H. L. Haeren, Julie Staals, Jim T. A. Dings, Olaf E. M. G. Schijns, Govert Hoogland, Sander M. J. van Kuijk, Dimitris Kapsokalyvas, Marc A. M. J. van Zandvoort, Hans Vink, Kim Rijkers
Summary: This study investigated the association between blood-brain barrier dysfunction, microvascular alterations and temporal lobe epilepsy. The results showed impaired neurovascular coupling mechanisms and reduced glycocalyx integrity in patients with drug-resistant TLE. These findings may provide new therapeutic targets for drug-resistant epilepsy.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Medicine, General & Internal
Song Lu, Min Chu, Xian Wang, Yating Wu, Yue Hou, Aihua Liu
Summary: This study evaluated changes in cognitive function, mood status, and quality of life in patients who underwent anterior temporal lobectomy. The results showed that the surgery significantly reduced epileptiform discharges, improved anxiety and depression symptoms, and enhanced quality of life without causing significant changes in cognitive function.
CHINESE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Kazuki Fukuma, Katsufumi Kajimoto, Tomotaka Tanaka, Shigetoshi Takaya, Katsuya Kobayashi, Akihiro Shimotake, Riki Matsumoto, Akio Ikeda, Kazunori Toyoda, Masafumi Ihara
Summary: The study found that the majority of post-stroke epilepsy patients exhibited perfusion abnormalities on subtraction SPECT, which showed high concordance with the location of stroke lesions, seizure symptoms, and EEG findings. Postictal SPECT can serve as a complementary tool to scalp EEG in diagnosing and localizing post-stroke epilepsy.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Krishna Pandu Wicaksono, Yasutaka Fushimi, Satoshi Nakajima, Yusuke Yokota, Sonoko Oshima, Sayo Otani, Azusa Sakurama, Atsushi Shima, Nobukatsu Sawamoto, Tomohisa Okada, Yuji Nakamoto
Summary: This study evaluated the performance of fast 3D-EPI QSM technique in terms of accuracy, reliability, and CMB detection. Results from phantom study and healthy volunteer study showed excellent reliability and accuracy of 3D-EPI QSM, as well as good CMB detection performance compared to GRE QSM.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Clinical Neurology
Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Satoshi Nakajima, Yusuke Yokota, Atsushi Shima, John Grinstead, Sinyeob Ahn, Nobukatsu Sawamoto, Ryosuke Takahashi, Yuji Nakamoto
Summary: The study assessed a new MRI imaging technique that can visualize neuromelanin in the substantia nigra with high resolution in a short scan time, showing potential for evaluating Parkinson's disease.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
J. Helen Cross, Churl-Su Kwon, Ali Akbar Asadi-Pooya, Ganna Balagura, Patricia Gomez-Iglesias, Alla Guekht, Julie Hall, Akio Ikeda, Nirmeen A. Kishk, Peter Murphy, Najib Kissani, Yahya Naji, Emilio Perucca, Juan Carlos Perez-Poveda, Emmanuel O. Sanya, Eugen Trinka, Dong Zhou, Samuel Wiebe, Nathalie Jette
Summary: The International League Against Epilepsy (ILAE) investigated the impact of the COVID-19 pandemic on patients with epilepsy (PWE), caregivers, and healthcare professionals, revealing increased seizure frequency among some PWE and caregivers, as well as difficulties in accessing medication and healthcare professionals. Healthcare professionals reported a rise in telemedicine use, with 40% of consultations conducted through this method, although barriers to care were identified.
Review
Clinical Neurology
Mark Hallett, Lourdes M. DelRosso, Rodger Elble, Raffaele Ferri, Fay B. Horak, Stephan Lehericy, Martina Mancini, Masao Matsuhashi, Riki Matsumoto, Muthuraman Muthuraman, Jan Raethjen, Hiroshi Shibasaki
Summary: Clinical neurophysiology studies play a crucial role in understanding the physiology of human movement and the pathophysiology and diagnosis of various movement disorders, utilizing a range of methods and techniques such as EMG, EEG, MEG, etc.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomohisa Okada, Shinya Handa, Bill Ding, Shin-ichi Urayama, Koji Fujimoto, Atsushi Shima, Daisuke Yoshii, Takashi Ayaki, Nobukatsu Sawamoto, Ryosuke Takahashi, Hirotaka Onoe, Tadashi Isa, Labros Petropoulos
Summary: The study aimed to demonstrate the capability of insertable inductively coupled volumetric coils in a human 7T MR system for MR microscopy. Results showed that the insertable coils provided high SNR and modest parallel imaging capability, successfully visualizing fine structures of brain specimens. These coils are easy to handle and enable MR microscopy in a human whole-body 7T MRI system.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryosuke Takahashi, Nobukatsu Sawamoto
Summary: This study investigates the correlation between motor impairments and striatal dopaminergic terminal degeneration and nigral neuromelanin-laden dopamine neuron loss in different stages of Parkinson's disease. The findings suggest that striatal dopaminergic terminal loss is a biomarker for early stage motor impairments, while nigral dopamine neuron loss is a biomarker for advanced stage motor impairments.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Hiroaki Sekiya, Shunsuke Koga, Yoshihisa Otsuka, Norio Chihara, Takehiro Ueda, Kenji Sekiguchi, Yukihiro Yoneda, Yasufumi Kageyama, Riki Matsumoto, Dennis W. Dickson
Summary: This study compared the clinical characteristics and outcomes between later onset MSA (LO-MSA) and usual onset MSA (UO-MSA), finding that LO-MSA patients had shorter survival time. The results suggest that MSA should be considered as a differential diagnosis in elderly patients with autonomic symptoms and movement disorders.
JOURNAL OF NEUROLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tomohisa Okada, Koji Fujimoto, Yasutaka Fushimi, Thai Akasaka, Dinh H. D. Thuy, Atsushi Shima, Nobukatsu Sawamoto, Naoya Oishi, Zhilin Zhang, Takeshi Funaki, Yuji Nakamoto, Toshiya Murai, Susumu Miyamoto, Ryosuke Takahashi, Tadashi Isa
Summary: Neuroimaging using the 7-Tesla human magnetic resonance system has gained popularity for its high signal-to-noise and contrast-to-noise ratios, providing high-resolution acquisitions and better contrast for detecting brain disorders. It allows for the measurement of a greater number of neurochemicals and visualization of small structures that are difficult to observe at lower magnetic field strengths.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Clinical Neurology
Shusuke Koto, Norio Chihara, Ritsu Akatani, Hiroko Nakano, Atsushi Hara, Kenji Sekiguchi, Riki Matsumoto, Tatsushi Toda
Summary: This study uncovered a favorable role of PD-1(+)CD8(+) T cells against multiple sclerosis and demonstrated that c-Maf-driven IL-10 is an immune regulatory machinery.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Genetics & Heredity
Kento Matoba, Norio Chihara, Wataru Satake, Hideki Tokuoka, Yoshihisa Otsuka, Takehiro Ueda, Kenji Sekiguchi, Masayuki Itoh, Riki Matsumoto
Summary: This study describes two long-surviving siblings with a mild phenotype of Joubert syndrome (JBTS) who carry a novel compound heterozygous missense variant in the CPLANE1 gene. The findings confirm the role of the CPLANE1 gene in JBTS and provide an opportunity for neurologists to recognize JBTS as a differential diagnosis for chronic progressive ataxia, especially in an aging society.
NEUROLOGY-GENETICS
(2022)
Article
Neurosciences
Kiyohide Usami, Riki Matsumoto, Anna Korzeniewska, Akihiro Shimotake, Masao Matsuhashi, Takuro Nakae, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Nathan E. Crone, Akio Ikeda
Summary: Noninvasive brain imaging studies have shown that higher visual processing of objects occurs in neural populations that are separable along broad semantic categories, particularly living versus nonliving objects. Our findings suggest that the visual processing of living objects relies on stronger causal interactions among sites within ventral temporal lobe (VTL), perhaps reflecting greater integration of visual feature processing.
Article
Clinical Neurology
Olivier Rossel, Felix Schlosser-Perrin, Hugues Duffau, Riki Matsumoto, Emmanuel Mandonnet, Francois Bonnetblanc
Summary: This study aimed to identify criteria for determining direct neurophysiological connections in intraoperative measurement of axono-cortical evoked potentials (ACEP). Through analysis of recorded results, specific characteristics of evoked responses were identified, allowing for differentiation between hotspot activity with direct connectivity to the stimulated site and neighboring activity.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Raffaele Dubbioso, Antonio Suppa, Marina A. J. Tijssen, Akio Ikeda
Summary: FAME/BAFME is a high-penetrant autosomal dominant condition characterized by cortical myoclonus and occasional/rare convulsive seizures. Neurophysiological findings suggest that cortical hyperexcitability in FAME/BAFME may be caused by abnormal neuronal network activity involving both cortical and subcortical structures, particularly the cerebellum. Advanced transcranial magnetic stimulation (TMS) protocols could be used to evaluate the functional connectivity between the cerebellum and cortical structures, and non-invasive brain stimulation techniques may be potential therapeutic tools to improve cortical excitability in FAME/BAFME.
Article
Clinical Neurology
Beatriz G. Giraldez, Jose M. Serratosa, Salvatore Striano, Akio Ikeda, Pasquale Striano, Antonietta Coppola
Summary: Familial adult myoclonus epilepsy (FAME) is an autosomal dominant condition characterized by myoclonic tremor and epilepsy, mainly occurring in adulthood. The clinical course is generally non-progressive or slowly progressive, and epilepsy can be controlled with appropriate medication, allowing individuals to have a normal life expectancy. However, the severity of myoclonus increases with age and can lead to disability in elderly individuals. Since routine genetic tests cannot detect the non-coding repeat expansions responsible for FAME, a clinical diagnosis accompanied by neurophysiological testing is essential for guiding the selection of specific genetic techniques by geneticists.
