Article
Clinical Neurology
Guillaume Mathey, Guillaume Pische, Marc Soudant, Sophie Pittion-Vouyovitch, Francis Guillemin, Marc Debouverie, Jonathan Epstein
Summary: Patients with benign multiple sclerosis were studied to determine the course of disability progression over a 30-year period. Factors associated with maintaining a benign status included young age at onset and good recovery after the first relapse. Patients who lost their benign status between years 10 and 30 followed a two-stage course, with disability accumulation being similar in all beyond a certain disability score. Those with lower disability scores at advanced age had longer periods of remaining in the benign state.
JOURNAL OF NEUROLOGY
(2021)
Article
Engineering, Electrical & Electronic
Allan Bojarski, Markus Bachmann, Johannes Boeer, Thomas Kraus, Christopher Wecklich, Ulrich Steinbrecher, Nuria Tous-Ramon, Kersten Schmidt, Patrick Klenk, Christo Grigorov, Marco Schwerdt, Manfred Zink
Summary: The TanDEM-X mission, in cooperation with TerraSAR-X, is designed to acquire SAR images for global DEM generation and exploration of new SAR techniques. The mission has successfully achieved its objectives with stable image quality and tailored ground segment. Long-term system monitoring results provide a valuable forerunner for future SAR missions.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2021)
Article
Clinical Neurology
Assunta Dal-Bianco, Guenther Grabner, Claudia Kronnerwetter, Michael Weber, Barbara Kornek, Gregor Kasprian, Thomas Berger, Fritz Leutmezer, Paulus Stefan Rommer, Siegfried Trattnig, Hans Lassmann, Simon Hametner
Summary: Iron rim lesions in multiple sclerosis patients signify a more severe disease course and propensity to develop progressive disease. Long-term follow-up reveals different dynamics of iron rim lesions in relapsing-remitting versus progressive disease, with potential implications for disease progression and brain damage.
Letter
Clinical Neurology
Robert A. Gross, Yan Yuan, Chris Keran, Janis M. Miyasaki
Summary: The study shows that aHSCT can prevent disability worsening in the majority of multiple sclerosis (MS) patients and induce durable improvement in disability, especially in patients with relapsing-remitting MS. The use of the BEAM + ATG conditioning protocol is associated with a more pronounced suppression of clinical relapses and MRI inflammatory activity.
Article
Clinical Neurology
Manuel Comabella, Jaume Sastre-Garriga, Pere Carbonell-Mirabent, Nicolas Fissolo, Carmen Tur, Sunny Malhotra, Deborah Pareto, Francesc X. Aymerich, Jordi Rio, Alex Rovira, Mar Tintore, Xavier Montalban
Summary: This study found that serum neurofilament light chain (sNfL) levels can be used as a prognostic biomarker for future long-term disability progression in patients with progressive multiple sclerosis (MS).
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Immunology
Pablo Arroyo-Pereiro, Lydia Garcia-Serrano, Francisco Morandeira, Blanca Urban, Virginia Mas, Mario Framil, Isabel Leon, Albert Munoz-Vendrell, Elisabet Matas, Lucia Romero-Pinel, Antonio Martinez-Yelamos, Sergio Martinez-Yelamos, Laura Bau
Summary: The potential of kappa-free light chain (kFLC) as a long-term prognostic marker for multiple sclerosis (MS) was explored in this study. The results showed no significant differences in kFLC index between the two groups with different disease courses, indicating that kFLC is unlikely to be a reliable marker for long-term prognosis in MS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Stefan Bittner, Frauke Zipp
Summary: This article discusses current views and concepts for targeting progressive multiple sclerosis (MS). Recent clinical studies have found a closer relationship between relapse-remitting and progressive MS, leading to the introduction of new concepts such as "progression independent of relapse activity". Research on molecular and imaging biomarkers for progressive MS holds promise for identifying high-risk patients at an earlier stage. Novel treatment approaches focus on neuroaxonal protection, myelin regeneration, and modulation of CNS inflammation. Despite some unsuccessful trials, important lessons can still be learned from novel trial designs.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Tjalf Ziemssen, Michael Lang, Stephan Schmidt, Holger Albrecht, Luisa Klotz, Judith Haas, Christoph Lassek, Stefan Lang, Veronika E. Winkelmann, Benjamin Ettle, Ulf Schulze-Topphoff
Summary: The 5-year real-world study in Germany evaluated the benefit-risk profile of fingolimod in patients with relapsing-remitting MS, showing sustained effectiveness with reduced relapse rates and stable disability status. The majority of patients continued fingolimod therapy, and adverse events were mostly non-serious and consistent with the known safety profile of the drug.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Manuel Comabella, Mar Tintore, Augusto Sao Aviles, Pere Carbonell-Mirabent, Sunny Malhotra, Alex Rovira, Nicolas Fissolo, Jan D. Luenemann, Xavier Montalban
Summary: This study evaluated the impact of viral infections on multiple sclerosis (MS) disease progression and found that antibody responses against viruses at disease onset are associated with long-term disease outcomes. The results suggest that immune responses against human cytomegalovirus (HCMV) at early stages have protective effects on long-term disability and inflammation disease outcomes, and immune responses against Epstein-Barr virus (EBV) may influence long-term disease prognosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Oncology
Walker M. Schmidt, Nirosha D. Perera, Francis K. Buadi, Suzanne R. Hayman, Shaji K. Kumar, Angela Dispenzieri, David Dingli, Joselle Cook, Martha Q. Lacy, Prashant Kapoor, Nelson Leung, Eli Muchtar, Rahma M. Warsame, Taxiarchis Kourelis, Moritz Binder, Wilson I. Gonsalves, William J. Hogan, Morie A. Gertz
Summary: This study retrospectively analyzed the outcomes and prognostic markers of 85 multiple myeloma patients who underwent allogeneic stem cell transplant. The overall survival and progression free survival were 1.7 years and 0.71 years, respectively. The five-year survival rates were 22.2% and 15.1%, respectively. The majority of patients relapsed or died within 2 years.
BLOOD CANCER JOURNAL
(2023)
Article
Pediatrics
Nicki Barker, Aditi Sinha, Catherine Jesson, Tahera Doctor, Omendra Narayan, Heather E. Elphick
Summary: This study investigated the use of long-term ventilation (LTV) in the UK paediatric population and compared the results with data collected 10 and 20 years ago. Data were collected from 25 LTV centres in the UK, showing a 2.5-fold increase in the number of children and young people using LTV in the last 10 years. The study identified notable changes in the types of conditions requiring LTV and the use of different ventilation methods.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Clinical Neurology
Antoine Gavoille, Fabien Rollot, Romain Casey, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, Jerome De Seze, Aurelie Ruet, Elisabeth Maillart, Pierre Labauge, Helene Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun-Frenay, Thibault Moreau, David Axel Laplaud, Eric Berger, Bruno Stankoff, Pierre Clavelou, Eric Thouvenot, Olivier Heinzlef, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Philippe Cabre, Abir Wahab, Laurent Magy, Jean-Philippe Camdessanche, Aude Maurousset, Solene Moulin, Nasr Haifa Ben, Dalia Dimitri Boulos, Karolina Hankiewicz, Jean-Philippe Neau, Corinne Pottier, Chantal Nifle, Muriel Rabilloud, Fabien Subtil, Sandra Vukusic
Summary: Using a causal inference approach, this study aimed to estimate the long-term effects of pregnancy on disability and relapse risk in multiple sclerosis (MS) patients. The study found no significant long-term effects of pregnancy on disability, but it did affect relapse risk during the perpartum and postpartum years.
Article
Clinical Neurology
Kyla A. McKay, Emilie Friberg, Neda Razaz, Kristina Alexanderson, Jan Hillert
Summary: The study pointed out that individuals with pediatric-onset multiple sclerosis (PoMS) tend to have lower educational achievements, earnings, and higher reliance on disability benefits compared to those without this condition, indicating that they face more challenges in their working-age life span.
Article
Clinical Neurology
Michael Guger, Christian Enzinger, Fritz Leutmezer, Franziska Di Pauli, Joerg Kraus, Stefan Kalcher, Erich Kvas, Thomas Berger
Summary: The study evaluated the long-term effectiveness of natalizumab (NTZ) in treating multiple sclerosis and identified several demographic, clinical, and radiological predictors related to long-term disease activity. It found that NTZ treatment led to stable disease course in relapse activity and progression for over 7 years, with factors such as higher relapse rate before treatment initiation, higher disability, shorter disease duration, and the absence of Gadolinium-enhancing MRI lesions being associated with reduced relapse risk. Additionally, older age at NTZ start was identified as the only significant risk factor for disease progression over the long-term.
JOURNAL OF NEUROLOGY
(2021)
Correction
Clinical Neurology
G. Boffa, L. Massacesi, M. Inglese
Summary: Despite equal numbers of women and men completing neurology residencies, the majority of AAN members are still men. Based on historical imbalance, it is estimated that women and men will be equal in number among neurologist AAN membership by 2047.
Article
Clinical Neurology
Alan J. Thompson, William Carroll, Olga Ciccarelli, Giancarlo Comi, Anne Cross, Alexis Donnelly, Anthony Feinstein, Robert J. Fox, Anne Helme, Reinhard Hohlfeld, Robert Hyde, Pamela Kanellis, Douglas Landsman, Catherine Lubetzki, Ruth Ann Marrie, Julia Morahan, Xavier Montalban, Bruno Musch, Sarah Rawlings, Marco Salvetti, Finn Sellebjerg, Caroline Sincock, Kathryn E. Smith, Jon Strum, Paola Zaratin, Timothy Coetzee
Summary: This paper reviews recent progress in progressive multiple sclerosis (MS), highlighting the need for a deeper understanding of underlying mechanisms, identification of therapeutic targets, and improved clinical trial design. A global research strategy proposed by the International Progressive MS Alliance aims to address challenges and improve quality of life for MS patients.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Neuroimaging
Carmen Tur, Francesco Grussu, Floriana De Angelis, Ferran Prados, Baris Kanber, Alberto Calvi, Arman Eshaghi, Thalis Charalambous, Rosa Cortese, Declan T. Chard, Jeremy Chataway, Alan J. Thompson, Olga Ciccarelli, Claudia A. M. Gandini Wheeler-Kingshott
Summary: Predicting disability in progressive multiple sclerosis (MS) is challenging due to the lack of established quantitative metrics characterizing spatial distribution of white matter (WM) lesions. A novel approach, SPACE-MS, was introduced to quantitatively characterize spatial distributional features of brain MS lesions, showing that lesions in lower parts of the brain and more isotropic spreading of lesions are associated with clinical deterioration in progressive MS. This approach may be applicable to other conditions with brain WM lesions.
NEUROIMAGE-CLINICAL
(2022)
Editorial Material
Clinical Neurology
Ana Zabalza, Alan J. Thompson, Xavier Montalban
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Respiratory System
Maire Curran, Audrey C. Tierney, Louise Collins, Lauren Kennedy, Ciara McDonnell, Andrew J. Jurascheck, Ali Sheikhi, Cathal Walsh, Brenda Button, Brian Casserly, Roisin Cahalan
Summary: This study aimed to assess the effectiveness of an intervention using wearable technology, goal setting, and text message feedback on physical activity (PA) and health outcomes in people with Cystic Fibrosis (CF). The results showed that personalized PA intervention using wearable technology, goal setting, and text message feedback can increase PA and aerobic capacity in people with CF.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Review
Agriculture, Dairy & Animal Science
Ann Cullinane, Marie Garvey, Cathal Walsh, James Gibbons, Alan Creighton
Summary: This study analyzed 996 academic papers and found a lack of scientific evidence linking non-structural respiratory diseases to poor performance in racehorses. Some researchers have found significant associations between low-grade exercise-induced pulmonary hemorrhage (EIPH) and mild to moderate asthma with poor racing performance, while others suggest they may be normal responses to training and the stable environment. The results indicate inconsistent support for the relationship between proposed diagnostic indicators and poor performance, highlighting the need for better quality evidence and standardized measurements of racehorse performance.
Article
Critical Care Medicine
Mary E. Walsh, Catherine Blake, Cathal D. Walsh, Louise Brent, Jan Sorensen
Summary: This study aimed to identify patient and hospital-level characteristics associated with time to surgery (TTS) in Ireland for hip fracture care. The results showed that factors such as male sex, higher ASA grade, lower pre-morbid mobility, inter-hospital transfer, weekday presentation, pre-operative medical physician assessment, intracapsular fracture type, arthroplasty surgery, general anesthesia, consultant grade of surgeon, and lower hospital-level orthopaedic surgical capacity were associated with longer TTS. On the other hand, the oldest age-group and pre-fracture nursing home residence were associated with shorter TTS. None of the explored protocols for expediting surgery were associated with TTS.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Clinical Neurology
John J. McCabe, Cathal Walsh, Sarah Gorey, Katie Harris, Pablo Hervella, Ramon Iglesias-Rey, Christina Jern, Linxin Li, Nobukazu Miyamoto, Joan Montaner, Annie Pedersen, Francisco Purroy, Peter M. Rothwell, Catherine Sudlow, Yuji Ueno, Mikel Vicente-Pascual, William Whiteley, Mark Woodward, Peter J. Kelly
Summary: This study investigated the association between blood inflammatory markers (hsCRP and IL-6) and recurrent major adverse cardiovascular events (MACE) and stroke in patients with ischemic stroke/transient ischemic attack. The results showed that both hsCRP and IL-6 were independently associated with MACE and recurrent stroke. These findings strengthen the rationale for conducting randomized trials of anti-inflammatory therapies for secondary prevention after ischemic stroke/TIA.
Review
Clinical Neurology
Krzysztof Selmaj, Bruce A. C. Cree, Michael Barnett, Alan Thompson, Hans-Peter Hartung
Summary: This review addresses the changes in treating patients with multiple sclerosis, emphasizing the benefits of initiating treatment with high-efficacy agents. Recent studies have shown that early treatment with high-efficacy agents leads to lower relapse rates and reduced disability progression.
JOURNAL OF NEUROLOGY
(2023)
Review
Psychiatry
David Mcevoy, Ross Brannigan, Lorcan Cooke, Emma Butler, Cathal Walsh, Ella Arensman, Mary Clarke
Summary: This study conducted an umbrella review to examine the risk and protective factors for self-harm in young people. The researchers identified several risk factors related to self-harm, with psychiatric disorders and adverse life events having the strongest evidence. Good family and friend relationships were found to be protective. The study also revealed that non-suicidal and suicidal self-harm shared many of the same risk factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Editorial Material
Clinical Neurology
Sarah L. Wright, Alan J. Thompson
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Alan J. Thompson, Marcello Moccia, Maria Pia Amato, Peter A. Calabresi, Marcia Finlayson, Annie Hawton, Fred D. Lublin, Ruth Ann Marrie, Xavier Montalban, Michael Panzara, Maria Pia Sormani, Jon Strum, Barbara G. Vickrey, Timothy Coetzee
Summary: The survey results show that stakeholders of multiple sclerosis (MS) believe that the current clinical course descriptors need to change and support a mechanism-driven framework for describing MS. Clinical validation and ease of communication with patients are the most important considerations when developing a new framework.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Psychiatry
Eamon Laird, Matthew P. Herring, Brian P. Carson, Catherine B. Woods, Cathal Walsh, Rose Anne Kenny, Charlotte Lund Rasmussen
Summary: This study found that moderate-to-vigorous physical activity (MVPA) can reduce the risk of depression among older adults with chronic illnesses. This is particularly important for older adults with type 2 diabetes, who are more likely to experience depressive symptoms. The study suggests that interventions should focus on promoting and ensuring compliance with MVPA guidelines among chronically-ill individuals, including those with type 2 diabetes, to prevent depression.
PSYCHIATRY RESEARCH
(2023)
Review
Clinical Neurology
Jannis Mueller, Alessandro Cagol, Johannes Lorscheider, Charidimos Tsagkas, Pascal Benkert, Ozgur Yaldizli, Jens Kuhle, Tobias Derfuss, Maria Pia Sormani, Alan Thompson, Cristina Granziera, Ludwig Kappos
Summary: Emerging evidence suggests that progression independent of relapse activity (PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting multiple sclerosis (RRMS). To date, there is no uniform agreed-upon definition of PIRA, limiting the comparability of published studies.
Article
Clinical Neurology
Nitin Sahi, Lukas Haider, Karen Chung, Ferran Prados Carrasco, Baris Kanber, Rebecca Samson, Alan J. Thompson, Claudia A. M. Gandini Wheeler-Kingshott, S. Anand Trip, Wallace Brownlee, Olga Ciccarelli, Frederik Barkhof, Carmen Tur, Henry Houlden, Declan Chard
Summary: This retrospective study explores the genetic influences on long-term disease course and severity in multiple sclerosis. The findings show that specific genes are associated with different pathological mechanisms of the disease, such as white matter inflammation, disability worsening, and the risk of developing secondary progressive multiple sclerosis. These findings are significant for a better understanding of the genetic factors and prognosis of multiple sclerosis.
BRAIN COMMUNICATIONS
(2023)
Article
Neuroimaging
Patrick Freund, Nico Papinutto, Antje Bischof, Michela Azzarito, Gina Kirkish, John Ashburner, Alan Thompson, Stephen L. Hauser, Roland G. Henry
Summary: In this study, a new tool was tested to simultaneously assess the regional distribution of atrophy in the brain and cervical cord of multiple sclerosis (MS) patients. The results showed that this tool can rapidly and accurately evaluate the severity of cord and thalamus atrophy, and its associations with disability and cognition in patients.
NEUROIMAGE-CLINICAL
(2022)