Article
Multidisciplinary Sciences
Alice Zanin, Malin Reinholdsson, Tamar Abzhandadze
Summary: This study aimed to investigate whether cognitive deficits screened at acute stroke units could explain subjective cognitive complaints 3 months after stroke. The results showed that intact cognition early after stroke was related to decreased odds of subjective cognitive complaints at the 3-month follow-up, highlighting the importance of both early cognitive screening after stroke and subjective cognitive complaints.
Article
Medicine, General & Internal
Maryline Couette, Stephanie Forte, Damien Oudin Doglioni, Armand Mekontso-Dessap, David Calvet, Kevin H. M. Kuo, Pablo Bartolucci
Summary: This study aimed to investigate the relationship between neurocognitive profiles and clinical characteristics in sickle cell disease (SCD) patients. A cohort study was conducted in adults with SCD who received comprehensive neuropsychological assessments. Cluster analysis based on neuropsychological testing scores was performed and the association with clinical profiles was examined. The results suggest that SCD patients with childhood stroke may be at higher risk of experiencing a global cognitive deficit profile. Therefore, early neurorehabilitation should be prioritized to reduce the long-term cognitive morbidity of SCD, in addition to existing stroke prevention methods.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Anna Maria Lopatkiewicz, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic
Summary: Early apathetic symptoms, but not depressive symptoms, are associated with worse outcomes after stroke.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Shaozhen Ji, Hong Sun, Xianglan Jin, Baoxin Chen, Jing Zhou, Jiayi Zhao, Xiao Liang, Wei Shen, Yunling Zhang, Piu Chan
Summary: This study investigated cognitive outcomes in patients with post-stroke subjective cognitive complaints (SCC) within 1 year after stroke and identified factors associated with cognitive recovery. It found that some patients experienced cognitive recovery after stroke, but those with a higher education level reporting SCC earlier had poorer cognitive recovery. Male sex, higher baseline MoCA scores, coffee intake, and thalamus lesions appeared to independently predict cognitive recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Wenjing Dong, Yaling Lu, Yujia Zhai, Yucong Bi, Yanbo Peng, Zhong Ju, Tan Xu, Xiaoyan Zhong, Yonghong Zhang, Chongke Zhong
Summary: Elevated plasma NPY levels are associated with a decreased risk of cognitive impairment in patients with acute ischemic stroke. Plasma NPY may serve as a predictive factor and potential therapeutic target for post-stroke cognitive impairment (PSCI).
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Valeria Guglielmi, Davide Quaranta, Giovanna Masone Iacobucci, Salvatore Citro, Irene Scala, Danilo Genovese, Valerio Brunetti, Camillo Marra, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to assess the cognitive impairment within 1 week after mechanical thrombectomy. It was found that some patients experienced cognitive impairment after the procedure, which may lead to worse neurological and functional outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Rehabilitation
Britta Nijsse, Daan P. J. Verberne, Johanna M. A. Visser-Meily, Marcel W. M. Post, Paul L. M. De Kort, Caroline M. Van Heugten
Summary: This study tracked long-term subjective cognitive complaints after stroke and found a significant increase in complaints from 2 months to 4 years post-stroke. It revealed that higher levels of cognitive complaints and lower scores on adaptive and maladaptive psychological factors in the early stages after stroke are important predictors of higher subjective cognitive complaints at 4 years post-stroke.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sophia X. Sui, Brenton Hordacre, Julie A. Pasco
Summary: Stroke is a common cause of death and disability, often leading to sarcopenia and cognitive dysfunction as common consequences. There is a lack of awareness and guidance for clinicians and researchers on how to address sarcopenia and cognitive dysfunction as comorbidities after stroke. This review synthesises current knowledge on the relationship between post-stroke sarcopenia and cognitive dysfunction, including physiological pathways, assessment tools, and interventions.
Article
Clinical Neurology
Jacob D. Jones, Rhiannon Rivas, Kenya Luna, Cameron A. Ryczek, Kelsey R. Thomas
Summary: According to the MDS, subjective cognitive complaints (SCC) are a diagnostic criterion for PD-MCI, but they are often not considered in classification. This study aimed to investigate the impact of inclusion/exclusion of SCC on the occurrence of PD-MCI and its association with cognitive decline and CSF markers. Results showed that including SCC decreased the rates of PD-MCI and that PD-MCI + SCC group had greater cognitive decline and higher levels of tau/ab and p-tau/ab.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Minwoo Lee, Na-Young Yeo, Hyo-Jeong Ahn, Jae-Sung Lim, Yerim Kim, Sang-Hwa Lee, Mi Sun Oh, Byung-Chul Lee, Kyung-Ho Yu, Chulho Kim
Summary: This PSCI cohort study aimed to determine the applicability of a machine learning approach for predicting PSCI after stroke. The findings indicate that machine-learning algorithms, particularly the extreme gradient boost and the artificial neural network models, can best predict cognitive outcomes after ischemic stroke.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Chongke Zhong, Zian Lu, Bizhong Che, Sifan Qian, Xiaowei Zheng, Aili Wang, Xiaoqing Bu, Jintao Zhang, Zhong Ju, Tan Xu, Yonghong Zhang
Summary: Plasma levels of choline and betaine were inversely associated with cognitive impairment after ischemic stroke, suggesting potential prognostic roles of these nutrients in poststroke cognitive impairment.
Article
Clinical Neurology
Yangfan Xu, Lingrong Yi, Yangyang Lin, Suiying Peng, Weiming Wang, Wujian Lin, Peize Chen, Weichao Zhang, Yujie Deng, Suimin Guo, Le Shi, Yuling Wang, D. William Molloy, Ronan O'Caoimh
Summary: The study demonstrated that in post-stroke rehabilitation patients, the Chinese version of Qmci can accurately identify PSD patients and is comparable to MoCA-CN, with a shorter assessment time. However, it had lower accuracy in identifying PSCIND patients, warranting further research for validation.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Li Gong, Haichao Wang, Xiaofeng Zhu, Qiong Dong, Qiuyue Yu, Bingjie Mao, Longyan Meng, Yanxin Zhao, Xueyuan Liu
Summary: A nomogram was developed and externally validated to predict post-stroke cognitive impairment (PSCI) among hospitalized population with minor stroke. Trimethylamine N-oxide (TMAO) was also investigated for its association with PSCI. The model had good accuracy and the plasma TMAO levels were higher in patients with cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Cell Biology
Lucia Perez-Blanco, Alba Felpete, Scott B. Patten, Sabela C. Mallo, Arturo X. Pereiro, Maria Campos-Magdaleno, Onesimo Juncos-Rabadan
Summary: This study found that both self-reported and informant-reported subjective cognitive complaints are associated with an increased risk of transitioning from cognitively unimpaired to mild cognitive impairment and/or dementia. The association appears to be stronger and more stable for informant-reported data, providing important information for distinguishing between normal aging and clinical states.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Julia Zinman, Arunima Kapoor, Kevin Si, Sajeevan Sujanthan, Alisia Southwell, Megan L. Cayley, Michelle N. Sicard, Karen Lien, Brian J. Murray, Krista Lanctot, Nathan Herrmann, Dar Dowlatshahi, Demetrios J. Sahlas, Gustavo Saposnik, Jennifer L. Mandzia, Leanne K. Casaubon, Ayman Hassan, Yael Perez, Richard H. Swartz
Summary: This study examined sex differences in the risk of cognitive impairment after stroke. Men showed a higher risk of cognitive impairment after adjusting for age, education, stroke severity, and vascular risk factors, suggesting that other factors may contribute to increased risk among men.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
A. F. Wolters, M. Heijmans, S. Michielse, A. F. G. Leentjens, A. A. Postma, J. F. A. Jansen, D. Ivanov, A. A. Duits, Y. Temel, M. L. Kuijf
Article
Clinical Neurology
Anne E. P. Mulders, Yasin Temel, Mehmet Tonge, Frederic L. W. V. J. Schaper, Vivianne van Kranen-Mastenbroek, Linda Ackermans, Pieter Kubben, Marcus L. F. Janssen, Annelien Duits
Summary: Despite optimal improvement in motor functioning, both short and long-term studies have reported small but consistent changes in cognitive functioning following STN-DBS in Parkinson's disease. However, only few patients showed clinically relevant cognitive decline and surgical characteristics were not significantly associated with cognitive change scores. From a cognitive point of view, DBS may be considered a relatively safe procedure.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Letter
Clinical Neurology
Annelien A. Duits, Lizzy M. M. Boots, Anne E. P. Mulders, Anja J. H. Moonen, Marjolein E. Vugt
MOVEMENT DISORDERS
(2021)
Article
Medicine, Research & Experimental
Tim A. M. Bouwens van der Vlis, Linda Ackermans, Anne E. P. Mulders, Casper A. Vrij, Koen Schruers, Yasin Temel, Annelien Duits, Albert F. G. Leentjens
Summary: Obsessive-compulsive disorder (OCD) is a disabling chronic psychiatric disorder with negative impact on quality of life. Deep brain stimulation (DBS) for severe therapy-resistant OCD shows promising results in modulating specific neural networks associated with symptom improvement.
Article
Clinical Neurology
Anja J. H. Moonen, Anne E. P. Mulders, Luc Defebvre, Annelien Duits, Berengere Flinois, Sebastian Kohler, Mark L. Kuijf, Anne-Claire Leterme, Dominique Servant, Marjolein de Vugt, Kathy Dujardin, Albert F. G. Leentjens
Summary: This study assessed the effectiveness of cognitive behavioral therapy (CBT) in treating anxiety in patients with Parkinson's disease. Results showed that CBT is an effective treatment for reducing situational and social anxiety, as well as avoidance behavior.
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Michael J. Bos, Dianne de Korte-de Boer, Ana Maria Alzate Sanchez, Annelien Duits, Linda Ackermans, Yasin Temel, Anthony R. Absalom, Wolfgang F. Buhre, Mark J. Roberts, Marcus L. F. Janssen
Summary: During STN DBS surgery, the addition of PSA did not show significant differences in motor and non-motor outcomes in PD patients compared to LA alone after twelve months. Both groups had similar changes in motor function, medication dosages, and cognitive function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Medicine, Research & Experimental
Tim A. M. Bouwens van der Vlis, Annelien A. Duits
Review
Medicine, Research & Experimental
Tim A. M. Bouwens van Der Vlis, Annelien Duits, Megan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens
Summary: Deep brain stimulation (DBS) is an effective treatment for refractory obsessive-compulsive disorder (OCD) and neuropsychological assessment plays a crucial role in monitoring the cognitive safety of the treatment. This systematic review found variable cognitive outcomes following DBS for OCD, particularly in domains such as attention, memory, and executive functioning. Further research is needed to better understand the cognitive safety and working mechanisms of DBS for OCD.
Article
Medicine, Research & Experimental
Tim A. M. Bouwens van der Vlis, Megan M. G. H. van de Veerdonk, Linda Ackermans, Albert F. G. Leentjens, Marcus L. F. Janssen, Mark L. Kuijf, Koen R. J. Schruers, Annelien Duits, Felix Gubler, Pieter Kubben, Yasin Temel
Summary: This study retrospectively analyzed adverse events (AEs) of deep brain stimulation (DBS) procedures and found that surgical site infections and wire tethering were the most common AEs. However, major AEs requiring aggressive treatment were rare. A uniform reporting system for surgical and hardware-related AEs in DBS surgery would be useful.
Article
Critical Care Medicine
Pauline van Gils, Caroline van Heugten, Jeannette Hofmeijer, Hanneke Keijzer, Sjoukje Nutma, Annelien Duits
Summary: This study examines the diagnostic value of the Montreal Cognitive Assessment (MoCA) in patients after out-of-hospital cardiac arrest (OHCA). The results show that the MoCA has good sensitivity and adequate specificity in identifying cognitive impairment, with a high negative predictive value.
Article
Medicine, General & Internal
Simona Klinkhammer, Janneke Horn, Johanna M. A. Visser-Meilij, Esmee Verwijk, Annelien Duits, Arjen J. C. Slooter, Caroline M. van Heugten
Summary: This large-scale prospective follow-up study aims to investigate COVID-19-related brain damage, neuropsychological dysfunction, and long-term impact on the well-being of patients and their close ones. The study hypothesizes that structural brain damage and cognitive dysfunction are more likely to occur in severely ill patients, while cognitive complaints, emotional distress, and impact on well-being may be less dependent on illness severity.
Article
Neurosciences
Joshua Harvey, Rick A. Reijnders, Rachel Cavill, Annelien Duits, Sebastian Kohler, Lars Eijssen, Bart P. F. Rutten, Gemma Shireby, Ali Torkamani, Byron Creese, Albert F. G. Leentjens, Katie Lunnon, Ehsan Pishva
Summary: This study aimed to predict cognitive outcomes in Parkinson's disease patients using machine learning models. The research found that clinical variables performed best in predicting cognitive impairment outcomes, and including biofluid and genetic/epigenetic variables slightly improved prediction performance.
NPJ PARKINSONS DISEASE
(2022)
Article
Psychology
Annelien A. Duits, Eva M. de Ronde, R. Saman Vinke, Sandra H. Vos, Rianne A. J. Esselink, Roy P. C. Kessels
Summary: Deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease may not affect facial emotion recognition 1 year after surgery, according to a study of 59 patients with pre- and postoperative assessments. However, it does not rule out the potential impact of facial emotion recognition on the outcome of the surgery.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Maud M. J. Daemen, Lizzy M. M. Boots, Mayke Oosterloo, Marjolein E. de Vugt, Annelien A. Duits
Summary: This study aims to provide insight into the challenges and facilitators HD caregivers face and their needs for a remote support program. The study found that caregivers face a paradox between self-care and caring for others, and challenges such as lack of HD awareness, taboo and shame, loneliness, concerns about heredity and children, and coping with HD symptoms. The study also identified facilitators such as social networks, professional support, openness, early communication, and daily structure. The findings will be used to develop a blended and self-management remote support program to empower caregivers.
AGING & MENTAL HEALTH
(2023)
Meeting Abstract
Clinical Neurology
Maud Daemen, Lizzy Boots, Annelien Duits, Mayke Oosterloo, Marjolein de Vugt
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
